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1. 发明申请

US20060030584A1 2,8-Disubstituted naphthyridine derivatives 失效
标题翻译： 2,8-二取代的萘啶衍生物
公开(公告)号：US20060030584A1
公开(公告)日：2006-02-09
申请号：US11196532
申请日：2005-08-03
申请人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
发明人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , C07D405/14
摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

2. 发明申请

US20080032991A1 2, 8-disubstituted Naphthyridine Derivatives 审中-公开
标题翻译： 2,8-二取代的萘啶衍生物
公开(公告)号：US20080032991A1
公开(公告)日：2008-02-07
申请号：US11872471
申请日：2007-10-15
申请人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
发明人： Gunnar Hanson , Roy Ware , Thomas Barta , He Huang
IPC分类号： A61K31/4375 , A61K31/4545 , A61K31/496 , A61P19/02 , A61P29/00 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04 , C07D405/14
摘要： Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译：公开了式A的化合物及其药学上可接受的盐，其中R 1，R 2，R 2，R 3， R 21，A 1，A 2，X和Z如本文所定义。式A的化合物可用于治疗与细胞分化相关的疾病和/或病症，例如癌症，炎症，关节炎，血管生成等。还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。

3. 发明申请

US20070078146A1 Substituted pyrazoles as p38 kinase inhibitors 失效
标题翻译：取代的吡唑作为p38激酶抑制剂
公开(公告)号：US20070078146A1
公开(公告)日：2007-04-05
申请号：US10840734
申请日：2004-05-05
申请人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
发明人： Ashok Naraian , Michael Clare , Paul Collins , Joyce Crich , Rajesh Devraj , Daniel Flynn , Lifeng Geng , Matthew Graneto , Cathleen Hanau , Gunnar Hanson , Susan Hartmann , Michael Hepperle , He Huang , Ish Khanna , Francis Koszyk , Shuyuan Liao , Suzanne Metz , Win Naing , Richard Partis , Thao Perry , Shashidhar Rao , Shaun Selness , Michael South , Michael Stealey , John Talley , Michael Vazquez , John Walker , Richard Weier , Xiangdong Xu , Syaulan Yang , Yi Yu
IPC分类号： A61K31/506 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D473/00 , C07D487/04 , C07D491/10 , C07D495/04
摘要： A class of pyrazole derivatives is described for use in treating p38 kinase medicated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
摘要翻译：描述了一类吡唑衍生物用于治疗p38激酶药物障碍。特别感兴趣的化合物由式IA定义，其中R 1，R 2，R 3和R 4是如说明书中所述。

4. 发明申请

US20050256180A1 Substituted pyrazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基化合物
公开(公告)号：US20050256180A1
公开(公告)日：2005-11-17
申请号：US11113926
申请日：2005-04-25
申请人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
发明人： Arija Bergmanis , Michael Clare , Joyce Crich , Lifeng Geng , Timothy Hagen , Gunnar Hanson , Stephen Houdek , He Huang , Donna Iula , Francis Koszyk , Shuyuan Liao , Scott Mohler , Maria Nguyen , Richard Partis , Michael Stealey , Michael Tollefson , Richard Weier , Xiangdong Xu , Dominique Bonafoux , Theresa Fletcher , Bruce Hamper , Patrick Lennon , Subo Liao , Suzanne Metz , David Oburn , Thomas Owen , Angela Scates , Michael Vazquez , Serge Wolfson
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P19/02 , A61P25/04 , A61P29/00 , A61P35/00 , C07D231/54 , C07D333/62 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4162
CPC分类号： C07D403/12 , C07D231/54 , C07D333/62 , C07D401/12 , C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.
摘要翻译：本发明涉及取代的吡唑基衍生物，包含这些的组合物，中间体，制备取代的吡唑基衍生物的方法，以及用于治疗癌症，炎症和炎症相关疾病如关节炎的方法。

5. 发明申请

US20050197338A1 Substituted pyrazole urea compounds for the treatment of inflammation 审中-公开
标题翻译：用于治疗炎症的取代的吡唑脲化合物
公开(公告)号：US20050197338A1
公开(公告)日：2005-09-08
申请号：US10970769
申请日：2004-10-21
申请人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
发明人： He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
IPC分类号： A61K31/415 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
CPC分类号： C07D403/10 , C04B35/632 , C07D231/38 , C07D401/12 , C07D403/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要： Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.
摘要翻译：式I的化合物：其中X 1，X 2，L 1，A，R，L 2， R 1，R 12，R 12，R 13，R 14和R 14，和 R 14a如本文所定义。

6. 外观设计

USD928329S1 Wearable health monitor 有权
公开(公告)号：USD928329S1
公开(公告)日：2021-08-17
申请号：US29707085
申请日：2019-09-26
申请人： He Huang , Shiyou Ai
设计人： He Huang , Shiyou Ai

7. 发明授权

US08814958B2 Liquid fuel with endothermic fuel-cracking catalyst 有权
标题翻译：液体燃料与吸热燃料裂解催化剂
公开(公告)号：US08814958B2
公开(公告)日：2014-08-26
申请号：US13188961
申请日：2011-07-22
申请人： He Huang
发明人： He Huang
IPC分类号： C10L1/12
CPC分类号： C10L1/1208 , C10L1/1216 , C10L1/1291 , C10L2200/0231 , C10L2200/0272 , C10L2230/22
摘要： A liquid fuel includes a hydrocarbon-based liquid fuel and an additive mixed with the hydrocarbon-based liquid fuel. The additive includes an endothermic fuel-cracking catalyst.
摘要翻译：液体燃料包括烃基液体燃料和与烃基液体燃料混合的添加剂。添加剂包括吸热燃料裂解催化剂。

8. 发明授权

US08661188B2 Parallel flash memory controller, chip and control method thereof 有权
标题翻译：并行闪存控制器，芯片及其控制方法
公开(公告)号：US08661188B2
公开(公告)日：2014-02-25
申请号：US12599497
申请日：2008-05-05
申请人： He Huang
发明人： He Huang
IPC分类号： G06F12/00
CPC分类号： G06F13/4239
摘要： A parallel flash memory controller, a chip, and a control method thereof are disclosed. First, an on-chip control bus sends flash memory control instructions in parallel to instruction parsing units (211) according to channels. Next, the instruction parsing units store (211) and parse the flash memory instructions corresponding to the flash memory channels, and sequentially send the flash memory control instruction to the flash memory control units (213). Then, the flash memory control units (213) send control instructions to the flash chips in the channels according to rows, and then the control instructions are processed in parallel in flash memory rows. In the present invention, the operations for each channel are performed independently in parallel, the flash memory control units (213) in the channels send the control instructions in series, and meanwhile, in each flash memory row, operations are concurrently performed in parallel. Therefore, the read/write rate of the flash memory is increased for many times, and the bottleneck in adopting flash memory chips to accomplish high-speed and large-capacity storage devices is effectively eliminated.
摘要翻译：公开了并行闪存控制器，芯片及其控制方法。首先，片上控制总线根据信道将指令解析单元（211）并行发送闪存控制指令。接下来，指令解析单元存储（211）并解析对应于闪存通道的闪存指令，并且将闪存控制指令顺序地发送到闪速存储器控制单元（213）。然后，闪速存储器控制单元（213）根据行将控制指令发送到通道中的闪存芯片，然后控制指令在闪存存储器行中并行处理。在本发明中，并行地进行各信道的动作，通道中的闪速存储器控制部（213）串联发送控制指令，同时在每个闪速存储器行中并行并行执行操作。因此，闪速存储器的读/写速率增加了许多次，并且有效地消除了采用闪存芯片来实现高速和大容量存储设备的瓶颈。

9. 发明申请

US20140004560A1 RHIZOPUS ORYZAE STRAIN, MUTAGENESIS AND SCREENING METHODS THEREOF, AND METHODS OF FERMENTING TO PRODUCE FUMARIC ACID 有权
标题翻译：红霉素ORYZAE菌株，MUTAGENESIS和筛选方法及其生产方法
公开(公告)号：US20140004560A1
公开(公告)日：2014-01-02
申请号：US13992233
申请日：2011-04-16
申请人： He Huang , Shuang Li , Qing Xu , Zhen Gao
发明人： He Huang , Shuang Li , Qing Xu , Zhen Gao
IPC分类号： C12P7/46
CPC分类号： C12P7/46 , C12N1/14 , C12N15/01 , C12R1/845
摘要： A rhizopus oryzae strain, mutagenesis and screening methods thereof, and methods of producing fumaric acid by fermentation. The strain is named as Rhizopus oryzae ME-F13, and deposited in China Center for Type Culture Collection with depository number CCTCC M 2010351. The strain is obtained by physically mutagenizing the original strain ME-F12 through ion injection, culturing the processed bacteria on the solid selective plate containing 2-D-deoxylucose (2-DG) and picking up 2-DG-resistant single colony. The strain is capable of simultaneously saccharifying starchy material and fermenting it to produce fumaric acid. With an improved enzymatic activity, the strain can be directly used to ferment raw starchy materials without needing pre-saccharifying.
摘要翻译：根霉菌株，其诱变和筛选方法，以及通过发酵产生富马酸的方法。该菌株被命名为米曲霉ME-F13，并存放于中国型号培养基中心，存放号码为CCTCC M 2010351.该菌株是通过离子注射物理诱变原始菌株ME-F12获得的，含有2-D脱氧葡萄糖（2-DG）的固体选择性板和拾取2-DG抗性单个菌落。该菌株能够同时糖化淀粉物质并将其发酵以产生富马酸。具有改善的酶活性，该菌株可以直接用于发酵生淀粉材料，而不需要预糖化。

10. 发明授权

US08557552B2 Selective neuronal nitric oxide synthase inhibitors 有权
标题翻译：选择性神经元一氧化氮合酶抑制剂
公开(公告)号：US08557552B2
公开(公告)日：2013-10-15
申请号：US13441683
申请日：2012-04-06
申请人： Richard B. Silverman , Haitao Ji , He Huang
发明人： Richard B. Silverman , Haitao Ji , He Huang
IPC分类号： C12N9/99
CPC分类号： C12N9/0073 , C07D401/06 , C07D401/14
摘要： Compounds and related methods for selective inhibition of neuronal nitric oxide synthase over inducible and endothelial isoforms, such compounds as can provide reduced cationic character and enhanced bioavailability.
摘要翻译：用于选择性抑制神经元一氧化氮合酶对诱导型和内皮同种型的化合物和相关方法，可提供降低的阳离子特征和增强的生物利用度。

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