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1. 发明授权

US06548788B2 Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system 失效
标题翻译：使用向心加速度驱动微流体系统中的流体运动的装置和方法
公开(公告)号：US06548788B2
公开(公告)日：2003-04-15
申请号：US09981007
申请日：2001-10-16
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： H05B316
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This system provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the system provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the system are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the system is also provided.
摘要翻译：该系统提供了执行微量分析和微合成分析和程序的方法和装置。具体地，该系统提供了一个微系统平台，用于与微操纵装置一起通过旋转来操纵平台，从而利用由平台的旋转产生的向心力，以通过嵌入在微平台中的微通道来激发流体运动。还提供了具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀的系统的微系统平台，以及使用这些微系统平台进行生物，酶，免疫和化学测定的方法。还提供了一种能够向系统的微系统平台传送电信号的电子主轴设计的转子。

2. 发明授权

US06719682B2 Electronic spindle for using centripetal acceleration to drive fluid movement in a microfluidics system 失效
标题翻译：用于使用向心加速度驱动微流体系统中的流体运动的电子主轴
公开(公告)号：US06719682B2
公开(公告)日：2004-04-13
申请号：US10414536
申请日：2003-04-15
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： B04B900
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译：本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。

3. 发明授权

US06302134B1 Device and method for using centripetal acceleration to device fluid movement on a microfluidics system 失效
标题翻译：在微流体系统上使用向心加速装置流体移动的装置和方法
公开(公告)号：US06302134B1
公开(公告)日：2001-10-16
申请号：US09526496
申请日：2000-03-15
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： F16K3102
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01F2215/0037 , B01F2215/0073 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L7/00 , B01L7/52 , B01L9/527 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译：本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。

4. 发明授权

US6063589A Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system 失效
标题翻译：使用向心加速度驱动微流体系统上的流体运动的装置和方法
公开(公告)号：US6063589A
公开(公告)日：2000-05-16
申请号：US83678
申请日：1998-05-22
申请人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
发明人： Gregory Kellogg , Stephen G. Kieffer-Higgins , Bruce L. Carvalho , Gene A. Davis , John P. Willis , Ted Minior , Laura L. Chapman , Mikayla Kob , Sarah D. Oeltjen , Shari Ommert , Alec Mian
IPC分类号： G01N33/48 , B01F13/00 , B01L3/00 , B01L7/00 , B01L9/00 , B81B1/00 , B81B7/04 , F16K13/10 , F16K31/00 , G01N1/10 , G01N21/07 , G01N31/20 , G01N33/483 , G01N35/00 , G01N37/00 , H01C17/06 , H01C17/065 , H01R39/64 , C12Q1/37
CPC分类号： H01R39/64 , B01F13/0059 , B01F15/0232 , B01F15/0233 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L7/52 , F16K31/002 , G01N21/07 , G01N35/00069 , H01C17/06586 , B01F2215/0037 , B01F2215/0073 , B01L2200/02 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2300/023 , B01L2300/0645 , B01L2300/0806 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1827 , B01L2300/1838 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0421 , B01L2400/0633 , B01L2400/0661 , B01L2400/0677 , B01L2400/0688 , B01L3/5025 , B01L3/502707 , B01L3/502753 , B01L9/527 , Y10S366/03 , Y10S464/90 , Y10T137/1797 , Y10T137/1812 , Y10T137/4643
摘要： This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.
摘要翻译：本发明提供了用于进行微量分析和微合成分析和方法的方法和装置。具体而言，本发明提供了一种微系统平台，用于与微操纵装置一起通过旋转来操纵平台，由此利用由平台的旋转产生的向心力，以激励通过嵌入在微平台中的微通道的流体运动。还提供了本发明的微系统平台，其具有微流体组件，电阻加热元件，温度感测元件，混合结构，毛细管和牺牲阀，以及使用这些微系统平台进行生物，酶，免疫学和化学测定的方法。还提供了一种能够向本发明的微系统平台传送电信号的电子主轴设计的转子。

5. 发明授权

US5202267A Sol capture immunoassay kit and procedure 失效
标题翻译：溶胶捕获免疫测定试剂盒和程序
公开(公告)号：US5202267A
公开(公告)日：1993-04-13
申请号：US177114
申请日：1988-04-04
申请人： Charles C. Ditlow , L. Edward Cannon , Francis X. Cole , Gene A. Davis , Eric C. Sigillo , Alicia G. Danti
发明人： Charles C. Ditlow , L. Edward Cannon , Francis X. Cole , Gene A. Davis , Eric C. Sigillo , Alicia G. Danti
IPC分类号： G01N33/53 , G01N33/543 , G01N33/58
CPC分类号： G01N33/585 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： An immunoassay procedure for detection of analytes in urine wherein an immunological reaction is conducted in an aqueous phase containing the urine and a filterable immunocomposite containing an inherently colored gold sol particle is formed if the assay is positive. The colored, gold sol particle containing immunocomposite is collected for direct visual observation on a filter element. False positive readings are minimized by (1) removing contaminants from the urine to prevent clogging of the filter element and non-specific binding of unreacted reactants thereto by contacting the urine with a porous contact element having a detergent material dispersed on its external and interstitial surfaces; (2) preventing non-specific binding of unreacted immunoreactive substances to the filter element by blocking the latter with polyvinyl pyrrolidone; and/or (3) including a green dye material in the aqueous reaction phase to improve the optical distinction after washing the collection filter between negative and positive results on the filter.
摘要翻译：用于检测尿液中分析物的免疫测定方法，其中在含有尿液的水相中进行免疫反应，并且如果测定为阳性，则形成含有固有着色的金溶胶颗粒的可过滤的免疫复合物。收集含有免疫复合物的彩色金溶胶颗粒，以便在过滤元件上进行直观目视观察。通过（1）从尿中除去污染物以防止过滤元件堵塞和未反应的反应物的非特异性结合使假阳性读数最小化，使尿与具有分散在其外部和间隙表面上的洗涤剂材料的多孔接触元件接触 ; （2）通过用聚乙烯吡咯烷酮封闭后者，防止未反应的免疫反应性物质与过滤元件的非特异性结合; 和/或（3）在水性反应相中包括绿色染料材料，以改善在过滤器上的负和正结果之后洗涤收集过滤器之后的光学区别。

6. 发明授权

US6083760A Sol capture immunoassay kit and procedure 失效
标题翻译：溶胶捕获免疫测定试剂盒和程序
公开(公告)号：US6083760A
公开(公告)日：2000-07-04
申请号：US998869
申请日：1992-12-30
申请人： Charles C. Ditlow , L. Edward Cannon , Francis X. Cole , Gene A. Davis , Eric C. Sigillo , Alicia G. Danti
发明人： Charles C. Ditlow , L. Edward Cannon , Francis X. Cole , Gene A. Davis , Eric C. Sigillo , Alicia G. Danti
IPC分类号： G01N33/53 , G01N33/543 , G01N33/58 , B01D37/02
CPC分类号： G01N33/585 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： An immunoassay procedure for detection of analytes in urine wherein an immunological reaction is conducted in an aqueous phase containing the urine and a filterable immunocomposite containing an inherently colored gold sol particle is formed if the assay is positive. The colored, gold sol particle containing immunocomposite is collected for direct visual observation on a filter element. False positive readings are minimized by (1) removing contaminants from the urine to prevent clogging of the filter element and non-specific binding of unreacted reactants thereto by contacting the urine with a porous contact element having a detergent material dispersed on its external and interstitial surfaces; (2) preventing non-specific binding of unreacted immunoreactive substances to the filter element by blocking the latter with polyvinyl pyrrolidone; and/or (3) including a green dye material in the aqueous reaction phase to improve the optical distinction after washing the collection filter between negative and positive results on the filter.
摘要翻译：用于检测尿液中分析物的免疫测定方法，其中在含有尿液的水相中进行免疫反应，并且如果测定为阳性，则形成含有固有着色的金溶胶颗粒的可过滤的免疫复合物。收集含有免疫复合物的彩色金溶胶颗粒，以便在过滤元件上进行直观目视观察。通过（1）从尿中除去污染物以防止过滤元件堵塞和未反应的反应物的非特异性结合使假阳性读数最小化，通过使尿与具有分散在其外部和间隙表面上的洗涤剂材料的多孔接触元件接触 ; （2）通过用聚乙烯吡咯烷酮封闭后者，防止未反应的免疫反应性物质与过滤元件的非特异性结合; 和/或（3）在水性反应相中包括绿色染料材料，以改善在过滤器上的负和正结果之后洗涤收集过滤器之后的光学区别。

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