专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09144583B2 Cell separation apparatus and methods of use 有权
标题翻译：细胞分离装置及使用方法
公开(公告)号：US09144583B2
公开(公告)日：2015-09-29
申请号：US11789188
申请日：2007-04-23
申请人： Gregory D. Ariff , Thomas Cannon , Jennifer L. Case , Christian L. Haller , Paul Kosnik , Charles P. Luddy , Craig A. Mauch , Erik Vossman , Stuart K. Williams
发明人： Gregory D. Ariff , Thomas Cannon , Jennifer L. Case , Christian L. Haller , Paul Kosnik , Charles P. Luddy , Craig A. Mauch , Erik Vossman , Stuart K. Williams
IPC分类号： A01N1/00 , A61K35/00 , A61P43/00 , C12M1/00 , A61K35/12
CPC分类号： C12M47/04 , A61K35/12 , C12M45/05 , C12M45/06 , C12M45/09
摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
摘要翻译：本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。

2. 发明申请

US20080014181A1 Cell separation apparatus and methods of use 有权
标题翻译：细胞分离装置及使用方法
公开(公告)号：US20080014181A1
公开(公告)日：2008-01-17
申请号：US11789188
申请日：2007-04-23
申请人： Gregory Ariff , Thomas Cannon , Jennifer Case , Christian Haller , Paul Kosnik , Charles Luddy , Craig Mauch , Erik Vossman , Stuart Williams
发明人： Gregory Ariff , Thomas Cannon , Jennifer Case , Christian Haller , Paul Kosnik , Charles Luddy , Craig Mauch , Erik Vossman , Stuart Williams
IPC分类号： A01N1/00 , A61K35/00 , A61P43/00 , C12M1/00
CPC分类号： C12M47/04 , A61K35/12 , C12M45/05 , C12M45/06 , C12M45/09
摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
摘要翻译：本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。

3. 发明授权

US08727965B2 Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells 有权
标题翻译：用脂肪基质细胞支持移植组织和移植工程阴茎组织的组织整合和统计学的方法和组合物
公开(公告)号：US08727965B2
公开(公告)日：2014-05-20
申请号：US12718805
申请日：2010-03-05
申请人： Stuart K Williams , Hyun Joon Paek , Erik Vossman
发明人： Stuart K Williams , Hyun Joon Paek , Erik Vossman
IPC分类号： A61F2/26
CPC分类号： A61F2/26
摘要： The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and/or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.
摘要翻译：本发明总体上涉及用于增强移植到受试者中的组织或细胞移植物的血管形成的方法，组合物和用途。特别地，本发明的一个方面提供方法和组合物，其包括使用群体的基质血管部分（SVF）细胞来包封或包围组织或细胞移植物以增强组织或细胞移植物的血管形成。本发明的另一方面提供了通过将一组SVF细胞与组织或细胞移植物组合以形成与SVF细胞混合的移植物来增强组织或细胞移植物血管形成的方法和组合物。另一方面提供一种组合物，其包含工程化的海绵体组织，其包含SVF细胞和海绵体细胞，其中所述SVF细胞可与海绵体细胞混合或包裹，以及其使用方法，例如用于治疗阳in的方法，以及勃起功能障碍和/或增强或构建阴茎。在一些实施方案中，SVF细胞可被普遍设计以分泌治疗性蛋白质或促血管生成因子。

4. 发明申请

US20110218396A1 METHODS AND COMPOSITIONS TO SUPPORT TISSUE INTEGRATION AND INOSCULATION OF TRANSPLANTED TISSUE AND TRANSPLANTED ENGINEERED PENILE TISSUE WITH ADIPOSE STROMAL CELLS 有权
标题翻译：支持组织整合的方法和组合物和移植组织和移植的工程化骨组织与ADIPOSE STROMAL CELL
公开(公告)号：US20110218396A1
公开(公告)日：2011-09-08
申请号：US12718805
申请日：2010-03-05
申请人： Stuart K. Williams , Hyun Joon Paek , Erik Vossman
发明人： Stuart K. Williams , Hyun Joon Paek , Erik Vossman
IPC分类号： A61F2/26
CPC分类号： A61F2/26
摘要： The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and/or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.
摘要翻译：本发明总体上涉及用于增强移植到受试者中的组织或细胞移植物的血管形成的方法，组合物和用途。特别地，本发明的一个方面提供方法和组合物，其包括使用群体的基质血管部分（SVF）细胞来包封或包围组织或细胞移植物以增强组织或细胞移植物的血管形成。本发明的另一方面提供了通过将一组SVF细胞与组织或细胞移植物组合以形成与SVF细胞混合的移植物来增强组织或细胞移植物血管形成的方法和组合物。另一方面提供一种组合物，其包含工程化的海绵体组织，其包含SVF细胞和海绵体细胞，其中所述SVF细胞可与海绵体细胞混合或包裹，以及其使用方法，例如用于治疗阳in的方法，以及勃起功能障碍和/或增强或构建阴茎。在一些实施方案中，SVF细胞可被普遍设计以分泌治疗性蛋白质或促血管生成因子。

5. 发明申请

US20140193852A9 ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE 审中-公开
标题翻译：在使用过程中使用的ADIPOSE组织收集和预处理设备
公开(公告)号：US20140193852A9
公开(公告)日：2014-07-10
申请号：US12437548
申请日：2009-05-07
申请人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
发明人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
IPC分类号： C12Q1/04 , C12N5/02 , C12M1/00
CPC分类号： C12M45/02 , C12M45/05 , C12M47/04
摘要： Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module.
摘要翻译：描述了用于预处理包含感兴趣的细胞的组织样品用于各种治疗程序的装置和方法。可以通过切碎和分离装置从组织样品中提取纤维材料，得到含有感兴趣细胞的非纤维样品，然后将其洗涤并离心以除去流体，油和污染物。然后可以将样品在大容量容器中消化，并且容器内的活塞可将所得释放的细胞悬浮液推动通过细胞浓缩器，例如中空纤维分离模块。

6. 发明申请

US20100285521A1 ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE 审中-公开
标题翻译：在使用过程中使用的ADIPOSE组织收集和预处理设备
公开(公告)号：US20100285521A1
公开(公告)日：2010-11-11
申请号：US12437548
申请日：2009-05-07
申请人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
发明人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
IPC分类号： C12Q1/04 , C12M1/00 , C12N5/02
CPC分类号： C12M45/02 , C12M45/05 , C12M47/04
摘要： Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module.
摘要翻译：描述了用于预处理包含感兴趣的细胞的组织样品用于各种治疗程序的装置和方法。可以通过切碎和分离装置从组织样品中提取纤维材料，得到含有感兴趣细胞的非纤维样品，然后将其洗涤并离心以除去流体，油和污染物。然后可以将样品在大容量容器中消化，并且容器内的活塞可将所得释放的细胞悬浮液推动通过细胞浓缩器，例如中空纤维分离模块。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式