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1. 发明授权

US08727965B2 Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells 有权
标题翻译：用脂肪基质细胞支持移植组织和移植工程阴茎组织的组织整合和统计学的方法和组合物
公开(公告)号：US08727965B2
公开(公告)日：2014-05-20
申请号：US12718805
申请日：2010-03-05
申请人： Stuart K Williams , Hyun Joon Paek , Erik Vossman
发明人： Stuart K Williams , Hyun Joon Paek , Erik Vossman
IPC分类号： A61F2/26
CPC分类号： A61F2/26
摘要： The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and/or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.
摘要翻译：本发明总体上涉及用于增强移植到受试者中的组织或细胞移植物的血管形成的方法，组合物和用途。特别地，本发明的一个方面提供方法和组合物，其包括使用群体的基质血管部分（SVF）细胞来包封或包围组织或细胞移植物以增强组织或细胞移植物的血管形成。本发明的另一方面提供了通过将一组SVF细胞与组织或细胞移植物组合以形成与SVF细胞混合的移植物来增强组织或细胞移植物血管形成的方法和组合物。另一方面提供一种组合物，其包含工程化的海绵体组织，其包含SVF细胞和海绵体细胞，其中所述SVF细胞可与海绵体细胞混合或包裹，以及其使用方法，例如用于治疗阳in的方法，以及勃起功能障碍和/或增强或构建阴茎。在一些实施方案中，SVF细胞可被普遍设计以分泌治疗性蛋白质或促血管生成因子。

2. 发明申请

US20110218396A1 METHODS AND COMPOSITIONS TO SUPPORT TISSUE INTEGRATION AND INOSCULATION OF TRANSPLANTED TISSUE AND TRANSPLANTED ENGINEERED PENILE TISSUE WITH ADIPOSE STROMAL CELLS 有权
标题翻译：支持组织整合的方法和组合物和移植组织和移植的工程化骨组织与ADIPOSE STROMAL CELL
公开(公告)号：US20110218396A1
公开(公告)日：2011-09-08
申请号：US12718805
申请日：2010-03-05
申请人： Stuart K. Williams , Hyun Joon Paek , Erik Vossman
发明人： Stuart K. Williams , Hyun Joon Paek , Erik Vossman
IPC分类号： A61F2/26
CPC分类号： A61F2/26
摘要： The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and/or enhance or construct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.
摘要翻译：本发明总体上涉及用于增强移植到受试者中的组织或细胞移植物的血管形成的方法，组合物和用途。特别地，本发明的一个方面提供方法和组合物，其包括使用群体的基质血管部分（SVF）细胞来包封或包围组织或细胞移植物以增强组织或细胞移植物的血管形成。本发明的另一方面提供了通过将一组SVF细胞与组织或细胞移植物组合以形成与SVF细胞混合的移植物来增强组织或细胞移植物血管形成的方法和组合物。另一方面提供一种组合物，其包含工程化的海绵体组织，其包含SVF细胞和海绵体细胞，其中所述SVF细胞可与海绵体细胞混合或包裹，以及其使用方法，例如用于治疗阳in的方法，以及勃起功能障碍和/或增强或构建阴茎。在一些实施方案中，SVF细胞可被普遍设计以分泌治疗性蛋白质或促血管生成因子。

3. 发明申请

US20140193852A9 ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE 审中-公开
标题翻译：在使用过程中使用的ADIPOSE组织收集和预处理设备
公开(公告)号：US20140193852A9
公开(公告)日：2014-07-10
申请号：US12437548
申请日：2009-05-07
申请人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
发明人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
IPC分类号： C12Q1/04 , C12N5/02 , C12M1/00
CPC分类号： C12M45/02 , C12M45/05 , C12M47/04
摘要： Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module.
摘要翻译：描述了用于预处理包含感兴趣的细胞的组织样品用于各种治疗程序的装置和方法。可以通过切碎和分离装置从组织样品中提取纤维材料，得到含有感兴趣细胞的非纤维样品，然后将其洗涤并离心以除去流体，油和污染物。然后可以将样品在大容量容器中消化，并且容器内的活塞可将所得释放的细胞悬浮液推动通过细胞浓缩器，例如中空纤维分离模块。

4. 发明申请

US20100285521A1 ADIPOSE TISSUE COLLECTION AND PRE-PROCESSING DEVICES FOR USE IN LIPOSUCTION PROCEDURE 审中-公开
标题翻译：在使用过程中使用的ADIPOSE组织收集和预处理设备
公开(公告)号：US20100285521A1
公开(公告)日：2010-11-11
申请号：US12437548
申请日：2009-05-07
申请人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
发明人： Erik Vossman , Shannon Iwami , Anthony Yang , Tom Cannon , Hyun Joon Paek
IPC分类号： C12Q1/04 , C12M1/00 , C12N5/02
CPC分类号： C12M45/02 , C12M45/05 , C12M47/04
摘要： Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to remove fluids, oil, and contaminants. The sample may then be digested in a large-volume container, and a piston within the container may push the resulting liberated cell suspension through a cell concentrator such as a hollow-fiber separation module.
摘要翻译：描述了用于预处理包含感兴趣的细胞的组织样品用于各种治疗程序的装置和方法。可以通过切碎和分离装置从组织样品中提取纤维材料，得到含有感兴趣细胞的非纤维样品，然后将其洗涤并离心以除去流体，油和污染物。然后可以将样品在大容量容器中消化，并且容器内的活塞可将所得释放的细胞悬浮液推动通过细胞浓缩器，例如中空纤维分离模块。

5. 发明申请

US20110027239A1 ADIPOSE-DERIVED STROMAL CELLS (ASC) AS DELIVERY TOOL FOR TREATMENT OF CANCER 审中-公开
标题翻译： ADIPOSE-DERIVED STROMAL CELLS（ASC）作为用于治疗癌症的递送工具
公开(公告)号：US20110027239A1
公开(公告)日：2011-02-03
申请号：US12511940
申请日：2009-07-29
申请人： Hyun Joon Paek
发明人： Hyun Joon Paek
IPC分类号： A61K35/12 , A61P35/04
CPC分类号： C12N15/111 , A61K35/28 , C12N2310/11 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： The present invention generally relates to use of adult Adipose-derived stromal cells (ASC) and genetically engineered ASC for the treatment of cancer. In particular, the present invention generally relates, in part to a method for treating a subject with cancer comprising administering to the subject a composition comprising engineered ASCs which have been modified to express a gene encoding at least one anti-cancer agent. In some embodiments, an anti-cancer agent is a pro-apoptotic agent. In some embodiments an anti-cancer agent is an agent which inhibits the expression of an oncogene.
摘要翻译：本发明一般涉及成年脂肪来源的基质细胞（ASC）和遗传工程化ASC用于治疗癌症的用途。特别地，本发明一般地涉及用于治疗患有癌症的受试者的方法，包括向受试者施用包含经修饰以表达编码至少一种抗癌药的基因的工程化ASC的组合物。在一些实施方案中，抗癌剂是促凋亡剂。在一些实施方案中，抗癌剂是抑制癌基因表达的药剂。

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