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1. 发明申请

US20080014181A1 Cell separation apparatus and methods of use 有权
标题翻译：细胞分离装置及使用方法
公开(公告)号：US20080014181A1
公开(公告)日：2008-01-17
申请号：US11789188
申请日：2007-04-23
申请人： Gregory Ariff , Thomas Cannon , Jennifer Case , Christian Haller , Paul Kosnik , Charles Luddy , Craig Mauch , Erik Vossman , Stuart Williams
发明人： Gregory Ariff , Thomas Cannon , Jennifer Case , Christian Haller , Paul Kosnik , Charles Luddy , Craig Mauch , Erik Vossman , Stuart Williams
IPC分类号： A01N1/00 , A61K35/00 , A61P43/00 , C12M1/00
CPC分类号： C12M47/04 , A61K35/12 , C12M45/05 , C12M45/06 , C12M45/09
摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
摘要翻译：本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。

2. 发明授权

US09144583B2 Cell separation apparatus and methods of use 有权
标题翻译：细胞分离装置及使用方法
公开(公告)号：US09144583B2
公开(公告)日：2015-09-29
申请号：US11789188
申请日：2007-04-23
申请人： Gregory D. Ariff , Thomas Cannon , Jennifer L. Case , Christian L. Haller , Paul Kosnik , Charles P. Luddy , Craig A. Mauch , Erik Vossman , Stuart K. Williams
发明人： Gregory D. Ariff , Thomas Cannon , Jennifer L. Case , Christian L. Haller , Paul Kosnik , Charles P. Luddy , Craig A. Mauch , Erik Vossman , Stuart K. Williams
IPC分类号： A01N1/00 , A61K35/00 , A61P43/00 , C12M1/00 , A61K35/12
CPC分类号： C12M47/04 , A61K35/12 , C12M45/05 , C12M45/06 , C12M45/09
摘要： The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.
摘要翻译：本发明提供了用于支持各种细胞疗法和组织工程方法的自动化装置。本发明提供了一种能够从用于细胞疗法和/或组织工程的组织样品中分离细胞的自动细胞分离装置。细胞分离装置可以与诸如细胞收集装置和/或Sodding装置的补充装置组合使用以支持各种疗法。自动化装置包括介质和组织解离化学储存器，过滤器，细胞分离器和通过支撑移植物基质或其它血管内装置的移植室的灌注流动回路。本发明还提供了使用本文所述装置制备的组织移植物和细胞样品在包括血管重建，组织和器官的再血管重建和重建以及治疗和预防疾病的多种疗法中的方法。

3. 发明申请

US20050186671A1 Automated bioculture and bioculture experiments system 有权
标题翻译：自动生物培养和生物培养实验系统
公开(公告)号：US20050186671A1
公开(公告)日：2005-08-25
申请号：US11063599
申请日：2005-02-24
申请人： Thomas Cannon , Laura Cohn , Peter Quinn , Paul Kosnik
发明人： Thomas Cannon , Laura Cohn , Peter Quinn , Paul Kosnik
IPC分类号： C12M1/00 , C12M3/00 , C12M3/06 , C12N5/08
CPC分类号： C12M41/00 , C12M23/42 , C12M23/48 , C12M29/04 , C12M29/10 , C12M37/00 , Y10S435/809
摘要： The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points. The integral flowpath cartridge aseptic sampling system provides for dynamic analysis of metabolic products or representative cells from the culture.
摘要翻译：本发明提供了一种用于精细细胞生物学研究工具和临床细胞生长和维持应用的反馈控制的生物培养平台。该系统提供单独的闭环流径柱，具有集成的无菌取样和路线到采集瓶或分析系统。该系统可以在标准实验室或其他孵化器中操作，以提供必要的气体和热环境。系统墨盒是模块化的，可以独立运行或统一的系统控制架构下运行，并提供用于研究和临床应用的细胞和细胞产品的放大生产。流路筒的多次重复允许单独的，但是重复的细胞培养生长和可以根据实验设计而变化的实验模型的倍数，或调节到细胞培养终点的期望的细胞发育。积分流路管柱无菌取样系统提供了对来自培养物的代谢产物或代表性细胞的动态分析。

4. 发明授权

US3970559A Drain guard 失效
标题翻译：排水守卫
公开(公告)号：US3970559A
公开(公告)日：1976-07-20
申请号：US534586
申请日：1974-12-19
申请人： Thomas Cannon , Frances G. H. Cannon , Jane E. H. Cowan , Bernard McCarthy
发明人： Thomas Cannon , Frances G. H. Cannon , Jane E. H. Cowan , Bernard McCarthy
IPC分类号： E03B9/10 , E03F5/06 , E03F5/08 , E03F1/00
CPC分类号： E03B9/10 , E03F5/06 , E03F5/08
摘要： A drain guard is disclosed having a tubular body with a funnel-shaped portion at its upper end. The tubular body has an annular recess extending about the inside periphery thereof proximate the bottom end of the guard. The recess receives a sealing grommet therein for sealing the space between a tube on which the guard is positioned and the inner periphery of the tubular portion of the guard. Stop lugs are positioned about the inner periphery of the tubular portion of the guard at the junction of the funnel-shaped end portion thereof for limiting the upward movement of the tube on which the guard is positioned through the drain guard. A liquid permeable seat is positioned on the funnel-shaped end portion of the drain to permit the ingress of water or other liquids with respect to the drain guard. In an alternative embodiment of the invention, a rubber grommet is affixed to the inside periphery of the drain guard at the junction of the tubular and funnel shaped portions thereof with the grommet serving to limit the upward movement of the tube on which the guard is positioned and to seal the space between the guard and the tube to inhibit the passage of liquids therebetween.
摘要翻译：公开了一种排水管，其上端具有漏斗形部分的管状体。管状体具有围绕其靠近护罩底端的内周延伸的环形凹部。该凹部在其中容纳密封垫圈，用于密封防护件所在的管与护罩的管状部分的内周之间的空间。止动凸耳围绕防护件的管状部分的内周边定位在其漏斗形端部的接合部处，以限制护罩在其上定位的管的向上运动通过排水管。液体可渗透的座位置在漏斗的漏斗形端部，以允许水或其他液体相对于排水管进入。在本发明的替代实施例中，橡胶垫圈在管状和漏斗状部分的接合部处与排水保护罩的内周边固定在一起，用于限制防护罩所在的管的向上运动并且密封防护件和管之间的空间以阻止液体之间的通过。

5. 发明授权

US4138066A Food grinder 失效
标题翻译：食物研磨机
公开(公告)号：US4138066A
公开(公告)日：1979-02-06
申请号：US792601
申请日：1977-05-02
申请人： Keith M. Mullins , Thomas K. Leppert , Thomas Cannon , Ronald R. Kerr , Ronn G. Smith
发明人： Keith M. Mullins , Thomas K. Leppert , Thomas Cannon , Ronald R. Kerr , Ronn G. Smith
IPC分类号： A47J19/00 , A47J44/00 , B02C18/30
CPC分类号： A47J19/00
摘要： A food grinder has an upstanding base unit within which is included an electric motor. A worm-driven gear linkage serves to deliver motion from the motor. Defined in one side of the base unit is a receptacle within which is received a cassette. The cassette includes a food grinding mechanism which receives motion from the linkage so as to operate that mechanism.
摘要翻译：食品研磨机具有直立的基本单元，其中包括电动机。蜗杆驱动齿轮联动装置用于从电动机传递运动。在基座单元的一侧中定义的是容纳件，其中容纳有盒。所述盒包括食物研磨机构，其接收来自所述连接件的运动，以便操作所述机构。

6. 发明申请

US20080032398A1 Automated bioculture and bioculture experiments system 审中-公开
标题翻译：自动生物培养和生物培养实验系统
公开(公告)号：US20080032398A1
公开(公告)日：2008-02-07
申请号：US11893430
申请日：2007-08-15
申请人： Thomas Cannon , Laura Cohn , Peter Quinn
发明人： Thomas Cannon , Laura Cohn , Peter Quinn
IPC分类号： C12M3/00 , C12M1/26 , C12N5/02
CPC分类号： C12M23/42 , C12M23/48 , C12M29/04 , C12M29/10 , C12M37/00 , C12M41/00 , Y10S435/809
摘要： The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points. The integral flowpath cartridge aseptic sampling system provides for dynamic analysis of metabolic products or representative cells from the culture.
摘要翻译：本发明提供了一种用于精细细胞生物学研究工具和临床细胞生长和维持应用的反馈控制的生物培养平台。该系统提供单独的闭环流径柱，具有集成的无菌取样和路线到采集瓶或分析系统。该系统可以在标准实验室或其他孵化器中操作，以提供必要的气体和热环境。系统墨盒是模块化的，可以独立运行或统一的系统控制架构下运行，并提供用于研究和临床应用的细胞和细胞产品的放大生产。流路筒的多次重复允许单独的，但是重复的细胞培养生长和可以根据实验设计而变化的实验模型的倍数，或调节到细胞培养终点的期望的细胞发育。积分流路管柱无菌取样系统提供了对来自培养物的代谢产物或代表性细胞的动态分析。

7. 发明授权

US4083467A Infant training tumbler 失效
标题翻译：婴儿训练滚筒
公开(公告)号：US4083467A
公开(公告)日：1978-04-11
申请号：US792600
申请日：1977-05-02
申请人： Keith M. Mullins , Thomas Cannon , Thomas K. Leppert , Thomas R. Burnell
发明人： Keith M. Mullins , Thomas Cannon , Thomas K. Leppert , Thomas R. Burnell
IPC分类号： A47G19/22
CPC分类号： A47G19/2272
摘要： An infant training tumbler includes an upright tubular housing within which is an upright internal web that divides the housing into a pair of longitudinal compartments. Affixed upon the upper end of the housing is a cap that completes a closure of the upper end of that one compartment. Openings in the cap permit the egress of liquid from the cap upon tilting of the housing. The geometrical relationships are such that the compartment is opposite the egress opening so that, upon a dropping of the housing, the openings are in a position that prevents significant spillage.
摘要翻译：婴幼儿训练转鼓包括一个直立的管状外壳，一个直立的内部腹板将外壳分成一对纵向隔间。固定在外壳的上端的是盖子，其完成了该隔间的上端的封闭。盖子上的开口允许在外壳倾斜时从盖子中排出液体。几何关系使得隔室与出口开口相对，使得在外壳下落时，开口处于防止显着溢出的位置。

8. 发明授权

US5247166A Form reader with linear CCD scanner and drum feed 失效
标题翻译：带有线性CCD扫描仪和滚筒进给的读卡器
公开(公告)号：US5247166A
公开(公告)日：1993-09-21
申请号：US902549
申请日：1992-06-22
申请人： Thomas Cannon , Daniel Smith , Mark Bowen
发明人： Thomas Cannon , Daniel Smith , Mark Bowen
IPC分类号： G06K19/00 , G06K7/14 , G06K13/08
CPC分类号： G06K13/08 , G06K7/14
摘要： A form reader especially for lottery forms with handwritten marks or bar codes includes a drum transport engaging the form, and a stepping motor advances the form circularly along a path around the drum, passing through a linear reading station elongated perpendicularly to the path. A light source illuminates the form at the read station and reflected light is incident on an elongated array of charge coupled device (CCD) light sensors via a focusing lens arrangement. An analog comparator coupled to a serial output of the CCD sensors digitizes encode and encodes each pixel in the elongated array repetitively during transport, sampling the reflectance of the form and defining an X-Y array of pixels. A digital processor coupled to an image memory analyzes the data for predetermined patterns such as handwritten marks, printed reference marks and/or printed bar code or OCR characters on the form. A throat sensor detects the form at an inlet to the reader for initiating operation of the stepping motor when the form is present. Form guides align the form generally to the transport path, and can be laterally movable for aligning one or both edges of the form to the transport path.
摘要翻译：特别是具有手写标记或条形码的彩票形式的表格阅读器包括接合该形式的鼓式传送器，并且步进电机沿着绕鼓的路径循环地前进，通过垂直于路径延伸的线性阅读站。光源照亮读站的形式，反射光通过聚焦透镜装置入射到电荷耦合器件（CCD）光传感器的细长阵列上。耦合到CCD传感器的串行输出的模拟比较器在传输期间重复编码和编码细长阵列中的每个像素，对形式的反射率进行采样并且定义X-Y像素阵列。耦合到图像存储器的数字处理器在表格上分析诸如手写标记，打印的参考标记和/或打印的条形码或OCR字符之类的预定图案的数据。喉部传感器检测在读取器的入口处的形式，用于当形式存在时启动步进电机的操作。形状引导件一般将该形式对准传送路径，并且可以横向移动，以将形式的一个或两个边缘对准传送路径。

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