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1. 发明授权

US06455032B1 Composition and method for protecting skin from UV induced immunosuppression and skin damage 有权
标题翻译：用于保护皮肤免受UV诱导的免疫抑制和皮肤损伤的组合物和方法
公开(公告)号：US06455032B1
公开(公告)日：2002-09-24
申请号：US09582317
申请日：2000-06-23
申请人： Graham Edmund Kelly , Alan James Husband
发明人： Graham Edmund Kelly , Alan James Husband
IPC分类号： A61K742
CPC分类号： A61Q19/004 , A61K8/492 , A61K8/498 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/404 , A61K31/4745 , A61K2800/92 , A61Q17/04 , A61Q19/00
摘要： Compositions and a method of protecting skin from either UV-induced immunosuppression or from UV-induced skin damage using a composition containing an extract of soy or clover, and/or the isoflavone compounds genistein, biochanin, dihydro-diadzein, formonentin, dihydro-geneistein, 2-dehydro-O-desmethyl-angolensin, tetrahydro-daidzein, equol, dehydro-equol, O-desmethyl-angolensin, or 6-hydroxy-O-desmethyl-angolensin.
摘要翻译：组合物和使用含有大豆或三叶草提取物和/或异黄酮化合物染料木黄酮，鹰嘴豆素，二氢 - 二酮糖，福音酮，二氢基质丝氨酸的组合物来保护皮肤免受UV诱导的免疫抑制或UV诱导的皮肤损伤的方法，2-脱氢-O-去甲基 - 血管紧张素，四氢 - 黄豆苷元，雌马酚，脱氢 - 牛尿酚，O-去甲基 - 血管紧张素或6-羟基-O-去甲基 - 血管紧张素。

2. 发明授权

US06599536B1 Therapy of estrogen-associated disorders 失效
标题翻译：雌激素相关疾病的治疗
公开(公告)号：US06599536B1
公开(公告)日：2003-07-29
申请号：US09647092
申请日：2000-12-05
申请人： Graham Edmund Kelly , Alan James Husband
发明人： Graham Edmund Kelly , Alan James Husband
IPC分类号： A61K3578
CPC分类号： A61K31/35 , A61K36/48 , A61K2300/00
摘要： A method for the treatment, prophylaxis, amelioration or prevention of disorders associated with abnormally high activity of steroidal estrogens, which includes administering to a human subject a composition comprising an isoflavone-containing extract of clover or chick peas, said extract comprising primarily biochanin, or a ratio of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries and/or diluents is described. Also described are compositions and uses comprising the isoflavone containing extracts.
摘要翻译：一种用于治疗，预防，改善或预防与异常高活性的甾族雌激素相关的疾病的方法，其包括向人类受试者施用包含含有异黄酮的三叶草或鹰嘴豆提取物的组合物，所述提取物主要包含生长激素或花呢素与一种或多种异黄酮组合的比例，其范围为约2:1至约5:1，任选与一种或多种药学上可接受的载体，赋形剂，助剂和/ 或稀释剂。还描述了包含含异黄酮的提取物的组合物和用途。

3. 发明授权

US07419998B2 Therapeutic methods and compositions involving isoflavones 失效
公开(公告)号：US07419998B2
公开(公告)日：2008-09-02
申请号：US11024512
申请日：2004-12-28
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/40 , A61K31/35 , A61K31/335 , A61K31/24 , A61K31/22 , A61K31/08 , A61K31/415 , A61K31/05
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H. C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CORC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.

4. 发明授权

US07714151B2 Aminated isoflavonoid derivatives and uses thereof 失效
标题翻译：氨基异黄酮衍生物及其用途
公开(公告)号：US07714151B2
公开(公告)日：2010-05-11
申请号：US10532074
申请日：2003-11-03
申请人： Graham Edmund Kelly , Andrew Heaton , Jane Faragalla , John Bremner
发明人： Graham Edmund Kelly , Andrew Heaton , Jane Faragalla , John Bremner
IPC分类号： C07D311/02
CPC分类号： A61K31/352 , C07D311/68
摘要： Aminated isoflavonoid synthesized by aminating the 4-keto group of isoflavanone and isoflavanone ring systems, pharmaceutical compositions containing same and uses thereof as therapeutic agents.
摘要翻译：通过胺化异黄酮和异黄烷酮环系的4-酮基合成的氨基异黄酮，含有其的药物组合物和其用作治疗剂。

5. 发明授权

US07648968B2 Methods of treating dermal ulcers using glucans 失效
标题翻译：使用葡聚糖治疗皮肤溃疡的方法
公开(公告)号：US07648968B2
公开(公告)日：2010-01-19
申请号：US11499904
申请日：2006-08-04
申请人： Graham Edmund Kelly
发明人： Graham Edmund Kelly
IPC分类号： A61K31/716 , A61K31/717 , A61K31/718 , A61K31/721 , A61K47/00
CPC分类号： A61Q17/04 , A61K8/73 , A61K31/716 , A61L26/0023 , A61Q19/004 , A61Q19/08 , C08B37/0024 , C12P19/04 , Y10S514/925 , Y10S514/928 , C08L5/00
摘要： The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of dermal ulcers. The water insoluble microparticulate glucans used in the compositions comprise branched β-(1,3)(1,6) glucan. The glucan compositions used in the present invention are essentially free of unbranched β-(1,3)(1,6) glucan and non-glucan components.
摘要翻译：本发明涉及使用包含水不溶性微粒葡聚糖的葡聚糖组合物在治疗皮肤溃疡中的方法。组合物中使用的水不溶性微粒葡聚糖包含支链β-（1,3）（1,6）葡聚糖。用于本发明的葡聚糖组合物基本上不含无支化的β-（1,3）（1,6）葡聚糖和非葡聚糖组分。

6. 发明授权

US07202273B2 Therapeutic methods and compositions involving isoflavones 失效
公开(公告)号：US07202273B2
公开(公告)日：2007-04-10
申请号：US10176762
申请日：2002-06-21
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/35 , A61K31/045 , A61K31/445
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2Rc where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CORC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl

7. 发明授权

US06562380B1 Methods for treating or reducing prediposition to breast cancer, pre-menstrual syndrome or symptoms associated with menopause by administration of phyto-estrogen 失效
标题翻译：通过施用植物雌激素治疗或减少经前综合征或与更年期相关的症状的倾向的方法
公开(公告)号：US06562380B1
公开(公告)日：2003-05-13
申请号：US08910837
申请日：1997-08-13
申请人： Graham Edmund Kelly
发明人： Graham Edmund Kelly
IPC分类号： A61K3578
CPC分类号： A61K31/35 , A23L11/05 , A23L11/07 , A23L33/11 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K36/48 , A61K38/08 , A61K2300/00
摘要： Phyto-estrogen-containing health supplement compositions containing any two or more of Genistein, Daidzein, Formononetin and Biochanin A, or the natural glycosides thereof are administered for treating or reducing predisposition to breast cancer, pre-menstrual syndrome or symptoms of menopause.
摘要翻译：给予含有染料木黄酮，大豆黄素，角叉菜胶蛋白素和鹰嘴豆素A或其天然糖苷中任意两种以上的含植物雌激素的健康补充剂组合物，用于治疗或减少乳腺癌的易感性，月经前期症状或更年期症状。

8. 发明授权

US07915308B2 Therapeutic methods and compositions involving isoflavones 失效
标题翻译：涉及异黄酮的治疗方法和组合物
公开(公告)号：US07915308B2
公开(公告)日：2011-03-29
申请号：US12177843
申请日：2008-07-22
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/35 , A61K31/045 , A61K31/445
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.
摘要翻译：描述了治疗方法，组合物和食品，其含有通式（1）所述的异黄酮化合物，其中Z为H，R 1为H，或其中RA为C 1-10烷基或氨基酸，R 2为H，OH的RACO 或ORB，其中RB是氨基酸，或CORA，其中RA如前所定义，W是H，A是H或OH，B选自（a），（b），（c）或W是H 并且A和B一起形成选自（d）或W，A和B的六元环，与它们相关的基团一起取代，包括（e）或W和A与其组合它们相关联，包括（f）和B是（g）其中R 3是H，其中RA如前所定义的CORA，其中RC是C 1-10烷基的CO 2 C或其中R B如前所定义的CORB，R 4是H，CORD，其中RD 是H，OH，C 1-10烷基或氨基酸，其中RC如前所定义的CO 2 CORE，其中RE是H，C 1-10烷基或氨基酸，COOH，CORC，其中RC如前所定义，或CONHRE，其中RE是像以前的defi R 5为H，其中RC如前所定义的CO 2 R C或其中RC和RE如前所定义的CORCORE，并且其中两个R 5基团连接至相同基团，它们相同或不同，R 6为H或羟基C 1 -10烷基，X优选为O，但可以为N或S，Y为（h），其中R 7为H或C 1-10烷基。

9. 发明授权

US07312344B2 Dimeric isoflavones 失效
标题翻译：二聚异黄酮
公开(公告)号：US07312344B2
公开(公告)日：2007-12-25
申请号：US10469957
申请日：2002-03-08
申请人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
发明人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
IPC分类号： C07D311/00
CPC分类号： C07D311/58 , C07D311/38
摘要： A compound of the general formula (I) or (II) wherein X is O, NR4 or S and R1-R8 are as defined in the specification
摘要翻译：通式（I）或（II）的化合物，其中X为O，NR 4或S且R 1 -R 8为如说明书中所定义

10. 发明授权

US06649648B1 Therapeutic methods and compositions involving isoflavones 有权
标题翻译：涉及异黄酮的治疗方法和组合物
公开(公告)号：US06649648B1
公开(公告)日：2003-11-18
申请号：US09254026
申请日：1999-08-05
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K3135
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.
摘要翻译：描述了治疗方法，组合物和食品，其含有通式（I）所述的异黄酮化合物，其中Z为H，R 1为H，或其中RA为C 1-10烷基或氨基酸，R 2为H，OH 或ORB，其中RB是氨基酸，或CORA，其中RA如前所定义，W是H，A是H或OH，B选自（a），（b），（c）或W是H 并且A和B一起形成选自（d）或W，A和B的六元环，与它们相关的基团一起取代，包括（e）或W和A与其组合它们相关联，包括（f）和B是（g）其中R 3是H，其中RA如前所定义的CORA，其中RC是C 1-10烷基的CO 2 C或其中R B如前所定义的CORB，R 4是H，CORD，其中RD 是H，OH，C 1-10烷基或氨基酸，其中RC如前所定义的CO 2 CORE，其中RE是H，C 1-10烷基或氨基酸，COOH，CORC，其中RC如前所定义，或CONHRE，其中RE是像以前的defi R 5为H，其中RC如前所定义的CO 2 R C或其中RC和RE如前所定义的CORCORE，并且其中两个R 5基团连接至相同基团，它们相同或不同，R 6为H或羟基C 1 -10烷基，X优选为O，但可以为N或S，Y为（h），其中R 7为H或C 1-10烷基。

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