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1. 发明授权

US07714151B2 Aminated isoflavonoid derivatives and uses thereof 失效
标题翻译：氨基异黄酮衍生物及其用途
公开(公告)号：US07714151B2
公开(公告)日：2010-05-11
申请号：US10532074
申请日：2003-11-03
申请人： Graham Edmund Kelly , Andrew Heaton , Jane Faragalla , John Bremner
发明人： Graham Edmund Kelly , Andrew Heaton , Jane Faragalla , John Bremner
IPC分类号： C07D311/02
CPC分类号： A61K31/352 , C07D311/68
摘要： Aminated isoflavonoid synthesized by aminating the 4-keto group of isoflavanone and isoflavanone ring systems, pharmaceutical compositions containing same and uses thereof as therapeutic agents.
摘要翻译：通过胺化异黄酮和异黄烷酮环系的4-酮基合成的氨基异黄酮，含有其的药物组合物和其用作治疗剂。

2. 发明授权

US07312344B2 Dimeric isoflavones 失效
标题翻译：二聚异黄酮
公开(公告)号：US07312344B2
公开(公告)日：2007-12-25
申请号：US10469957
申请日：2002-03-08
申请人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
发明人： Andrew Heaton , Graham Edmund Kelly , Naresh Kumar
IPC分类号： C07D311/00
CPC分类号： C07D311/58 , C07D311/38
摘要： A compound of the general formula (I) or (II) wherein X is O, NR4 or S and R1-R8 are as defined in the specification
摘要翻译：通式（I）或（II）的化合物，其中X为O，NR 4或S且R 1 -R 8为如说明书中所定义

3. 发明授权

US07488494B2 Compositions and therapeutic methods involving isoflavones and analogues thereof 失效
标题翻译：涉及异黄酮及其类似物的组合物和治疗方法
公开(公告)号：US07488494B2
公开(公告)日：2009-02-10
申请号：US10704385
申请日：2003-11-07
申请人： Andrew Heaton , Naresh Kumar , Graham Edmund Kelly , Alan Husband
发明人： Andrew Heaton , Naresh Kumar , Graham Edmund Kelly , Alan Husband
IPC分类号： A61K47/22 , A61K31/47 , C07D335/04 , C07D311/04
CPC分类号： C07D311/26 , A23L33/10 , A23L33/11 , A23V2002/00 , C07D311/36 , C07D311/38 , C07D311/58 , C07D471/06 , A23V2250/2116 , A23V2200/30
摘要： Isoflavone compounds are described and recommended as therapeutic agents. Exemplified and preferred compounds are (a). Indications show compounds have good competitive binding to estrogen receptors. This is exemplified
摘要翻译：描述和推荐异黄酮化合物作为治疗剂。示例性和优选的化合物是（a）。适应症显示化合物与雌激素受体具有良好的竞争性结合。这是例证

4. 发明授权

US07419998B2 Therapeutic methods and compositions involving isoflavones 失效
公开(公告)号：US07419998B2
公开(公告)日：2008-09-02
申请号：US11024512
申请日：2004-12-28
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/40 , A61K31/35 , A61K31/335 , A61K31/24 , A61K31/22 , A61K31/08 , A61K31/415 , A61K31/05
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H. C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CORC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.

5. 发明授权

US07915308B2 Therapeutic methods and compositions involving isoflavones 失效
标题翻译：涉及异黄酮的治疗方法和组合物
公开(公告)号：US07915308B2
公开(公告)日：2011-03-29
申请号：US12177843
申请日：2008-07-22
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/35 , A61K31/045 , A61K31/445
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.
摘要翻译：描述了治疗方法，组合物和食品，其含有通式（1）所述的异黄酮化合物，其中Z为H，R 1为H，或其中RA为C 1-10烷基或氨基酸，R 2为H，OH的RACO 或ORB，其中RB是氨基酸，或CORA，其中RA如前所定义，W是H，A是H或OH，B选自（a），（b），（c）或W是H 并且A和B一起形成选自（d）或W，A和B的六元环，与它们相关的基团一起取代，包括（e）或W和A与其组合它们相关联，包括（f）和B是（g）其中R 3是H，其中RA如前所定义的CORA，其中RC是C 1-10烷基的CO 2 C或其中R B如前所定义的CORB，R 4是H，CORD，其中RD 是H，OH，C 1-10烷基或氨基酸，其中RC如前所定义的CO 2 CORE，其中RE是H，C 1-10烷基或氨基酸，COOH，CORC，其中RC如前所定义，或CONHRE，其中RE是像以前的defi R 5为H，其中RC如前所定义的CO 2 R C或其中RC和RE如前所定义的CORCORE，并且其中两个R 5基团连接至相同基团，它们相同或不同，R 6为H或羟基C 1 -10烷基，X优选为O，但可以为N或S，Y为（h），其中R 7为H或C 1-10烷基。

6. 发明授权

US06649648B1 Therapeutic methods and compositions involving isoflavones 有权
标题翻译：涉及异黄酮的治疗方法和组合物
公开(公告)号：US06649648B1
公开(公告)日：2003-11-18
申请号：US09254026
申请日：1999-08-05
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K3135
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2RC where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CO2RC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl.
摘要翻译：描述了治疗方法，组合物和食品，其含有通式（I）所述的异黄酮化合物，其中Z为H，R 1为H，或其中RA为C 1-10烷基或氨基酸，R 2为H，OH 或ORB，其中RB是氨基酸，或CORA，其中RA如前所定义，W是H，A是H或OH，B选自（a），（b），（c）或W是H 并且A和B一起形成选自（d）或W，A和B的六元环，与它们相关的基团一起取代，包括（e）或W和A与其组合它们相关联，包括（f）和B是（g）其中R 3是H，其中RA如前所定义的CORA，其中RC是C 1-10烷基的CO 2 C或其中R B如前所定义的CORB，R 4是H，CORD，其中RD 是H，OH，C 1-10烷基或氨基酸，其中RC如前所定义的CO 2 CORE，其中RE是H，C 1-10烷基或氨基酸，COOH，CORC，其中RC如前所定义，或CONHRE，其中RE是像以前的defi R 5为H，其中RC如前所定义的CO 2 R C或其中RC和RE如前所定义的CORCORE，并且其中两个R 5基团连接至相同基团，它们相同或不同，R 6为H或羟基C 1 -10烷基，X优选为O，但可以为N或S，Y为（h），其中R 7为H或C 1-10烷基。

7. 发明授权

US06497906B1 Dietary supplements comprising soy hypocotyls containing at least one isoflavone 失效
标题翻译：膳食补充剂包含含有至少一种异黄酮的大豆胚轴
公开(公告)号：US06497906B1
公开(公告)日：2002-12-24
申请号：US09547100
申请日：2000-04-11
申请人： Graham Edmund Kelly
发明人： Graham Edmund Kelly
IPC分类号： A61K3578
CPC分类号： A61K31/35 , A23L11/05 , A23L11/07 , A23L33/11 , A61K31/353 , A61K31/7048 , A61K36/185 , A61K36/48 , A61K38/08 , A61K2300/00
摘要： Composition enriched with natural phyto-estrogens or analogs thereof selected from Genistein, Daidzein, Formomometin, and Biochanin A. These may be used as food additives, tablets, or capsules for promoting health in cases of cancer, premenstrual syndrome, menopause, or hypercholestrolaemia.
摘要翻译：富含天然植物雌激素或其类似物的组合物，其选自染料木黄酮，大豆黄素，形成子蛋白和生姜粉A.这些可以用作在癌症，经前期综合征，绝经期或高胆固醇血症的情况下促进健康的食品添加剂，片剂或胶囊。

8. 发明授权

US06242594B1 Process for glucan preparation and therapeutic uses of glucan 失效
标题翻译：葡聚糖制备方法和葡聚糖的治疗用途
公开(公告)号：US06242594B1
公开(公告)日：2001-06-05
申请号：US08894773
申请日：1997-12-02
申请人： Graham Edmund Kelly
发明人： Graham Edmund Kelly
IPC分类号： C07H100
CPC分类号： A61Q17/04 , A61K8/73 , A61K31/716 , A61L26/0023 , A61Q19/004 , A61Q19/08 , C08B37/0024 , C12P19/04 , Y10S514/925 , Y10S514/928 , C08L5/00
摘要： A process for the production of &bgr;-3-(1,3)(1,6) glucan from a glucan containing cellular source is described, together with compositions and uses/methods of treatment involving glucan. The process of the invention comprises the steps of: (a) extracting glucan containing cells with alkali and heat, in order to remove alkali soluble components; (b) acid extracting the cells of step (a) with an acid and heat to form a suspension; (c) extracting the suspension obtained of step (b) or recovered hydrolyzed cells with an organic solvent which is non-miscible with water and which has a density greater than that of water separating the resultant aqueous phase, solvent containing phase and interface so that substantially only the aqueous phase comprising &bgr;-(1,3)(1,6) glucan particulate material remains; wherein the extraction with said organic solvent provides separation of glucan subgroups comprising branched &bgr;-(1,3)(1,6)-glucan, and essentially unbranched &bgr;-(1,3) glucan which is associated with residual non-glucan contaminents; and (d) drying the glucan material from step (c) to give microparticulate glucan.
摘要翻译：描述了从含葡聚糖的细胞来源生产β-3-（1,3）（1,6）葡聚糖的方法，以及涉及葡聚糖的组合物和用途/治疗方法。本发明的方法包括以下步骤：（a）用碱和热提取含葡聚糖的细胞，以除去碱溶性组分; （b）用酸和热将酸步骤（a）的细胞萃取以形成悬浮液; （c）用与水不溶的有机溶剂提取步骤（b）获得的悬浮液或回收的水解细胞，其密度大于分离所得水相，含溶剂相和界面的水的密度，使得基本上只剩下包含β-（1,3）（1,6）葡聚糖颗粒材料的水相; 其中用所述有机溶剂萃取提供葡聚糖亚组的分离，所述葡聚糖亚组包含与残留的非葡聚糖污染物相关的支链β-（1,3）（1,6） - 葡聚糖和基本上未分支的β-（1,3）葡聚糖; 和（d）干燥步骤（c）的葡聚糖材料，得到微粒葡聚糖。

9. 发明授权

US07648968B2 Methods of treating dermal ulcers using glucans 失效
标题翻译：使用葡聚糖治疗皮肤溃疡的方法
公开(公告)号：US07648968B2
公开(公告)日：2010-01-19
申请号：US11499904
申请日：2006-08-04
申请人： Graham Edmund Kelly
发明人： Graham Edmund Kelly
IPC分类号： A61K31/716 , A61K31/717 , A61K31/718 , A61K31/721 , A61K47/00
CPC分类号： A61Q17/04 , A61K8/73 , A61K31/716 , A61L26/0023 , A61Q19/004 , A61Q19/08 , C08B37/0024 , C12P19/04 , Y10S514/925 , Y10S514/928 , C08L5/00
摘要： The present invention is directed to methods of using glucan compositions, comprising water insoluble microparticulate glucans, in the treatment of dermal ulcers. The water insoluble microparticulate glucans used in the compositions comprise branched β-(1,3)(1,6) glucan. The glucan compositions used in the present invention are essentially free of unbranched β-(1,3)(1,6) glucan and non-glucan components.
摘要翻译：本发明涉及使用包含水不溶性微粒葡聚糖的葡聚糖组合物在治疗皮肤溃疡中的方法。组合物中使用的水不溶性微粒葡聚糖包含支链β-（1,3）（1,6）葡聚糖。用于本发明的葡聚糖组合物基本上不含无支化的β-（1,3）（1,6）葡聚糖和非葡聚糖组分。

10. 发明授权

US07202273B2 Therapeutic methods and compositions involving isoflavones 失效
公开(公告)号：US07202273B2
公开(公告)日：2007-04-10
申请号：US10176762
申请日：2002-06-21
申请人： Graham Edmund Kelly , George Eustace Joannou
发明人： Graham Edmund Kelly , George Eustace Joannou
IPC分类号： A61K31/35 , A61K31/045 , A61K31/445
CPC分类号： A61K8/498 , A61K8/35 , A61K8/492 , A61K31/12 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/4745 , A61K2800/522 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C07C45/46 , C07C45/673 , C12P7/26 , C12P17/04 , C12P17/10 , A61K2300/00 , C07C49/83 , C07C49/84
摘要： Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (1), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R2 is H, OH, or ORB where RB is an amino acid, or CORA where RA is as previously defined, W is H, A is H or OH, and B is selected from (a), (b), (c), or W is H, and A and B taken together form a six-membered ring selected from (d), or W, A and B taken with the groups with which they are associated comprise (e), or W and A taken together with the groups with which they are associated comprise (f) and B is (g) wherein R3 is H, CORA where RA is as previously defined, CO2Rc where RC is C1-10alkyl, or CORB where RB is as previously defined, R4 is H, CORD where RD is H, OH, C1-10alkyl or an amino acid, CO2RC where RC is as previously defined, CORE where RE is H, C1-10alkyl or an amino acid, COOH, CORC where RC is as previously defined, or CONHRE where RE is as previously defined, R5 is H, CORC where RC is as previously defined, or CORCORE where RC and RE are as previously defined, and where the two R5 groups are attached to the same group they are the same or different, R6 is H or hydroxy C1-10alkyl, X is preferably O, but may be N or S, and Y is (h) where R7 is H, or C1-10alkyl

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