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1. 发明授权

US06706869B1 Map kinase phosphatases and polynucleotides encoding them 失效
标题翻译：映射激酶磷酸酶和编码它们的多核苷酸
公开(公告)号：US06706869B1
公开(公告)日：2004-03-16
申请号：US09311021
申请日：1999-05-13
申请人： Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Michael J. Agostino
发明人： Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Michael J. Agostino
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

2. 发明申请

US20080139452A1 Secreted proteins and polynucleotides encoding them 审中-公开
公开(公告)号：US20080139452A1
公开(公告)日：2008-06-12
申请号：US12000468
申请日：2007-12-13
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
IPC分类号： A61K38/00 , C07K14/00 , A61P43/00
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.

3. 发明授权

US07344861B2 Secreted proteins and polynucleotides encoding them 失效
标题翻译：分泌蛋白质和编码它们的多核苷酸
公开(公告)号：US07344861B2
公开(公告)日：2008-03-18
申请号：US11395249
申请日：2006-04-03
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
IPC分类号： C12N5/10 , C12N15/12 , C12N15/62
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

4. 发明授权

US08084197B2 Identification of molecular sequence signatures and methods involving the same 有权
标题翻译：鉴定分子序列特征及涉及相同的方法
公开(公告)号：US08084197B2
公开(公告)日：2011-12-27
申请号：US11745987
申请日：2007-05-08
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.
摘要翻译：用于分析衍生自靶核酸和不同序列多核苷酸探针之间的杂交测定的杂交数据的新颖方法和方法涉及选择定义用于序列特征的参考序列的探针组，并且基于其杂交获得关于靶核酸分子的性质的有用数据到探头。所述方法对于确定靶是否含有核酸或多肽序列特征，靶是否编码基因家族的成员，或者靶是否衍生自任何数量的基因之一是有用的。

5. 发明授权

US07135285B2 Identification of molecular sequence signatures and methods involving the same 有权
公开(公告)号：US07135285B2
公开(公告)日：2006-11-14
申请号：US10099442
申请日：2002-03-14
申请人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
发明人： David J. Lockhart , Gordon G. Wong , Pennina Langer-Safer
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C12Q2565/515
摘要： Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

6. 发明授权

US07122633B2 Natural killer stimulatory factor 失效
标题翻译：自然杀伤刺激因子
公开(公告)号：US07122633B2
公开(公告)日：2006-10-17
申请号：US10358395
申请日：2003-02-05
申请人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Stanley F. Wolf , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K14/64
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

7. 发明授权

US5908763A DNA encoding GM-CSF and a method of producing GM-CSF protein 失效
标题翻译：编码GM-CSF的DNA和生产GM-CSF蛋白的方法
公开(公告)号：US5908763A
公开(公告)日：1999-06-01
申请号：US287019
申请日：1994-08-08
申请人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong , Elizabeth A. Wang
发明人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong , Elizabeth A. Wang
IPC分类号： A61K38/00 , C07K14/535 , C12N15/27 , C12N15/70 , C12N15/81 , C12N15/85 , C07K14/53 , C12N15/63
CPC分类号： C12N15/85 , C07K14/535 , C12N15/70 , C12N15/81 , A61K38/00 , C12N2800/206 , C12N2830/00 , C12N2830/702 , C12N2840/105 , C12N2840/44
摘要： A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises:preparing RNA from a cell that produces CSF;preparing polyadenylated messenger RNA from said RNA;preparing single stranded cDNA from said messenger RNA;converting the single stranded cDNA to double stranded cDNA;inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies;picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool;transfecting the plasmid DNA into suitable host cells for expressing CSF protein;culturing the transfected cells and assaying the supernatant for CSF activity; andselecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e. CSF/cDNA), a microorganism or cell line transformed with a recombinant vector containing such CSF/cDNA, and a method for producing CSF protein by expressing said CSF/cDNA by culturing a microorganism or cell line. The invention also provides a method of purifying the CSF proteins and the purified proteins so produced.
摘要翻译：描述了制备和分离含有CSF / cDNA的转化载体的方法。该方法包括：从产生CSF的细胞制备RNA; 从所述RNA制备聚腺苷酸化的信使RNA; 从所述信使RNA制备单链cDNA; 将单链cDNA转化为双链cDNA; 将双链cDNA插入转化载体并用所述载体转化细菌以形成菌落; 分别取200至500个菌落的池，每个池中分离出质粒DNA; 将质粒DNA转染到合适的宿主细胞中以表达CSF蛋白; 培养转染的细胞并测定上清液的CSF活性; 并选择CSF阳性池并筛选用于制备池的菌落以鉴定具有CSF活性的菌落。还描述了编码具有CSF活性的蛋白质（即CSF / cDNA）的cDNA，用含有这种CSF / cDNA的重组载体转化的微生物或细胞系，以及通过培养表达所述CSF / cDNA来产生CSF蛋白的方法微生物或细胞系。本发明还提供了纯化CSF蛋白质和如此制备的纯化蛋白质的方法。

8. 发明授权

US5811523A Antibodies to natural killer stimulatory factor 失效
公开(公告)号：US5811523A
公开(公告)日：1998-09-22
申请号：US956240
申请日：1997-10-22
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi , Stanley F. Wolf
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24
CPC分类号： C07K14/5434 , C07K14/52 , A61K38/00
摘要： A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.

9. 发明授权

US06555658B2 Antibodies to natural killer stimulatory factor 失效
标题翻译：抗自然杀伤刺激因子的抗体
公开(公告)号：US06555658B2
公开(公告)日：2003-04-29
申请号：US09924703
申请日：2001-08-09
申请人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
发明人： Giorgio Trinchieri , Bice Perussia , Steven C. Clark , Gordon G. Wong , Rodney Hewick , Michiko Kobayashi
IPC分类号： C07K1624
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/52
摘要： This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
摘要翻译：本申请涉及与人外周血淋巴细胞体外诱导γ干扰素生成能力的新型均质人细胞因子天然杀伤剂刺激因子（NKSF）反应的抗体，以及含有该抗体的药物制剂。

10. 发明授权

US06410229B1 Expression monitoring by hybridization to high density nucleic acid arrays 有权
标题翻译：通过与高密度核酸阵列杂交进行表达监测
公开(公告)号：US06410229B1
公开(公告)日：2002-06-25
申请号：US09212004
申请日：1998-12-14
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与RNA转录物互补衍生自RNA转录物的核酸; 并定量阵列中的杂交核酸。

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