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1. 发明授权

US08273245B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and methods for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08273245B2
公开(公告)日：2012-09-25
申请号：US13292903
申请日：2011-11-09
申请人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
发明人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

2. 发明授权

US07955504B1 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US07955504B1
公开(公告)日：2011-06-07
申请号：US11243937
申请日：2005-10-04
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。

3. 发明授权

US08137554B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08137554B2
公开(公告)日：2012-03-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。该方法首先形成纳米晶体纤维素的水性分散体。然后形成包含水分散体和沸点高于水的有机液体的混合物。然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

4. 发明申请

US20120074062A1 MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHODS FOR THEIR MANUFACTURE AND USE 有权
标题翻译：微流体装置，包含聚合膜的特别过滤装置及其制造和使用方法
公开(公告)号：US20120074062A1
公开(公告)日：2012-03-29
申请号：US13292903
申请日：2011-11-09
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

5. 发明申请

US20110253629A1 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US20110253629A1
公开(公告)日：2011-10-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D61/24 , B01D35/18
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。该方法首先形成纳米晶体纤维素的水性分散体。然后形成包含水分散体和沸点高于水的有机液体的混合物。然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

6. 发明申请

US20120292246A1 MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHOD FOR THEIR MANUFACTURE AND USE 审中-公开
标题翻译：微流体装置，包含聚合膜的特别过滤装置及其制造和使用方法
公开(公告)号：US20120292246A1
公开(公告)日：2012-11-22
申请号：US13560721
申请日：2012-07-27
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

7. 发明授权

US06399018B1 Powdered material rapid production tooling method and objects produced therefrom 失效
标题翻译：粉末材料快速生产加工方法和由此产生的物体
公开(公告)号：US06399018B1
公开(公告)日：2002-06-04
申请号：US09293706
申请日：1999-04-16
申请人： Randall M. German , Timothy J. Weaver , Julian A. Thomas , Sundar V. Atre , Anthony Griffo
发明人： Randall M. German , Timothy J. Weaver , Julian A. Thomas , Sundar V. Atre , Anthony Griffo
IPC分类号： B22F700
CPC分类号： B22F3/22 , B22F3/26 , B22F2998/00 , C22C1/1015 , C22C1/1036 , Y10T428/12007 , B22F5/007 , B22F1/0014 , B22F2207/01
摘要： Solid objects are made by means of a novel multi-step forming, debinding, sintering and infiltrating process, using a metal-ceramic composition. In this process, the mixture is held for a period of time to degas and settle the powdered material from a liquid binder. The packed geometry is then heated to above the melting temperature of the binder to remove the binder portion of the solid geometry. Upon removal of the binder the binder-free solid geometry is raised to a temperature where the metal pre-sinters together into a three-dimensional rigid matrix with interconnected porosity to form a solid precursor. The porous matrix includes the particulate ceramic material and a first metal, which are at least partially sintered. A molten second metal is then introduced to the fill the porous matrix and form an infiltrated matrix. In addition to speed of production, improvements associated with this method include a solid object having improved thermal conductivity, hardness, wear resistance and reduced shrinkage as compared with the rapid tooling techniques taught in the prior art.
摘要翻译：通过使用金属 - 陶瓷组合物的新型多步骤成形，脱脂，烧结和渗透方法制备固体物体。在该方法中，将混合物保持一段时间以从液体粘合剂中脱气并沉淀粉末状材料。然后将包装的几何形状加热到粘合剂的熔融温度以上以除去固体几何形状的粘合剂部分。在去除粘合剂后，将不含粘合剂的固体几何形状升高到金属预先烧结成具有相互连接的多孔性的三维刚性基质以形成固体前体的温度。多孔基体包括颗粒陶瓷材料和至少部分烧结的第一金属。然后将熔融的第二金属引入填充多孔基质并形成渗透的基质。除了生产速度之外，与现有技术中教导的快速加工技术相比，与该方法相关的改进包括具有改善的导热性，硬度，耐磨性和减小的收缩率的固体物体。

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