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1. 发明授权

US07955504B1 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US07955504B1
公开(公告)日：2011-06-07
申请号：US11243937
申请日：2005-10-04
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。

2. 发明申请

US20120074062A1 MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHODS FOR THEIR MANUFACTURE AND USE 有权
标题翻译：微流体装置，包含聚合膜的特别过滤装置及其制造和使用方法
公开(公告)号：US20120074062A1
公开(公告)日：2012-03-29
申请号：US13292903
申请日：2011-11-09
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

3. 发明申请

US20110253629A1 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US20110253629A1
公开(公告)日：2011-10-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D61/24 , B01D35/18
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。该方法首先形成纳米晶体纤维素的水性分散体。然后形成包含水分散体和沸点高于水的有机液体的混合物。然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

4. 发明授权

US08137554B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08137554B2
公开(公告)日：2012-03-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成装置的装置。通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。还公开了包含复合膜的透析器。为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。该方法首先形成纳米晶体纤维素的水性分散体。然后形成包含水分散体和沸点高于水的有机液体的混合物。然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

5. 发明申请

US20120292246A1 MICROFLUIDIC DEVICES, PARTICULARLY FILTRATION DEVICES COMPRISING POLYMERIC MEMBRANES, AND METHOD FOR THEIR MANUFACTURE AND USE 审中-公开
标题翻译：微流体装置，包含聚合膜的特别过滤装置及其制造和使用方法
公开(公告)号：US20120292246A1
公开(公告)日：2012-11-22
申请号：US13560721
申请日：2012-07-27
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
IPC分类号： B01D63/00
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

6. 发明授权

US08273245B2 Microfluidic devices, particularly filtration devices comprising polymeric membranes, and methods for their manufacture and use 有权
标题翻译：微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法
公开(公告)号：US08273245B2
公开(公告)日：2012-09-25
申请号：US13292903
申请日：2011-11-09
申请人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
发明人： Goran Nadezda Jovanovic , Sundar V. Atre , Brian Kevin Paul , Vincent Thomas Remcho , Chih-hung Chang
IPC分类号： B01D63/00 , B01D61/00 , C02F1/44
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译：本公开描述了可用于微量流体纯化，分离和合成的装置。这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。本发明的装置可以与其他微型装置组合以制造系统。例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。

7. 发明申请

US20120298037A1 MICROCHEMICAL NANOFACTORIES 审中-公开
标题翻译：微生物纳米生物
公开(公告)号：US20120298037A1
公开(公告)日：2012-11-29
申请号：US13489118
申请日：2012-06-05
申请人： Brian Kevin Paul , Chih-hung Chang , Vincent Thomas Remcho
发明人： Brian Kevin Paul , Chih-hung Chang , Vincent Thomas Remcho
IPC分类号： B05C11/00
CPC分类号： C07D255/02 , B01F5/0475 , B01F5/0641 , B01F5/0646 , B01F5/0647 , B01F13/0062 , B01F13/0066 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00914 , B01J2219/00916 , B01J2219/00972 , B01L3/502707 , B01L2200/0631 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/0655 , C08L101/005 , G01N27/44791 , G01N30/0005 , G01N30/6095
摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.
摘要翻译：公开了用于化学合成和/或分析的装置，系统和方法的实施例。公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。这种装置或其部分通常具有约1微米至约100微米的尺寸。为了实现合成方法，所公开的设备的实施例通常包括至少一个单元操作，例如混合器，阀，分离器，检测器及其组合。单个装置可以串联耦合并联，以形成用于制备化合物的系统。单独的设备或系统也可以与已知的设备和过程组合使用。

8. 发明授权

US07507380B2 Microchemical nanofactories 失效
标题翻译：微化学纳米工艺
公开(公告)号：US07507380B2
公开(公告)日：2009-03-24
申请号：US11086074
申请日：2005-03-21
申请人： Chih-Hung Chang , Brian Kevin Paul , Vincent Thomas Remcho
发明人： Chih-Hung Chang , Brian Kevin Paul , Vincent Thomas Remcho
IPC分类号： B01J8/00 , B01J10/00 , B32B3/20 , B32B3/12
CPC分类号： B01F5/0475 , B01F5/0485 , B01F13/0062 , B01F13/0066 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00833 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00912 , B01J2219/00914 , B01J2219/00916 , B01J2219/0097 , B01J2219/00972 , C08G83/003 , F28F2210/02 , Y10T428/24562 , Y10T428/24612 , Y10T428/24661 , Y10T428/24744
摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one valve, and often plural, selectively actuatable valves. Detectors, including optical detectors, also can be used to detect product and other materials as they flow by, or are otherwise presented to, the detector. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. The apparatus is particularly useful for making compounds requiring iterative reaction schemes, and further can be used to make compounds having morphological structures that resemble the morphology of the apparatus itself, such as dendrimers.
摘要翻译：公开了用于化学合成和/或分析的装置，系统和方法的实施例。公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。这种装置或其部分通常具有约1微米至约100微米的尺寸。为了实现合成过程，所公开的设备的实施例通常包括至少一个阀，并且通常是多个可选择性致动的阀。检测器，包括光学检测器，也可用于检测产品和其他材料，因为它们流过或以其他方式呈现给检测器。单个装置可以串联耦合并联，以形成用于制备化合物的系统。该装置对于制备需要迭代反应方案的化合物特别有用，并且还可用于制备具有类似于装置本身形态的形态结构的化合物，例如树枝状大分子。

9. 发明授权

US06913877B1 Methods for detecting bioactive compounds 失效
标题翻译：检测生物活性化合物的方法
公开(公告)号：US06913877B1
公开(公告)日：2005-07-05
申请号：US10024654
申请日：2001-12-17
申请人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
发明人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
IPC分类号： A61K9/14 , A61K35/60 , C12Q1/00 , C12Q1/02 , C12Q1/04 , G01N33/542
CPC分类号： G01N33/542 , C12Q1/04
摘要： Methods of detecting bioactive compounds include exposing compounds to one or more classes of chromatophores and measuring or sensing associated changes in one or more of the chromatophores. Representative methods permit identification and quantification of neurotransmitters, toxins, hormones, and chemical warfare agents with or without prior knowledge of the content of a sample. In some examples, chromatophores based on Betta fish are used. Cytosensor apparatus using such chromatophores include means for exposing chromatophores to a sample and optical detection systems for assessing changes in chromatophore optical properties. Compounds can be identified or quantified based on a red-green-blue or hue saturation-value representations of transmitted or reflected light or based on other characterizations of transmitted or reflected light.
摘要翻译：检测生物活性化合物的方法包括将化合物暴露于一类或多种色素，并测量或检测一种或多种色素中的相关变化。代表性的方法允许在有或没有样品内容的知识的情况下鉴定和定量神经递质，毒素，激素和化学战剂。在一些实例中，使用基于Betta鱼的色素。使用这种色素的细胞传感器装置包括用于将染色体暴露于样品的装置和用于评估染色质光学性质变化的光学检测系统。可以基于透射或反射光的红 - 绿 - 蓝或色相饱和度值表示或基于透射或反射光的其它表征来鉴定或量化化合物。

10. 发明授权

US08128822B2 MECS dialyzer 有权
标题翻译： MECS透析器
公开(公告)号：US08128822B2
公开(公告)日：2012-03-06
申请号：US11576804
申请日：2005-10-06
申请人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
发明人： David M. Browning , James R. Curtis , Goran Nadezda Jovanovic , Brian Kevin Paul , Sundar Atre
IPC分类号： B01D61/28 , B01D61/24
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention is related to hemodialysis, and more particularly, to a dialyser with improved efficiency of mass transfer across a dialysis membrane utilizing microchannel separation provided in accordance with embodiments of the present invention. In accordance with an embodiment, a dialyzer is provided comprising a plurality of semipermeable membrane sheets and a plurality of flow separators. The membrane sheets and flow are arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannel layers. Each microchannel layer comprises a plurality of first microchannels and a plurality of second microchannels. The first and second microchannels of each microchannel layer are in fluid communication with each other via one of the plurality of membrane sheets therebetween. The MECS dialyzer is characterized as having a high surface to volume ratio and a high mass transfer coefficient.
摘要翻译：本发明涉及血液透析，更具体地说，涉及使用根据本发明的实施方案提供的利用微通道分离的透析膜的传质效率提高的透析器。根据一个实施例，提供一种透析器，其包括多个半透膜和多个分流器。膜片和流动被布置成交替配置并且耦合到限定多个平行微通道层的薄片叠层中。每个微通道层包括多个第一微通道和多个第二微通道。每个微通道层的第一和第二微通道之间通过多个膜片之一彼此流体连通。 MECS透析器的特征在于具有高的表面与体积比和高的传质系数。

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