专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06927246B2 Polymers functionalized with fluorescent boronate motifs and methods for making them 有权
标题翻译：用荧光硼酸盐图案功能化的聚合物及其制备方法
公开(公告)号：US06927246B2
公开(公告)日：2005-08-09
申请号：US10075415
申请日：2002-02-14
申请人： Glenn Noronha , Jonathan Reilly , Joseph C. Walsh , Brooks Cochran , Aaron M. Heiss , Bill C. Ponder , David J. Vachon
发明人： Glenn Noronha , Jonathan Reilly , Joseph C. Walsh , Brooks Cochran , Aaron M. Heiss , Bill C. Ponder , David J. Vachon
IPC分类号： C07F5/02 , G01N33/66 , C08K5/55
CPC分类号： C07F5/025 , G01N33/66 , Y10T436/144444
摘要： Improved polymer matrices which incorporate fluorescent biosensor molecules as well as methods of making and using these polymer matrices are described. Such matrices can be used in fluorescent biosensors and biosensor systems, including those which are used in the detection of polyhydroxylated analytes such as glucose. The properties of the polymer matrices of the invention renders biosensors utilizing such matrices particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述了掺入荧光生物传感器分子的改进的聚合物基质以及制备和使用这些聚合物基质的方法。这些基质可用于荧光生物传感器和生物传感器系统，包括用于检测多羟基化分析物如葡萄糖的那些。本发明的聚合物基质的性质使得利用这种基质的生物传感器特别适合于检测和测量体内葡萄糖浓度。

2. 发明授权

US07045361B2 Analyte sensing via acridine-based boronate biosensors 失效
标题翻译：通过基于吖啶的硼酸盐生物传感器进行分析物检测
公开(公告)号：US07045361B2
公开(公告)日：2006-05-16
申请号：US09952563
申请日：2001-09-12
申请人： Aaron M. Heiss , Joseph C. Walsh , David J. Vachon , Glenn Noronha , Jonathan Reilly , Bill C. Ponder , William P. Van Antwerp
发明人： Aaron M. Heiss , Joseph C. Walsh , David J. Vachon , Glenn Noronha , Jonathan Reilly , Bill C. Ponder , William P. Van Antwerp
IPC分类号： G01N21/64 , G01N33/58 , G01N33/66
CPC分类号： G01N33/66 , C12Q1/54 , Y10T436/144444
摘要： Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a linker moiety and (3) a boronate substrate recognition/binding moiety, which binds polyhydroxylate analytes, such as glucose. These biosensor molecules further include a “switch” element that is drawn from the electronic interactions among these submolecular components. This fluorescent switch is generally “off” in the absence of bound polyhydroxylate analyte and is generally “on” in the presence of bound polyhydroxylate analyte. Thus, the reversible binding of a polyhydroxylate analyte essentially turns the fluorescent switch “on” and “off”. This property of the biosensor molecules, as well as their ability to emit fluorescent light at greater than about 500 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述荧光生物传感器分子，荧光生物传感器和系统，以及制造和使用这些生物传感器分子和系统的方法。这些生物传感器分子解决了在大于约500nm的波长处获得荧光发射的问题。生物传感器分子通常包括（1）基于吖啶的荧光团，（2）接头部分和（3）结合多羟基化合物分析物如葡萄糖的硼酸酯底物识别/结合部分。这些生物传感器分子还包括从这些亚分子组分之间的电子相互作用中抽出的“开关”元件。在不存在结合的多羟基甲酸盐分析物的情况下，该荧光开关通常是“关闭”的，并且在结合的多羟基化合物分析物的存在下通常是“开”的。因此，多羟基化合物分析物的可逆结合基本上使得荧光开关“开”和“关”。生物传感器分子的这种性质以及它们在大于约500nm处发射荧光的能力使得这些生物传感器分子特别适用于检测和测量体内葡萄糖浓度。

3. 发明授权

US06766183B2 Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers 有权
标题翻译：长波荧光团传感器化合物等聚合物中的荧光传感器化合物
公开(公告)号：US06766183B2
公开(公告)日：2004-07-20
申请号：US10033240
申请日：2001-12-28
申请人： Joseph C. Walsh , Aaron M. Heiss , Glenn Noronha , David J. Vachon , Stephen M. Lane , Joe H. Satcher, Jr. , Thomas A. Peyser , William Peter Van Antwerp , John Joseph Mastrototaro
发明人： Joseph C. Walsh , Aaron M. Heiss , Glenn Noronha , David J. Vachon , Stephen M. Lane , Joe H. Satcher, Jr. , Thomas A. Peyser , William Peter Van Antwerp , John Joseph Mastrototaro
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/14532 , C12Q1/005 , G01N33/66 , Y10T436/143333 , Y10T436/144444
摘要： Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical biosensor molecules include a fluorophore that includes an iminium ion, a linker moiety that includes a group that is an anilinic type of relationship to the fluorophore and a boronate substrate recognition/binding moiety, which binds glucose. The fluorescence molecules modulated by the presence or absence of polyhydroxylated analytes such as glucose. This property of these molecules of the invention, as well as their ability to emit fluorescent light at greater than about 650 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述荧光生物传感器分子，荧光生物传感器和系统，以及制造和使用这些生物传感器分子和系统的方法。这些生物传感器分子的实施例在大于约650nm的波长处表现出荧光发射。典型的生物传感器分子包括包含亚胺离子的荧光团，连接部分，其包含与荧光团相关的苯胺型的基团和结合葡萄糖的硼酸酯底物识别/结合部分。通过存在或不存在多羟基化分析物如葡萄糖来调节荧光分子。本发明的这些分子的这种性质以及它们在大于约650nm发射荧光的能力使得这些生物传感器分子特别适用于检测和测量体内葡萄糖浓度。

4. 发明授权

US06642015B2 Hydrophilic polymeric material for coating biosensors 有权
标题翻译：用于涂覆生物传感器的亲水性聚合材料
公开(公告)号：US06642015B2
公开(公告)日：2003-11-04
申请号：US09753095
申请日：2000-12-29
申请人： David J. Vachon , Brooks B. Cochran , Bill C. Ponder
发明人： David J. Vachon , Brooks B. Cochran , Bill C. Ponder
IPC分类号： C12Q154
CPC分类号： C08G18/61 , C08G18/5024 , C08G18/6685 , C09D175/02 , C12Q1/002 , Y10T428/31551 , Y10T428/31663
摘要： Disclosed is a biocompatible membrane comprising a hydrophilic polyurea composition. The hydrophilic polyurea composition comprises the product of a reaction mixture comprising (a) an amino terminated polysiloxane, (b) a hydrophilic polymer selected from the group consisting of a diamino terminated copolymer of polypropylene glycol and polyethylene glycol, polyethylene glycol, polypropylene glycol and diamino polyethylene glycol having an average molecular weight of from about 400 to about 2000, and (c) a diisocyanate selected from the group consisting of hexamethylene-1,6-diisocyanate, dicyclohexylmethane 4,4′-diisocyanate, and isophorone diisocyanate, and constituting about 50 mole % of the reaction mixture. In this mixture, (a) and (b) constitute a polymeric portion of the reaction mixture, and the hydrophilic polyurea composition has a ratio of its diffusion coefficient for oxygen to its diffusion coefficient for glucose of from about 2,000 to about 10,000. Also provided are biosensors coated with a membrane of the invention, and methods of using such biosensors to measure an analyte in a tissue of a subject.
摘要翻译：公开了包含亲水性聚脲组合物的生物相容性膜。亲水性聚脲组合物包含反应混合物的产物，该反应混合物包含（a）氨基封端的聚硅氧烷，（b）亲水性聚合物，其选自聚丙二醇与聚乙二醇的二氨基封端的共聚物，聚乙二醇，聚丙二醇和二氨基平均分子量为约400至约2000的聚乙二醇和（c）选自六亚甲基-1,6-二异氰酸酯，二环己基甲烷4,4'-二异氰酸酯和异佛尔酮二异氰酸酯的二异氰酸酯，并且构成约 50摩尔％的反应混合物。在该混合物中，（a）和（b）构成反应混合物的聚合物部分，亲水性聚脲组合物的氧扩散系数与其对葡萄糖的扩散系数的比例为约2,000至约10,000。还提供了涂覆有本发明的膜的生物传感器，以及使用这种生物传感器来测量受试者组织中的分析物的方法。

5. 发明授权

US07313444B2 Self-anchoring coronary sinus lead 有权
标题翻译：自固定冠状动脉窦导联
公开(公告)号：US07313444B2
公开(公告)日：2007-12-25
申请号：US10081457
申请日：2002-02-21
申请人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
发明人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An implantable cardiac lead system suitable for placement in the coronary sinus region of the heart. The lead system comprises a lead having two or more non-helical bends in its distal portion. The two or more non-helical bends cooperate to prevent the lead from dislodgment or displacement inside the coronary sinus. The lead system may further comprise a stylet suitable for steering the lead into at least one of the coronary sinus vein, great cardiac vein, left marginal vein, left posterior ventricular vein, and small cardiac vein. The stylet is tapered in its distal portion to provide enhanced maneuverability and steerability inside the coronary sinus region. The lead system may also comprise an introducer which aids in introducing the lead into the heart.
摘要翻译：适用于放置在心脏冠状静脉窦区域的可植入心脏引导系统。引导系统包括在其远端部分中具有两个或多个非螺旋形弯曲部的引线。两个或更多个非螺旋形弯曲合作以防止铅在冠状窦内发生移位或移位。引导系统还可以包括适于将引线引导到冠状静脉窦静脉，大心静脉，左边缘静脉，左后脑室静脉和小心静脉中的至少一个的探针。探针在其远端部分逐渐变细，以在冠状窦区域内提供增强的机动性和可操纵性。引导系统还可以包括有助于将引入引入心脏的导引器。

6. 发明授权

US5531780A Implantable stimulation lead having an advanceable therapeutic drug delivery system 失效
标题翻译：植入式刺激引线具有可推进的治疗药物递送系统
公开(公告)号：US5531780A
公开(公告)日：1996-07-02
申请号：US268701
申请日：1994-06-30
申请人： David J. Vachon
发明人： David J. Vachon
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0575
摘要： A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion to the point of either passive or active fixation. The drug delivery element may be rigid and serve to center the means, preferably a helix, for active fixation of the lead in the myocardium.
摘要翻译：具有探针的起搏引线引入从远端末端电极可推进的抗炎药物递送元件。该元件优选形成为可模制的生物相容性复合材料。该元件具有生物相容的基质材料，其可与药物和治疗剂组合以通过共溶或扩散至被动或主动固定点来递送药物和试剂。药物递送元件可以是刚性的，并且用于使装置（优选螺旋）居中以用于主动固定心肌中的铅。

7. 发明授权

US5324324A Coated implantable stimulation electrode and lead 失效
标题翻译：涂层可植入刺激电极和铅
公开(公告)号：US5324324A
公开(公告)日：1994-06-28
申请号：US960670
申请日：1992-10-13
申请人： David J. Vachon , John R. Helland
发明人： David J. Vachon , John R. Helland
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable stimulation lead having an anti-inflammatory coating on the exposed surface area of the distal tip electrode. The coating is a semi-viscous or gelatinous material having the ability to absorb physiological fluids to provide electrical conductivity through the coating. The coating preferably has a matrix having an innate hypo-inflammatory property which can be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion, or alternatively the matrix material can be used as a coating to keep the electrode surface electrochemically clean prior to and during implant.
摘要翻译：一种植入式刺激引线，其在远端尖端电极的暴露表面区域上具有抗炎涂层。该涂层是具有吸收生理流体以提供穿过涂层的导电性的能力的半粘性或凝胶状材料。涂层优选具有先天性低发炎特性的基质，其可以与药物和治疗剂组合以通过共溶或扩散递送药物和试剂，或者可替代地，基质材料可用作保护电极的涂层在植入前和植入过程中进行表面电化学清洁。

8. 发明申请

US20140303541A1 Medical Devices, Wound Dressings, and Methods for Dressing Wounds 审中-公开
标题翻译：医疗器械，伤口敷料和伤口敷料的方法
公开(公告)号：US20140303541A1
公开(公告)日：2014-10-09
申请号：US13299196
申请日：2011-11-17
申请人： David J. Vachon
发明人： David J. Vachon
IPC分类号： A61F13/02 , A61M25/02
CPC分类号： A61F13/0213 , A61F13/00063 , A61M2025/0273
摘要： Medical devices, wound dressings, and methods of dressing wounds are described. Devices and methods using silicone and pharmaceutically active agents are described. Devices including covers and bases are described.
摘要翻译：描述了医疗装置，伤口敷料和敷料伤口的方法。描述了使用硅酮和药物活性剂的装置和方法。描述包括盖和底座的装置。

9. 发明授权

US07153265B2 Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance 有权
公开(公告)号：US07153265B2
公开(公告)日：2006-12-26
申请号：US10127745
申请日：2002-04-22
申请人： David J. Vachon
发明人： David J. Vachon
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , C12Q1/006
摘要： A biosensor including an external surface, and an accessory material in close proximity to the external surface. The accessory material includes a coating containing a hydrophilic material and/or a fiber modified to deliver a therapeutic agent. The biosensor modifies a biological response to the biosensor upon contact with a tissue, such as upon implantation into the skin of a subject, thereby reducing biofouling, inflammation and other undesirable tissue responses that interfere with biosensor performance. The biosensor can be any biocompatible sensor, suitable for short- or long-term use. Preferably, the biosensor is an enzymatic or electrochemical sensor, such as a glucose sensor. Also provided are a method of producing a biosensor and a method of delivering a biologically active substance to a subject.

10. 发明授权

US06340421B1 Microelectrogravimetric method for plating a biosensor 有权
标题翻译：用于电镀生物传感器的微电子重量法
公开(公告)号：US06340421B1
公开(公告)日：2002-01-22
申请号：US09642623
申请日：2000-08-18
申请人： David J. Vachon , Jenn-Hann Wang
发明人： David J. Vachon , Jenn-Hann Wang
IPC分类号： C25D500
CPC分类号： C12Q1/001
摘要： Disclosed is a method for microelectrogravimetrically depositing an electroactive species onto an electrode or a plurality of electrodes comprising dispensing a solution containing the electroactive species from a microdispenser to form a hanging drop of the solution and contacting the electrode with the hanging drop of the solution, wherein the electrode is electrically coupled with the microdispenser to form an electrochemical cell, and applying a potential to the electrochemical cell. The application of the potential effects deposition of the electroactive species onto the electrode. The method of the invention eliminates the need for immersion of the electrode in a bath, reduces the volume of solution required by a factor of at least 10-100, and avoids uneven depletion of various components of the solution over successive applications. The method reduce costs, provides increased reproducibility in the plating process and avoids contamination of the solution, and is particularly suited for plating of enzymes, such as glucose oxidase, or metals, such as platinum, onto electrodes for use as biosensors.
摘要翻译：公开了一种将电活性物质微电离沉积在电极或多个电极上的方法，包括从微分配器中分配含有电活性物质的溶液以形成悬滴液并使电极与溶液的悬滴接触，其中电极与微型分散器电耦合以形成电化学电池，并向电化学电池施加电位。将电活性物质沉积在电极上的潜在效应的应用。本发明的方法消除了将电极浸入浴中的需要，将所需溶液的体积减少至少10-100倍，并避免了在连续应用中溶液的各种组分的不均匀耗尽。该方法降低成本，在电镀过程中提供增加的再现性并避免溶液的污染，并且特别适用于将酶如葡萄糖氧化酶或诸如铂的金属电镀到用作生物传感器的电极上。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式