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1. 发明授权

US12102823B2 Device, system, and method for delivery of an implantable cardiac lead and associated active agent delivery component 有权
公开(公告)号：US12102823B2
公开(公告)日：2024-10-01
申请号：US17121994
申请日：2020-12-15
申请人： Pacesetter, Inc.
发明人： Christopher Jenney
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/0575 , A61N1/0568 , A61N1/37512
摘要： Delivery of implantable active agent delivery components includes implanting a distal lead end of a lead into tissue at an implantation site. A delivery stylet is then inserted through a lead lumen of the lead. The delivery stylet includes a stylet body having a distal stylet end and an active agent delivery component detachably coupled to the distal stylet end. The active agent delivery component is inserted into the tissue at the implantation site by extending the distal stylet end of the delivery stylet from a distal lead end of the lead such that the active agent delivery component is inserted into the tissue at the implantation site. The active agent delivery component is then detached within the tissue at the implantation site and the delivery stylet may be retracted and removed from the lead lumen.

2. 发明申请

US20180169399A1 ELECTROPORATION SYSTEM FOR CONTROLLED LOCALIZED THERAPEUTICS DELIVERY 审中-公开
公开(公告)号：US20180169399A1
公开(公告)日：2018-06-21
申请号：US15738443
申请日：2016-06-24
申请人： NewSouth Innovations Pty Limited
发明人： Gary David Housley , Nigel Hamilton Lovell , Jeremy Pinyon , Edward Norman Crawford , Cherylea Browne
IPC分类号： A61N1/04 , A61N1/32 , A61N1/05 , A61N1/08 , A61B18/00 , A61B34/10
CPC分类号： A61N1/0412 , A61B18/00 , A61B34/10 , A61B2018/00071 , A61B2018/00154 , A61B2018/00767 , A61N1/0424 , A61N1/0529 , A61N1/0541 , A61N1/0575 , A61N1/08 , A61N1/327
摘要： Embodiments of the present invention provide an electroporation system comprising an electroporation probe having at least two contiguous electrodes configured to be inserted into biological tissue for electroporation treatment, and a pulse generator electrically connected to the probe and configured to drive the electroporation probe using a sequence of one or more electric pulses to cause current transmission through the probe and induce a non-uniform electric field in the biological tissue proximate the probe electrodes. Treatment tissue can be targeted by controlling the probe configuration, carrier solution characteristics and parameters of the electroporation pulse sequence to achieve predictable electroporation outcomes. This electroporation control method can also reduce potentially toxic effects of electroporation treatment.

3. 发明申请

US20170239464A1 ELECTRODE HEAD AND ELECTRODE LINE 审中-公开
公开(公告)号：US20170239464A1
公开(公告)日：2017-08-24
申请号：US15589137
申请日：2017-05-08
申请人： BIOTRONIK SE & Co. KG
发明人： Kerstin Taeubert , Lisa Hinrichsen , Patrick Poplien , Hartmut Lenski , Thomas Guenther
IPC分类号： A61N1/05
CPC分类号： A61N1/0568 , A61N1/0565 , A61N1/0575
摘要： An electrode head of an implantable electrode line, including an elongate housing which has a longitudinal axis and includes at least two housing parts, which are cylinder-segment-shaped at least in portions and are fixedly joined together.

4. 发明授权

US08585641B2 Neurotoxic agents and medical devices therefor 有权
标题翻译：神经毒剂及其医疗器械
公开(公告)号：US08585641B2
公开(公告)日：2013-11-19
申请号：US13287231
申请日：2011-11-02
申请人： Haris J. Sih
发明人： Haris J. Sih
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61N1/3625 , A61N1/057 , A61N1/0575
摘要： Devices to treat nerves which innervate blood vessels are provided.
摘要翻译：提供治疗神经支配血管的装置。

5. 发明授权

US08535260B2 Devices, systems, and methods for localized drug delivery 有权
标题翻译：用于局部药物递送的装置，系统和方法
公开(公告)号：US08535260B2
公开(公告)日：2013-09-17
申请号：US12579125
申请日：2009-10-14
申请人： Ghassan S. Kassab , Jose A. Navia, Sr.
发明人： Ghassan S. Kassab , Jose A. Navia, Sr.
IPC分类号： A61M31/00
CPC分类号： A61M25/01 , A61K9/0024 , A61L31/148 , A61L31/16 , A61L2430/20 , A61M37/00 , A61N1/0575 , A61N1/37205
摘要： Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
摘要翻译：用于局部药物递送的装置，系统和方法。在局部药物递送方法的至少一个实施方案中，该方法包括以下步骤：在管内放置可再吸收的装置，将管在哺乳动物身体内或哺乳动物体内的组织和/或器官附近引入哺乳动物体内，以及锚定可再吸收的装置到组织和/或器官。本文还公开了可用于执行这种方法的装置和系统，其中示例性装置包括至少一种药物释放部分，其具有随时间释放的至少一种药物和与所述至少一种药物混合的粘合剂，以及至少一种可再吸收的锚定部分耦合到至少一个药物释放部分。

6. 发明申请

US20110282422A1 ACTIVE FIXATION LEADS AND METHOD OF ASSEMBLY 有权
标题翻译：主动固定引线和组装方法
公开(公告)号：US20110282422A1
公开(公告)日：2011-11-17
申请号：US13088017
申请日：2011-04-15
申请人： David R. Wulfman , Douglas D. Pagoria , Joseph Walker
发明人： David R. Wulfman , Douglas D. Pagoria , Joseph Walker
IPC分类号： A61N1/05 , B23P25/00
CPC分类号： A61N1/0573 , A61N1/056 , A61N1/057 , A61N1/0575 , A61N1/0587 , A61N1/375 , Y10T29/49002 , Y10T29/49826 , Y10T29/4998
摘要： An active fixation lead may have a lead body formed at least in part from an inner member and an outer sheath. The inner member may include a pace/sense lumen and one or more cable lumens. The inner member may include one or more longitudinally extending crumple zones that are configured to reduce stress within the pace/sense lumen that could otherwise be caused by compressive forces applied to the lead.
摘要翻译：主动固定引线可以具有至少部分地由内部构件和外部护套形成的引线体。内部构件可以包括脚步/感测腔和一个或多个电缆腔。内部构件可以包括一个或多个纵向延伸的折叠区域，其被配置为减少脚步/感觉腔内的应力，否则可能由施加到引线的压缩力引起。

7. 发明授权

US07998105B2 Method of treating coronary arteries with perivascular delivery of therapeutic agents 有权
标题翻译：治疗剂血管周围输送治疗冠状动脉的方法
公开(公告)号：US07998105B2
公开(公告)日：2011-08-16
申请号：US10671270
申请日：2003-09-24
申请人： Peter A. Altman
发明人： Peter A. Altman
IPC分类号： A61N1/30
CPC分类号： A61K9/127 , A61B18/1492 , A61B2017/00247 , A61B2018/00011 , A61B2018/00351 , A61B2018/00392 , A61B2018/00577 , A61B2018/00839 , A61B2018/1425 , A61B2018/1435 , A61B2218/002 , A61K9/1676 , A61K9/50 , A61K9/5084 , A61M2025/0089 , A61N1/0575
摘要： A method of treating the intraluminal disease in a coronary artery by injecting therapeutic agents perivascularly into the myocardium near the site of disease.
摘要翻译：一种通过将治疗剂血管周围注射到疾病部位附近的心肌中来治疗冠状动脉腔内疾病的方法。

8. 发明申请

US20110112619A1 HELIX FIXATION MECHANISM 有权
标题翻译： HELIX固定机构
公开(公告)号：US20110112619A1
公开(公告)日：2011-05-12
申请号：US12882778
申请日：2010-09-15
申请人： Arthur J. Foster , Matthew J. Miller
发明人： Arthur J. Foster , Matthew J. Miller
IPC分类号： A61N1/05
CPC分类号： A61N1/0575 , A61N2001/0578
摘要： An implantable lead may have a distal assembly including a coupler and a fixation helix secured to the coupler. The fixation helix may be formed of a filar having a non-circular cross-sectional profile having a major dimension and a minor dimension. The major dimension may be disposed transversely to a longitudinal axis of the helical electrode.
摘要翻译：可植入引线可以具有包括耦合器的远端组件和固定到耦合器的固定螺旋。固定螺旋可以由具有主要尺寸和次要尺寸的非圆形横截面轮廓的丝状体形成。主要尺寸可以横向于螺旋形电极的纵向轴线设置。

9. 发明申请

US20100094256A1 DEVICES, SYSTEMS, AND METHODS FOR LOCALIZED DRUG DELIVERY 有权
标题翻译：用于本地化药物递送的设备，系统和方法
公开(公告)号：US20100094256A1
公开(公告)日：2010-04-15
申请号：US12579125
申请日：2009-10-14
申请人： Ghassan S. Kassab , Jose A. Navia, SR.
发明人： Ghassan S. Kassab , Jose A. Navia, SR.
IPC分类号： A61M37/00
CPC分类号： A61M25/01 , A61K9/0024 , A61L31/148 , A61L31/16 , A61L2430/20 , A61M37/00 , A61N1/0575 , A61N1/37205
摘要： Devices, systems, and methods for localized drug delivery. In at least one embodiment of a method of localized drug delivery, the method comprises the steps of placing a resorbable device within a tube, introducing the tube within a mammalian body at or near a tissue and/or organ within the mammalian body, and anchoring the resorbable device to the tissue and/or organ. Devices and systems useful for performing such a method are also disclosed herein, wherein an exemplary device comprises at least one drug release portion having at least one drug to be released over time and a binder intermixed with the at least one drug, and at least one resorbable anchor portion coupled to the at least one drug release portion.
摘要翻译：用于局部药物递送的装置，系统和方法。在局部药物递送方法的至少一个实施方案中，该方法包括以下步骤：在管内放置可再吸收的装置，将管在哺乳动物身体内或哺乳动物体内的组织和/或器官附近引入哺乳动物体内，以及锚定可再吸收的装置到组织和/或器官。本文还公开了可用于执行这种方法的装置和系统，其中示例性装置包括至少一种药物释放部分，其具有随时间释放的至少一种药物和与所述至少一种药物混合的粘合剂，以及至少一种可再吸收的锚定部分耦合到至少一个药物释放部分。

10. 发明授权

US07630761B2 Method and apparatus for modifying tissue to improve electrical stimulation efficacy 失效
标题翻译：用于修饰组织以改善电刺激功效的方法和装置
公开(公告)号：US07630761B2
公开(公告)日：2009-12-08
申请号：US11267654
申请日：2005-11-04
申请人： Rodney W. Salo , Joseph M. Pastore , Haris J. Sih , Jihong Qu
发明人： Rodney W. Salo , Joseph M. Pastore , Haris J. Sih , Jihong Qu
IPC分类号： A61N1/18
CPC分类号： A61N1/36557 , A61K48/005 , A61K48/0083 , A61M5/14276 , A61M2205/054 , A61N1/0568 , A61N1/0575 , A61N1/3605 , A61N1/3628 , A61N1/3706
摘要： A biologic agent delivery system provides for delivery of a biologic agent to a stimulation site to which electrical stimulation pulses are to be delivered from an electrical stimulation device. Examples of the electrical stimulation device include cardiac pacemakers and neural stimulators. The biologic agent modifies tissue property to lower the stimulation threshold of the stimulation site. The genetic modification of the tissue property improves efficacy and/or energy efficiency of an electrical stimulation therapy.
摘要翻译：生物剂递送系统提供将生物剂递送到刺激部位，电刺激脉冲从电刺激装置输送到刺激部位。电刺激装置的实例包括心脏起搏器和神经刺激器。生物制剂改变组织特性以降低刺激部位的刺激阈值。组织性质的遗传修饰改善电刺激疗法的功效和/或能量效率。

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