会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 7. 发明授权
    • Aromatic amide compounds and their production and use
    • 芳香族酰胺化合物及其生产和使用
    • US5480907A
    • 1996-01-02
    • US882025
    • 1992-05-13
    • Kyozo HayashiMunekazu Iinuma
    • Kyozo HayashiMunekazu Iinuma
    • C07C235/38C07D311/12C07D311/14C07D311/20A61K31/35
    • C07D311/12C07C235/38C07D311/14C07D311/20
    • Aromatic amide compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, a lower alkyl or lower alkoxy group; Ar is an optionally substituted aromatic group; the groupC - - - -Cis C.dbd.C or HC--CH; X is hydrogen, CH.sub.2 COOH or CH.sub.2 CONHAr; and Y is hydrogen or COOH; provided that when X is CH.sub.2 COOH or Y is COOH, the COOH may be taken together with the adjacent hydroxy group on the benzene ring to form a lactone ring by dehydration, a quinone form thereof or a pharmaceutically acceptable salt thereof have potent nerve growth factor (NGF) secretion inducing activity, and are thus useful as a drug for the treatment or prophylaxis of degenerative nervous system disorders such as senilic dementis, and Alzheimer's disease.
    • 下式的芳族酰胺化合物:其中R 1,R 2和R 3独立地是氢,低级烷基或低级烷氧基; Ar是任选取代的芳族基团; C - - - C为C = C或HC-CH; X是氢,CH 2 COOH或CH 2 CONHAr; Y为氢或COOH; 条件是当X是CH 2 COOH或Y是COOH时,COOH可以与苯环上的相邻羟基一起与脱水形成内酯环,其醌形式或其药学上可接受的盐具有有效的神经生长因子 NGF)分泌诱导活性,因此可用作治疗或预防退行性神经系统疾病如老年性痴呆和阿尔茨海默氏病的药物。