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1. 发明授权

US5480907A Aromatic amide compounds and their production and use 失效
标题翻译：芳香族酰胺化合物及其生产和使用
公开(公告)号：US5480907A
公开(公告)日：1996-01-02
申请号：US882025
申请日：1992-05-13
申请人： Kyozo Hayashi , Munekazu Iinuma
发明人： Kyozo Hayashi , Munekazu Iinuma
IPC分类号： C07C235/38 , C07D311/12 , C07D311/14 , C07D311/20 , A61K31/35
CPC分类号： C07D311/12 , C07C235/38 , C07D311/14 , C07D311/20
摘要： Aromatic amide compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, a lower alkyl or lower alkoxy group; Ar is an optionally substituted aromatic group; the groupC - - - -Cis C.dbd.C or HC--CH; X is hydrogen, CH.sub.2 COOH or CH.sub.2 CONHAr; and Y is hydrogen or COOH; provided that when X is CH.sub.2 COOH or Y is COOH, the COOH may be taken together with the adjacent hydroxy group on the benzene ring to form a lactone ring by dehydration, a quinone form thereof or a pharmaceutically acceptable salt thereof have potent nerve growth factor (NGF) secretion inducing activity, and are thus useful as a drug for the treatment or prophylaxis of degenerative nervous system disorders such as senilic dementis, and Alzheimer's disease.
摘要翻译：下式的芳族酰胺化合物：其中R 1，R 2和R 3独立地是氢，低级烷基或低级烷氧基; Ar是任选取代的芳族基团; C - - - C为C = C或HC-CH; X是氢，CH 2 COOH或CH 2 CONHAr; Y为氢或COOH; 条件是当X是CH 2 COOH或Y是COOH时，COOH可以与苯环上的相邻羟基一起与脱水形成内酯环，其醌形式或其药学上可接受的盐具有有效的神经生长因子 NGF）分泌诱导活性，因此可用作治疗或预防退行性神经系统疾病如老年性痴呆和阿尔茨海默氏病的药物。

2. 发明申请

US20130296425A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR A PERIPHERAL NERVE DISORDER INDUCED BY ANTI-CANCER AGENTS 审中-公开
标题翻译：由抗癌药物引起的外周神经疾病的预防或治疗药物
公开(公告)号：US20130296425A1
公开(公告)日：2013-11-07
申请号：US13979665
申请日：2012-01-30
申请人： Munekazu Iinuma , Shoei Furukawa , Mitsuru Naiki , Tomoyuki Okada , Tomonori Matsumoto , Kazuyoshi Sawada
发明人： Munekazu Iinuma , Shoei Furukawa , Mitsuru Naiki , Tomoyuki Okada , Tomonori Matsumoto , Kazuyoshi Sawada
IPC分类号： C07C69/533
CPC分类号： C07C69/533 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K31/23 , A61K31/231 , A61K45/06 , A61K47/6951 , B82Y5/00
摘要： An object of the present invention is to provide a drug which is effective for prophylaxis or therapy of peripheral nerve disorder occurred as a side effect of the administration of anti-cancer agents.The present invention is to provide a drug containing an ester of C10 fatty acid as an active ingredient for prophylaxis or therapy of peripheral nerve disorder induced by administration of a drug containing at least one of anti-cancer agents. The drug of the present invention containing the compound as an active ingredient is highly useful as a drug for prophylaxis or therapy of peripheral nerve disorder induced by administration of anti-cancer agents.
摘要翻译：本发明的目的是提供一种对预防或治疗作为施用抗癌剂的副作用发生的周围神经障碍有效的药物。本发明提供一种含有C10脂肪酸酯作为活性成分的药物，用于预防或治疗通过施用含有至少一种抗癌剂的药物而引起的周围神经障碍。含有该化合物作为活性成分的本发明药物作为用于预防或治疗通过施用抗癌剂而引起的周围神经障碍的药物是非常有用的。

3. 发明授权

US06939892B2 Compositions for treating or preventing malaria and method of treating malaria 失效
标题翻译：用于治疗或预防疟疾的组合物和治疗疟疾的方法
公开(公告)号：US06939892B2
公开(公告)日：2005-09-06
申请号：US10258435
申请日：2001-04-26
申请人： Tomio Takeuchi , Yusuke Wataya , Munekazu Iinuma , Hye-Sook Kim , Hiroomi Watabe , Hiroshi Naganawa , Yoshikazu Takahashi
发明人： Tomio Takeuchi , Yusuke Wataya , Munekazu Iinuma , Hye-Sook Kim , Hiroomi Watabe , Hiroshi Naganawa , Yoshikazu Takahashi
IPC分类号： A61K31/351 , A61P33/06 , C07D407/14 , A61K31/35 , A61K31/365
CPC分类号： C07D407/14 , A61K31/351 , Y02A50/411
摘要： An antibiotic SF2487 substance having the formula (I) or a salt thereof possesses an antimalarial activity against the proliferation of malarial parasites and is therefore useful as an antimalarial drug.
摘要翻译：具有式（I）的抗生素SF2487物质或其盐具有抗疟疾寄生虫增殖的抗疟活性，因此可用作抗疟药。

4. 发明申请

US20050048135A1 Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect 失效
标题翻译：倍半萜类衍生物具有脂肪细胞分化抑制作用
公开(公告)号：US20050048135A1
公开(公告)日：2005-03-03
申请号：US10485801
申请日：2002-08-09
申请人： Munekazu Iinuma , Toshiyuki Tanaka , Makoto Ubukata , Nobuyasu Matsuura , Masashi Yamada , Hiroto Suzuki
发明人： Munekazu Iinuma , Toshiyuki Tanaka , Makoto Ubukata , Nobuyasu Matsuura , Masashi Yamada , Hiroto Suzuki
IPC分类号： A23L1/30 , A61K31/335 , A61K31/365 , A61K36/28 , A61P1/16 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P19/02 , A61P19/06 , A61P43/00 , C07D307/93 , C07D493/04 , A61K31/12 , A61K31/045 , A61K35/78
CPC分类号： C07D307/93 , A23L33/105 , A61K31/335 , A61K36/28 , C07D493/04
摘要： An inhibitor of the rennin-angiotensin system is useful for the treatment or prevetion of the lipodystrophy syndrome, e.g. in AIDS patients also receiving anti-retroviral therapy.
摘要翻译：肾素 - 血管紧张素系统的抑制剂可用于治疗或预防脂肪营养不良综合征，例如，艾滋病患者也接受抗逆转录病毒治疗。

5. 发明授权

US5414015A Anti-skin tumor promoting composition 失效
标题翻译：抗皮肤肿瘤促进作用
公开(公告)号：US5414015A
公开(公告)日：1995-05-09
申请号：US2091
申请日：1993-01-08
申请人： Takao Konoshima , Harukuni Tokuda , Munekazu Iinuma , Mizuo Mizuno
发明人： Takao Konoshima , Harukuni Tokuda , Munekazu Iinuma , Mizuo Mizuno
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/30
CPC分类号： A61K31/35
摘要： An anti-skin tumor promotor comprising a compound of the general formula ##STR1## wherein R means a hydrogen atom or a hydroxyl group. The promotor may be an extract of the crude drug Scutellaria or a synthetic compound.
摘要翻译：一种抗皮肤肿瘤促进剂，其包含通式“IMAGE”的化合物，其中R表示氢原子或羟基。促进剂可以是黄芩生物药物或合成化合物的提取物。

6. 发明授权

US08987486B2 Trans-2-decenoic acid derivative and pharmaceutical agent containing the same 有权
标题翻译：反式-2-癸烯酸衍生物和含有它的药剂
公开(公告)号：US08987486B2
公开(公告)日：2015-03-24
申请号：US13883205
申请日：2011-11-01
申请人： Munekazu Iinuma , Shoei Furukawa , Mitsuru Naiki , Tomonori Matsumoto , Hachiro Sugimoto
发明人： Munekazu Iinuma , Shoei Furukawa , Mitsuru Naiki , Tomonori Matsumoto , Hachiro Sugimoto
IPC分类号： C07C57/02 , A61K31/231 , C07C327/30 , C07C217/08 , C07C219/20 , C07C233/09 , C07C233/38 , C07C327/22 , C07C69/533 , C07C219/08 , C07C323/12 , C07D295/13
CPC分类号： C07C327/30 , A61K31/231 , C07C57/02 , C07C69/533 , C07C217/08 , C07C219/08 , C07C219/20 , C07C233/09 , C07C233/38 , C07C323/12 , C07C327/22 , C07C2601/08 , C07C2601/14 , C07D295/13
摘要： An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.
摘要翻译：本发明的目的是提供一种新的反式-2-癸烯酸衍生物或其药学上可接受的盐，并提供含有所述化合物作为活性成分并具有高度安全的神经营养因子样活性的药剂，或减轻由施用抗癌剂引起的副作用的作用。作为本发明化合物的反式-2-癸烯酸衍生物或其药学上可接受的盐，具体由式（1）表示：（式中，Y为-O-，-NR-或-S- ，R为氢原子，烷基，二烷基氨基烷基等，W为二烷基氨基烷基等取代基），作为痴呆，阿尔茨海默病，帕金森病等预防或治疗剂等药剂具有相当高的用途，抑郁症等，脊髓损伤的治疗或修复剂。

7. 发明申请

US20100204498A1 AGENT HAVING NEUROTROPHIC FACTOR-LIKE ACTIVITY 审中-公开
标题翻译：具有神经营养因子活性的药剂
公开(公告)号：US20100204498A1
公开(公告)日：2010-08-12
申请号：US12678671
申请日：2008-09-18
申请人： Munekazu Iinuma , Shoei Furukawa
发明人： Munekazu Iinuma , Shoei Furukawa
IPC分类号： C07C59/185
CPC分类号： A61K31/20 , A61K31/201 , A61K31/23 , A61K31/231
摘要： The present invention provides a pharmaceutical agent having high safety and a neurotrophic factor-like activity, which contains, as an active ingredient, any one compound included in fatty acids each having 8 carbon atoms (C8) or having 10 carbon atoms (C10) to 12 carbon atoms (C12) or fatty acid esters thereof, such as 3,7-dimethyloctanoic acid ethyl ester, geranic acid ethyl ester, and the like, each of which has 8 carbon atoms (C8), decanoic acid methyl ester, trans-2-decenoic acid, trans-2-decenoic acid methyl ester, trans-2-decenoic acid ethyl ester, trans-2-decenoic acid-2-decenyl ester, trans-2-decenoic acid cyclohexyl ester, trans-2-decenoic acid isopropyl ester, trans-3-decenoic acid methyl ester, trans-9-decenoic acid methyl ester, and the like, each of which has 10 carbon atoms (C10), trans-10-undecenoic acid methyl ester, trans-10-undecenoic acid ethyl ester, and the like, each of which has 11 carbon atoms (C11), and dodecanoic acid, and the like, each of which has 12 carbon atoms (C12), or salts thereof or prodrugs thereof.
摘要翻译：本发明提供一种具有高安全性和神经营养因子样活性的药剂，其含有作为活性成分的包含在各自具有8个碳原子（C8）或10个碳原子（C10）的脂肪酸中的任何一种化合物， 12个碳原子（C12）或其脂肪酸酯，例如3,7-二甲基辛酸乙酯，香叶酸乙酯等，它们各自具有8个碳原子（C8），癸酸甲酯， 2-癸烯酸，反式-2-癸烯酸甲酯，反式-2-癸烯酸乙酯，反式-2-癸烯-2-癸烯基酯，反式-2-癸烯酸环己酯，反式-2-癸烯酸异丙酯，反式-3-癸烯酸甲酯，反式-9-癸烯酸甲酯等，各自具有10个碳原子（C10），反式-10-十一碳烯酸甲酯，反式-10-十一碳烯酸酸性乙酯等，各自具有11个碳原子（C11）和十二烷酸等，其各自具有12个碳原子原子（C12）或其盐或其前药。

8. 发明授权

US06992068B2 Cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents, immunosuppressants, drugs, cosmetics, foods and food materials 失效
标题翻译：细胞因子产生抑制剂，保护和促进肝功能的药物，抗炎剂，免疫抑制剂，药物，化妆品，食品和食品材料
公开(公告)号：US06992068B2
公开(公告)日：2006-01-31
申请号：US10311136
申请日：2001-06-13
申请人： Minoru Yoshida , Toshihiro Nakayama , Hiroichi Nagai , Munekazu Iinuma
发明人： Minoru Yoshida , Toshihiro Nakayama , Hiroichi Nagai , Munekazu Iinuma
IPC分类号： A61K31/70
CPC分类号： A61Q19/00 , A23L33/105 , A61K8/63 , A61K8/97 , A61K31/70 , A61K36/48
摘要： Highly safe cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Brazilian licorice extract and periandrins, which are constituents thereof, have excellent characteristics of showing effects of inhibiting cytokine production and protecting and promoting liver function, an anti-inflammatory effect and an immunosuppressive effect without any harmful side effects. Thus use of Brazilian licorice extract or periandrins as cytokine production inhibitors makes it possible to inhibit inflammations in various diseases such as rheumatoid arthritis. These substances are also usable as agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Moreover, foods, cosmetics, sweeteners and food materials containing Brazilian licorice extract exert the effects as described above.
摘要翻译：高度安全的细胞因子产生抑制剂，保护和促进肝功能的药物，抗炎药和免疫抑制剂。作为其成分的巴西甘草提取物和周质蛋白具有显示抑制细胞因子产生的作用，保护和促进肝功能，抗炎作用和免疫抑制作用而没有任何有害副作用的优异特征。因此，使用巴西甘草提取物或周质蛋白作为细胞因子产生抑制剂可以抑制各种疾病如类风湿性关节炎的炎症。这些物质也可用作保护和促进肝功能，抗炎剂和免疫抑制剂的药剂。此外，含有巴西甘草提取物的食品，化妆品，甜味剂和食物材料发挥如上所述的效果。

9. 发明授权

US5399723A Anti-MRSA compound 失效
标题翻译：抗MRSA化合物
公开(公告)号：US5399723A
公开(公告)日：1995-03-21
申请号：US55966
申请日：1993-04-30
申请人： Munekazu Iinuma , Hironori Tsuchiya , Masaru Sato , Shu Fujiwara
发明人： Munekazu Iinuma , Hironori Tsuchiya , Masaru Sato , Shu Fujiwara
IPC分类号： A61K31/35 , A61K31/352 , A61P31/04 , C07D311/28 , C07D311/32 , C07D311/40 , C07D311/74
CPC分类号： C07D311/32
摘要： An anti-MRSA compound comprising of the formula ##STR1## which is generally extracted from the root of Sophora exigua. The usage of this compound is for methicillin-resistant Staphylococcus aureus.
摘要翻译：一种抗MRSA化合物，其包含通常从苦参（Sophora exigua）的根中提取的式“IMAGE”。该化合物的用途是耐甲氧西林金黄色葡萄球菌。

10. 发明申请

US20160374986A1 PPARs AGONIST ACTIVITY ENHANCING DRUG 有权
标题翻译： PPARs AGONIST活动增强药物
公开(公告)号：US20160374986A1
公开(公告)日：2016-12-29
申请号：US15260434
申请日：2016-09-09
申请人： Munekazu Iinuma , Tsujimoto Chemical Co., Ltd.
发明人： Munekazu Iinuma
IPC分类号： A61K31/366 , A61K9/00
CPC分类号： A61K31/366 , A61K9/0053 , C07D309/32
摘要： A lifestyle disease improving drug is disclosed that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons. Methods for enhancing PPARα, γ and δ agonist activities in vertebrates or medically treating a vertebrate are disclosed. The methods include providing a composition of an active ingredient, the lifestyle disease improving drug, in a biologically acceptable medium and administering an effective amount of the composition to a vertebrate.
摘要翻译：公开了一种生活方式改善药物，其增强PPARα，δ和γ激动剂活性，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，烷基含有4个，5个或6个碳。公开了增强脊椎动物中PPARα，γ和δ激动剂活性或医学治疗脊椎动物的方法。所述方法包括在生物可接受的培养基中提供活性成分的组合物，生活方式改善药物，并向脊椎动物施用有效量的组合物。

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