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1. 发明授权

US4999348A Liquid crystal containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions 失效
标题翻译：含有化妆品和药物组合物的液晶以及利用这些组合物的方法
公开(公告)号：US4999348A
公开(公告)日：1991-03-12
申请号：US131458
申请日：1987-12-11
申请人： Gheorghe Cioca , James A. Hayward , Manuel L. Tan , Morris Herstein , Walter P. Smith
发明人： Gheorghe Cioca , James A. Hayward , Manuel L. Tan , Morris Herstein , Walter P. Smith
IPC分类号： A61K8/02 , A61K8/67 , A61K9/127 , A61K31/07 , A61K31/23 , A61K31/355 , A61Q19/00
CPC分类号： A61Q19/00 , A61K31/07 , A61K31/23 , A61K31/355 , A61K8/0295 , A61K8/671 , A61K8/678 , A61K9/1274 , A61Q19/08
摘要： Cosmetic and pharmaceutical compositions and methods comprising delivery systems for the controlled release and enhanced penetration of biologically active materials (e.g., Vitamin A) to the skin. The delivery systems comprise cholesteric liquid crystals wherein the active material is retained within the lamellar molecular structure (i.e., between the molecular sheets) of the cholesteric liquid crystal.
摘要翻译：化妆品和药物组合物和方法包括用于控制释放和增强生物活性物质（例如维生素A）渗透到皮肤中的递送系统。递送系统包括胆甾型液晶，其中活性材料保留在胆甾醇型液晶的层状分子结构内（即分子片之间）。

2. 发明授权

US4530828A Nail conditioner 失效
标题翻译：指甲护发素
公开(公告)号：US4530828A
公开(公告)日：1985-07-23
申请号：US419023
申请日：1982-09-16
申请人： Walter P. Smith , Sergio Nacht
发明人： Walter P. Smith , Sergio Nacht
IPC分类号： A61K8/00 , A45D20060101 , A61K20060101 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/42 , A61K8/46 , A61K8/63 , A61K8/64 , A61K8/65 , A61K8/92 , A61K31/00 , A61K47/00 , A61Q3/00 , A61Q3/02 , A61K7/04 , A61K7/06
CPC分类号： A61K8/342 , A61K8/31 , A61K8/37 , A61K8/42 , A61K8/463 , A61K8/63 , A61K8/64 , A61Q3/00
摘要： A nail conditioning composition comprising an aqueous emulsion of sodium lauryl sulfate, urea and hydrolyzed animal protein in the aqueous phase and mineral oil, cholesterol and a lipid in the oil phase, said lipid being cetyl alcohol, cetyl palmitate or a base salt of palmitic or stearic acids. The composition moisturizes and imparts flexibility to the nail and softens the cuticle area.
摘要翻译：一种指甲调理组合物，其包含月桂基硫酸钠，尿素水解乳液和水相中的水解动物蛋白质，矿物油，胆固醇和油相中的脂质，所述脂质是鲸蜡醇，棕榈酸十六烷酯或棕榈酸或其盐硬脂酸。该组合物润湿并赋予指甲柔韧性并软化角质层面积。

3. 发明授权

US4851215A Pantethine component for hair permanent waving 失效
标题翻译：用于头发永久挥舞的Pantethine组件
公开(公告)号：US4851215A
公开(公告)日：1989-07-25
申请号：US728205
申请日：1985-04-29
申请人： Walter P. Smith , Geoffrey R. Hawkins , David Yeung
发明人： Walter P. Smith , Geoffrey R. Hawkins , David Yeung
IPC分类号： A61K8/00 , A61K20060101 , A61K8/44 , A61K8/46 , A61Q5/04
CPC分类号： A61Q5/04 , A61K8/447
摘要： Pantethine and pantetheine in permanent waving operations for hair to increase waving efficiency.
摘要翻译：永久性挥发性操作为头发增加挥发效能的潘婷和泛ant胺。

4. 发明授权

US5869540A Herbal treatments for improving skin appearance 失效
标题翻译：用于改善皮肤外观的草药治疗
公开(公告)号：US5869540A
公开(公告)日：1999-02-09
申请号：US625751
申请日：1996-03-29
申请人： Walter P. Smith
发明人： Walter P. Smith
IPC分类号： A61K8/97 , A61K9/08 , A61K36/00 , A61K36/539 , A61K36/84 , A61Q19/00 , A61Q19/08 , A01N25/00 , A61K47/00
CPC分类号： A61Q19/08 , A61K36/84 , A61K8/97
摘要： The invention provides herbal treatments for aged skin employing valerian extracts and other active herbal agents that are effective as relaxants. Surprisingly, mere ingestion of valerian tea on a daily basis is effective to reduce deep wrinkles. The treatments are particularly effective on persons afflicted by stress and are shown by clinical tests to reduce wrinkles and acne lesions and to improve skin texture and skin color without an increase in puffiness such as might be expected from mere hydration of the skin. The herbal agents can be administered either in a tea or a topical composition, and a combination of the two treatments is particularly effective. A preferred herbal agent is an aqueous valerian root extract. Other herbal agents include extracts of passion flower and mullein.
摘要翻译：本发明提供使用缬草提取物和作为松弛剂有效的其它活性中草药的老化皮肤的草药治疗。令人惊讶的是，每天只摄入缬草茶有效减少深层皱纹。治疗对患有压力的人特别有效，并且通过临床试验显示出减少皱纹和痤疮损伤并改善皮肤纹理和肤色，而不会增加浮肿，例如可能仅由皮肤水合而预期。草药可以在茶或局部组合物中施用，并且两种处理的组合是特别有效的。优选的草药是缬草水提取物。其他中草药包括激情花和毛列侬的提取物。

5. 发明授权

US5587396A Method of ameliorating cellulite by disrupting the barrier function of the stratum corneum 失效
标题翻译：通过破坏角质层的屏障功能来改善脂肪团的方法
公开(公告)号：US5587396A
公开(公告)日：1996-12-24
申请号：US296513
申请日：1994-08-26
申请人： Walter P. Smith
发明人： Walter P. Smith
IPC分类号： A61K8/365 , A61K8/67 , A61K8/68 , A61Q19/06 , A61K31/19
CPC分类号： A61K8/68 , A61K8/365 , A61K8/671 , A61Q19/06
摘要： New topically applied treatments for cellulite are shown by comparative data to effect structural improvements in cellulite-afflicted thigh area tissues including skin-thickening, thigh-firming and thigh-reduction. The disclosed treatments disrupt the skin's water barrier and elevate trans-epidermal water loss (TEWL) for extended periods of weeks or months and include methods of mechanical or solvent action, for example, tape stripping, or acetone washes. Preferred treatments use creams with active ingredients such as lactic acid to elevate TEWL, a retinoid, preferably vitamin A palmitate to disrupt barrier rebuilding and prolong elevation of TEWL levels, and a cerebroside to inhibit lipid synthesis and intensify the TEWL elevation. Diuretics, for immediate esthetic improvements, anti-irritants and anti-oxidants for irritation control are optional ingredients.
摘要翻译：通过比较数据显示新的局部应用的脂肪团治疗，以实现在脂肪组织变化的大腿区域组织中的结构改善，包括皮肤增厚，大腿紧固和大腿减少。所公开的治疗方法破坏皮肤的水屏障并且延长表皮水分流失（TEWL）延长的周或数月，并且包括机械或溶剂作用的方法，例如带剥离或丙酮洗涤。优选的治疗方法使用乳酸等活性成分的乳膏来提升TEWL，类视黄醇，优选维生素A棕榈酸酯，以破坏屏障重建并延长TEWL水平的升高，以及脑苷脂抑制脂质合成并加强TEWL升高。用于立即美观改善的利尿剂，抗刺激剂和抗氧化剂用于刺激控制是任选成分。

6. 发明授权

US5028428A Anti-irritant and desensitizing compositions and methods of their use 失效
标题翻译：抗刺激和脱敏组合物及其使用方法
公开(公告)号：US5028428A
公开(公告)日：1991-07-02
申请号：US230444
申请日：1988-08-09
申请人： Walter P. Smith , Nicholas J. Pelliccione , Kenneth D. Marenus , Daniel H. Maes
发明人： Walter P. Smith , Nicholas J. Pelliccione , Kenneth D. Marenus , Daniel H. Maes
IPC分类号： A61K8/96 , A61K8/00 , A61K8/34 , A61K8/97 , A61K36/00 , A61K36/18 , A61P17/00 , A61P39/02 , A61Q9/04 , A61Q17/00
CPC分类号： A61K8/97 , A61Q17/00 , A61K2800/75 , Y10S514/886 , Y10S514/887
摘要： Compositions and methods for reducing the adverse reaction of skin to chemicals and compositions that contact the skin, e.g., topical cosmetic and pharmaceutical preparations, and to contact physical irritants. The active ingredient of the composition of the invention comprises a hydro-alcoholic extract of Cola nitida.

7. 发明授权

US4839164A Trehalose containing cosmetic composition and method of using it 失效
标题翻译：含海藻糖的化妆品组合物及其使用方法
公开(公告)号：US4839164A
公开(公告)日：1989-06-13
申请号：US17781
申请日：1987-02-24
申请人： Walter P. Smith
发明人： Walter P. Smith
IPC分类号： A61K8/44 , A61K8/60 , A61K8/64 , A61K8/66 , A61K8/67 , A61Q5/02 , A61Q5/12 , A61Q19/00
CPC分类号： A61Q1/06 , A61K8/447 , A61K8/60 , A61K8/606 , A61K8/64 , A61K8/66 , A61K8/671 , A61Q19/00 , A61Q5/02 , A61Q5/12 , Y10S514/847 , Y10S514/937 , Y10S514/938 , Y10S514/944
摘要： The present invention relates to a cosmetic composition and to a method of using that composition to enhance the penetration of topically applied ingredients into the cells of the skin. The composition preferably comprises:(a) at least one cosmetic ingredient selected from the group consisting of retinyl palmitate at a concentration of about 0.01 to about 1% by weight, pantethine or a cosmetically acceptable ester of pantethine at a concentration of about 0.1 to about 2% by weight, superoxide dismutase at a concentration of about 0.001 to about 1% by weight, and epidermal growth factor at a concentration of about 0.001 to about 1% by weight;(b) about 0.1 to about 20% by weight of trehalose; and(c) a cosmetically acceptable vehicle.
摘要翻译：本发明涉及一种化妆品组合物和使用该组合物来增强局部施用成分渗入皮肤细胞的方法。所述组合物优选包含：（a）至少一种选自浓度为约0.01至约1重量％的视黄醇棕榈酸酯的化妆品成分，泛奈胺或潘尼泰的美容上可接受的酯，浓度为约0.1至约浓度为约0.001至约1重量％的超氧化物歧化酶，浓度为约0.001至约1重量％的表皮生长因子; （b）约0.1至约20重量％的海藻糖; 和（c）美容上可接受的载体。

8. 发明授权

US4786493A Hair protection composition 失效
标题翻译：头发保护组成
公开(公告)号：US4786493A
公开(公告)日：1988-11-22
申请号：US800999
申请日：1985-11-22
申请人： Walter P. Smith , Frederick J. Penna
发明人： Walter P. Smith , Frederick J. Penna
IPC分类号： A61K8/00 , A61K8/34 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/64 , A61K8/65 , A61K8/66 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61K7/06 , A61K7/42 , A61K7/44 , A61K9/12
CPC分类号： A61K8/447 , A61K8/345 , A61K8/46 , A61K8/66 , A61Q17/04 , A61Q5/02 , A61Q5/06 , A61Q5/12 , Y10S514/944
摘要： Disclosed are a composition for protecting hair from damage caused by exposure to ultraviolet light and a method of using the composition. The composition comprises:(a) a first component selected from the group consisting of a material having superoxide dismutase activity, ascorbic acid, Cytochrome C, mixtures of nicotinamide dehydrogenase and lactate dehydrogenase, uric acid, uric acid salts, and mixtures thereof;(b) a second component selected from the group consisting of mannitol, catalase, and mixtures thereof, and(c) a third component selected from the group consisting of a disulfide, a thiol, and mixtures thereof, said disulfide and said thiol each having a molecular weight of at least about 100.
摘要翻译：公开了一种用于保护头发免受暴露于紫外线的损害的组合物和使用该组合物的方法。该组合物包含：（a）选自具有超氧化物歧化酶活性的物质，抗坏血酸，细胞色素C，烟酰胺脱氢酶和乳酸脱氢酶的混合物，尿酸，尿酸盐及其混合物的第一组分; （b）选自甘露醇，过氧化氢酶及其混合物的第二组分，和（c）选自二硫化物，硫醇及其混合物的第三组分，所述二硫化物和所述硫醇各自具有分子量至少约100。

9. 发明授权

US4534964A Hair conditioning shampoo 失效
标题翻译：头发调理洗发水
公开(公告)号：US4534964A
公开(公告)日：1985-08-13
申请号：US569528
申请日：1984-01-12
申请人： Morris S. Herstein , Walter P. Smith , Geoffrey R. Hawkins
发明人： Morris S. Herstein , Walter P. Smith , Geoffrey R. Hawkins
IPC分类号： A61K8/41 , A61K8/46 , A61K31/16 , A61Q5/12 , C11D1/94 , A61K7/06
CPC分类号： A61Q5/12 , A61K8/416 , A61K8/466 , Y10S514/873
摘要： An aqueous hair conditioning shampoo composition comprising about 0.5-10 percent by weight of cocamidopropyl hydroxysultaine and about 0.1-6 percent by weight of a quaternary halide of an N,N,N-trialkylaminoalkylene gluconamide.
摘要翻译：包含约0.5-10重量％的椰油酰胺丙基羟基磺基甜菜碱和约0.1-6重量％的N，N，N-三烷基氨基亚烷基葡糖酸酰胺的季卤化物的水性洗发剂组合物。

10. 发明授权

US4362682A Chip-free staple fiber process 失效
标题翻译：无芯片短纤维工艺
公开(公告)号：US4362682A
公开(公告)日：1982-12-07
申请号：US179583
申请日：1980-08-21
申请人： Gerald A. Berg , Hermann Buchert , Steve R. Duffy , Richard E. Harder , E. R. Higgs , Louis D. Hoblit , James R. Ryffel , Walter P. Smith , Edwin L. Stenzel
发明人： Gerald A. Berg , Hermann Buchert , Steve R. Duffy , Richard E. Harder , E. R. Higgs , Louis D. Hoblit , James R. Ryffel , Walter P. Smith , Edwin L. Stenzel
IPC分类号： D01C1/04 , D01D4/02 , D01D5/092 , D01F6/60 , D01G1/00 , D01D9/10
CPC分类号： D01D5/092 , D01F6/60
摘要： An equilibrium melt from a standard hydrolytic or anionic polymerization of caprolactam is spun at a temperature between about 230.degree. and 270.degree. C. through a spinnerette, preferably one having a multiplicity of holes spaced from each other in an asymmetric arrangement, the spinning take-away speed being less than about 250 meters/minute. The molten strands of polycaprolactam are quenched in two phases: (1) gas at a temperature of less than 20.degree. C. is directed from a first entrance in a crosscurrent flow upon the face of the spinnerette and upon the molten polycaprolactam strands immediately adjacent thereto, and is exhausted adjacent to the back of the spinnerette; and (2) gas at a temperature of less than 20.degree. C. is directed in a countercurrent flow from a second entrance downstream from the first entrance with respect to the direction of movement of the polycaprolactam strands; whereby the surface temperature of the polycaprolactam strands is reduced to 30.degree.-70.degree. C. A drawing and crimping lubricant and antistatic agent is then applied to the surface of the polycaprolactam strands, which are then drawn at a total draw ratio between 3 and 5. The polycaprolactam strands are then crimped and cut into staple lengths, which are subsequently washed in multiple stages, dried, and packaged for subsequent use or sale.
摘要翻译：来自己内酰胺的标准水解或阴离子聚合的平衡熔体在约230℃至270℃的温度下通过纺丝板纺丝，优选为具有以不对称布置彼此间隔开的多个孔的纺丝纱，远离速度小于约250米/分钟。聚己内酰胺的熔融线股分两个阶段骤冷：（1）温度低于20℃的气体以旋流流动的第一入口从喷丝板的表面和直接相邻的熔融聚己内酰胺链并且在喷丝板的背面附近被耗尽; 和（2）温度低于20℃的气体相对于聚己内酰胺束的运动方向以来自第一入口下游的第二入口的逆流流动; 从而将聚己内酰胺股线的表面温度降低至30°-70℃。然后将拉伸和卷曲润滑剂和抗静电剂施加到聚己内酰胺股线的表面上，然后以总拉伸比3至5 然后将聚己内酰胺股线卷曲并切割成短纤维，随后将其洗涤多个阶段，干燥并包装以备后续使用或销售。

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