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    • 5. 发明授权
    • Cosmetic skin-renewal-stimulating composition with long-term irritation
control
    • 化妆品皮肤更新刺激组合物具有长期的刺激控制
    • US5616332A
    • 1997-04-01
    • US410387
    • 1995-03-27
    • Morris Herstein
    • Morris Herstein
    • A61K8/365A61K8/41A61Q17/00A61K7/00A61K7/48
    • A61K8/41A61K8/365A61Q17/00A61Q19/08A61K2800/75Y10S514/847Y10S514/859
    • A cosmetic skin-renewal stimulating composition suitable for daily use by consumers and providing anti-aging benefits with control of delayed irritation. The invention adds small quantities of a naturally occurring small-molecule, biologically active, aliphatic aminodiol lipid, for example sphingosine, to cosmetics incorporating a skin-renewal stimulating acid, for example lactic, hydroxybenzoic or retinoic acid, to provide control of deferred hyperproliferative allergenicity induced by the skin-renewal stimulating acid. Comparative data show a beneficial control of long-term irritation induced by several weeks of daily use of a variety of skin-renewal stimulating acids. The novel activity is displayed by sphingosine alone among several classes of biologically active skin lipids, in a selective and surprising manner. The results suggest applicability of the invention to wider classes of cell-proliferation agents for the control of deferred hyperproliferative allergenicity.
    • 一种适合消费者日常使用的化妆品皮肤更新刺激组合物,并提供抗衰老的好处,控制延迟刺激。 本发明将少量天然存在的小分子,生物活性的脂族氨基二醇脂质(例如鞘氨醇)添加到掺入皮肤更新刺激酸(例如乳酸,羟基苯甲酸或视黄酸)的化妆品中,以提供对延缓的过度增殖变应原性的控制 由皮肤更新刺激酸诱导。 比较数据显示对日常使用各种皮肤更新刺激酸的几周引起的长期刺激的有益控制。 这种新型活性以选择性和令人惊讶的方式由单独的鞘氨醇单独显示在几类生物活性皮肤脂质中。 结果表明本发明适用于更广泛类型的细胞增殖剂用于控制延缓的过度增殖变应原性。