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1. 发明申请

US20100285985A1 Methods and Systems for the Generation of Plurality of Security Markers and the Detection Therof 审中-公开
标题翻译：用于生成多种安全标记的方法和系统及其检测方法
公开(公告)号：US20100285985A1
公开(公告)日：2010-11-11
申请号：US12690799
申请日：2010-01-20
申请人： Minghwa Liang , James A. Hayward , Lawrence Jung
发明人： Minghwa Liang , James A. Hayward , Lawrence Jung
IPC分类号： C40B30/04 , C40B50/00 , C40B50/06 , C40B40/06
CPC分类号： G07D7/14 , C08L89/00 , C09D7/65 , C09D11/00 , C12Q1/6816 , C12Q2563/185
摘要： This invention pertains to methods for generating large quantities of DNA security markers by combinatorial variation techniques using polymorphic fragment length DNA for unique identification security marker applications such as explosive ink used in dye/smoke pack and cash carrying boxes.
摘要翻译：本发明涉及通过使用多态性片段长度DNA的组合变异技术产生大量DNA安全标记的方法，用于独特的鉴定安全标记应用，例如用于染料/烟雾包装和现金携带盒中的爆炸性油墨。

2. 发明授权

US06183774B2 Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts 有权
标题翻译：通过包封在用烷基铵脂肪酸盐形成的脂质囊泡中来稳定维生素A衍生物
公开(公告)号：US06183774B2
公开(公告)日：2001-02-06
申请号：US09375683
申请日：1999-08-17
申请人： Duncan T. Aust , Michael A. Ross , James M. Wilmott , James A. Hayward
发明人： Duncan T. Aust , Michael A. Ross , James M. Wilmott , James A. Hayward
IPC分类号： A61K9127
CPC分类号： A61K9/1272
摘要： The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.
摘要翻译：本发明提供了选自视黄醇，视黄酯以及与烷基铵脂肪酸盐形成的脂质体中的任意组合的维生素A衍生物及其制造方法。本发明的脂质体可以在预设的触发条件发生时递送维生素A衍生物质。本发明优选的脂质体是阳离子脂质体。本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。包封的维生素A衍生物因此被脂质体稳定。因此，本发明还提供了一种将维生素A衍生物稳定化在这种脂质体中的方法。本发明的脂质体用于提供用于治疗皮肤的局部皮肤治疗制剂。

3. 发明授权

US08420400B2 System and method for authenticating tablets 有权
标题翻译：用于验证平板电脑的系统和方法
公开(公告)号：US08420400B2
公开(公告)日：2013-04-16
申请号：US11954055
申请日：2007-12-11
申请人： James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
发明人： James A. Hayward , Ming-Hwa Liang , Stephane Shu-Kin-So
IPC分类号： G01N33/00 , C12Q1/68
CPC分类号： C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
摘要： A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material.
摘要翻译：描述了用于认证和验证正品的药物的方法。用于鉴定片剂的方法包括将与特定的核酸碱基序列相关联的特定核酸材料施用于片剂或胶囊。该方法还包括收集片剂样品并通过检测特定的核酸材料来验证片剂是真实的。

4. 发明申请

US20120052125A1 Cholesteryl Sulfate-Containing Composition As A Haemostatic 审中-公开
标题翻译：含有硫酸胆固醇的组合物作为止血剂
公开(公告)号：US20120052125A1
公开(公告)日：2012-03-01
申请号：US13055951
申请日：2009-08-04
申请人： Martin Wieland , James A. Hayward
发明人： Martin Wieland , James A. Hayward
IPC分类号： A61K31/575 , A61K9/14 , B05D3/00 , B29C71/00 , B29C35/16 , A61K9/00 , A61P7/04
CPC分类号： A61L15/44 , A61L15/20 , A61L15/28 , A61L15/32 , A61L24/0015 , A61L24/08 , A61L24/102 , A61L27/20 , A61L27/24 , A61L27/54 , A61L2300/222 , A61L2300/418 , A61L2300/45 , A61L2400/04
摘要： The present invention relates to a composition comprising a wound dressing device and cholesteryl sulfate and especially to a composition containing cholesteryl sulfate and at least one carrier material for use as a haemostatic agent, as well as to a method for its preparation and use.
摘要翻译：本发明涉及包含伤口敷料装置和胆固醇硫酸盐的组合物，特别涉及含有胆固醇硫酸盐和至少一种用作止血剂的载体材料的组合物，以及其制备和使用方法。

5. 发明申请

US20090042191A1 SYSTEM AND METHOD FOR SECURE DOCUMENT PRINTING AND DETECTION 有权
标题翻译：用于安全文件打印和检测的系统和方法
公开(公告)号：US20090042191A1
公开(公告)日：2009-02-12
申请号：US11954044
申请日：2007-12-11
申请人： James A. Hayward , Ming-Hwa Liang , John Davis
发明人： James A. Hayward , Ming-Hwa Liang , John Davis
IPC分类号： C12Q1/68 , G01N33/00
CPC分类号： C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , C09D11/38 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
摘要： A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The method also comprises collecting a sample of either the ink or toner compound and verifying the ink or toner is genuine by detecting the particular nucleic acid material.
摘要翻译：描述用于认证和验证正品的物品的方法。用于认证该项目的方法包括将与特定核酸碱基序列相关联的特定核酸材料施加到墨盒内的墨盒或调色剂外壳内的调色剂化合物中。该方法还包括收集油墨或调色剂化合物的样品，并通过检测特定的核酸材料来验证油墨或调色剂是真实的。

6. 发明授权

US5874105A Lipid vesicles formed with alkylammonium fatty acid salts 失效
标题翻译：由烷基铵脂肪酸盐形成的脂质囊泡
公开(公告)号：US5874105A
公开(公告)日：1999-02-23
申请号：US594175
申请日：1996-01-31
申请人： David C. Watkins , Thomas J. Vichroski , James A. Hayward
发明人： David C. Watkins , Thomas J. Vichroski , James A. Hayward
IPC分类号： A61K9/127
CPC分类号： A61K9/1272
摘要： A liposome for use in encapsulating both hydrophobic and hydrophilic substances (i.e., a "payload"),is disclosed which is capable of delivering their load upon the occurrence of a trigger or control condition. The liposomes are formed to stably encapsulate a particular active agent to form a delivery vehicle for the agent. The liposomes of the delivery vehicle are stable in a particular environment but become unstable or permeable if passed from the stable environment (e.g., characteristic of a particular pH and/or temperature and/or ionic strength) to a changed or unstable environment, thereby delivering their payload.
摘要翻译：公开了一种用于封装疏水和亲水物质（即“有效载荷”）的脂质体，其能够在发生触发或控制条件时传递其负载。形成脂质体以稳定地包封特定的活性剂以形成药剂的递送载体。递送载体的脂质体在特定环境中是稳定的，但是如果从稳定的环境（例如，特定的pH和/或温度和/或离子强度的特征）传递到改变或不稳定的环境，则其变得不稳定或可渗透，由此递送他们的有效载荷。

7. 发明授权

US08435541B2 Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities 有权
标题翻译：用于抑制基质金属蛋白酶并提供抗氧化活性的局部组合物
公开(公告)号：US08435541B2
公开(公告)日：2013-05-07
申请号：US12874884
申请日：2010-09-02
申请人： Joseph D. Ceccoli , Brian Costello , James A. Hayward , Konstantinos M. Lahanas
发明人： Joseph D. Ceccoli , Brian Costello , James A. Hayward , Konstantinos M. Lahanas
IPC分类号： A61K8/97
CPC分类号： A61Q19/08 , A61K8/64 , A61K8/97 , A61K8/9706 , A61K2800/782 , A61Q19/005
摘要： A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.
摘要翻译：本发明的用于提供基质金属蛋白酶（MMP）抑制活性的皮肤护理方案，金属蛋白酶（TIMP）诱导活性的组织抑制剂）和立即和延迟的抗氧化活性的局部组合物。优选地，所述局部组合物包含至少一种MMP抑制剂，TIMP诱导剂，银耳银耳（雪母）提取物，山茶花（绿茶）叶提取物和丁香菊（Eugenia caryophyllus）（丁香）提取物。该组合物可用于抗皱和抗衰老产品，为皮肤提供弹性，坚固度，色调和质地，改善细纹并防止皮肤损伤。

8. 发明授权

US08415164B2 System and method for secure document printing and detection 有权
标题翻译：用于安全文件打印和检测的系统和方法
公开(公告)号：US08415164B2
公开(公告)日：2013-04-09
申请号：US11954044
申请日：2007-12-11
申请人： James A. Hayward , Ming-Hwa Liang , John Davis
发明人： James A. Hayward , Ming-Hwa Liang , John Davis
IPC分类号： G01N33/00 , C12Q1/68
CPC分类号： C12Q1/6816 , C08K5/09 , C09D7/63 , C09D11/03 , C09D11/38 , Y10T436/14 , Y10T436/143333 , Y10T442/2508 , C12Q2563/185
摘要： A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The method also comprises collecting a sample of either the ink or toner compound and verifying the ink or toner is genuine by detecting the particular nucleic acid material.
摘要翻译：描述用于认证和验证正品的物品的方法。用于认证该项目的方法包括将与特定核酸碱基序列相关联的特定核酸材料施加到墨盒内的墨盒或调色剂外壳内的调色剂化合物中。该方法还包括收集油墨或调色剂化合物的样品，并通过检测特定的核酸材料来验证油墨或调色剂是真实的。

9. 发明申请

US20120058140A1 TOPICAL COMPOSITIONS FOR INHIBITING MATRIX METALLOPROTEASES AND PROVIDING ANTIOXIDATIVE ACTIVITIES 有权
标题翻译：用于抑制基质金属元素和提供抗氧化活性的主题组合物
公开(公告)号：US20120058140A1
公开(公告)日：2012-03-08
申请号：US12874884
申请日：2010-09-02
申请人： Joseph D. Ceccoli , Brian Costello , James A. Hayward , Konstantinos M. Lahanas
发明人： Joseph D. Ceccoli , Brian Costello , James A. Hayward , Konstantinos M. Lahanas
IPC分类号： A61K8/97 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/64 , A61K8/97 , A61K8/9706 , A61K2800/782 , A61Q19/005
摘要： A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.
摘要翻译：本发明的用于提供基质金属蛋白酶（MMP）抑制活性的皮肤护理方案，金属蛋白酶（TIMP）诱导活性的组织抑制剂）和立即和延迟的抗氧化活性的局部组合物。优选地，所述局部组合物包含至少一种MMP抑制剂，TIMP诱导剂，银耳银耳（雪母）提取物，山茶花（绿茶）叶提取物和丁香菊（Eugenia caryophyllus）（丁香）提取物。该组合物可用于抗皱和抗衰老产品，为皮肤提供弹性，坚固度，色调和质地，改善细纹并防止皮肤损伤。

10. 发明授权

US5942501A Cyclodextrin derivative complex 失效
标题翻译：环糊精衍生物复合物
公开(公告)号：US5942501A
公开(公告)日：1999-08-24
申请号：US699150
申请日：1996-08-16
申请人： James A. Hayward , James Maioriello , Joseph D. Ceccoli
发明人： James A. Hayward , James Maioriello , Joseph D. Ceccoli
IPC分类号： A61K31/60 , A61K47/48 , A61K31/72 , A01N37/36
CPC分类号： B82Y5/00 , A61K31/60 , A61K47/48969
摘要： A salicylic acid (SA) and derivitized beta cyclodextrin complex provides that the SA display increased solubility in water. The complex includes about 0.1 to about 10.0 percent salicylic acid, about 0.1 to about 75.0 percent derivatized beta cyclodextrin and about 0.1 to about 50.0 percent water.
摘要翻译：水杨酸（SA）和衍生的β-环糊精复合物提供SA显示增加在水中的溶解度。复合物包括约0.1至约10.0％的水杨酸，约0.1至约75.0％的衍生的β-环糊精和约0.1至约50.0％的水。

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