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1. 发明申请

US20090260847A1 Data Transmission Cable and Method for Producing a Data Transmission Cable 审中-公开
标题翻译：数据传输电缆和数据传输电缆的制造方法
公开(公告)号：US20090260847A1
公开(公告)日：2009-10-22
申请号：US12427389
申请日：2009-04-21
申请人： Gerold Tobben , Bernd Janssen
发明人： Gerold Tobben , Bernd Janssen
IPC分类号： H01B11/00 , H01B13/22
CPC分类号： H01B11/203 , H01B11/1091
摘要： A data transmission cable (2) comprises at least one pair of wires (4) comprising two wires (6) lying parallel to each other, each with an electrical conductor (8) surrounded by an insulation (10). The pair of wires (4) is sheathed over its length by a foil (12) with an electrically conducting inner side (14) and an electrically insulating outer side (16). To improve the electrical properties of the data transmission cable (2), the foil (12) has a longitudinal fold (18), so that the inner side (14) is directed outward, an additional wire (20), which contacts the inner side (14) made to face outward, being laid on the foil (12).
摘要翻译：数据传输电缆（2）包括至少一对线（4），其包括彼此平行放置的两条电线（6），每条电线（8）由绝缘体（10）包围。一对电线（4）通过具有导电内侧（14）和电绝缘外侧（16）的箔（12）在其长度上被覆盖。为了改善数据传输电缆（2）的电气性能，箔片（12）具有纵向折叠（18），使得内侧（14）被引导向外，附加的线（20）接触内部（14）面向外，被放置在箔（12）上。

2. 发明申请

US20120095024A1 TOLUIDINE SULFONAMIDES AND THEIR USE 审中-公开
标题翻译：托洛芬磺酰胺及其用途
公开(公告)号：US20120095024A1
公开(公告)日：2012-04-19
申请号：US13142519
申请日：2009-12-30
申请人： Jorge Alonson , Arantxa Encionas Lopez , Marcel Muelbaler , Lochen Ammenn , Bernd Vendt , Joe Lewis , Christoph Schultes , Bernd Janssen
发明人： Jorge Alonson , Arantxa Encionas Lopez , Marcel Muelbaler , Lochen Ammenn , Bernd Vendt , Joe Lewis , Christoph Schultes , Bernd Janssen
IPC分类号： A61K31/505 , C07D213/64 , C07D213/84 , C07D239/28 , C07D333/38 , A61K31/41 , A61K31/4418 , A61K31/381 , A61P35/00 , A61P9/00 , A61P29/00 , A61P19/02 , A61P11/06 , A61P1/00 , A61P17/06 , A61P17/00 , A61P17/14 , A61P17/02 , A61P35/02 , A61P27/06 , C07D307/52 , C07C311/21 , C07D333/20 , C07D213/42 , A61K31/341 , A61K31/18 , A61P35/04 , C07D257/04
CPC分类号： C07C311/21 , C07C311/29 , C07C311/39 , C07D207/335 , C07D207/34 , C07D213/42 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/74 , C07D213/84 , C07D213/85 , C07D231/12 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D307/52 , C07D307/84 , C07D333/20 , C07D333/38
摘要： The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).
摘要翻译：本发明提供抑制细胞增殖和细胞分裂并抑制缺氧诱导因子（HIF）介导的转录和在缺氧条件下的信号传导的新型化合物。一方面，本发明的化合物可用于制备用于治疗或预防选自以下的疾病或病症的药物：炎性疾病，过度增殖性疾病或病症，缺氧相关病理学和一种以血管过度为特征的疾病。还提供了包含本发明化合物和可用于治疗或预防所述疾病或病症的第二治疗剂或辐射的药物组合物。在第一方面，本发明涉及具有式（I）结构的化合物。

3. 发明授权

US07662786B2 Dolastatin 15 derivatives 有权
标题翻译： Dolastatin 15衍生物
公开(公告)号：US07662786B2
公开(公告)日：2010-02-16
申请号：US11406512
申请日：2006-04-18
申请人： Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
发明人： Bernd Janssen , Teresa Barlozzari , Andreas Haupt , Thomas Zierke , Andreas Kling
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , C12P19/34
摘要： Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a β-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
摘要翻译：本发明的化合物包括作为式I的肽，ABDEF-（G）r-（K）sL（I）及其酸式盐的细胞生长抑制剂，其中A，B，D，E，F，G和K 是α-氨基酸残基，s和r各自独立地为0或1.L为单价基团，例如氨基，N-取代氨基，β-羟基氨基，酰肼基，烷氧基，硫代烷氧基，氨氧基或肟基。本发明还包括用于治疗哺乳动物（例如人）中的癌症的方法，包括向所述哺乳动物施用有效量的药学上可接受的组合物中的式I化合物。

4. 发明申请

US20060059463A1 Remote build and management for software applications 审中-公开
标题翻译：远程构建和管理软件应用程序
公开(公告)号：US20060059463A1
公开(公告)日：2006-03-16
申请号：US10937992
申请日：2004-09-10
申请人： Bernd Janssen , Banikumar Maiti
发明人： Bernd Janssen , Banikumar Maiti
IPC分类号： G06F9/44
CPC分类号： G06F8/71 , G06F8/447
摘要： Techniques for remotely building and managing software applications are provided. Computer code of the principal developer (e.g., source code, object code or libraries) that is not to be shared with external parties is stored on a restricted internal server while computer code of a third party supplier or customer is stored on a shared server by the supplier. A daemon executes on the restricted server to access the computer code on the shared server, download the computer code to the restricted server and call the internal compiler, linker, etc. to build the complete software application. The build is then stored or uploaded on the shared server (by the daemon) for the supplier or customer to access. Files related to the build that are desirable not to share (e.g., map files and all sensitive source code files) can be stored on the restricted server.
摘要翻译：提供远程构建和管理软件应用程序的技术。不与外部共享的主要开发人员的计算机代码（例如，源代码，目标代码或库）存储在受限的内部服务器上，而第三方供应商或客户的计算机代码由供应商。守护进程在受限服务器上执行，以访问共享服务器上的计算机代码，将计算机代码下载到受限服务器，并调用内部编译器，链接器等构建完整的软件应用程序。然后将构建存储或上传到共享服务器（由守护程序）供供应商或客户访问。与构建相关的不希望共享的文件（例如，映射文件和所有敏感源代码文件）可以存储在受限服务器上。

5. 发明申请

US20060009392A1 Antineoplastic peptides 有权
标题翻译：抗肿瘤肽
公开(公告)号：US20060009392A1
公开(公告)日：2006-01-12
申请号：US11179074
申请日：2005-07-11
申请人： Wilhelm Amberg , Teresa Barlozzari , Harald Bernard , Ernst Buschmann , Andreas Haupt , Hans-Guenther Hege , Bernd Janssen , Andreas Kling , Helmut Lietz , Kurt Ritter , Martina Ullrich , Jurgen Weymann , Thomas Zierke
发明人： Wilhelm Amberg , Teresa Barlozzari , Harald Bernard , Ernst Buschmann , Andreas Haupt , Hans-Guenther Hege , Bernd Janssen , Andreas Kling , Helmut Lietz , Kurt Ritter , Martina Ullrich , Jurgen Weymann , Thomas Zierke
IPC分类号： A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K5/101 , C07K7/02
摘要： The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.
摘要翻译：本发明提供了式I的抗肿瘤肽，<？in-line-formula description =“In-line formula”end =“lead”？> R＆lt; 2＆gt; N-CHX-CO-ABDE-（G）在线式描述=“在线公式”end =“tail”？>其中R 1， / SUP>，R 2，X，A，B，D，E，G，K和S具有说明书中所述的含义。该化合物具有抗肿瘤活性。

6. 发明授权

US5196532A Diaryl-substituted heterocyclic compounds, their preparation and drugs and cosmetics obtained therefrom 失效
公开(公告)号：US5196532A
公开(公告)日：1993-03-23
申请号：US717264
申请日：1991-06-18
申请人： Hans-Heiner Wuest , Bernd Janssen , William V. Murray , Michael P. Wachter , Stanley Bell
发明人： Hans-Heiner Wuest , Bernd Janssen , William V. Murray , Michael P. Wachter , Stanley Bell
IPC分类号： C07D207/32 , C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/22 , C07D231/24 , C07D233/54 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24
CPC分类号： C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/22 , C07D231/24 , C07D233/64 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/107 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24
摘要： Compounds of formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo,L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.20 -alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine,R.sup.9 and R.sup.10 are each hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.6 -alkanoyl or are each benzoyl which is unsubstituted or substituted as for R.sup.8, or R.sup.9 and R.sup.10, together with the nitrogen atom to which they are bonded, form a saturated, 5-membered or 6-membered heterocyclic radical which may contain oxygen as the second heteroatom,R.sup.11 is hydrogen, C.sub.1 -C.sub.4 -alkyl, --OR.sup.13 or --NR.sup.14 R.sup.15, where R.sup.13 is hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.8 -alkyl, aryl or aralkyl which is unsubstituted or substituted by chlorine, bromine, methyl, methoxy or nitro, substitution in the case of the aralkyl group being in the aryl moiety, and where R.sup.14 and R.sup.15 are each hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.6 -alkyl or an aralkyl or aryl group which is unsubstituted or substituted as for R.sup.13, or R.sup.14 and R.sup.15, together with the nitrogen atom to which they are bonded, form a heterocyclic radical as defined above for R.sup.9 and R.sup.10, andR.sup.12 is C.sub.1 14 C.sub.4 -alkyl,and compounds of formula Ia ##STR3## where R.sup.3, R.sup.4, R.sup.6 and L have the abovementined meanings and R.sup.17 is hydrogen or hydroxyl, and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.

7. 发明授权

US5087743A Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom 失效
标题翻译：二苯甲酮衍生物，其制备方法及其制备的药物和化妆品
公开(公告)号：US5087743A
公开(公告)日：1992-02-11
申请号：US469063
申请日：1990-01-23
申请人： Bernd Janssen , Hans-Heiner Wuest
发明人： Bernd Janssen , Hans-Heiner Wuest
IPC分类号： A61K31/085 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/67 , A61K31/10 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/255 , A61K31/66 , A61P17/00 , A61P29/00 , A61P35/00 , A61P39/02 , A61Q19/00 , C07C39/17 , C07C43/20 , C07C43/205 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C49/643 , C07C59/68 , C07C59/70 , C07C63/44 , C07C65/21 , C07C65/24 , C07C65/26 , C07C69/035 , C07C69/76 , C07C69/773 , C07C69/92 , C07C69/94 , C07C205/34 , C07C205/37 , C07C211/60 , C07C215/76 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/84 , C07C217/86 , C07C219/34 , C07C223/02 , C07C223/06 , C07C225/16 , C07C225/22 , C07C229/36 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/44 , C07C233/47 , C07C233/55 , C07C233/75 , C07C233/80 , C07C235/42 , C07C237/30 , C07C239/02 , C07C239/08 , C07C255/51 , C07C255/54 , C07C259/10 , C07C309/42 , C07C309/46 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/40 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/22 , C07C327/30 , C07D257/04 , C07F9/38 , C07F9/40
CPC分类号： C07F9/3834 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/46 , A61K8/671 , A61Q19/00 , C07C205/34 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/75 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C39/17 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C59/70 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07F9/4021 , C07C2102/10
摘要： Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R.sup.1 -R.sup.6 have the meanings specified in the description, and the preparation thereof are described.The substances are suitable for controlling diseases and as cosmetic agents.
摘要翻译：描述了其中A和R 1 -R 6具有说明书中规定的含义的式I的（I）的二苯基杂烷基衍生物及其制备。该物质适用于控制疾病和化妆品。

8. 发明授权

US4906652A Azolymethyloxiranes and their use as crop protection agents 失效
标题翻译： Azolymethyloxiranes及其作为作物保护剂的用途
公开(公告)号：US4906652A
公开(公告)日：1990-03-06
申请号：US183448
申请日：1988-04-14
申请人： Stefan Karbach , Bernd Janssen , Norbert Meyer , Hubert Sauter , Eberhard Ammermann , Ernst-Heinrich Pommer
发明人： Stefan Karbach , Bernd Janssen , Norbert Meyer , Hubert Sauter , Eberhard Ammermann , Ernst-Heinrich Pommer
IPC分类号： C07D405/06 , A01N43/50 , A01N43/653 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07D233/56 , C07D249/08
摘要： Compounds of the formula ##STR1## where R, Hal and Z have the meanings given in the disclosure. The compounds are suitable for use as fungicides.
摘要翻译：其中R，Hal和Z具有本公开中给出的含义的式“IMAGE”的化合物。该化合物适用于杀真菌剂。

9. 发明授权

US4607045A Azolylmethylcycloacetals, their preparation and their use as drugs 失效
标题翻译：唑基甲基环缩醛，它们的制备及其作为药物的用途
公开(公告)号：US4607045A
公开(公告)日：1986-08-19
申请号：US691851
申请日：1985-01-16
申请人： Bernd Janssen , Friedrich-Wilhelm Kohlmann , Walter Wesenberg , Wolfgang Heberle
发明人： Bernd Janssen , Friedrich-Wilhelm Kohlmann , Walter Wesenberg , Wolfgang Heberle
IPC分类号： C07D405/06 , A61K31/41 , A61K31/415 , A61P31/04 , A61P31/10 , C07D317/00 , C07D319/00 , C07D319/06 , C07D521/00 , A01N43/50 , A01N43/653
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D319/06
摘要： Azolylmethylcycloacetals of the formula I ##STR1## where R is phenyl which can be substituted by halogen, or is C.sub.1 -C.sub.6 -alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, Z is CH or N, and m is 0 or 1, and their physiologically tolerated addition salts with acids and their preparation are described.The novel substances have an antimycotic action.
摘要翻译：式I的唑基甲基环缩醛其中R是可以被卤素取代的苯基，或是C 1 -C 6烷基，R 1是氢或C 1 -C 3烷基，Z是CH或N，m是0 或1，并且描述了它们与酸的生理学耐受加成盐及其制备。新物质具有抗真菌作用。

10. 发明授权

US08440626B2 Antineoplastic peptides 有权
标题翻译：抗肿瘤肽
公开(公告)号：US08440626B2
公开(公告)日：2013-05-14
申请号：US12869314
申请日：2010-08-26
申请人： Wilhelm Amberg , Teresa Barlozzari , Harald Bernard , Ernst Buschmann , Andreas Haupt , Hans-Guenther Hege , Bernd Janssen , Andreas Kling , Helmut Lietz , Kurt Ritter , Martina Ullrich , Jurgen Weymann , Thomas Zierke
发明人： Wilhelm Amberg , Teresa Barlozzari , Harald Bernard , Ernst Buschmann , Andreas Haupt , Hans-Guenther Hege , Bernd Janssen , Andreas Kling , Helmut Lietz , Kurt Ritter , Martina Ullrich , Jurgen Weymann , Thomas Zierke
IPC分类号： A61K38/00 , A61K38/08 , A61P35/00 , C07K7/00
CPC分类号： C07K7/06 , A61K38/00 , C07K5/101 , C07K7/02
摘要： The present invention provides antineoplastic peptides of formula I, I R1R2N-CHX-CO-A-B-D-E-(G)S-K wherein R1, R2, X, A, B, D, E, G, K and s have the meanings stated in the description. The compounds have antineoplastic activity.
摘要翻译：本发明提供式I的抗肿瘤肽I R1R2N-CHX-CO-ABDE-（G）SK，其中R1，R2，X，A，B，D，E，G，K和s具有说明书中所述的含义。该化合物具有抗肿瘤活性。

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