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1. 发明申请

US20050003519A1 Method for the fabrication of a "lab on chip" from photoresist material for medical diagnostic applications 失效
标题翻译：用于从用于医疗诊断应用的光致抗蚀剂材料制造“芯片上的实验室”的方法
公开(公告)号：US20050003519A1
公开(公告)日：2005-01-06
申请号：US10486681
申请日：2002-08-05
申请人： Gerhard Jobst , Thomas Gamp
发明人： Gerhard Jobst , Thomas Gamp
IPC分类号： G01N33/543 , C12M1/34 , B05D3/00 , C12M3/00
CPC分类号： G01N33/54366 , G01N33/54353 , G01N33/5438
摘要： The present invention relates to a device for performing immuno assays (“biochip” or “lab on chip” respectively), a procedure for its fabrication and the use of the device for performing immuno assays. Furthermore the present invention relates to the use of a photo lithographically patternable dry film photo resist based on a material with functional chemical groups for the immobilization of biomolecules.
摘要翻译：本发明涉及用于进行免疫测定的装置（“生物芯片”或“芯片上的实验室”），其制造方法和用于进行免疫测定的装置的使用。此外，本发明涉及基于具有用于固定生物分子的功能化学基团的材料的光刻图案的干膜光致抗蚀剂的用途。

2. 发明授权

US07691623B2 Method for the fabrication of a “lab on chip” from photoresist material for medical diagnostic applications 失效
标题翻译：用于从用于医疗诊断应用的光致抗蚀剂材料制造“芯片上的实验室”的方法
公开(公告)号：US07691623B2
公开(公告)日：2010-04-06
申请号：US10486681
申请日：2002-08-05
申请人： Gerhard Jobst , Thomas Gamp
发明人： Gerhard Jobst , Thomas Gamp
IPC分类号： C12M1/34
CPC分类号： G01N33/54366 , G01N33/54353 , G01N33/5438
摘要： The present invention relates to a device for performing immuno assays (“biochip” or “lab on chip” respectively), a procedure for its fabrication and the use of the device for performing immuno assays. Furthermore the present invention relates to the use of a photo lithographically patternable dry film photo resist based on a material with functional chemical groups for the immobilization of biomolecules.
摘要翻译：本发明涉及用于进行免疫测定的装置（“生物芯片”或“芯片上的实验室”），其制造方法和用于进行免疫测定的装置的使用。此外，本发明涉及基于具有用于固定生物分子的功能化学基团的材料的光刻图案的干膜光致抗蚀剂的用途。

3. 发明申请

US20100010323A1 Temperature-compensated in-vivo sensor 审中-公开
标题翻译：温度补偿体内传感器
公开(公告)号：US20100010323A1
公开(公告)日：2010-01-14
申请号：US12563685
申请日：2009-09-21
申请人： Gerhard Jobst
发明人： Gerhard Jobst
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B2560/0252
摘要： A reagent matrix composition disposed on an electrically conductive electrode to form an in-vivo sensor for a predefined analyte includes a first hydrogel layer containing an enzyme that is a substrate for the analyte adjacent the electrically conductive electrode and a composite membrane layer disposed onto the first hydrogel layer where the composite layer includes a membrane hydrogel containing a plurality of microspheres. The plurality of microspheres is made of a material having no or little permeability to the analyte and a substantially high permeability to oxygen.
摘要翻译：设置在导电电极上以形成用于预定分析物的体内传感器的试剂基质组合物包括含有作为邻近导电电极的分析物的底物的酶的第一水凝胶层和设置在第一水凝胶层，其中复合层包括含有多个微球的膜水凝胶。多个微球体由对分析物没有或几乎没有渗透性的材料制成，并且对氧气具有基本上高的渗透性。

4. 发明申请

US20130032493A1 Sensor Arrangement for Continuously Monitoring Analytes in a Biological Fluid 审中-公开
标题翻译：用于连续监测生物液体中的分析物的传感器布置
公开(公告)号：US20130032493A1
公开(公告)日：2013-02-07
申请号：US13519939
申请日：2010-12-22
申请人： Anton Karlsson , Anders Carlsson , Gerhard Jobst
发明人： Anton Karlsson , Anders Carlsson , Gerhard Jobst
IPC分类号： G01N27/327 , G01N27/26
CPC分类号： C12Q1/001
摘要： A sensor for continuous detection of one or more analytes in a liquid flow, comprising an array of electrodes together forming an essentially planar sensing surface and a flow distributor with a flow inlet a flow channel and a flow outlet in order to establish a liquid flow of analytes along the sensing surface. The flow inlet and the flow outlet are located in a plane different to the plane of the sensing surface. The array of electrodes is arranged so that, in the direction from the flow inlet to the flow outlet, the array of electrodes consecutively comprises a first blank electrode, at least one measuring electrode, a second blank electrode, at least one measuring electrode and optionally a third blank electrode.
摘要翻译：一种用于在液体流中连续检测一种或多种分析物的传感器，包括一起形成基本上平面的感测表面的电极阵列和具有流动入口的流动分配器，流动通道和流出口用于建立液体流动分析物沿着感测面。流入口和流出口位于与感测表面平面不同的平面中。电极阵列被布置成使得在从流入口到流出口的方向上，电极阵列连续地包括第一空白电极，至少一个测量电极，第二空白电极，至少一个测量电极和任选地第三空白电极。

5. 发明授权

US09101304B2 On-line measuring system of body substances 有权
标题翻译：身体物质在线测量系统
公开(公告)号：US09101304B2
公开(公告)日：2015-08-11
申请号：US13000708
申请日：2009-07-02
申请人： Stefan Lindgren , Anders Carlsson , Anton Karlsson , Henrik Falkén , Gerhard Jobst
发明人： Stefan Lindgren , Anders Carlsson , Anton Karlsson , Henrik Falkén , Gerhard Jobst
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486 , A61B5/1495
CPC分类号： A61B5/14532 , A61B5/14525 , A61B5/14528 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412
摘要： A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).
摘要翻译：一种用于连续测量体液成分的测量系统（100），所述测量系统（100）包括微透析导管或探针（110），所述微透析导管或探针（110）包括放置在血流或组织液中的微透析膜（116）。测量系统还包括用于连续测量已经通过微透析膜（116）的流体中存在的物质的浓度的流通传感器（200）。测量系统（100）还包括废物容器（126）。

6. 发明申请

US20090275815A1 Temperature-compensated in-vivo sensor 审中-公开
标题翻译：温度补偿体内传感器
公开(公告)号：US20090275815A1
公开(公告)日：2009-11-05
申请号：US12503376
申请日：2009-07-15
申请人： Charles Bickoff , Thomas H. Peterson , Gerhard Jobst
发明人： Charles Bickoff , Thomas H. Peterson , Gerhard Jobst
IPC分类号： A61B5/1473
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/6848 , A61B2560/0252
摘要： An in-vivo sensor assembly includes an assembly body having a body proximal end and a body distal end, a plurality of sensor elements including at least an analyte sensor element containing an enzyme that is a substrate of the analyte to be measured, a reference sensor element and a temperature sensor element disposed at or near the body distal end wherein the at least an analyte sensor element and the reference sensor element are exposed to the sample fluid and the temperature sensor is capable of measuring the temperature of and adjacent to the analyte sensor element, and an electrical coupling means disposed at the body proximal end and configured to couple to the at least an analytical sensor element, the reference sensor element and the temperature sensor element.
摘要翻译：体内传感器组件包括具有身体近端和身体远端的组件主体，多个传感器元件至少包括分析物传感器元件，所述分析物传感器元件包含作为待测量分析物的基底的酶，参考传感器元件和设置在身体远端处或附近的温度传感器元件，其中至少分析物传感器元件和参考传感器元件暴露于样品流体，并且温度传感器能够测量分析物传感器的温度并与其相邻元件和设置在身体近端处并且被配置为耦合到至少一个分析传感器元件，参考传感器元件和温度传感器元件的电耦合装置。

7. 发明授权

US06801041B2 Sensor having electrode for determining the rate of flow of a fluid 有权
标题翻译：传感器具有用于确定流体流速的电极
公开(公告)号：US06801041B2
公开(公告)日：2004-10-05
申请号：US10145837
申请日：2002-05-14
申请人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
发明人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
IPC分类号： G01N2702
CPC分类号： G01F1/64 , C12Q1/006
摘要： Sensors that are capable measuring the rate of flow of a fluid that passes over the electrodes of the sensor. In these sensors, an electrode, designated the flow rate-determining electrode, is used in conjunction with the conventional electrodes, e.g., the working electrode, the reference electrode, and the counter electrode, to determine the rate of flow of the fluid. In one aspect, this invention provides a sensor for measuring the concentration of an analyte in a sample of fluid when the sample flows continuously over the electrodes of the sensor, especially when the rate of flow of the sample is relatively low. In another aspect, this invention provides a method for measuring the concentration of an analyte in a sample of fluid, wherein the rate of flow of the sample varies during the period of time that the sensor is in place. In a preferred embodiment, the sensor employs four electrodes, namely, a working electrode, a reference electrode, a counter electrode, and a flow rate-determining electrode. Alternatively, a single electrode that performs both the function of the reference electrode and the function of the counter electrode can replace the reference electrode and the counter electrode. In addition, a dummy electrode or a blank electrode can be used to compensate for interference from electrochemically active species. The reagent(s) specific to the analyte of interest is required to be deposited on the working electrode.
摘要翻译：能够测量通过传感器电极的流体流速的传感器。在这些传感器中，与常规电极（例如工作电极，参比电极和对电极）结合使用称为流速确定电极的电极，以确定流体的流速。一方面，本发明提供一种传感器，用于当样品连续地流过传感器的电极时，特别是当样品的流速相对较低时，用于测量流体样品中分析物的浓度。在另一方面，本发明提供了一种用于测量流体样品中分析物浓度的方法，其中样品的流速在传感器就位的时间段内变化。在优选实施例中，传感器使用四个电极，即工作电极，参考电极，对电极和流速确定电极。或者，执行参考电极的功能和对电极的功能的单个电极可以替代参考电极和对电极。此外，可以使用虚拟电极或空白电极来补偿来自电化学活性物质的干扰。需要将特定于目标分析物的试剂沉积在工作电极上。

8. 发明申请

US20110213230A1 On-Line Measuring System of Body Substances 有权
标题翻译：体内在线测量系统
公开(公告)号：US20110213230A1
公开(公告)日：2011-09-01
申请号：US13000708
申请日：2009-07-02
申请人： Stefan Lindgren , Anders Carlsson , Anton Karlsson , Henrik Falkén , Gerhard Jobst
发明人： Stefan Lindgren , Anders Carlsson , Anton Karlsson , Henrik Falkén , Gerhard Jobst
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/14525 , A61B5/14528 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/412
摘要： A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).
摘要翻译：一种用于连续测量体液成分的测量系统（100），所述测量系统（100）包括微透析导管或探针（110），所述微透析导管或探针（110）包括放置在血流或组织液中的微透析膜（116）。测量系统还包括用于连续测量已经通过微透析膜（116）的流体中存在的物质的浓度的流通传感器（200）。测量系统（100）还包括废物容器（126）。

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