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1. 发明授权

US08888716B2 Multiple-biosensor article 有权
标题翻译：多生物传感器文章
公开(公告)号：US08888716B2
公开(公告)日：2014-11-18
申请号：US13494212
申请日：2012-06-12
申请人： Yi Wang , Jared Lee Watkin , Chad Harold Mace , Michael Robert Zocchi , Shridhara Alva Karinka , Mark E. Tess
发明人： Yi Wang , Jared Lee Watkin , Chad Harold Mace , Michael Robert Zocchi , Shridhara Alva Karinka , Mark E. Tess
IPC分类号： B65D81/00 , A61B5/1486 , G01N33/487
CPC分类号： G01N27/27 , A61B5/1486 , A61B2562/0295 , G01N27/3272 , G01N33/4875
摘要： An article suitable for conducting one or more assays with an apparatus, e.g., a meter, for determining the presence or concentration of an analyte in a sample of biological fluid. The article contains a plurality of biosensors arranged in such a manner that each of the biosensors can be utilized before the article must be removed from the apparatus.
摘要翻译：适于用仪器（例如仪表）进行一个或多个测定的用于确定生物流体样品中分析物的存在或浓度的物品。所述制品包含多个生物传感器，所述生物传感器以这样的方式布置，即在所述制品必须从所述装置中取出之前，可以使用每个所述生物传感器。

2. 发明授权

US08409425B2 Biosensor coating composition and methods thereof 有权
标题翻译：生物传感器涂料组合物及其制备方法
公开(公告)号：US08409425B2
公开(公告)日：2013-04-02
申请号：US13568974
申请日：2012-08-07
申请人： Nigel John Forrow , Shridhara Alva Karinka
发明人： Nigel John Forrow , Shridhara Alva Karinka
IPC分类号： G01N27/26 , A61L17/00 , B05D1/00
CPC分类号： C12Q1/001 , C12Q1/004 , C12Q1/006
摘要： The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
摘要翻译：本公开提供了用于包含释放聚合物的生物传感器的试剂组合物，制备这种生物传感器的方法和包含释放聚合物的试剂组合物的膜。试剂组合物包含释放聚合物和有效分析物检测量酶，酶辅助因子和能够在生物传感器中起作用的氧化还原化合物作为（i）与工作电极相关联的氧化还原介体（ii）与参比电极或（iii）与工作电极相关的氧化还原介体和用于参比电极的氧化还原对。

3. 发明授权

US08163160B2 Biosensor having improved hematocrit and oxygen biases 有权
标题翻译：生物传感器具有改善的血细胞比容和氧气偏倚
公开(公告)号：US08163160B2
公开(公告)日：2012-04-24
申请号：US12815169
申请日：2010-06-14
申请人： Nigel J. Forrow , Shridhara Alva Karinka
发明人： Nigel J. Forrow , Shridhara Alva Karinka
IPC分类号： G01N27/327 , G01N33/50 , G01F1/64
CPC分类号： C12Q1/006 , C12Q1/004
摘要： The present invention provides reagent compositions, and analyte measuring devices and methods that utilize the reagent compositions.
摘要翻译：本发明提供了试剂组合物以及利用试剂组合物的分析物测量装置和方法。

4. 发明申请

US20100019784A1 Analyte Sensor with Insertion Monitor, and Methods 审中-公开
标题翻译：带插入式监测器的分析物传感器及方法
公开(公告)号：US20100019784A1
公开(公告)日：2010-01-28
申请号：US12571107
申请日：2009-09-30
申请人： Yi Wang , Joseph A. Vivolo , Shridhara Alva Karinka
发明人： Yi Wang , Joseph A. Vivolo , Shridhara Alva Karinka
IPC分类号： G01R27/08
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , A61B2562/085 , A61B2562/227 , C12Q1/006
摘要： A sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector.
摘要翻译：一种传感器，以及用于使用诸如库仑法，电流分析法和电位法等技术测定生物流体如血液或血清中的分析物如葡萄糖或乳酸盐的浓度的方法。传感器包括工作电极和对电极，并且可以包括插入监视轨迹，以确定传感器在连接器中的正确定位。

5. 发明申请

US20090255811A1 BIOSENSOR COATING COMPOSITION AND METHODS THEREOF 有权
标题翻译：生物传感器涂层组合物及其方法
公开(公告)号：US20090255811A1
公开(公告)日：2009-10-15
申请号：US12102374
申请日：2008-04-14
申请人： Nigel John Forrow , Shridhara Alva Karinka
发明人： Nigel John Forrow , Shridhara Alva Karinka
IPC分类号： G01N27/26 , B05D5/12 , C12Q1/25 , C12Q1/32 , B05D3/06
CPC分类号： C12Q1/001 , C12Q1/004 , C12Q1/006
摘要： The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The reagent compositions comprise a release polymer and an effective analyte detecting amount of an enzyme an enzyme cofactor and a redox compound capable of acting in a biosensor as (i) a redox mediator associated with a working electrode (ii) a redox couple associated with a reference electrode or (iii) the redox mediator associated with the working electrode and the redox couple for the reference electrode.
摘要翻译：本公开提供了用于包含释放聚合物的生物传感器的试剂组合物，制备这种生物传感器的方法和包含释放聚合物的试剂组合物的膜。试剂组合物包含释放聚合物和有效分析物检测量酶，酶辅助因子和能够在生物传感器中起作用的氧化还原化合物作为（i）与工作电极相关联的氧化还原介体（ii）与参比电极或（iii）与工作电极相关的氧化还原介体和用于参比电极的氧化还原对。

6. 发明授权

US06939450B2 Device having a flow channel 有权
标题翻译：具有流通道的装置
公开(公告)号：US06939450B2
公开(公告)日：2005-09-06
申请号：US10266548
申请日：2002-10-08
申请人： Shridhara Alva Karinka , Mark E. Tess
发明人： Shridhara Alva Karinka , Mark E. Tess
IPC分类号： B01L3/00 , C12Q1/00 , G01N27/403 , G01N33/487 , G01N27/327 , B01L3/02 , G01N21/00
CPC分类号： B01L3/502723 , B01L2300/0645 , B01L2300/0825 , B01L2400/0406 , B01L2400/0688 , C12Q1/001 , G01N27/3272
摘要： A device having a flow channel, wherein at least one flow-terminating interface is used to control the flow of liquid in the flow channel. The flow-terminating interface prevents the flow of the liquid beyond the interface. In one aspect, the invention provides a sensor, such as, for example, a biosensor, in the form of a strip, the sensor being suitable for electrochemical or optical measurement. The sensor comprises a base layer and a cover layer, and the base layer is separated from the cover layer by a spacer layer. The base layer, cover layer, and spacer layer define a flow channel into which a liquid sample is drawn therein and flows therethrough by means of capillary attraction. The flow of the sample is terminated by a flow-terminating interface positioned in the flow channel.
摘要翻译：一种具有流动通道的装置，其中使用至少一个流动终止界面来控制流动通道中的液体的流动。流动终止界面防止液体流过界面。在一个方面，本发明提供一种传感器，例如带状的传感器，例如生物传感器，该传感器适用于电化学或光学测量。传感器包括基底层和覆盖层，并且基底层通过间隔层与覆盖层分离。基层，覆盖层和间隔层限定了流动通道，液体样品在其中被抽吸到其中并通过毛细管吸引流过其中。样品的流动由位于流动通道中的流动终止界面终止。

7. 发明授权

US06801041B2 Sensor having electrode for determining the rate of flow of a fluid 有权
标题翻译：传感器具有用于确定流体流速的电极
公开(公告)号：US06801041B2
公开(公告)日：2004-10-05
申请号：US10145837
申请日：2002-05-14
申请人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
发明人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
IPC分类号： G01N2702
CPC分类号： G01F1/64 , C12Q1/006
摘要： Sensors that are capable measuring the rate of flow of a fluid that passes over the electrodes of the sensor. In these sensors, an electrode, designated the flow rate-determining electrode, is used in conjunction with the conventional electrodes, e.g., the working electrode, the reference electrode, and the counter electrode, to determine the rate of flow of the fluid. In one aspect, this invention provides a sensor for measuring the concentration of an analyte in a sample of fluid when the sample flows continuously over the electrodes of the sensor, especially when the rate of flow of the sample is relatively low. In another aspect, this invention provides a method for measuring the concentration of an analyte in a sample of fluid, wherein the rate of flow of the sample varies during the period of time that the sensor is in place. In a preferred embodiment, the sensor employs four electrodes, namely, a working electrode, a reference electrode, a counter electrode, and a flow rate-determining electrode. Alternatively, a single electrode that performs both the function of the reference electrode and the function of the counter electrode can replace the reference electrode and the counter electrode. In addition, a dummy electrode or a blank electrode can be used to compensate for interference from electrochemically active species. The reagent(s) specific to the analyte of interest is required to be deposited on the working electrode.
摘要翻译：能够测量通过传感器电极的流体流速的传感器。在这些传感器中，与常规电极（例如工作电极，参比电极和对电极）结合使用称为流速确定电极的电极，以确定流体的流速。一方面，本发明提供一种传感器，用于当样品连续地流过传感器的电极时，特别是当样品的流速相对较低时，用于测量流体样品中分析物的浓度。在另一方面，本发明提供了一种用于测量流体样品中分析物浓度的方法，其中样品的流速在传感器就位的时间段内变化。在优选实施例中，传感器使用四个电极，即工作电极，参考电极，对电极和流速确定电极。或者，执行参考电极的功能和对电极的功能的单个电极可以替代参考电极和对电极。此外，可以使用虚拟电极或空白电极来补偿来自电化学活性物质的干扰。需要将特定于目标分析物的试剂沉积在工作电极上。

8. 发明授权

US08465425B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08465425B2
公开(公告)日：2013-06-18
申请号：US12495807
申请日：2009-06-30
申请人： Adam Heller , Benjamin Jay Feldman , Shridhara Alva Karinka , Yi Wang , John R. Galasso
发明人： Adam Heller , Benjamin Jay Feldman , Shridhara Alva Karinka , Yi Wang , John R. Galasso
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/7445 , A61B2562/0295
摘要： In aspects of the present disclosure, an auto turn on blood glucose monitoring unit including a calibration unit integrated with one or more components of an analyte monitoring system is provided. Also disclosed are methods, systems, devices and kits for providing the same.

9. 发明授权

US08354012B2 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：US08354012B2
公开(公告)日：2013-01-15
申请号：US12038928
申请日：2008-02-28
申请人： Terence Alan Reid , Shridhara Alva Karinka , Milind P. Nagale , Yi Wang , Gurdial Sanghera
发明人： Terence Alan Reid , Shridhara Alva Karinka , Milind P. Nagale , Yi Wang , Gurdial Sanghera
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e.g., a dual-purpose reference/counter electrode.
摘要翻译：一种电化学电池，用于检测和定量液体样品中的分析物，特别是具有小体积的液体样品。在优选实施例中，电化学电池包括导电层和绝缘层的组件。电化学电池可以通过在绝缘基板上交替地沉积导电材料和绝缘材料来形成。优选地，离绝缘基板最远的层是绝缘层，以在处理电化学电池期间最小化导电层的损伤。在另一个实施例中，导电层和绝缘层的组合可以形成在绝缘基板的两个主表面上。该组件可以包括至少一个工作电极和至少一个其它电极，例如双用途参考/对电极。

10. 发明授权

US08346337B2 Analyte monitoring device and methods of use 有权
标题翻译：分析物监测装置及使用方法
公开(公告)号：US08346337B2
公开(公告)日：2013-01-01
申请号：US12495803
申请日：2009-06-30
申请人： Adam Heller , Benjamin Jay Feldman , Shridhara Alva Karinka , Yi Wang , John R. Galasso
发明人： Adam Heller , Benjamin Jay Feldman , Shridhara Alva Karinka , Yi Wang , John R. Galasso
IPC分类号： A61B5/04 , A61B5/00 , G01N27/00
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/4839 , A61B5/7242 , A61B5/7445 , C12Q1/006 , G01N33/66 , G06F19/00
摘要： In aspects of the present disclosure, a multi compatible or universal blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that require calibration code and test strips that do not require calibration code. Also disclosed are methods, systems, devices and kits for providing the same.
摘要翻译：在本公开的方面，包括校准单元的多个兼容或通用血糖监测单元与分析物监测系统的一个或多个组件集成，以提供与体外测试条的兼容性，所述体外测试条需要校准代码，而不需要校准代码需要校准代码。还公开了用于提供其的方法，系统，装置和套件。

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