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1. 发明申请

US20110224576A1 METHODS AND DEVICES FOR TISSUE COLLECTION AND ANALYSIS 审中-公开
标题翻译：用于组织收集和分析的方法和装置
公开(公告)号：US20110224576A1
公开(公告)日：2011-09-15
申请号：US13046738
申请日：2011-03-12
申请人： George W. Jackson , Charles Houssiere
发明人： George W. Jackson , Charles Houssiere
IPC分类号： A61B10/02
CPC分类号： A61B10/0233 , A61B10/0283
摘要： The present invention is directed to methods and devices for tissue collection and analysis, and particularly to methods and devices for collecting, preserving and analyzing biopsy samples. In one aspect, a method for collecting a tissue sample includes disposing a collection device proximate and/or within a tissue, such as of a body, drawing in at least a portion of the tissue into the collection device, adhering the at least a portion of the tissue to at least a portion of the collection device and separating the sample and collection device from the remainder of the tissue and/or body. In general, the method of adhering the tissue sample to the collection device may also preserve the tissue sample, such as, for example, by altering the temperature of the tissue sample. In one embodiment, the method of adhering the tissue sample to the collection device includes lowering the temperature of the collection device and thus the tissue sample such that the tissue sample may adhere to the collection device and may also be preserved against degradation.
摘要翻译：本发明涉及用于组织收集和分析的方法和装置，特别涉及用于收集，保存和分析活组织检查样品的方法和装置。在一个方面，一种用于收集组织样本的方法包括将收集装置设置在组织（例如身体）附近和/或内部，将组织的至少一部分拉入收集装置，将至少一部分的至少一部分收集装置，并将样品和收集装置与组织和/或身体的其余部分分离。通常，将组织样本粘附到收集装置的方法也可以保留组织样本，例如通过改变组织样本的温度。在一个实施例中，将组织样本粘附到收集装置的方法包括降低收集装置和因此组织样本的温度，使得组织样本可以粘附到收集装置并且还可以防止降解。

2. 发明授权

US09035034B2 Functional ligands to target molecules 有权
标题翻译：功能配体靶向分子
公开(公告)号：US09035034B2
公开(公告)日：2015-05-19
申请号：US13748566
申请日：2013-01-23
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： C07H21/04 , C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2320/11 , C12N2330/31
摘要： The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.
摘要翻译：本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。本发明还涉及与靶分子具有亲和力结合的功能性配体。本发明还涉及用于产生例如功能性生物分子，特别是功能性核酸的方法，所述功能性生物分子与另一生物分子例如受体分子的功能活性结合。本文使用的多于一个或多个靶标通常可以包括不同类型的靶标，和/或还可以包括在不同条件下的多种单一类型的靶标，例如温度，pH，化学环境和/ 或任何其他适当的条件。

3. 发明申请

US20130245243A1 FUNCTIONAL LIGANDS TO TARGET MOLECULES 有权
标题翻译：功能配对目标分子
公开(公告)号：US20130245243A1
公开(公告)日：2013-09-19
申请号：US13748566
申请日：2013-01-23
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16 , C12N2320/11 , C12N2330/31
摘要： The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.
摘要翻译：本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。本发明还涉及与靶分子具有亲和力结合的功能性配体。本发明还涉及用于产生例如功能性生物分子，特别是功能性核酸的方法，所述功能性生物分子与另一生物分子例如受体分子的功能活性结合。本文使用的多于一个或多个靶标通常可以包括不同类型的靶标，和/或还可以包括在不同条件下的多种单一类型的靶标，例如温度，pH，化学环境和/ 或任何其他适当的条件。

4. 发明授权

US6103078A Methods for preparing membranes with fluid distribution passages 失效
标题翻译：用流体分配通道制备膜的方法
公开(公告)号：US6103078A
公开(公告)日：2000-08-15
申请号：US390740
申请日：1999-09-07
申请人： G. Duncan Hitchems , Harry Jabs , Craig C. Andrews , Oliver J. Murphy , William White , George W. Jackson , Charles L. C. Tennakoon
发明人： G. Duncan Hitchems , Harry Jabs , Craig C. Andrews , Oliver J. Murphy , William White , George W. Jackson , Charles L. C. Tennakoon
IPC分类号： B01D61/44 , B01D61/52 , C08J5/22 , H01M8/10 , C25B13/00
CPC分类号： H01M8/1088 , B01D61/445 , B01D61/52 , C08J5/2275 , H01M8/1023 , H01M8/1039 , H01M8/106 , H01M8/1072 , C08J2323/12 , H01M2300/0082 , Y02P70/56
摘要： The present invention provides improved ionically conducting membranes having internal passages therethrough and methods for making the improved membranes. The membranes may be formed from any ionically conducting material. In particular, the membranes may be formed of a single ionically conducting material, such as in a cation-conductive or anion-conductive membrane, or a plurality of ionically conducting material, such as in a bipolar membrane having a cation-selective region, an anion-selective region, and an interfacial region between the anion-selective region and the cation-selective region.
摘要翻译：本发明提供了具有内部通道的改进的离子导电膜及其制备方法。膜可以由任何离子导电材料形成。特别地，膜可以由单个离子导电材料形成，例如在阳离子导电或阴离子导电膜中，或多个离子导电材料，例如具有阳离子选择性区域的双极膜，阴离子选择性区域以及阴离子选择性区域和阳离子选择性区域之间的界面区域。

5. 发明授权

US5846446A Ice making bag 失效
标题翻译：制冰袋
公开(公告)号：US5846446A
公开(公告)日：1998-12-08
申请号：US848610
申请日：1997-04-29
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： F25C1/24
CPC分类号： F25C1/243
摘要： A first ice making bag (110) comprises a first envelope (112) which comprises a first envelope top (112T) and a first envelope bottom (112B). The first ice making bag (110) further comprises a first binding (114) which comprises a first peripheral binding (114A). A first left peripheral opening binding (114AL), and a first right peripheral opening binding (114AR). The first left peripheral opening binding (114AL) and the first right peripheral opening binding (114AR) form a gap therebetween. The first binding (114) functions to form a pocket between the first envelope top (112T) and the first envelope bottom (112B). The first ice making bag (110) further comprises at least one first opening binding (114B) forming an air channel between the first left peripheral opening binding (114AL) or the first right peripheral opening binding (114AR) and the at least one first opening binding (114B). An user holds the first ice making bag (110) in a vertical position pouring liquid in through the gap into the pocket formed between the first envelope top (112T) and a first envelope bottom (112B) and placing the first ice making bag (110) in a freezer to form first ice (118). The air channel functions to facilitate release of air previously entrapped in the pocket during filing.
摘要翻译：第一制冰袋（110）包括第一封套（112），其包括第一封套顶部（112T）和第一封套底部（112B）。第一制冰袋（110）还包括包括第一外围装订件（114A）的第一装订件（114）。第一左周边开口装订（114AL）和第一右周边开口装订（114AR）。第一左周边开口装订（114AL）和第一右周围开口装订（114AR）在其间形成间隙。第一装订（114）用于在第一封套顶部（112T）和第一封套底部（112B）之间形成一个凹槽。第一制冰袋（110）还包括在第一左周围开口装订（114AL）或第一右周围开口装订（114AR）和至少一个第一开口（114AR）之间形成空气通道的至少一个第一开口装订（114B）绑定（114B）。使用者将第一制冰袋（110）保持在垂直位置，将液体通过间隙倾倒入形成在第一封套顶部（112T）和第一封套底部（112B）之间的凹穴中，并将第一制冰袋（110））在冷冻器中形成第一个冰（118）。空气通道用于在归档期间促进先前夹在口袋中的空气的释放。

6. 发明授权

US5813185A Spacer reciever for a wall form tie rod 失效
标题翻译：隔墙接收器用于墙形拉杆
公开(公告)号：US5813185A
公开(公告)日：1998-09-29
申请号：US639574
申请日：1996-04-29
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： E04C5/16 , E04G17/065 , E04B1/02 , E04C3/30
CPC分类号： E04C5/16 , E04C5/165 , E04G17/0657 , Y10S411/901 , Y10S411/903
摘要： A tie rod assembly for use with forms for forming a wall of pourable, curable material. Each assembly has a rod having opposite threaded ends and two spacers. Each of the spacers has a first conical section having a recessed opening at an apex region of a concave conical guide surface and a hexagonal recess surrounding the apex region, and a second conical section having a threaded bore communicating with the apex opening. The threaded bore has a coil thread nut integrated with the conical second section. The concave conical guide presents a target for directing a remotely inserted bolt towards the apex region for engagement with the coil thread nut.
摘要翻译：一种用于形成可浇注的可固化材料壁的形式的拉杆组件。每个组件具有具有相对的螺纹端和两个间隔件的杆。每个间隔件具有第一锥形部分，其具有在凹形锥形引导表面的顶点区域处的凹入开口和围绕顶点区域的六边形凹槽，以及具有与顶点开口连通的螺纹孔的第二锥形部分。螺纹孔具有与锥形第二部分一体化的线圈螺母。凹形圆锥形引导件提供用于将远程插入的螺栓朝向顶点区域引导以与线圈螺纹螺母接合的目标。

7. 发明授权

US5112155A Connector for assembling components of scaffolding 失效
标题翻译：用于组装脚手架组件的连接器
公开(公告)号：US5112155A
公开(公告)日：1992-05-12
申请号：US787426
申请日：1991-11-04
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： E04G7/30
CPC分类号： E04G7/308 , E04G7/305 , Y10T403/30
摘要： A connector for assembling components of scaffolding is disclosed comprising a barrel having an opposite end having a longitudinally extending slot. A pivot pin and an abutment pin extends across the slot and mounted at the opposite end of the barrel. A free hanging latch has an offset aperture for pivotally mounting onto the pivot pin and a channel for receiving the abutment pin. One end of the channel is configured to abut with the abutment pin when the latch is in a locked position and the other end of the channel being configured to abut the abutment pin when the latch is in an unlocked position. The latch has a tab which is offset beyond the end of the barrel whereby pressing on the tab, the latch pivots from the locked position to the unlocked position allowing egress of the brace from the connector.
摘要翻译：公开了一种用于组装脚手架组件的连接器，其包括具有相对端的具有纵向延伸狭槽的筒体。枢轴销和邻接销延伸穿过槽并安装在桶的相对端。自由悬挂闩锁具有用于枢转地安装到枢转销上的偏移孔和用于接收抵靠销的通道。当闩锁处于锁定位置时，通道的一端构造成与邻接销抵接，并且当闩锁处于解锁位置时，通道的另一端构造成抵靠邻接销。闩锁具有突出部，其突出超过筒的端部，由此按压突出部，闩锁从锁定位置枢转到解锁位置，从而允许从连接器排出支架。

8. 发明申请

US20160264970A1 Methods and compositions for backscattering interferometry 审中-公开
标题翻译：用于后向散射干涉测量的方法和组成
公开(公告)号：US20160264970A1
公开(公告)日：2016-09-15
申请号：US15065837
申请日：2016-03-09
申请人： George W. Jackson , Darryl Bornhop
发明人： George W. Jackson , Darryl Bornhop
IPC分类号： C12N15/115 , G01N21/77 , G01N21/47 , G01N33/53
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/531 , G01N21/47 , G01N33/5308 , G01N33/542 , G01N2021/4709
摘要： The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.
摘要翻译：本发明涉及用于增强背景散射干涉测量（BSI）检测生物分子相互作用的方法和组合物，特别涉及利用无标记的适配子增强BSI的方法和组合物，更具体地涉及利用高构象变化适体增强BSI的方法和组合物，当适体与其靶分子结合时，其可能在构象上改变。

9. 发明申请

US20120165225A1 FUNCTIONAL BIOMOLECULES AND METHODS 有权
标题翻译：功能生物分子和方法
公开(公告)号：US20120165225A1
公开(公告)日：2012-06-28
申请号：US12121658
申请日：2008-05-15
申请人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
发明人： Victor G. Stepanov , Yamei Liu , George E. Fox , George W. Jackson , Roger J. McNichols
IPC分类号： C40B40/02 , C12N1/21 , C12N15/63
CPC分类号： C12N15/1048
摘要： The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.
摘要翻译：本发明一般涉及新的功能化生物分子和产生这种生物分子的方法。生物分子通常可以包括可由活生物体产生的核酸，肽，多组分分子复合物和/或任何其它分子产物。本发明进一步涉及被操作以产生这种官能化生物分子的细胞和/或生物。本发明考虑的细胞包括原核细胞以及真核细胞。功能化生物分子通过使用标准分子生物学技术引入细胞的材料产生，或通过标准重组技术并入细胞的基因组核酸中。进一步考虑的是使用这种细胞来封存细胞内的靶分子。

10. 发明申请

US20120121533A1 NUCLEIC ACID LIGANDS TO LL37 审中-公开
标题翻译：核酸配偶至LL37
公开(公告)号：US20120121533A1
公开(公告)日：2012-05-17
申请号：US13296163
申请日：2011-11-14
申请人： George W. Jackson
发明人： George W. Jackson
IPC分类号： A61K31/80 , A61P17/00 , C07H21/04
CPC分类号： C12N15/115 , A61K31/713 , C12N2310/16 , C12N2310/334 , C12N2310/335
摘要： The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.
摘要翻译：本发明涉及LL37的核酸配体，用于产生所述核酸配体的方法，以及利用所述核酸配体的方法。在一个示例性实施方案中，例如，本发明涉及对LL37肽，前体和/或其部分表现出高特异性结合亲和力的核酸配体。此外，核酸配体可以与LL37的天然配体竞争性结合，并且还可以抑制和/或干扰LL37功能，例如通过结合LL37。

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