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1. 发明授权

US5146793A Fluid seal 失效
标题翻译：流体密封
公开(公告)号：US5146793A
公开(公告)日：1992-09-15
申请号：US418103
申请日：1989-10-06
申请人： George E. Sgourakes , Stanislaw Koziol
发明人： George E. Sgourakes , Stanislaw Koziol
IPC分类号： G01N30/24 , F16J15/32 , F16J15/40 , G01N1/00 , G01N30/18 , G01N30/22
CPC分类号： G01N30/18 , F16J15/3204 , G01N35/1079
摘要： A sealing means is provided that may be used, among other things, for sample injection apparatus used in liquid chromatography. The seal includes a jacket having a central bore through which a hypodermic needle containing a sample is inserted. The jacket includes a U-shaped cross section having an inner axial surface and an outer axial surface. Metal cylindrical bands which function as springs are positioned tightly against the inner and outer axial surfaces respectively. Each band has a slot extending through its thickness and along its entire axial length.

2. 发明授权

US5114161A Fluid seal 失效
标题翻译：流体密封
公开(公告)号：US5114161A
公开(公告)日：1992-05-19
申请号：US661782
申请日：1991-03-20
申请人： George E. Sgourakes , Stanislaw Koziol
发明人： George E. Sgourakes , Stanislaw Koziol
IPC分类号： G01N30/24 , F16J15/32 , F16J15/40 , G01N1/00 , G01N30/18 , G01N30/22
CPC分类号： G01N30/18 , F16J15/3204 , G01N35/1079
摘要： A sealing means is provided that may be used, among other things, for sample injection apparatus used in liquid chromatography. The seal includes a jacket having a central bore through which a hypodermic needle containing a sample is inserted. The jacket includes a U-shaped cross section having an inner axial surface and an outer axial surface. Metal cylindrical bands which function as springs are positioned tightly against the inner and outer axial surfaces respectively. Each band has a slot extending through its thickness and along its entire axial length.
摘要翻译：提供了一种密封装置，其可以用于液相色谱中使用的样品注射装置。密封件包括具有中心孔的护套，通过该护套插入含有样品的皮下注射针。护套包括具有内轴向表面和外轴向表面的U形横截面。用作弹簧的金属圆柱带分别紧密地定位在内和外轴向表面上。每个带具有延伸穿过其厚度并沿其整个轴向长度的槽。

3. 发明授权

US4852466A Floating diaphragm apparatus 失效
标题翻译：浮动隔膜装置
公开(公告)号：US4852466A
公开(公告)日：1989-08-01
申请号：US50167
申请日：1987-05-15
申请人： Mark D. Freeman , John L. Koukol, Jr. , Stanislaw Koziol , George E. Sgourakes
发明人： Mark D. Freeman , John L. Koukol, Jr. , Stanislaw Koziol , George E. Sgourakes
IPC分类号： G01L19/06 , G01L7/08
CPC分类号： G01L7/082
摘要： Floating the diaphragm portion of a diaphragm sensor in the pressurizing fluid frees the diaphragm from exterior housing forces, and makes overall manufacture and replacement inexpensive. A diaphragm can be protected from exterior stress by interspersing a channel between the diaphragm edge and the closure and support structure of an enclosing housing. By extending the channel and incorporating an adequate seal, the diaphragm structure may be made replaceable. The replaceable diaphragm further allows use of a smaller amount of costly materials, and makes repair less costly.
摘要翻译：将隔膜传感器的隔膜部分浮动在加压流体中可以使隔膜从外部外壳力释放，并使整体制造和更换成本低廉。可以通过在隔膜边缘与封闭件之间的通道和包围壳体的支撑结构间隔开通道来保护隔膜免受外部应力。通过延伸通道并结合适当的密封，可以使隔膜结构可更换。可替换的隔膜进一步允许使用较少量的昂贵的材料，并使维修成本更低。

4. 发明授权

US4520678A Small line-size vortex meter 失效
标题翻译：小型线尺涡流仪
公开(公告)号：US4520678A
公开(公告)日：1985-06-04
申请号：US531561
申请日：1983-09-13
申请人： Stanislaw Koziol , George E. Sgourakes
发明人： Stanislaw Koziol , George E. Sgourakes
IPC分类号： G01F1/32
CPC分类号： G01F1/3254
摘要： A small line-size vortex meter comprising a small-diameter flow tube cast with an integral vortex-shedding bar and an external sensor housing. The outer surface of the housing is formed with an approximately circular recess extending towards the flow tube and communicating with the interior of the tube through side-by-side impulse ports located adjacent one end of the vortex-shedding bar. Inserted into the central region of the recess is a sensor body having diaphragms on opposite sides to respond to vortex pressure fluctuations transmitted through the impulse ports to chambers along the sides of the sensor body. The sensor body comprises an oil-filled capsule with the diaphragms serving to transmit the pressure fluctuations to a piezo-electric sensor element which produces corresponding electrical signals.
摘要翻译：一种小型直径的流量计，其包括一个具有一体式涡流脱落杆和一个外部传感器外壳的小直径流量管。壳体的外表面形成有大致圆形的凹槽，该凹槽朝着流动管延伸，并且通过与涡流脱落杆的一端相邻的并排脉冲端口与管的内部连通。插入到凹部的中心区域中的传感器主体具有在相对侧上的隔膜，以响应通过脉冲端口传递的涡流压力波动，沿着传感器主体的侧面。传感器主体包括一个充满油的胶囊，其中隔膜用于将压力波动传递到产生相应电信号的压电传感器元件。

5. 发明授权

US08035088B2 Device, apparatus and methods for mass spectrometry 有权
标题翻译：用于质谱的装置，装置和方法
公开(公告)号：US08035088B2
公开(公告)日：2011-10-11
申请号：US12593313
申请日：2008-03-19
申请人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
发明人： Michael J. Tomany , Joseph A. Jarrell , Stanislaw Koziol , Wade P. Leveille
IPC分类号： H01J49/04 , H01J49/26 , B01D59/44
CPC分类号： G01N30/724 , H01J49/0445 , Y10T29/49718 , Y10T137/85938
摘要： The invention comprises apparatus for use with atmospheric pressure ionization sources in which an aerosol is formed from a solution of a sample. The aerosol is received in a hollow member and discharged outside the chamber of the ionization source in order to reduce contamination of the ionization source itself by involatile material in the solution and by previously analysed samples. The hollow member is easily removable from the ionization source to facilitate cleaning and replacement. Ionization sources, mass spectrometers, and ion mobility spectrometers comprising the apparatus are also described.
摘要翻译：本发明包括与大气压电离源一起使用的装置，其中气溶胶由样品溶液形成。气溶胶被容纳在中空构件中并且排出到电离源的室外，以便通过溶液中的非挥发性材料和先前分析的样品来减少电离源本身的污染。中空构件容易从电离源移除，以便于清洁和更换。还描述了包括该装置的电离源，质谱仪和离子迁移谱仪。

6. 发明申请

US20090218487A1 MASS-SPECTROMETER INTERFACE HOUSING 有权
标题翻译：质谱仪接口接口
公开(公告)号：US20090218487A1
公开(公告)日：2009-09-03
申请号：US11917771
申请日：2006-06-26
申请人： Joseph A. Jarrell , Stanislaw Koziol , Peter Pino , Theodore D. Ciolkosz
发明人： Joseph A. Jarrell , Stanislaw Koziol , Peter Pino , Theodore D. Ciolkosz
IPC分类号： H01J49/00
CPC分类号： H01J49/0431 , G01N30/7266 , G01N2030/8895
摘要： An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed.
摘要翻译：用于进行化学分析的装置包括质谱模块和接口模块，其处理用于传送到质谱模块的样品材料。接口模块包括具有用于进入容器室的开口的容器，用于阻塞开口的门，设置在门和容器之间的密封构件以及互锁。如果门处于关闭位置并且密封构件适当地设置在门和容器之间以密封容器，则联锁由密封构件致动。如果门处于关闭位置并且密封构件被适当地布置，密封构件可选地包括操作者可见的指示器部分。

7. 发明申请

US20120024399A1 Electrospray Interface To A Microfluidic Substrate 有权
标题翻译：微流体基板的电喷雾界面
公开(公告)号：US20120024399A1
公开(公告)日：2012-02-02
申请号：US13202363
申请日：2010-03-05
申请人： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
发明人： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
IPC分类号： B23P19/00
CPC分类号： B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
摘要： A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
摘要翻译：液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。微流体衬底具有流体孔，通道将流体供应到通道。墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。第二壁具有狭槽，盒通过该槽进入腔室。当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并与微流体衬底中的一个流体孔隙建立流体连通。

8. 发明授权

US07863561B2 Mass-spectrometer interface housing 有权
标题翻译：质谱仪界面外壳
公开(公告)号：US07863561B2
公开(公告)日：2011-01-04
申请号：US11917771
申请日：2006-06-26
申请人： Joseph A. Jarrell , Stanislaw Koziol , Peter Pino , Theodore D. Ciolkosz
发明人： Joseph A. Jarrell , Stanislaw Koziol , Peter Pino , Theodore D. Ciolkosz
IPC分类号： H01J49/00
CPC分类号： H01J49/0431 , G01N30/7266 , G01N2030/8895
摘要： An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed.
摘要翻译：用于进行化学分析的装置包括质谱模块和接口模块，其处理用于传送到质谱模块的样品材料。接口模块包括具有用于进入容器室的开口的容器，用于阻塞开口的门，设置在门和容器之间的密封构件以及互锁。如果门处于关闭位置并且密封构件适当地设置在门和容器之间以密封容器，则联锁由密封构件致动。如果门处于关闭位置并且密封构件被适当地布置，密封构件可选地包括操作者可见的指示器部分。

9. 发明授权

US09482650B2 Static and dynamic seals 有权
标题翻译：静态和动态密封
公开(公告)号：US09482650B2
公开(公告)日：2016-11-01
申请号：US13520462
申请日：2011-01-11
申请人： Marc E. Lemelin , Tony A. Lin , Mark W. Moeller , Stanislaw Koziol , James E. Usowicz
发明人： Marc E. Lemelin , Tony A. Lin , Mark W. Moeller , Stanislaw Koziol , James E. Usowicz
IPC分类号： F16J15/02 , G01N30/60 , F16J15/10 , G01N30/20
CPC分类号： G01N30/6026 , F16J15/102 , G01N30/20 , G01N2030/202 , Y10T29/49
摘要： Described are techniques for use with a sealing member forming a static seal or a dynamic seal at a surface thereof. The sealing member has at least the surface thereof formed from one of VESPEL® SCP 5000 material or VESPEL® SCP 50094 material.
摘要翻译：描述了与在其表面上形成静态密封件或动态密封件的密封构件一起使用的技术。密封件至少具有由VESPEL®SCP 5000材料或VESPEL®SCP 50094材料之一形成的表面。

10. 发明授权

US09095791B2 Electrospray interface to a microfluidic substrate 有权
标题翻译：与微流体基质的电喷雾界面
公开(公告)号：US09095791B2
公开(公告)日：2015-08-04
申请号：US13202363
申请日：2010-03-05
申请人： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
发明人： David P. Prentice , Russell L. Keene , Stanislaw Koziol , Joseph D. Michienzi , Paul E. Linderson , Gary W. Bertone
IPC分类号： B01D15/10 , B01L3/00 , G01N30/60 , G01N30/72 , H01J49/16 , G01N27/447 , B05B1/02 , B05B1/00
CPC分类号： B01D15/10 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L3/563 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0883 , B05B1/00 , B05B1/02 , G01N27/44791 , G01N30/6095 , G01N30/72 , G01N30/7233 , G01N30/724 , G01N30/7266 , H01J49/167 , Y10T137/598 , Y10T436/24
摘要： A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.
摘要翻译：液相色谱模块包括容纳具有用于输送流体的通道的微流体基板的微流体盒。微流体衬底具有流体孔，通道将流体供应到通道。墨盒的一侧具有喷嘴开口，每个与微流体基板中的流体孔对准并且接收流体喷嘴。夹紧组件具有可移动到夹紧位置的柱塞和限定腔室的端部壳体。端部壳体的一个壁具有流体块，流体喷嘴延伸到腔室中。第二壁具有狭槽，盒通过该槽进入腔室。当墨盒在腔室中移动到夹紧位置时，柱塞将墨盒推向流体块，使得每个流体喷嘴进入一个喷嘴开口并且与微流体衬底中的一个流体孔隙建立流体连通。

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