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1. 发明申请

US20130085385A1 SURGICAL LIGHTING SOURCES FOR USE WITH FLUOPHORE-TAGGED MONOCLONAL ANTIBODIES OR FLUOROPHORE-TAGGED TUMOR AVID COMPOUNDS 审中-公开
标题翻译：使用荧光标记的单克隆抗体或荧光标记肿瘤化合物的外科照明光源
公开(公告)号：US20130085385A1
公开(公告)日：2013-04-04
申请号：US13477895
申请日：2012-05-22
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61B5/00 , A61B17/3205
CPC分类号： A61B5/0071 , A61B1/00039 , A61B1/043 , A61B1/0684 , A61B1/0692 , A61B17/3205 , G01J3/10 , G01N21/6447 , G01N21/6456 , G01N2021/6439
摘要： The present invention describes light source devices to provide white and blue (401-510 nm) light for the in vivo identification of diseased tissue using fluorescence based tissue targeting. The light source devices are configured with a variety of LED lights capable of emitting white and blue light with at least one excitation wavelength in the range from about 401 nm to about 500 nm (for example, 470 nm to 495 nm) to irradiate an in vivo body part of a subject containing tumor or diseased tissue. The tumor or diseased tissue has fluorophore-tagged targeting constructs attached. The fluorophores used in the targeting constructs have emission spectra greater than 515 nm. The fluorescence emanating from the fluorescent targeting construct in response to the excitation wavelength is directly viewed with long-pass filtered (515 nm) lenses and is used to determine the location and/or surface area of the diseased tissue in the subject. Fluorescence based surgical identification provides more accurate disease resection.
摘要翻译：本发明描述了使用基于荧光的组织靶向来提供白色和蓝色（401-510nm）光用于体内鉴定患病组织的光源装置。光源装置配置有能够发射白光和蓝光的各种LED灯，其具有在约401nm至约500nm（例如，470nm至495nm）范围内的至少一个激发波长以照射受试者的体内部分含有肿瘤或病变组织。肿瘤或病变组织具有附着的荧光团标记的靶向构建体。靶向构建体中使用的荧光团具有大于515nm的发射光谱。从荧光靶向构建体响应于激发波长发出的荧光直接用长通滤波（515nm）透镜观察，并用于确定受试者中病变组织的位置和/或表面积。基于荧光的手术识别提供更准确的疾病切除。

2. 发明申请

US20090137909A1 METHOD FOR IMAGING AND TREATING ORGANS AND TISSUES 有权
标题翻译：成像和处理组织和组织的方法
公开(公告)号：US20090137909A1
公开(公告)日：2009-05-28
申请号：US12212582
申请日：2008-09-17
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61N5/00 , A61B5/00 , A61B5/05
CPC分类号： A61B5/417 , A61B5/0071 , A61B5/0084 , A61B5/0091 , A61B6/037 , A61K49/0002 , A61K49/0043 , A61K49/005 , A61K51/0406 , A61K51/0491 , A61K51/083 , A61K51/088 , A61K51/103 , A61K51/1036 , A61K51/1048 , A61K51/1051 , A61K51/1054 , A61K51/1063 , A61K51/1072
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.
摘要翻译：本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。该方法包括在一个基因组或通过提供对组织或器官的进入的途径中肠胃外注射哺乳动物受试者，该组合物包含用荧光团和治疗同位素分子标记的抗体/片段的组合物，其特异性结合靶向器官，组织或细胞。

3. 发明申请

US20120190925A1 METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES 审中-公开
标题翻译：组合成像和处理组织和组织的方法
公开(公告)号：US20120190925A1
公开(公告)日：2012-07-26
申请号：US13358380
申请日：2012-01-25
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61B1/06 , A61B1/005 , A61B1/00
CPC分类号： A61K49/0058 , A61B1/00165 , A61B1/043 , A61B1/0638 , A61B1/0669 , A61B1/0692 , A61B5/0071 , A61B18/20 , A61K47/6807 , A61K51/1045 , A61K51/1051 , A61K51/1054 , A61K51/106 , A61K51/1063 , A61K51/1066 , A61K51/1072
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection.
摘要翻译：本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。该方法包括在包含单克隆抗体（嵌合，人源化，完全人），部分抗体，Fab片段，抗体片段的组合物的组织或器官进入的场所或通过途径的肠胃外注射哺乳动物受试者用含有或不添加特异性结合靶向器官，组织或细胞的治疗性化疗分子的荧光团标记。切除哺乳动物物种内的原发恶性组织（使用荧光靶向构建体的荧光）提供了在原始肿瘤切除时将所有体积肿瘤识别为荧光的优点。

4. 发明授权

US08463365B2 Method for imaging and treating organs and tissues 有权
标题翻译：成像和治疗器官和组织的方法
公开(公告)号：US08463365B2
公开(公告)日：2013-06-11
申请号：US12212582
申请日：2008-09-17
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61B6/00
CPC分类号： A61B5/417 , A61B5/0071 , A61B5/0084 , A61B5/0091 , A61B6/037 , A61K49/0002 , A61K49/0043 , A61K49/005 , A61K51/0406 , A61K51/0491 , A61K51/083 , A61K51/088 , A61K51/103 , A61K51/1036 , A61K51/1048 , A61K51/1051 , A61K51/1054 , A61K51/1063 , A61K51/1072
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method includes parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition including an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.
摘要翻译：本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。该方法包括在一个基因组或通过提供对组织或器官的进入的途径中肠胃外注射哺乳动物受试者，该组合物包括用荧光团和治疗同位素分子标记的抗体/片段的组合物，其特异性结合靶向器官，组织或细胞。

5. 发明授权

US06652836B2 Method for viewing tumor tissue located within a body cavity 有权
标题翻译：用于观察位于体腔内的肿瘤组织的方法
公开(公告)号：US06652836B2
公开(公告)日：2003-11-25
申请号：US09832297
申请日：2001-04-09
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61B1000
CPC分类号： A61K49/0056 , A61B5/0059 , A61B5/416 , A61K49/0052 , A61K49/0058
摘要： Methods are provided for in vivo detection of diseased tissue in a subject, such as tumor tissue located in a body opening, by administering to the subject a biologically compatible fluorescing targeting construct that binds to or is specifically taken up by the diseased tissue. The observer directly views fluorescence emanating from the fluorescing targeting construct bound to or taken up by the diseased tissue upon irradiation of the targeting construct with excitation light having at least one wavelength in the range from 401 nm to about 495 nm, but preferably lacking light having a wavelength above about 500 nm, so as to determine the location and/or surface area of the diseased tissue in the subject. Since excitation wavelength does not penetrate through tissue, as is the practice in near IR diagnostics, the diseased or abnormal tissue is exposed to the excitation light either surgically or by means of an endoscopic device. Preferably a filter is used to filter out any wavelengths in the excitation light greater than about 500 nm.
摘要翻译：提供了用于体内检测受试者中的患病组织，例如位于体内开放的肿瘤组织，通过向受试者施用与病变组织结合或特异性地被患病组织吸收的生物相容的荧光靶向构建体。观察者直接观察到荧光靶向构建体发出的荧光发射结构，其在靶向构建体照射后具有至少一个波长在401nm至约495nm范围内的激发光束时被患病组织吸收或吸收，但是优选地，波长高于约500nm，以确定受试者中病变组织的位置和/或表面积。由于激发波长不穿透组织，如近红外线诊断中的做法，病变或异常组织通过外科手术或内窥镜装置暴露于激发光。优选地，使用滤光器来滤出大于约500nm的激发光中的任何波长。

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