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1. 发明申请

US20170129964A1 USES OF MONOCLONAL ANTIBODY 8H9 有权
公开(公告)号：US20170129964A1
公开(公告)日：2017-05-11
申请号：US15365803
申请日：2016-11-30
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： Nai-Kong V. CHEUNG
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A01K2217/05 , A61K51/1066 , A61K51/1078 , A61K2039/505 , C07K16/3053 , C07K16/3084 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

2. 发明申请

US20140161814A1 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
标题翻译：单克隆抗体8H9的用途
公开(公告)号：US20140161814A1
公开(公告)日：2014-06-12
申请号：US13958902
申请日：2013-08-05
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： Nai-Kong V. CHEUNG
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A01K2217/05 , A61K51/1066 , A61K51/1078 , A61K2039/505 , C07K16/3053 , C07K16/3084 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.
摘要翻译：本发明提供了包含有效量的单克隆抗体8H9或其衍生物和合适的载体的组合物。本发明提供了包含有效量的单克隆抗体8H9或其衍生物和药学上可接受的载体的药物组合物。本发明还提供除单克隆抗体8H9之外的抗体，其包含能够与单克隆抗体8H9结合相同抗原的单克隆抗体8H9或其衍生物的互补决定区。本发明提供能够竞争性抑制单克隆抗体8H9结合的物质。本发明还提供单克隆抗体8H9或其衍生物的分离的scFv。本发明还提供了8H9抗原。本发明还提供抑制肿瘤细胞生长的方法，包括使所述肿瘤细胞与适量的单克隆抗体8H9或其衍生物接触。

3. 发明授权

US08501471B2 Uses of monoclonal antibody 8H9 有权
公开(公告)号：US08501471B2
公开(公告)日：2013-08-06
申请号：US12797081
申请日：2010-06-09
申请人： Nai-Kong V. Cheung
发明人： Nai-Kong V. Cheung
IPC分类号： C12N5/07
CPC分类号： C07K16/30 , A01K2217/05 , A61K51/1066 , A61K51/1078 , A61K2039/505 , C07K16/3053 , C07K16/3084 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

4. 发明申请

US20100310571A1 USES OF MONOCLONAL ANTIBODY 8H9 有权
标题翻译：单克隆抗体8H9的用途
公开(公告)号：US20100310571A1
公开(公告)日：2010-12-09
申请号：US12797081
申请日：2010-06-09
申请人： Nai-Kong V. CHEUNG
发明人： Nai-Kong V. CHEUNG
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/30 , A01K2217/05 , A61K51/1066 , A61K51/1078 , A61K2039/505 , C07K16/3053 , C07K16/3084 , C07K16/4266 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.
摘要翻译：本发明提供了包含有效量的单克隆抗体8H9或其衍生物和合适的载体的组合物。本发明提供了包含有效量的单克隆抗体8H9或其衍生物和药学上可接受的载体的药物组合物。本发明还提供除单克隆抗体8H9之外的抗体，其包含能够与单克隆抗体8H9结合相同抗原的单克隆抗体8H9或其衍生物的互补决定区。本发明提供能够竞争性抑制单克隆抗体8H9结合的物质。本发明还提供单克隆抗体8H9或其衍生物的分离的scFv。本发明还提供了8H9抗原。本发明还提供抑制肿瘤细胞生长的方法，包括使所述肿瘤细胞与适量的单克隆抗体8H9或其衍生物接触。

5. 发明授权

US4965392A Chelating compounds for metal-radionuclide labeled proteins 失效
标题翻译：金属放射性核素标记蛋白质的螯合化合物
公开(公告)号：US4965392A
公开(公告)日：1990-10-23
申请号：US172004
申请日：1988-03-23
申请人： Alan R. Fritzberg , Sudhakar Kasina , Tripuraneni N. Rao , Jean-Luc VanderHeyden , Ananthachari Srinivasan
发明人： Alan R. Fritzberg , Sudhakar Kasina , Tripuraneni N. Rao , Jean-Luc VanderHeyden , Ananthachari Srinivasan
IPC分类号： A61K51/04 , A61K51/08 , A61K51/10 , C07B59/00 , C07F13/00 , C07K5/093 , G01N33/534
CPC分类号： G01N33/534 , A61K51/0478 , A61K51/1066 , A61K51/1093 , C07B59/004 , C07F13/005 , C07K5/0819 , A61K2121/00 , A61K2123/00
摘要： Chelated radionuclide compositions are provided for conjugation to polypeptides and carbohydrates. The resulting conjugates may be used in diagnosis and therapy. Chelating compounds are disclosed.
摘要翻译：螯合放射性核素组合物用于与多肽和碳水化合物结合。所得到的缀合物可用于诊断和治疗。公开了螯合化合物。

6. 发明申请

US20170157275A1 ANTIBODY FRAGMENTS FOR DETECTING CANCER AND METHODS OF USE 审中-公开
公开(公告)号：US20170157275A1
公开(公告)日：2017-06-08
申请号：US15325696
申请日：2015-07-10
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
发明人： Jayanth Panyam , Stephen Kalscheuer
IPC分类号： A61K51/10 , A61K49/00 , G01N33/574 , C07K16/30 , G01N33/68
CPC分类号： A61K51/1066 , A61K47/6855 , A61K47/6865 , A61K47/6869 , A61K47/6929 , A61K49/0039 , A61K49/0093 , A61K51/1027 , A61K51/1051 , C07K16/30 , C07K2317/21 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/30 , G01N33/57415 , G01N33/5743 , G01N33/57434 , G01N33/6857 , G01N2400/40
摘要： The present invention relates to diagnostic and therapeutic agents comprising recombinant antibody fragments to bind a protein associated with cancer and methods of use of these diagnostic and therapeutic agents.

7. 发明申请

US20150140609A1 Anti-alpha(v)beta(6) Antibodies 有权
标题翻译：抗α（v）beta（6）抗体
公开(公告)号：US20150140609A1
公开(公告)日：2015-05-21
申请号：US14444701
申请日：2014-07-28
申请人： BIOGEN IDEC MA INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Shelia M. Violette , Paul H. Weinreb , Kenneth J. Simon , Dean Sheppard , Diane R. Leone
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Q mediated diseases.
摘要翻译：特异性结合M.96的单克隆抗体。还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。

8. 发明申请

US20140316186A1 ANTIBODIES TO TIP-1 AND GRP78 有权
标题翻译：抗体TIP-1和GRP78
公开(公告)号：US20140316186A1
公开(公告)日：2014-10-23
申请号：US14166251
申请日：2014-01-28
申请人： The Washington University
发明人： Dennis E. Hallahan , Heping Yan
IPC分类号： C07K16/30 , A61B19/00 , A61N5/10 , A61K49/00 , A61K51/10
CPC分类号： C07K16/30 , A61B5/4848 , A61B6/032 , A61B6/463 , A61B6/481 , A61B6/508 , A61B90/361 , A61K39/3955 , A61K49/0058 , A61K51/1045 , A61K51/1066 , A61K51/1093 , A61N5/10 , A61N2005/1087 , A61N2005/1098 , C07K16/18 , C07K16/3023 , C07K16/3053 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/94
摘要： The present invention is directed towards isolated antibodies that bind to GRP78 and TIP-1.
摘要翻译：本发明涉及结合GRP78和TIP-1的分离的抗体。

9. 发明申请

US20120190925A1 METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES 审中-公开
标题翻译：组合成像和处理组织和组织的方法
公开(公告)号：US20120190925A1
公开(公告)日：2012-07-26
申请号：US13358380
申请日：2012-01-25
申请人： George A. Luiken
发明人： George A. Luiken
IPC分类号： A61B1/06 , A61B1/005 , A61B1/00
CPC分类号： A61K49/0058 , A61B1/00165 , A61B1/043 , A61B1/0638 , A61B1/0669 , A61B1/0692 , A61B5/0071 , A61B18/20 , A61K47/6807 , A61K51/1045 , A61K51/1051 , A61K51/1054 , A61K51/106 , A61K51/1063 , A61K51/1066 , A61K51/1072
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection.
摘要翻译：本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。该方法包括在包含单克隆抗体（嵌合，人源化，完全人），部分抗体，Fab片段，抗体片段的组合物的组织或器官进入的场所或通过途径的肠胃外注射哺乳动物受试者用含有或不添加特异性结合靶向器官，组织或细胞的治疗性化疗分子的荧光团标记。切除哺乳动物物种内的原发恶性组织（使用荧光靶向构建体的荧光）提供了在原始肿瘤切除时将所有体积肿瘤识别为荧光的优点。

10. 发明申请

US20090311174A1 Method For Treating Cancer 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：US20090311174A1
公开(公告)日：2009-12-17
申请号：US11996270
申请日：2006-07-21
申请人： Barry John Allen
发明人： Barry John Allen
IPC分类号： A61K51/10 , A61P35/00
CPC分类号： A61K51/1066 , A61K51/1045 , A61K51/1051
摘要： The present invention relates to methods, kits, compositions and uses thereof for treating cancer. In particular, the present invention relates to methods, kits, compositions and uses thereof for the treatment of metastatic cancer, the treatment of angiogenesis associated with metastatic cancer, inhibiting formation of vasculature associated with metastatic cancer, killing pericytes associated with metastatic cancer and killing cancer cells contiguous with tumour capillaries associated with metastatic cancer, comprising a killing agent conjugated to a protein, and wherein said killing agent conjugated to said protein binds to at least one cell associated with the metastatic cancer.
摘要翻译：本发明涉及用于治疗癌症的方法，试剂盒，组合物和用途。特别地，本发明涉及用于治疗转移性癌症的方法，试剂盒，组合物及其用途，治疗与转移性癌症相关的血管生成，抑制与转移性癌症相关的脉管系统形成，杀死与转移性癌症相关的周细胞和杀死癌症与与转移性癌症相关的肿瘤毛细管连续的细胞，包含与蛋白质缀合的杀伤剂，并且其中与所述蛋白质缀合的所述杀伤剂与至少一种与转移性癌症相关的细胞结合。

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