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1. 发明授权

US6054588A Heterocyclic vinyl ethers 失效
标题翻译：杂环乙烯基醚
公开(公告)号：US6054588A
公开(公告)日：2000-04-25
申请号：US304624
申请日：1999-05-04
申请人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Heinz Stadler , Jurgen Wichmann , Thomas Johannes Woltering
发明人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Heinz Stadler , Jurgen Wichmann , Thomas Johannes Woltering
IPC分类号： A61K31/41 , A61K31/4164 , A61K31/4174 , A61K31/4196 , A61P1/08 , A61P13/02 , A61P21/02 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P25/36 , A61P27/02 , A61P29/00 , C07D233/60 , C07D249/08 , C07D257/04 , C07D521/00
CPC分类号： C07D257/04 , A61K31/41 , A61K31/4174 , A61K31/4196 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The compounds of the formula ##STR1## wherein R signifies halogen or lower alkyl;n signifies 0-3;R.sup.1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substituted by amino, lower alkyl-amino or di-lower alkylamino; acetyl or cycloalkyl-carbonyl; and ##STR2## signifies an aromatic 5-membered residue which is bonded via a N-atom and which contains further 1-3 N atoms in addition to the linking N atom,as well as their pharmaceutically acceptable salts as therapeutically active substances, especially for the control or prevention of acute and/or chronic neurological disorders.
摘要翻译：下式的化合物其中R表示卤素或低级烷基; n表示0-3; R1表示低级烷基; 环烷基任选被羟基，卤素，低级烷氧基或低级烷基取代的苄基; 任选被氨基，低级烷基 - 氨基或二 - 低级烷基氨基取代的苯甲酰基; 乙酰基或环烷基 - 羰基; 并且表示通过N-原子键合并且除了连接的N原子之外还含有1-3个N原子的芳族5元残基以及它们的药学上可接受的盐作为治疗活性物质，特别是用于对照或预防急性和/或慢性神经障碍。

2. 发明授权

US5958931A Phenyl-substituted 5H-thiazolo�3,2-A!pyrimidine derivative glutamate receptor antagonists 失效
标题翻译：苯基取代的5H-噻唑并[3,2-A]嘧啶衍生物谷氨酸受体拮抗剂
公开(公告)号：US5958931A
公开(公告)日：1999-09-28
申请号：US115191
申请日：1998-07-14
申请人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Jurgen Wichmann , Thomas Johannes Woltering
发明人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Jurgen Wichmann , Thomas Johannes Woltering
IPC分类号： C07D239/22 , A61K31/00 , A61K31/505 , A61K31/519 , A61P1/08 , A61P9/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P27/02 , A61P43/00 , C07D239/00 , C07D239/40 , C07D277/00 , C07D513/04
CPC分类号： C07D513/04 , C07D239/40
摘要： The invention is concerned with compounds of the general formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, phenyl or benzyl,R.sup.2 is lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n N(R.sup.13)(R.sup.14), --(CH.sub.2).sub.n N(R.sup.13)(R.sup.14) or --N(R.sup.15)(CH.sub.2).sub.n N(R.sup.13)(R.sup.14),R.sup.3 -R.sup.12 are hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, --N(R.sup.13).sub.2, phenyl, phenyloxy, benzyl or benzyloxy, orR.sup.6 and R.sup.7 together are a benzene ring,R.sup.13 -R.sup.15 are hydrogen, lower alkyl or cycloalkyl andn is 1-5,as well as their pharmaceutically acceptable salts.
摘要翻译：本发明涉及下列通式的化合物：其中R1是氢，低级烷基，苯基或苄基，R2是低级烷基，低级烷氧基，-O（CH2）nN（R13）（R14）， - （CH2）nN（R13））（R14）或-N（R15）（CH2）nN（R13）（R14），R3-R12是氢，卤素，三氟甲基，低级烷基，环烷基，低级烷氧基，羟基，硝基，氰基，-N（R13） 2，苯基，苯氧基，苄基或苄氧基，或R6和R7一起是苯环，R13-R15是氢，低级烷基或环烷基，n是1-5，以及它们的药学上可接受的盐。

3. 发明授权

US06248901B1 Heterocyclic vinyl ethers 失效
标题翻译：杂环乙烯基醚
公开(公告)号：US06248901B1
公开(公告)日：2001-06-19
申请号：US09304909
申请日：1999-05-04
申请人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Heinz Stadler , Jürgen Wichmann , Thomas Johannes Woltering
发明人： Geo Adam , Sabine Kolczewski , Vincent Mutel , Heinz Stadler , Jürgen Wichmann , Thomas Johannes Woltering
IPC分类号： C07D24908
CPC分类号： C07D257/04 , A61K31/41 , A61K31/4174 , A61K31/4196 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The compounds of the formula wherein R signifies halogen or lower alkyl; n signifies 0-3; R1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substituted by amino, lower alkylamino or di-lower alkylamino; acetyl or cycloalkyl-carbonyl; and signifies an aromatic 5-membered residue which is bonded via a N-atom and which contains further 1-3 N atoms in addition to the linking N atom, as well as their pharmaceutically acceptable salts as therapeutically active substances, especially for the control or prevention of acute and/or chronic neurological disorders.
摘要翻译：化合物R表示卤素或低级烷基; n表示0-3; R1表示低级烷基; 环烷基任选被羟基，卤素，低级烷氧基或低级烷基取代的苄基; 任选被氨基，低级烷基氨基或二 - 低级烷基氨基取代的苯甲酰基; 乙酰基或环烷基 - 羰基; 并且通过N-原子键合并且除了连接的N原子还含有1-3个N原子的芳族5元残基以及它们的药学上可接受的盐作为治疗活性物质，特别是用于控制或预防的急性和/或慢性神经障碍。

4. 发明授权

US6113527A Diaza-spiro[3,5] nonane derivatives 失效
标题翻译： Diaza-spiro [3,5]壬烷衍生物
公开(公告)号：US6113527A
公开(公告)日：2000-09-05
申请号：US330851
申请日：1999-06-11
申请人： Geo Adam , Andrea Cesura , Fran.cedilla.ois Jenck , Sabine Kolczewski , Stephan Rover , Jurgen Wichmann
发明人： Geo Adam , Andrea Cesura , Fran.cedilla.ois Jenck , Sabine Kolczewski , Stephan Rover , Jurgen Wichmann
IPC分类号： C07D401/00 , A61K31/00 , A61K31/438 , A61P3/04 , A61P9/10 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D471/10 , A61K31/44 , C07D221/20
CPC分类号： C07D471/10
摘要： The invention relates to compounds of the general formula ##STR1## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;R.sup.2 is .dbd.O or hydrogen,R.sup.3 is hydrogen, isoindolyl-1,3-dione, lower alkoxy, lower alkyl, amino, benzyloxy, --CH.sub.2 OR.sup.5 or --CH.sub.2 N(R.sup.5).sub.2 ;R.sup.4 is hydrogen or --CH.sub.2 OR.sup.5 ;R.sup.5 is hydrogen or lower alkyl; ##STR2## is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; to racemic mixtures and their corresponding enantiomers and or pharmaceutically acceptable acid addition salts thereof.The compounds of the present invention are agonists of the orphamin FQ (OFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
摘要翻译：本发明涉及以下通式的化合物：其中R 1为C 6-12 - 环烷基，任选被低级烷基或C（O）O低级烷基，茚满-1-基或茚满-2-基取代，任选被低级烷基取代; 苊-1-基; 双环[3.3.1]壬-9-基，八氢 - 茚-2-基; 2,3-二氢-1H-苯并芬-1-基; 2,3,3a，4,5,6-六氢-1H-吩酚-1-基，十氢 - 薁-2-基; 双环[6.2.0]癸-9-基; 十氢萘-1-基，十氢萘-2-基; 四氢 - 萘-1-基，四氢 - 萘-2-基或2-氧代-1,2-二苯基 - 乙基; R2是= O或氢，R3是氢，异吲哚基-1,3-二酮，低级烷氧基，低级烷基，氨基，苄氧基，-CH 2 OR 5或-CH 2 N（R 5）2; R4是氢或-CH2OR5; R5是氢或低级烷基; 是环己基或苯基，任选被低级烷基，卤素或烷氧基取代; 外消旋混合物及其相应的对映异构体和/或其药学上可接受的酸加成盐。本发明的化合物是衍生物FQ（OFQ）受体的激动剂，因此可用于治疗与该受体有关的疾病。

5. 发明授权

US6075034A Spiro[piperidine-4,1'-pyrrolo [3,4-C] pyrrole]derivatives 失效
标题翻译：螺[哌啶-4,1'-吡咯并[3,4-C]吡咯]衍生物
公开(公告)号：US6075034A
公开(公告)日：2000-06-13
申请号：US330857
申请日：1999-06-11
申请人： Geo Adam , Frank Dautzenberg , Sabine Kolczewski , Stephan Rover , Jurgen Wichmann
发明人： Geo Adam , Frank Dautzenberg , Sabine Kolczewski , Stephan Rover , Jurgen Wichmann
IPC分类号： C07D401/14 , A01N43/42 , A61K31/00 , A61K31/395 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/445 , A61K31/505 , A61K31/535 , A61P3/04 , A61P3/12 , A61P9/12 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D20060101 , C07D209/00 , C07D221/00 , C07D471/10 , C07D471/20 , C07D487/20 , C07D498/10 , C07D513/10
CPC分类号： C07D471/20
摘要： The present invention relates to compounds of the general formula whereinR.sup.1 is C.sub.5-12 -cycloalkyl, optionally substituted by lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl; octahydro-inden-2-yl; 1,2,3,4-tetrahydro-naphthalen-1-yl; 1,2,3,4-tetrahydro-naphthalen-2-yl; naphthalen-lower alkyl-1-yl; naphthalen-lower alkyl-2-yl; acenaphthen-1-yl; and 5-isopropyl-2-methyl-bicyclo[3.1.0]hex-3-yl;R.sup.2, R.sup.3 are hydrogen; hydroxy; lower alkyl; .dbd.O; or phenyl, optionally substituted by lower allyl, halogen or alkoxy;R.sup.4 is hydrogen; lower alkyl; --(CH.sub.2).sub.n CH(OH)CF.sub.3 ; --(CH.sub.2).sub.n C.sub.3-6 -cycloalkyl; phenyl; benzyl; tetrahydrofuran-3-yl; --(CH.sub.2).sub.n OCH.sub.2 C.sub.6 H.sub.5 ; --(CH.sub.2).sub.n morpholinyl; 3-methyl-oxetan-3-yl-methyl; --(CH.sub.2).sub.n CH.sub.2 OH; --S(O).sub.2 -lower alkyl; --C(O)-lower alkyl; --C(O)CF.sub.3 ; --C(O)(CH.sub.2).sub.n OCH.sub.3 ; --(CH.sub.2).sub.n C(O)N(lower alkyl).sub.2 ; --S(O).sub.2 heteroaryl; --C(O)heteroaryl; --S(O).sub.2 -phenyl; --S(O).sub.2 --N(lower alkyl).sub.2 ; --C(O)--C.sub.3-6 -cycloalkyl; --C(O)O-phenyl; or --C(O)O-lower alkyl:R.sup.5 is hydrogen; halogen; lower alkyl; trifluoromethyl or lower alkoxy;n is 0-3;and to pharmaceutically acceptable acid addition salts thereofThe compounds of formula I and their salts are useful as in the treatment of psychiatric, neurological and physiological disorders.
摘要翻译：本发明涉及以下通式的化合物：其中R 1为任选被低级烷基取代的C 5-12 - 环烷基; 十氢萘-1-基; 十氢萘-2-基; 茚满-1-基或茚满-2-基，任选被低级烷基取代; 十氢 - 薁-2-基; 双环[6.2.0]癸-9-基; 苊-1-基; 双环[3.3.1]壬-9-基; 2,3-二氢-1H-苯并芬-1-基; 2,3,3a，4,5,6-六氢-1H-苯并芬-1-基; 八氢茚-2-基; 1,2,3,4-四氢 - 萘-1-基; 1,2,3,4-四氢 - 萘-2-基; 萘 - 低级烷基-1-基; 萘 - 低级烷基-2-基; 苊-1-基; 和5-异丙基-2-甲基 - 双环[3.1.0]己-3-基; R2，R3是氢; 羟基; 低级烷基 = O; 或苯基，任选被低级烯丙基，卤素或烷氧基取代; R4是氢; 低级烷基 - （CH 2）n CH（OH）CF 3; - （CH 2）n C 3-6 - 环烷基; 苯基; 苄基; 四氢呋喃-3-基; - （CH 2）n OCH 2 C 6 H 5; - （CH2）nmorpholinyl; 3-甲基 - 氧杂环丁烷-3-基 - 甲基; - （CH 2）n CH 2 OH; -S（O）2 - 低级烷基; -C（O） - 低级烷基; -C（O）CF 3; -C（O）（CH 2）n OCH 3; - （CH 2）n C（O）N（低级烷基）2; -S（O）2杂芳基; -C（O）杂芳基; -S（O）2 - 苯基; -S（O）2 -N（低级烷基）2; -C（O）-C 3-6 - 环烷基; -C（O）O-苯基; 或-C（O）O-低级烷基：R5是氢; 卤素; 低级烷基三氟甲基或低级烷氧基; n为0-3; 和其药学上可接受的酸加成盐。式I化合物及其盐可用于治疗精神病学，神经学和生理学疾病。

6. 发明授权

US5869500A Pyridone compounds useful in treating Alzheimer's disease 失效
标题翻译：可用于治疗阿尔茨海默病的吡啶酮化合物
公开(公告)号：US5869500A
公开(公告)日：1999-02-09
申请号：US976541
申请日：1997-11-24
申请人： Gerda Huber Trottmann , Roland Jakob-Roetne , Sabine Kolczewski , Roger David Norcross , Thomas Johannes Woltering
发明人： Gerda Huber Trottmann , Roland Jakob-Roetne , Sabine Kolczewski , Roger David Norcross , Thomas Johannes Woltering
IPC分类号： C07D455/02 , C07D455/06 , C07D471/14 , C07D495/14 , A61K31/44 , A61K31/38 , A61K31/40 , A61K31/55
CPC分类号： C07D471/14 , C07D455/02 , C07D455/06 , C07D495/14
摘要： The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula ##STR1## where A, R.sup.1, R.sup.3, R.sup.4, and R.sup.7 are described herein and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which are connected with an inhibition of .beta.-amyloid peptide activity, especially for the treatment of Alzheimer's disease.
摘要翻译：本发明涉及使用本文所述的式Ⅰ，R1，R3，R4和R7的式和其三价环吡啶酮化合物及其药学上可接受的盐，用于生产药物用于预防或治疗与抑制β-淀粉样蛋白肽活性相关的疾病，特别是用于治疗阿尔茨海默病。

7. 发明授权

US6030984A Pyridone compounds useful in treating Alzheimer's disease 失效
标题翻译：可用于治疗阿尔茨海默病的吡啶酮化合物
公开(公告)号：US6030984A
公开(公告)日：2000-02-29
申请号：US161853
申请日：1998-09-28
申请人： Gerda Huber Trottmann , Roland Jakob-Roetne , Sabine Kolczewski , Roger David Norcross , Thomas Johannes Woltering
发明人： Gerda Huber Trottmann , Roland Jakob-Roetne , Sabine Kolczewski , Roger David Norcross , Thomas Johannes Woltering
IPC分类号： C07D455/02 , C07D455/06 , C07D471/14 , C07D495/14 , A61K31/44 , A61K31/38 , A61K31/40 , A61K31/55 , C07D401/00
CPC分类号： C07D471/14 , C07D455/02 , C07D455/06 , C07D495/14
摘要： The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R.sup.1, R.sup.3, R.sup.4, and R.sup.7 are described herein and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which are connected with an inhibition of .beta.-amyloid peptide activity, especially for the treatment of Alzheimer's disease.
摘要翻译：本发明涉及使用下式的双和三环吡啶酮化合物，其中A，R 1，R 3，R 4和R 7在此描述及其药学上可接受的盐用于制备用于预防或治疗疾病的药物与β-淀粉样蛋白肽活性的抑制有关，特别是用于治疗阿尔茨海默氏病。

8. 发明授权

US06642247B2 Di-or triaza-spiro [4,5] decane derivatives 失效
标题翻译：二 - 或三氮杂螺[4,5]癸烷衍生物
公开(公告)号：US06642247B2
公开(公告)日：2003-11-04
申请号：US09330724
申请日：1999-06-11
申请人： Geo Adam , Andrea Cesura , François Jenck , Sabine Kolczewski , Stephan Röver , Jürgen Wichmann
发明人： Geo Adam , Andrea Cesura , François Jenck , Sabine Kolczewski , Stephan Röver , Jürgen Wichmann
IPC分类号： A61K31438
CPC分类号： C07D471/10 , C07D513/10
摘要： The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R2 is hydrogen; lower alkyl; ═O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is —CH(OH)—; —C(O)—; —CHR3—; —CR3═; —O—; —S—; —CH(COOR4)— or C(COOR4)═; Y is —CH2—; —CH═; —CH(COOR4)—, —C(COOR4)═; or —C(CN)—; R3 is hydrogen or lower alkoxy; R4 is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.
摘要翻译：本发明涉及通式化合物R 1的化合物是任选被低级烷基或-C（O）O-低级烷基取代的C 6-10 - 环烷基; 十氢萘-1-基; 十氢萘-2-基; 茚满-1-基或茚满-2-基，任选被低级烷基取代; 十氢 - 薁-2-基; 双环[6.2.0]癸-9-基; 苊-1-基; 2,3-二氢-1H-苯并芬-1-基; 2,3,3a，4,5,6-六氢-1H-吩酚-1-基或八氢 - 茚-2-基; R 2是氢; 低级烷基任选被低级烷基，卤素或烷氧基取代的O或苯基;是任选被低级烷基，卤素或烷氧基取代的环己基或苯基; X是-CH（OH） - ; -C（O） - ; -CHR 3 - ; -CR 3 = -O-; -S-; -CH（COOR 4） - 或C（COOR 4）=; Y是-CH 2 - ; -CH =; -CH（COOR 4） - ， - C（COOR 4）=; 或-C（CN） - ; R 3是氢或低级烷氧基; R 4是低级烷基，环烷基，苯基或苄基，a或b任选是另外的键，以及其药学上可接受的酸加成盐该化合物是孤儿素FQ（QFQ）受体的激动剂，因此可用于治疗与该受体有关的疾病。

9. 发明授权

US06172075B2 Di-or triaza-spiro [4,5] decane derivatives 有权
公开(公告)号：US06172075B2
公开(公告)日：2001-01-09
申请号：US09330724
申请日：1999-06-11
申请人： Geo Adam , Andrea Cesura , François Jenck , Sabine Kolczewski , Stephan Röver , J{umlaut over (u)}rgen Wichmann
发明人： Geo Adam , Andrea Cesura , François Jenck , Sabine Kolczewski , Stephan Röver , J{umlaut over (u)}rgen Wichmann
IPC分类号： A61K31438
摘要： The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; acenaphthen-1-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl or octahydro-inden-2-yl; R2 is hydrogen; lower alkyl; ═O or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; {circumflex over (A)} is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen or alkoxy; X is —CH(OH)—; —C(O)—; —CHR3—; —CR3═; —O—; —S—; —CH(COOR4)— or —C(COOR4)—; Y is —CH2—; —CH═; —CH(COOR4)—, —C(COOR4)═; or —C(CN)—; R3 is hydrogen or lower alkoxy; R4 is lower alkyl, cycloalkyl, phenyl, or benzyl and either a or b is optionally an additional bond, and to pharmaceutically acceptable acid addition salts thereof. The compounds are agonists of the orphanin FQ (QFQ) receptor and therefore useful in the treatment of diseases, related to this receptor.

10. 发明授权

US08399674B2 Quinolines 失效
标题翻译：喹啉
公开(公告)号：US08399674B2
公开(公告)日：2013-03-19
申请号：US13359933
申请日：2012-01-27
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C11D11/0017 , C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C11D3/001 , C11D3/50 , C11D3/502 , C11D17/0086
摘要： The present invention relates to 2-aminoquinolines of formula I wherein R1, R2 and R3 are as defined in the specification, as 5-HT5A receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.
摘要翻译：本发明涉及式I的2-氨基喹啉，其中R 1，R 2和R 3如本说明书中所定义，为5-HT5A受体拮抗剂，其制备方法，含有它们的药物组合物及其用于治疗CNS障碍的用途。

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