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1. 发明申请

US20090227583A1 2-AMINOQUINOLINES 失效
标题翻译： 2-氨基喹啉
公开(公告)号：US20090227583A1
公开(公告)日：2009-09-10
申请号：US12394072
申请日：2009-02-27
申请人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： A61K31/5377 , C07D215/38 , C07D417/12 , A61K31/47 , A61K31/4709 , C07D413/12 , C07D401/12 , A61K31/506 , A61K31/496 , A61P25/22 , A61P25/24 , A61P25/00
CPC分类号： C07D215/38 , C07D401/04 , C07D401/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to compounds of formula (I) wherein A, R1, R2, R3, R4, and R5 are as described herein, pharmaceutical compositions containing them, and methods for their manufacture. These compounds are 5-HT5A receptor antagonistsand are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.
摘要翻译：本发明涉及其中A，R 1，R 2，R 3，R 4和R 5如本文所述的式（I）化合物，含有它们的药物组合物及其制备方法。这些化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠道疾病。

2. 发明申请

US20080081907A1 2-AMINOQUINOLINE DERIVATIVES 失效
标题翻译： 2-氨基喹啉衍生物
公开(公告)号：US20080081907A1
公开(公告)日：2008-04-03
申请号：US11859045
申请日：2007-09-21
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D405/14 , C07D215/38 , C07D401/02 , C07D413/14 , C07D417/14 , C07D409/02 , C07D405/02
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein X, Y, Ar1, and Ar2 are as defined in the specification.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Ar 1和Ar 2如本说明书中所定义。

3. 发明授权

US08399674B2 Quinolines 失效
标题翻译：喹啉
公开(公告)号：US08399674B2
公开(公告)日：2013-03-19
申请号：US13359933
申请日：2012-01-27
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C11D11/0017 , C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C11D3/001 , C11D3/50 , C11D3/502 , C11D17/0086
摘要： The present invention relates to 2-aminoquinolines of formula I wherein R1, R2 and R3 are as defined in the specification, as 5-HT5A receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.
摘要翻译：本发明涉及式I的2-氨基喹啉，其中R 1，R 2和R 3如本说明书中所定义，为5-HT5A受体拮抗剂，其制备方法，含有它们的药物组合物及其用于治疗CNS障碍的用途。

4. 发明授权

US07994324B2 2-aminoquinoline derivatives 失效
标题翻译： 2-氨基喹啉衍生物
公开(公告)号：US07994324B2
公开(公告)日：2011-08-09
申请号：US12394092
申请日：2009-02-27
申请人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D215/48 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.
摘要翻译：本发明涉及2-氨基喹啉衍生物，特别是式（I）的化合物，其中R 1和R 2如本文所述，含有这些化合物的药物组合物及其制备方法。本发明的化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社会恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆症，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神疾病或胃肠疾病。

5. 发明授权

US07989628B2 2-aminoquinolines 失效
标题翻译： 2-氨基喹啉
公开(公告)号：US07989628B2
公开(公告)日：2011-08-02
申请号：US12394083
申请日：2009-02-27
申请人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D405/12
摘要： The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their manufacture. The compounds are 5-HT5A receptor antagonists and are useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.
摘要翻译：本发明涉及式I的2-氨基喹啉衍生物，其中Z，R 1和Ar 1如本文所定义，含有它们的药物组合物，其制备方法。这些化合物是5-HT5A受体拮抗剂，可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠疾病。

6. 发明授权

US07825253B2 2-aminoquinoline derivatives 失效
标题翻译： 2-氨基喹啉衍生物
公开(公告)号：US07825253B2
公开(公告)日：2010-11-02
申请号：US11859045
申请日：2007-09-21
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein X, Y, Ar1, and Ar2 are as defined in the specification.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中X，Y，Ar 1和Ar 2如说明书中所定义。

7. 发明申请

US20090227584A1 2-AMINOQUINOLINE DERIVATIVES 失效
标题翻译： 2-氨基喹啉衍生物
公开(公告)号：US20090227584A1
公开(公告)日：2009-09-10
申请号：US12394092
申请日：2009-02-27
申请人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： A61K31/5377 , C07D215/38 , A61K31/47 , A61P25/24 , A61P25/22 , A61P25/00 , C07D413/12 , C07D401/12 , A61K31/4709
CPC分类号： C07D215/38 , C07D215/48 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I) wherein R1 and R2 are as described herein, pharmaceutical compositions containing such compounds, and methods for their manufacture. The compounds of the invention are 5-HT5A receptor antagonists useful in the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.
摘要翻译：本发明涉及2-氨基喹啉衍生物，特别是式（I）的化合物，其中R 1和R 2如本文所述，含有这些化合物的药物组合物及其制备方法。本发明的化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐怖症，社会恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆症，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神疾病或胃肠疾病。

8. 发明申请

US20090088451A1 QUINOLINES 审中-公开
标题翻译：金刚石
公开(公告)号：US20090088451A1
公开(公告)日：2009-04-02
申请号：US12233625
申请日：2008-09-19
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： A61K31/47 , C07D215/38
CPC分类号： C11D11/0017 , C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C11D3/001 , C11D3/50 , C11D3/502 , C11D17/0086
摘要： The present invention relates to 2-aminoquinolines of formula I wherein R1, R2 and R3 are as defined in the specification, as 5-HT5A receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.
摘要翻译：本发明涉及式I的2-氨基喹啉，其中R1，R2和R3如说明书中所定义，作为5-HT5A受体拮抗剂，其制备方法，含有它们的药物组合物及其用于治疗CNS障碍的用途。

9. 发明授权

US07923561B2 Quinolines 失效
标题翻译：喹啉
公开(公告)号：US07923561B2
公开(公告)日：2011-04-12
申请号：US11946947
申请日：2007-11-29
申请人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： C07D215/38
CPC分类号： C07D215/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12
摘要： The present invention relates to 2-Aminoquinoline derivatives of general formula I and pharmaceutically-acceptable acid-addition salts thereof, wherein R1, R2 and X are as defined in the specification. The compounds may be used as 5-HT5A receptor antagonists. The present invention relates also to processes for making such a compound and a pharmaceutical composition comprising such a compound. Compounds of the present invention are useful in the prevention and/or treatment of anxiety depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, withdrawal from abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders and gastrointestinal disorders.
摘要翻译：本发明涉及通式I的2-氨基喹啉衍生物及其药学上可接受的酸加成盐，其中R1，R2和X如说明书中所定义。该化合物可以用作5-HT5A受体拮抗剂。本发明还涉及制备这种化合物的方法和包含这种化合物的药物组合物。本发明的化合物可用于预防和/或治疗焦虑抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆症，饮食行为，性功能障碍，睡眠障碍，戒毒，运动障碍如帕金森病，精神疾病和胃肠道疾病。

10. 发明申请

US20090233927A1 2-AMINOQUINOLINES 失效
标题翻译： 2-氨基喹啉
公开(公告)号：US20090233927A1
公开(公告)日：2009-09-17
申请号：US12398415
申请日：2009-03-05
申请人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
发明人： Sabine Kolczewski , Claus Riemer , Olivier Roche , Lucinda Steward , Juergen Wichmann , Thomas Woltering
IPC分类号： A61K31/47 , C07D215/38 , C07D413/02 , A61K31/5377 , A61P25/00
CPC分类号： C07D405/12 , C07D215/38 , C07D491/08
摘要： The present invention is concerned with 2-aminoquinoline derivatives of formula I wherein R1 and R2 are as described herein and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them, and methods for their manufacture. These compounds are 5-HT5A receptor antagonists, useful for the prevention and/or treatment of depression, anxiety disorders, schizophrenia, panic disorders, agoraphobia, social phobia, obsessive compulsive disorders, post-traumatic stress disorders, pain, memory disorders, dementia, disorders of eating behaviors, sexual dysfunction, sleep disorders, abuse of drugs, motor disorders such as Parkinson's disease, psychiatric disorders or gastrointestinal disorders.
摘要翻译：本发明涉及式I的2-氨基喹啉衍生物，其中R 1和R 2如本文所述及其药学上可接受的盐，含有它们的药物组合物及其制备方法。这些化合物是可用于预防和/或治疗抑郁症，焦虑障碍，精神分裂症，恐慌症，广场恐惧症，社交恐惧症，强迫症，创伤后应激障碍，疼痛，记忆障碍，痴呆症，饮食行为障碍，性功能障碍，睡眠障碍，药物滥用，运动障碍如帕金森病，精神病或胃肠道疾病。

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