专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11932845B2 Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds 有权
公开(公告)号：US11932845B2
公开(公告)日：2024-03-19
申请号：US14405390
申请日：2013-06-03
申请人： Genomatica, Inc.
发明人： Priti Pharkya , Anthony P. Burgard , Stephen J. Van Dien , Robin E. Osterhout , Mark J. Burk , John D. Trawick , Michael P. Kuchinskas , Brian Steer
IPC分类号： C12N9/18 , C12P7/42 , C12P7/52 , C12N1/20 , C12P7/18 , C12N15/52 , C12N1/14 , C12N1/16 , C12N15/63 , C07C31/20 , C07C59/01 , C08G18/28 , C08G18/32 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02
CPC分类号： C12N1/20 , C07C31/207 , C07C59/01 , C08G18/284 , C08G18/3206 , C08G63/06 , C08G63/16 , C08G63/181 , C08G69/02 , C12N1/14 , C12N1/16 , C12N9/18 , C12N15/52 , C12N15/63 , C12P7/18 , C12P7/42 , C12Y301/01 , Y02P20/52
摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.

2. 发明授权

US11753663B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto 有权
公开(公告)号：US11753663B2
公开(公告)日：2023-09-12
申请号：US14652727
申请日：2013-12-16
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P17/10 , C12P13/02 , C12P7/24 , C12P19/02 , C12P7/44 , C12P13/00 , C12N9/04 , C08G63/78 , C08G73/02 , C08G69/16 , C08G69/08 , C12N15/52 , A23L29/00
CPC分类号： C12P17/10 , A23L29/065 , C08G63/78 , C08G69/08 , C08G69/16 , C08G73/0213 , C12N9/0006 , C12N15/52 , C12P7/24 , C12P7/44 , C12P13/001 , C12P13/005 , C12Y101/01244
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.

3. 发明申请

US20210277426A1 ENGINEERED MICROORGANISMS & METHODS FOR IMPROVED CROTYL ALCOHOL PRODUCTION 有权
公开(公告)号：US20210277426A1
公开(公告)日：2021-09-09
申请号：US16953050
申请日：2020-11-19
申请人： Genomatica, Inc.
发明人： Stephanie J. Culler , Nicholas Eakley , Kevin Gregory Hoff , Robin E. Osterhout , Priti Pharkya , Erik C. Ralph , Stephen J. Van Dien
IPC分类号： C12P5/02 , C12N9/04 , C12N9/02 , C12P7/16 , C12P7/04
摘要： Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.

4. 发明申请

US20210147883A1 METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES 有权
公开(公告)号：US20210147883A1
公开(公告)日：2021-05-20
申请号：US16785510
申请日：2020-02-07
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Priti Pharkya , Tae Hoon Yang , Jungik Choi
IPC分类号： C12P7/18 , C12N9/02 , C12N9/12 , C12N9/16 , C12N15/52 , C12N1/20 , C12N9/00 , C07K14/245 , C12P7/42 , C12N9/52 , C12N9/88
摘要： The invention is directed to a non-naturally occurring microbial organism comprising a first attenuation of a succinyl-CoA synthetase or transferase and at least a second attenuation of a succinyl-CoA converting enzyme or a gene encoding a succinate producing enzyme within a multi-step pathway having a net conversion of succinyl-CoA to succinate.

5. 发明授权

US10626422B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1.4-butanediol related thereto 有权
公开(公告)号：US10626422B2
公开(公告)日：2020-04-21
申请号：US14424404
申请日：2013-08-27
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/18 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P7/24 , C12P19/02
CPC分类号： C12P7/18 , C07D207/12 , C08G18/3206 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N9/88 , C12P7/24 , C12P19/02 , C12Y101/01244 , C12Y101/02007 , C12Y105/0102 , C12Y201/01 , C12Y101/01224 , C12Y201/0109 , C12Y402/01 , Y02P20/52
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.

6. 发明授权

US10273508B2 Microorganisms for the production of 1,4-butanediol and related methods 有权
公开(公告)号：US10273508B2
公开(公告)日：2019-04-30
申请号：US15148759
申请日：2016-05-06
申请人： Genomatica, Inc.
发明人： Stephen J. Van Dien , Anthony P. Burgard , Robert Haselbeck , Catherine J. Pujol-Baxley , Wei Niu , John D. Trawick , Harry Yim , Mark J. Burk , Robin E. Osterhout , Jun Sun
IPC分类号： C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/16 , C12N9/88 , C12P7/18 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

7. 发明申请

US20190062758A1 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS 审中-公开
公开(公告)号：US20190062758A1
公开(公告)日：2019-02-28
申请号：US15925301
申请日：2018-03-19
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Stephen J. Van Dien , Anthony P. Burgard , Wei Niu
IPC分类号： C12N15/52 , B01D3/00 , C12N15/70 , C12P17/04 , C12P7/52 , C12P7/42 , C12P7/18 , C12N9/00 , C12N9/88 , C12N9/02 , C12N9/04 , C12N15/81
摘要： The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided is a method for the production of 4-HB. The method includes culturing a non-naturally occurring microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase or α-ketoglutarate decarboxylase under substantially anaerobic conditions for a sufficient period of time to produce monomeric 4-hydroxybutanoic acid (4-HB). Further provided is a method for the production of BDO. The method includes culturing a non-naturally occurring microbial biocatalyst, comprising a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-hydroxybutyrate kinase, phosphotranshydroxybutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase for a sufficient period of time to produce 1,4-butanediol (BDO). The 4-HB and/or BDO products can be secreted into the culture medium.

8. 发明授权

US09909150B2 Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto 有权
公开(公告)号：US09909150B2
公开(公告)日：2018-03-06
申请号：US14071318
申请日：2013-11-04
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12P7/04 , C12P7/18 , C12P7/24 , C12N1/20 , C12N1/16 , C12N1/14 , C12P7/20 , C12N9/04 , C12N9/06 , C12N9/10 , C12N15/52
CPC分类号： C12P7/24 , C12N1/14 , C12N1/16 , C12N1/20 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/52 , C12P7/04 , C12P7/18 , C12P7/20 , C12Y101/01244 , C12Y105/0102
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol. Also provided herein are methods for using such an organism to produce 1,2-propanediol, n-propanol, 1,3-propanediol or glycerol.

9. 发明申请

US20130316426A1 METHODS FOR SYNTHESIS OF OLEFINS AND DERIVATIVES 有权
标题翻译：烯烃和衍生物的合成方法
公开(公告)号：US20130316426A1
公开(公告)日：2013-11-28
申请号：US13887140
申请日：2013-05-03
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Priti Pharkya , Stephen J. Van Dien , Anthony P. Burgard , Christophe H. Schilling
IPC分类号： C07C51/38 , C07C67/32
CPC分类号： C07C51/353 , C07C51/38 , C07C57/04 , C07C67/08 , C07C67/32 , C07C67/333 , C12P7/40 , C12P7/46 , C12P7/62 , Y02P20/125 , C07C69/60 , C07C69/54
摘要： The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
摘要翻译：本发明提供了制备丙烯酸的方法。该方法包括在交叉复分解转化催化剂存在下使富马酸与足够量的乙烯接触，以产生约2摩尔丙烯酸/摩尔富马酸。还提供了丙烯酸酯。该方法包括在交叉复分解转化催化剂存在下使富马酸二酯与足够量的乙烯接触，以产生每摩尔富马酸二酯约2摩尔丙烯酸酯。提供了用于生产丙烯酸或丙烯酸酯的方法的综合方法，其将富马酸的生物生产与易位转化相结合。还提供丙烯酸和丙烯酸酯生产。

10. 发明申请

US20230136909A1 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 3-HYDROXYISOBUTYRATE OR METHACRYLIC ACID RELATED THERETO 有权
公开(公告)号：US20230136909A1
公开(公告)日：2023-05-04
申请号：US17833695
申请日：2022-06-06
申请人： Genomatica, Inc.
发明人： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC分类号： C12N15/52 , C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N9/04 , C12N9/06 , C12N9/10 , C12P7/62
摘要： Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式