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1. 发明申请

US20170305875A1 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE 审中-公开
公开(公告)号：US20170305875A1
公开(公告)日：2017-10-26
申请号：US15642947
申请日：2017-07-06
申请人： Givaudan S.A.
发明人： Fridtjof SCHRÖDER , Urs MUELLER , Jürg Daniel OETIKER
IPC分类号： C07D307/92 , C07C69/608 , C07C67/475 , C07C51/38 , C07C57/26 , C07C403/20 , C07C67/32 , C07C2601/16 , C07C2601/14
CPC分类号： C07D307/92 , C07C51/38 , C07C57/26 , C07C67/32 , C07C67/475 , C07C69/608 , C07C403/20 , C07C2601/14 , C07C2601/16 , C07C2602/48
摘要： Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2

2. 发明申请

US20170008828A1 METHODS FOR THE SYNTHESIS OF OLEFINS AND DERIVATIVES 审中-公开
标题翻译：烯烃和衍生物的合成方法
公开(公告)号：US20170008828A1
公开(公告)日：2017-01-12
申请号：US15182245
申请日：2016-06-14
申请人： Genomatica, Inc.
发明人： Mark J. Burk , Priti Pharkya , Stephen J. Van Dien , Anthony P. Burgard , Christophe H. Schilling
IPC分类号： C07C51/353 , C12P7/46 , C12P7/62 , C07C67/08
CPC分类号： C07C51/353 , C07C51/38 , C07C57/04 , C07C67/08 , C07C67/32 , C07C67/333 , C12P7/40 , C12P7/46 , C12P7/62 , Y02P20/125 , C07C69/60 , C07C69/54
摘要： The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
摘要翻译：本发明提供了制备丙烯酸的方法。该方法包括在交叉复分解转化催化剂存在下使富马酸与足够量的乙烯接触，以产生约2摩尔丙烯酸/摩尔富马酸。还提供了丙烯酸酯。该方法包括在交叉复分解转化催化剂存在下使富马酸二酯与足够量的乙烯接触，以产生每摩尔富马酸二酯约2摩尔丙烯酸酯。提供了用于生产丙烯酸或丙烯酸酯的方法的综合方法，其将富马酸的生物生产与易位转化相结合。还提供丙烯酸和丙烯酸酯生产。

3. 发明申请

US20150344396A1 METHOD FOR PRODUCING 3,5-DIMETHYLDODECANOIC ACID 有权
标题翻译：生产3,5-二羟基胆酸的方法
公开(公告)号：US20150344396A1
公开(公告)日：2015-12-03
申请号：US14713623
申请日：2015-05-15
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Naoki Ishibashi , Akihiro Baba , Takeshi Kinsho
IPC分类号： C07C51/38 , C07F3/02 , C07C67/343
CPC分类号： C07C51/38 , C07C51/09 , C07C55/02 , C07C67/32 , C07C67/343 , C07C67/347 , C07F3/02 , C07C69/34 , C07C69/24 , C07C53/126 , C07C55/21
摘要： Provided is a process for producing 3,5-dimethyldodecanoic acid, which is an active ingredient of the pheromone of California prionus. More specifically provided is a method for producing 3,5-dimethyldodecanoic acid (5) comprising the steps of converting 2-methylnonyl halide (1) to a 2-methylnonyl metal reagent (2), and reacting the 2-methylnonyl metal reagent (2) with 2-ethylidene malonic acid ester (3) to form 2-(1,3-dimethyldecyl)malonic acid ester (4) as a result of 1,4-addition of the 2-methylnonyl metal reagent (2) to the 2-ethylidene malonic acid ester (3), as shown in the following scheme:
摘要翻译：提供了一种生产3,5-二甲基十二烷酸的方法，其是加利福尼亚朊病毒的信息素的活性成分。更具体地提供3,5-二甲基十二烷酸（5）的制造方法，其特征在于，将2-甲基壬基卤（1）转化成2-甲基壬基金属试剂（2），将2-甲基壬基金属试剂（2））与2-亚乙基丙二酸酯（3）反应形成2-（1,3-二甲基癸基）丙二酸酯（4），其结果是将2-甲基壬基金属试剂（2）1,4-二 - 亚乙基丙二酸酯（3），如下列方案所示：

4. 发明申请

US20150094476A1 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS PREPARATION AND USE 有权
标题翻译： 2-（烷氧基或芳氧基羰基）-4-甲基-6-（2,6,6-三甲基环己基-1-环己基）十六烷-2-烯酸化合物，其制备和使用
公开(公告)号：US20150094476A1
公开(公告)日：2015-04-02
申请号：US14563312
申请日：2014-12-08
申请人： Givaudan, S.A.
发明人： Fridtjof SCHRÖDER , Urs MUELLER , Jürg Daniel OETIKER
IPC分类号： C07D307/92 , C07C67/475 , C07C57/26
CPC分类号： C07D307/92 , C07C51/38 , C07C57/26 , C07C67/32 , C07C67/475 , C07C69/608 , C07C403/20 , C07C2601/14 , C07C2601/16 , C07C2602/48
摘要： Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2
摘要翻译：式1的化合物，其中R是氢，烷基或取代的烷基，芳基或取代的芳基，是芳香成分合成中的有用中间体，例如Ambrox 2

5. 发明授权

US08933253B2 2-(Alkoxy or aryloxy carbonyl)-4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl)hex-2-enoic acid compunds, its preparation and use 有权
标题翻译： 2-（烷氧基或芳氧基羰基）-4-甲基-6-（2,6,6-三甲基环己-1-烯基）己-2-烯酸，其制备和使用
公开(公告)号：US08933253B2
公开(公告)日：2015-01-13
申请号：US13995368
申请日：2011-12-21
申请人： Fridtjof Schröder , Urs Mueller , Jürg Daniel Oetiker
发明人： Fridtjof Schröder , Urs Mueller , Jürg Daniel Oetiker
IPC分类号： C07C403/20 , C07D307/92
CPC分类号： C07D307/92 , C07C51/38 , C07C57/26 , C07C67/32 , C07C67/475 , C07C69/608 , C07C403/20 , C07C2601/14 , C07C2601/16 , C07C2602/48
摘要： Compounds of the formula 1 wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2.
摘要翻译：式1的化合物，其中R是氢，烷基或取代的烷基，芳基或取代的芳基，在芳香成分如Ambrox 2的合成中是有用的中间体。

6. 发明申请

US20120116112A1 PROCESS FOR THE PREPARATION OF FUNCTIONALISED BENZOCYCLOBUTENES, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID 失效
标题翻译：功能性苄基胆碱酯酶的制备方法，以及合成IVABRADINE及其与药物接受酸的添加剂的应用
公开(公告)号：US20120116112A1
公开(公告)日：2012-05-10
申请号：US13341311
申请日：2011-12-30
申请人： Jean-Louis PEGLION , Olivier Baudoin , Nicolas Audic , Manon Chaumontet , Riccardo Piccardi
发明人： Jean-Louis PEGLION , Olivier Baudoin , Nicolas Audic , Manon Chaumontet , Riccardo Piccardi
IPC分类号： C07C69/74 , C07C211/19 , C07C233/60 , C07C255/00 , C07C62/12
CPC分类号： C07C51/38 , C07B37/10 , C07B2200/07 , C07C62/34 , C07C67/317 , C07C67/32 , C07C69/753 , C07C69/757 , C07C253/30 , C07C2602/22 , C07D223/16 , C07F7/1804 , C07C69/76 , C07C255/47
摘要： Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification.Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
摘要翻译：制备式（IV）化合物的方法：其中R 1 -R 6如说明书中所定义。在伊伐溴丁的合成中的应用，其与药学上可接受的酸及其水合物的加成盐。

7. 发明申请

US20100016580A1 Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 失效
标题翻译：用于制备官能化苯并环丁烯的方法，以及在药物可接受的酸合成伊伐布拉德及其加成盐中的应用
公开(公告)号：US20100016580A1
公开(公告)日：2010-01-21
申请号：US12460208
申请日：2009-07-15
申请人： Jean-Louis Peglion , Olivier Baudoin , Nicolas Audic , Manon Chaumontet , Riccardo Piccardi
发明人： Jean-Louis Peglion , Olivier Baudoin , Nicolas Audic , Manon Chaumontet , Riccardo Piccardi
IPC分类号： C07D223/16 , C07C41/01
CPC分类号： C07C51/38 , C07B37/10 , C07B2200/07 , C07C62/34 , C07C67/317 , C07C67/32 , C07C69/753 , C07C69/757 , C07C253/30 , C07C2602/22 , C07D223/16 , C07F7/1804 , C07C69/76 , C07C255/47
摘要： Process for the preparation of compounds of formula (IV): wherein R1, R2, R3 and R4, which may be identical or different, each represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C1-C6)alkoxy group, a fluorine atom, a chlorine atom, a protected amine group, a protected hydroxyl group, an alkoxycarbonyl group in which the alkoxy group is linear or branched (C1-C6), or a CF3 group, or R1═R4═H and R2 and R3 together with the carbon atoms carrying them form a 1,3-dioxolane group, R5 represents a saturated or unsaturated, linear or branched (C1-C6)alkyl group, a linear or branched (C1-C6)hydroxyalkyl group in which the hydroxyl function is protected, or a CO2R7 group in which R7 is a linear or branched (C1-C6)alkyl group, R6 represents a cyano group or a CO2R8 group in which R8 is a linear or branched (C1-C6)-alkyl group. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
摘要翻译：制备式（IV）化合物的方法：其中可以相同或不同的R 1，R 2，R 3和R 4各自表示氢原子，直链或支链（C 1 -C 6）烷基，直链或支链（C1-C6）烷氧基，氟原子，氯原子，被保护的胺基，保护的羟基，烷氧基为直链或支链的烷氧基羰基（C1-C6）或CF3基，或 R1-R4-H和R2和R3与携带它们的碳原子一起形成1,3-二氧戊环基团，R 5表示饱和或不饱和的直链或支链（C 1 -C 6）烷基，直链或支链（C1- C6）羟基官能团的羟烷基或其中R 7为直链或支链（C 1 -C 6）烷基的CO 2 R 7基团，R 6表示其中R 8为直链或支链的氰基或CO 2 R 8基团（ C1-C6） - 烷基。在伊伐溴丁的合成中的应用，其与药学上可接受的酸及其水合物的加成盐。

8. 发明授权

US07550626B2 Process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids or carboxylic esters 失效
标题翻译：制备外消旋烷基-5-卤代-4-烯羧酸或羧酸酯的方法
公开(公告)号：US07550626B2
公开(公告)日：2009-06-23
申请号：US11995553
申请日：2006-07-03
申请人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
发明人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
IPC分类号： C07C69/62 , C07C53/15
CPC分类号： C07C51/09 , C07C67/32 , C07C67/343 , C07C57/52 , C07C69/65
摘要： A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-4-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and R2 is a C1-C4-alkyl radical, in the presence of a metal alkoxide of the formula MOR3, in which M may be Na, K or Li, and R3 is a C1-C4-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C1-C6 alcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function.
摘要翻译：制备式（I）的外消旋烷基-5-卤代-4-甲酸及其酯的方法，其中R是C1-C6-烷基，R1是H或C1-4 - 烷基，X是氯溴或碘，其包括：a）在式MOR 3的金属醇盐存在下使式（II）的烷基丙二酸二烷基酯（其中R如上定义，R 2是C 1 -C 4 - 烷基）其中M可以是Na，K或Li，R3是C1-C4-烷基，在有机溶剂中与1,3-二卤丙烯反应，得到相应的烯丙基化丙二酸酯，然后b）完全转化后，加入无机盐和C 1 -C 6醇反应混合物，将反应混合物加热至回流温度，然后c）通过萃取或直接蒸馏从反应混合物中分离所需的式（I）外消旋酯，和d）如果外消旋酸是所需的最终产物，水解酯的功能。

9. 发明申请

US20080207943A1 Process for Preparing Racemic Alkyl-5-Halopent-4-Enecarboxylic Acids or Carboxylic Esters 失效
标题翻译：制备外消旋烷基-5-卤代-4-烯羧酸或羧酸酯的方法
公开(公告)号：US20080207943A1
公开(公告)日：2008-08-28
申请号：US11995553
申请日：2006-07-03
申请人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
发明人： Peter Pojarliev , Gerhard Steinbauer , Christian Burger
IPC分类号： C07C69/65 , C07C57/52 , C07C67/00 , C07C51/00
CPC分类号： C07C51/09 , C07C67/32 , C07C67/343 , C07C57/52 , C07C69/65
摘要： A process for preparing racemic alkyl-5-halopent-4-enecarboxylic acids and esters thereof of the formula (I), in which R is a C1-C6-alkyl radical, R1 is H or C1-4-alkyl and X is chlorine, bromine or iodine, which comprises a) reacting a dialkyl alkylmalonate of the formula (II),in which R is as defined above and R2 is a C1-C4-alkyl radical, in the presence of a metal alkoxide of the formula MOR3, in which M may be Na, K or Li, and R3 is a C1-C4-alkyl radical, and in an organic solvent, with 1,3-dihalopropene to give the corresponding allylated malonate, then b) after full conversion, adding an inorganic salt and a C1-C6 alcohol to the reaction mixture, heating the reaction mixture to reflux temperature, then c) isolating the desired racemic ester of the formula (I) from the reaction mixture by extraction or direct distillation and d) if the racemic acid is the desired end product, hydrolyzing the ester function.
摘要翻译：制备式（I）的外消旋烷基-5-卤代-4-甲酸及其酯的方法，其中R是C 1 -C 6 - 烷基，R 1是H或C 1-4 - 烷基，X是氯，溴或碘，其包括：a）使式（II）的烷基丙二酸二烷基酯），其中R如上所定义，R 2是C 1 -C 4 - 烷基，在金属的存在下式MOR 3的醇盐，其中M可以是Na，K或Li，R 3是C 1 -C 3 在有机溶剂中与1,3-二卤代丙烯反应，得到相应的烯丙基化丙二酸酯，然后b）完全转化后，加入无机盐和C 1 H 2 向反应混合物中加入反应混合物，加热反应混合物至回流温度，然后c）通过萃取或直接蒸馏从反应混合物中分离所需式（I）外消旋酯，d ）如果比赛麦克酸是所需的最终产物，水解酯的功能。

10. 发明申请

US20070191630A1 PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOATE AND OPTICALLY ACTIVE FORM THEREOF 审中-公开
标题翻译：制备（4E）-5-氯-2-异丙基-4-丁烯酸的方法及其光学活性形式
公开(公告)号：US20070191630A1
公开(公告)日：2007-08-16
申请号：US11691873
申请日：2007-03-27
申请人： Toshitsugu Sakaeda , Nobuaki Mori , Hideto Kanoh
发明人： Toshitsugu Sakaeda , Nobuaki Mori , Hideto Kanoh
IPC分类号： C07C69/62
CPC分类号： C12P41/005 , C07C67/32 , C07C67/343 , C12P7/62 , C07C69/65
摘要： To provide a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate in high yield and efficiently. A compound (2) is reacted with a base in the presence of an aprotic solvent and then with (1E)-1,3-dichloro-1-propene in the same reaction vessel to obtain a compound (3), and then either of —COOR moieties in the compound (3) is replaced with a hydrogen atom in the same reaction vessel to obtain a compound (4): wherein R is a lower alkyl group or an aralkyl group.
摘要翻译：提供以高产率和高效率生产（4E）-5-氯-2-异丙基-4-戊烯酸酯的方法。化合物（2）在非质子溶剂存在下与碱反应，然后与（1E）-1,3-二氯-1-丙烯在同一反应容器中反应，得到化合物（3），然后化合物（3）中的-COOR部分被同一反应容器中的氢原子代替，得到化合物（4）：其中R是低级烷基或芳烷基。

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