专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06565869B1 Use of CNTF (ciliary neurotrophic factor) receptor activators for the treatment of obesity 有权
标题翻译：使用CNTF（睫状神经营养因子）受体激活剂治疗肥胖
公开(公告)号：US06565869B1
公开(公告)日：2003-05-20
申请号：US09308368
申请日：1999-07-19
申请人： Gennaro Ciliberto , Patrizia Costa , Giacomo Paonessa , Domenico Lazzaro , Isabelle Gloaguen , Annalise Di Marco , Anna De Martis , Ralph Laufer , Riccardo Cortese
发明人： Gennaro Ciliberto , Patrizia Costa , Giacomo Paonessa , Domenico Lazzaro , Isabelle Gloaguen , Annalise Di Marco , Anna De Martis , Ralph Laufer , Riccardo Cortese
IPC分类号： A61F202
CPC分类号： A61K38/185 , A61K38/2264 , A61K48/00 , A61K2300/00
摘要： The present invention refers to the use of hCNTF (human ciliary neurotrophic factor), mutants thereof or other molecules that activate the CNTF receptor, for the preparation of drugs for the treatment of obesity and associated disease, for example hyperglycemia. FIG. 1 shows the anti-obesity effect of hCNTF and leptin on body weight (left panels) and on food intake (right panels) in genetically obese mice and in mice with diet-induced obesity (DIO).
摘要翻译：本发明涉及hCNTF（人纤维神经营养因子），其突变体或活化CNTF受体的其它分子用于制备用于治疗肥胖症和相关疾病例如高血糖症的药物的用途。图。图1显示了基因肥胖小鼠和饮食诱导的肥胖（DIO）小鼠中hCNTF和瘦素对体重（左图）和食物摄取（右图）的抗肥胖作用。

2. 发明授权

US06960558B2 Method of screening for anti-obesity agents using ciliary neutrophic factor receptor 有权
标题翻译：筛选使用睫状中性白细胞因子受体的抗肥胖剂的方法
公开(公告)号：US06960558B2
公开(公告)日：2005-11-01
申请号：US10356191
申请日：2003-01-31
申请人： Gennaro Ciliberto , Isabelle Gloaguen , Annalise Di Marco , Anna Demartis , Ralph Laufer , Riccardo Cortese
发明人： Gennaro Ciliberto , Isabelle Gloaguen , Annalise Di Marco , Anna Demartis , Ralph Laufer , Riccardo Cortese
IPC分类号： A61K45/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61K48/00 , A61P3/04 , A61P3/10 , A61P43/00 , A61K31/00 , G01N33/53
CPC分类号： A61K38/185 , A61K38/2264 , A61K48/00 , A61K2300/00
摘要： The present invention relates to methods for screening for anti-obesity agents using the ciliary neutrophic factor receptor.
摘要翻译：本发明涉及使用睫状中性因子受体筛选抗肥胖剂的方法。

3. 发明授权

US06706261B1 Compositions and methods comprising immunogenic muteins of interleukin-6 失效
标题翻译：包含白介素-6的免疫原性突变蛋白的组合物和方法
公开(公告)号：US06706261B1
公开(公告)日：2004-03-16
申请号：US09559950
申请日：2000-04-27
申请人： Gennaro Ciliberto , Rocco Savino , Riccardo Cortese
发明人： Gennaro Ciliberto , Rocco Savino , Riccardo Cortese
IPC分类号： C07K1454
CPC分类号： A61K39/0008 , A61K2039/55505
摘要： Cytokines, including muteins thereof, which are biologically inactive in humans but remain immunogenic, are used in pharmaceutical compositions to promote a neutralizing immune response against native cytokines when administered to a subject in need thereof to treat homeostatic disorders and disorders associated with an overproduction of cytokines.
摘要翻译：在药物组合物中使用细胞因子，包括其在人体中具有生物学活性但保持免疫原性的突变蛋白，以在施用于有需要的受试者时治疗对于天然细胞因子的中和免疫应答，以治疗与细胞因子过量产生相关的体内平衡疾病和病症。

4. 发明申请

US20130150563A1 LIPID-CONJUGATED ANTIBODIES 审中-公开
标题翻译： LIPID-CONJUGATED抗体
公开(公告)号：US20130150563A1
公开(公告)日：2013-06-13
申请号：US13808982
申请日：2011-07-08
申请人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
发明人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
IPC分类号： C07K16/08
CPC分类号： C07K16/08 , A61K47/6851 , A61K51/1006 , A61K51/1027 , C07K16/1063 , C07K16/28 , C07K2317/77
摘要： The present invention relates to novel lipid-conjugated antibodies for use in the treatment or the prevention of diseases, including but not limited to cancer, metabolic diseases including but not limited to hyperglycemia and diabetes, obesity, hypertension, hypercholesterolemia, allergy, asthma, Alzheimer's disease, and infectious diseases including but not limited to diseases caused by viruses, bacteria and fungi.
摘要翻译：本发明涉及用于治疗或预防疾病（包括但不限于癌症），代谢疾病，包括但不限于高血糖症和糖尿病，肥胖症，高血压，高胆固醇血症，变态反应，哮喘，阿尔茨海默病疾病和传染病，包括但不限于病毒，细菌和真菌引起的疾病。

5. 发明申请

US20080286275A1 Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication 有权
标题翻译：针对抑制Hcv复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US20080286275A1
公开(公告)日：2008-11-20
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12P21/00 , A61P31/12 , C12N5/00 , C07H21/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

6. 发明授权

US06265169B1 Method based on the use of bacteriophages for the detection biological molecules in biological samples 有权
标题翻译：基于使用噬菌体检测生物样品中生物分子的方法
公开(公告)号：US06265169B1
公开(公告)日：2001-07-24
申请号：US09424302
申请日：2000-02-17
申请人： Riccardo Cortese , Paolo Monaci
发明人： Riccardo Cortese , Paolo Monaci
IPC分类号： C12Q168
CPC分类号： C12Q1/682 , C12Q1/6804 , C12Q1/70 , G01N33/566
摘要： The present invention refers to a method that allows the use of filamentous bacteriophages to detect the presence of molecules of interest in biological samples. It consists of a series of combined operations, which are drawn up and defined according to the characteristics of the phages employed. These have, exposed on the surfaces of the capsid, at least one molecule, generally but not exclusively of proteic nature, capable of binding at least one molecule of interest present in the biological sample. Detection of the presence of the molecule takes place, according to the method of the invention, using the association between the molecule exposed on the surfaces of the phage and the genome of the phage itself. The ability to form specific complexes typical of the molecule exposed on the capsid enables formation of phage-molecule of interest complexes, which can be detected by means of amplification of known sequences in the phage DNA. The method according to the invention is extremely sensitive and can be used in particular for diagnostic and prognostic purposes.
摘要翻译：本发明涉及允许使用丝状噬菌体来检测生物样品中感兴趣的分子的存在的方法。它由一系列联合作业组成，根据所采用的噬菌体的特点制定和定义。这些具有暴露在衣壳表面上的至少一种能够结合存在于生物样品中的至少一个目标分子的分子，通常但不仅限于蛋白质性质。使用暴露在噬菌体表面上的分子与噬菌体本身的基因组之间的关联，根据本发明的方法发生分子存在的检测。形成在衣壳上暴露的分子典型的特异性复合物的能力能够形成感兴趣的噬菌体分子复合物，其可以通过噬菌体DNA中已知序列的扩增来检测。根据本发明的方法是非常敏感的，并且可以特别用于诊断和预后目的。

7. 发明授权

US09895431B1 Simian adenoviral vectors encoding malaria antigen 有权
公开(公告)号：US09895431B1
公开(公告)日：2018-02-20
申请号：US12595576
申请日：2008-04-10
申请人： Arturo Reyes , Adrian Hill , Geraldine O'Hara , Stefano Colloca , Riccardo Cortese
发明人： Arturo Reyes , Adrian Hill , Geraldine O'Hara , Stefano Colloca , Riccardo Cortese
IPC分类号： A61K39/00 , A61K39/015 , A61P35/00 , A61P33/06 , C12N15/861 , A61P37/04 , C12N15/86
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55561 , C07K14/445 , C07K14/78 , C07K16/205 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y02A50/412 , Y10S435/975
摘要： The invention provides recombinant adenoviral vectors which are capable of eliciting immunity against the pre-erythrocytic stage of the life cycle of the malaria parasite. In particular, the invention provides a recombinant, replication deficient simian adenoviral vector which encodes an antigen comprising the thrombospondin-related adhesion protein (TRAP), and also immunogenic compositions (e.g. vaccines) comprising the vector and methods of using such compositions.

8. 发明授权

US09718863B2 Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof 有权
公开(公告)号：US09718863B2
公开(公告)日：2017-08-01
申请号：US13147193
申请日：2010-02-06
申请人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
发明人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
IPC分类号： C07K14/005 , A61K39/12 , A61K39/235 , C12N7/00 , C12N15/861 , C12N15/86 , A61K39/00 , A61K48/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.

9. 发明申请

US20110129498A1 VACCINE FOR THE PREVENTION AND THERAPY OF HCV INFECTIONS 审中-公开
标题翻译：疫苗预防和治疗HCV感染
公开(公告)号：US20110129498A1
公开(公告)日：2011-06-02
申请号：US12995807
申请日：2009-06-03
申请人： Riccardo Cortese , Alfredo Nicosia
发明人： Riccardo Cortese , Alfredo Nicosia
IPC分类号： A61K39/29 , C07K14/18 , C07H21/00 , C12N15/63 , A61P31/14 , A61P37/04
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/5256 , A61K2039/53 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234
摘要： The present invention relates to CD81-binding peptides of the hepatitis virus C(HCV) E2 glycoprotein, which are devoid of or mutated within the amino-terminal 27 amino acids of the mature E2 envelope glycoprotein, or variant thereof which retains the ability to bind to CD81. Furthermore, the present invention provides polypeptides comprising said CD81-binding peptide, polynucleotides encoding the CD81-binding peptide, and expression cassettes and vectors comprising the polynucleotide of the invention. Moreover, the present invention relates to compositions comprising the CD81-binding peptide, the polynucleotide encoding the CD81-binding peptide, the expression cassette, or the vector, and an adjuvant. Furthermore, the present invention provides a pharmaceutical composition comprising the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, or the composition of the invention, and a pharmaceutically acceptable excipient, carrier, or diluent. Moreover, the present invention provides the CD81-binding peptide, the polynucleotide, the expression cassette, the vector, the composition, or the pharmaceutical composition of the invention for induction of an immune response, preferably a broad specificity immune response, against HCV in a mammal, and methods for inducing a therapeutic and/or prophylactic immune response against HCV in a mammal, preferably against HCV of various genotypes.
摘要翻译：本发明涉及在成熟E2包膜糖蛋白的氨基末端27个氨基酸中缺失或突变的肝炎病毒C（HCV）E2糖蛋白的CD81结合肽或其变体，其保持结合能力到CD81。此外，本发明提供了包含所述CD81结合肽，编码CD81结合肽的多核苷酸和包含本发明的多核苷酸的表达盒和载体的多肽。此外，本发明涉及包含CD81结合肽，编码CD81结合肽，表达盒或载体的多核苷酸和佐剂的组合物。此外，本发明提供了包含本发明的CD81结合肽，多核苷酸，表达盒，载体或组合物以及药学上可接受的赋形剂，载体或稀释剂的药物组合物。此外，本发明提供本发明的CD81结合肽，多核苷酸，表达盒，载体，组合物或药物组合物，用于诱导针对HCV的免疫应答，优选广泛的特异性免疫应答哺乳动物和用于在哺乳动物中诱导针对HCV的治疗和/或预防性免疫应答的方法，优选地针对各种基因型的HCV。

10. 发明授权

US07034108B1 Mimotopes of hypervariable region 1 of the E2 glycoprotein of HCV and uses thereof 失效
标题翻译： HCV的E2糖蛋白的高变区1的模拟表位及其用途
公开(公告)号：US07034108B1
公开(公告)日：2006-04-25
申请号：US09463098
申请日：1999-05-14
申请人： Alfredo Nicosia , Armin Lahm , Anna Tramontano , Riccardo Cortese
发明人： Alfredo Nicosia , Armin Lahm , Anna Tramontano , Riccardo Cortese
IPC分类号： C07K7/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Peptides which are mimotopes of the hypervariable region 1 (HVR1) of the putative envelope protein E2 of hepatitis C virus (HCV) are provided, useful in obtaining antibodies and raising an immune response cross-reactive against different strains of HCV.
摘要翻译：提供作为丙型肝炎病毒（HCV）的推定的包膜蛋白E2的高变区1（HVR1）的模拟表位的肽，其可用于获得抗体并提高对不同HCV株的交叉反应的免疫应答。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式