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1. 发明授权

US09895431B1 Simian adenoviral vectors encoding malaria antigen 有权
公开(公告)号：US09895431B1
公开(公告)日：2018-02-20
申请号：US12595576
申请日：2008-04-10
申请人： Arturo Reyes , Adrian Hill , Geraldine O'Hara , Stefano Colloca , Riccardo Cortese
发明人： Arturo Reyes , Adrian Hill , Geraldine O'Hara , Stefano Colloca , Riccardo Cortese
IPC分类号： A61K39/00 , A61K39/015 , A61P35/00 , A61P33/06 , C12N15/861 , A61P37/04 , C12N15/86
CPC分类号： A61K39/015 , A01K2227/105 , A01K2267/0337 , A61K39/39 , A61K2039/5256 , A61K2039/545 , A61K2039/55561 , C07K14/445 , C07K14/78 , C07K16/205 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , Y02A50/412 , Y10S435/975
摘要： The invention provides recombinant adenoviral vectors which are capable of eliciting immunity against the pre-erythrocytic stage of the life cycle of the malaria parasite. In particular, the invention provides a recombinant, replication deficient simian adenoviral vector which encodes an antigen comprising the thrombospondin-related adhesion protein (TRAP), and also immunogenic compositions (e.g. vaccines) comprising the vector and methods of using such compositions.

2. 发明授权

US09526777B2 Methods for the induction of ebola virus-specific immune responses comprising administering a replication-defective chimpanzee adenovirus vector expressing the ebola virus glycoprotein 有权
标题翻译：用于诱导埃博拉病毒特异性免疫应答的方法，包括给予表达埃博拉病毒糖蛋白的复制缺陷型黑猩猩腺病毒载体
公开(公告)号：US09526777B2
公开(公告)日：2016-12-27
申请号：US13641655
申请日：2011-04-15
申请人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
发明人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
IPC分类号： A61K39/295 , A61K39/12 , A61K39/00
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2760/14134
摘要： This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebola virus (EBOV) or Marburg virus (MARV).
摘要翻译：本发明提供用于诱导免疫应答的疫苗和针对用于人类预防性疫苗的禽流感病毒感染的保护。特别地，本发明提供了表达来自埃博拉病毒（EBOV）或马尔堡病毒（MARV）的不同菌株的病毒蛋白的黑猩猩腺病毒载体。

3. 发明授权

US07598362B2 Hepatitis C virus vaccine 有权
标题翻译：丙型肝炎病毒疫苗
公开(公告)号：US07598362B2
公开(公告)日：2009-10-06
申请号：US10492178
申请日：2002-10-10
申请人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
发明人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
IPC分类号： C07H21/04 , C12N7/00
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有非活性NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒或DNA质粒疫苗的组分，其提供用于产生针对HCV的HCV特异性细胞介导的免疫（CMI）应答的广泛范围的抗原。

4. 发明授权

US09718863B2 Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof 有权
公开(公告)号：US09718863B2
公开(公告)日：2017-08-01
申请号：US13147193
申请日：2010-02-06
申请人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
发明人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
IPC分类号： C07K14/005 , A61K39/12 , A61K39/235 , C12N7/00 , C12N15/861 , C12N15/86 , A61K39/00 , A61K48/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved seroprevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.

5. 发明授权

US08142794B2 Hepatitis C virus vaccine 有权
标题翻译：丙型肝炎病毒疫苗
公开(公告)号：US08142794B2
公开(公告)日：2012-03-27
申请号：US12396747
申请日：2009-03-03
申请人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
发明人： Emilio A. Emini , David C. Kaslow , Andrew J. Bett , John W. Shiver , Alfredo Nicosia , Armin Lahm , Alessandra Luzzago , Riccardo Cortese , Stefano Colloca
IPC分类号： C12N7/00 , C07H21/04
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有非活性NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒或DNA质粒疫苗的组分，其提供用于产生针对HCV的HCV特异性细胞介导的免疫（CMI）应答的广泛范围的抗原。

6. 发明申请

US20120027788A1 SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF 有权
标题翻译： SIMIAN ADENOVIRUS核酸和氨基酸序列，含有它们的载体及其用途
公开(公告)号：US20120027788A1
公开(公告)日：2012-02-02
申请号：US13147193
申请日：2010-02-06
申请人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
发明人： Stefano Colloca , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Maria Ambrosio
IPC分类号： A61K39/235 , C12N15/57 , C07K14/075 , C12N15/63 , A61P37/04 , A61K48/00 , C12N1/21 , C12N1/19 , C12N5/10 , A61P31/20 , C12N15/34 , C12N7/01
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/235 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2710/16634 , C12N2740/16134 , C12N2770/24234
摘要： The present invention relates to novel adenovirus strains with an improved sero-prevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.
摘要翻译：本发明涉及具有改善的血清流行性的新型腺病毒株。一方面，本发明涉及腺病毒衣壳蛋白如六邻体，五邻体和纤维蛋白及其片段的分离多肽和编码该多肽的多核苷酸。还提供了包含根据本发明的分离的多核苷酸和包含根据本发明的分离的多核苷酸或多肽的腺病毒的载体和包含所述载体，腺病毒，多肽和/或多核苷酸的药物组合物。本发明还涉及分离的多核苷酸，分离的多肽，载体，腺病毒和/或药物组合物用于治疗或预防疾病的用途。

7. 发明申请

US20130101618A1 CHIMPANZEE ADENOVIRAL VECTOR-BASED FILOVIRUS VACCINES 有权
标题翻译： CHIMPANZEE腺病毒载体的FILOVIRUS疫苗
公开(公告)号：US20130101618A1
公开(公告)日：2013-04-25
申请号：US13641655
申请日：2011-04-15
申请人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
发明人： Nancy J. Sullivan , Gary J. Nabel , Clement Asiedu , Cheng Cheng , Alfredo Nicosia , Riccardo Cortese , Virginia Ammendola , Stefano Colloca
IPC分类号： A61K39/12
CPC分类号： C12N15/86 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2760/14134
摘要： This invention provides vaccines for inducing an immune response and protection against filovirus infection for use as a preventative vaccine in humans. In particular, the invention provides chimpanzee adenoviral vectors expressing filovirus proteins from different strains of Ebolavirus (EBOV) or Marburg virus (MARV).
摘要翻译：本发明提供用于诱导免疫应答的疫苗和针对用于人类预防性疫苗的禽流感病毒感染的保护。特别地，本发明提供了表达来自不同的埃博病毒（EBOV）或马尔堡病毒（MARV）病毒的病毒蛋白的黑猩猩腺病毒载体。

8. 发明申请

US20130150563A1 LIPID-CONJUGATED ANTIBODIES 审中-公开
标题翻译： LIPID-CONJUGATED抗体
公开(公告)号：US20130150563A1
公开(公告)日：2013-06-13
申请号：US13808982
申请日：2011-07-08
申请人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
发明人： Antonello Pessi , Alfredo Nicosia , Riccardo Cortese
IPC分类号： C07K16/08
CPC分类号： C07K16/08 , A61K47/6851 , A61K51/1006 , A61K51/1027 , C07K16/1063 , C07K16/28 , C07K2317/77
摘要： The present invention relates to novel lipid-conjugated antibodies for use in the treatment or the prevention of diseases, including but not limited to cancer, metabolic diseases including but not limited to hyperglycemia and diabetes, obesity, hypertension, hypercholesterolemia, allergy, asthma, Alzheimer's disease, and infectious diseases including but not limited to diseases caused by viruses, bacteria and fungi.
摘要翻译：本发明涉及用于治疗或预防疾病（包括但不限于癌症），代谢疾病，包括但不限于高血糖症和糖尿病，肥胖症，高血压，高胆固醇血症，变态反应，哮喘，阿尔茨海默病疾病和传染病，包括但不限于病毒，细菌和真菌引起的疾病。

9. 发明申请

US20080286275A1 Antigen Binding Proteins Directed Against Scavenger Receptor B1 that Inhibit Hcv Replication 有权
标题翻译：针对抑制Hcv复制的清道夫受体B1的抗原结合蛋白
公开(公告)号：US20080286275A1
公开(公告)日：2008-11-20
申请号：US11631765
申请日：2005-07-01
申请人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
发明人： Riccardo Cortese , Alessandra Luzzago , Alfredo Nicosia , Alessandra Vitelli
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12P21/00 , A61P31/12 , C12N5/00 , C07H21/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

10. 发明授权

US06265169B1 Method based on the use of bacteriophages for the detection biological molecules in biological samples 有权
标题翻译：基于使用噬菌体检测生物样品中生物分子的方法
公开(公告)号：US06265169B1
公开(公告)日：2001-07-24
申请号：US09424302
申请日：2000-02-17
申请人： Riccardo Cortese , Paolo Monaci
发明人： Riccardo Cortese , Paolo Monaci
IPC分类号： C12Q168
CPC分类号： C12Q1/682 , C12Q1/6804 , C12Q1/70 , G01N33/566
摘要： The present invention refers to a method that allows the use of filamentous bacteriophages to detect the presence of molecules of interest in biological samples. It consists of a series of combined operations, which are drawn up and defined according to the characteristics of the phages employed. These have, exposed on the surfaces of the capsid, at least one molecule, generally but not exclusively of proteic nature, capable of binding at least one molecule of interest present in the biological sample. Detection of the presence of the molecule takes place, according to the method of the invention, using the association between the molecule exposed on the surfaces of the phage and the genome of the phage itself. The ability to form specific complexes typical of the molecule exposed on the capsid enables formation of phage-molecule of interest complexes, which can be detected by means of amplification of known sequences in the phage DNA. The method according to the invention is extremely sensitive and can be used in particular for diagnostic and prognostic purposes.
摘要翻译：本发明涉及允许使用丝状噬菌体来检测生物样品中感兴趣的分子的存在的方法。它由一系列联合作业组成，根据所采用的噬菌体的特点制定和定义。这些具有暴露在衣壳表面上的至少一种能够结合存在于生物样品中的至少一个目标分子的分子，通常但不仅限于蛋白质性质。使用暴露在噬菌体表面上的分子与噬菌体本身的基因组之间的关联，根据本发明的方法发生分子存在的检测。形成在衣壳上暴露的分子典型的特异性复合物的能力能够形成感兴趣的噬菌体分子复合物，其可以通过噬菌体DNA中已知序列的扩增来检测。根据本发明的方法是非常敏感的，并且可以特别用于诊断和预后目的。

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