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1. 发明授权

US5972019A Mechanical clot treatment device 失效
标题翻译：机械凝血治疗装置
公开(公告)号：US5972019A
公开(公告)日：1999-10-26
申请号：US869346
申请日：1997-06-05
申请人： Erik T. Engelson , Gene Samson , Kim Nguyen , Rose Y. Wong
发明人： Erik T. Engelson , Gene Samson , Kim Nguyen , Rose Y. Wong
IPC分类号： A61B17/00 , A61B17/22 , A61F2/82 , A61M25/00 , A61M25/04 , A61M25/10 , A61M29/00 , A61M29/02
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320725 , A61B17/32075 , A61B2017/22034 , A61B2017/2212 , A61F2/013 , A61M2025/1095 , A61M25/10 , A61M29/02
摘要： This is a medical device. In particular, it is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding cage assembly. The cage assembly is preferably radio-opaque. The proximal end of the cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment. The cage assembly may have a generally conical distal or "trailing" portion when expanded and also a proximal section. The cage assembly may be used for collecting emboli or for displacing them to allow blood flow to resume. The proximal section may have various uses, e.g., for centering the collector assembly in the vascular lumen or for gathering larger amounts of the targeted clot or to act as a passageway for fluid flow. The assembly further may have an actuator which permits or causes the collector assembly to expand after deployment.
摘要翻译：这是一种医疗器械。特别地，它是通常通过血管内导管递送的手术装置。它可以以几种方式使用。例如，它可以用于打开邻近血栓的清晰通道，以允许血液和药物绕过凝块。它可以用于刺穿和去除血栓。这些血栓通常在曲折的脉管系统中发现。该设备包括几个部分。该装置具有核心元件，通常为芯线。围绕芯元件的远端放置的是可折叠但优选自膨胀的笼组件。笼组件优选地是不透射线的。保持架的近端通常被固定到致动器上，以允许在展开之后使笼膨胀。当膨胀时，笼组件可以具有大致锥形的远侧或“后退”部分，并且还具有近端部分。笼组件可以用于收集栓塞或用于移位它们以允许血流恢复。近端部分可以具有各种用途，例如用于将收集器组件对准在血管腔中或用于收集更大量的目标凝块或用作流体流动的通道。组件还可具有致动器，该致动器允许或导致收集器组件在展开之后膨胀。

2. 发明授权

US5827201A Micro-braided guidewire 失效
标题翻译：微编导丝
公开(公告)号：US5827201A
公开(公告)日：1998-10-27
申请号：US686887
申请日：1996-07-26
申请人： Gene Samson , Kim Nguyen
发明人： Gene Samson , Kim Nguyen
IPC分类号： A61M25/01 , A61B5/00 , A61M20060101 , A61M25/00 , A61M25/09 , A61M25/16 , B21F17/00 , B21F99/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09091 , A61M2025/09141 , A61M2025/09175
摘要： This is a composite guidewire for use in a catheter. It is used in medical procedures that involve accessing specifically targeted inner body areas without major surgery. The composite guidewire is especially useful for accessing peripheral soft tissue targets. The guidewire may be a multi-section guidewire assembly preferably having super-elastic alloy ribbon braided reinforcements along at least a portion of the core. The guidewire core may be of a stainless steel or a high elasticity metal alloy, preferably a Ni--Ti alloy. A variation of the guidewire also preferably includes a braid on the exterior of the core wire with an exterior polymeric coating to the most distal portion of the assembly and preferably assembled using adhesives such as epoxies.
摘要翻译：这是用于导管的复合导丝。它用于医疗手术，涉及专门针对的内部身体区域而无需大手术。复合导丝对于接近外周软组织靶是特别有用的。导丝可以是多段导丝组件，优选地具有沿着芯的至少一部分的超弹性合金带编织加强件。导丝芯可以是不锈钢或高弹性金属合金，优选Ni-Ti合金。导丝的变体还优选地包括在芯线的外部上的编织物，其具有到组件的最远端部分的外部聚合物涂层，并且优选地使用诸如环氧树脂的粘合剂来组装。

3. 发明授权

US6143013A High performance braided catheter 失效
标题翻译：高性能编织导管
公开(公告)号：US6143013A
公开(公告)日：2000-11-07
申请号：US641259
申请日：1996-04-30
申请人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
发明人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
IPC分类号： A61M25/00 , A61M25/16 , A61M29/00
CPC分类号： A61M25/005 , A61M2025/0081 , A61M25/0053 , A61M25/0054
摘要： This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
摘要翻译：这是导管组件和导管组件的一部分。该导管组件可用于进入体内的组织靶，通常是通过血管系统可接近的靶。本发明的中心是使用位于导管主体内的编织金属加强构件，通常为超弹性合金带，以形成具有特别薄壁，受控刚度，高抗扭结性的导管，以及从扭结情况完全恢复体内。编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。由于在刚性部分中存在刚性聚合物管或金属管或合成材料，所以导管组件的近端部分通常比较远的部分更坚硬。

4. 发明授权

US06186978B1 Braid reinforced infusion catheter with inflatable membrane 失效
标题翻译：带充气膜的编织增强输液导管
公开(公告)号：US06186978B1
公开(公告)日：2001-02-13
申请号：US08903719
申请日：1997-07-31
申请人： Gene Samson , Hong Doan , Kim Nguyen
发明人： Gene Samson , Hong Doan , Kim Nguyen
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M25/005 , A61M25/1002 , A61M25/1011 , A61M2025/1052 , A61M2025/1054
摘要： This is a surgical device particularly a perfusion catheter having an inflatable membrane or balloon located at the distal end of the catheter shaft. The catheter shaft is comprised of an outer tubing assembly and an inner tubing assembly separated by an open annulus for inflating and deflating the inflatable membrane. The assembly may additionally comprise an inflatable membrane which is detachable. The outer tubing assembly is made up of at least one polymeric layer and a braid which may be polymeric or metallic, perhaps of a super-elastic alloy. At least a portion of the inner tubing assembly is made up of at least one polymeric layer and preferably a super-elastic metallic braid. The inner tubing assembly includes a lumen through which a guidewire may pass. It is further desirable that the inner tubing assembly include a coil member which generally is coextensive with the balloon along its axis. That lumen is preferably lined with a lubricious polymer. The outer tubing assembly allows the profile of the catheter to be minimized and yet provides significant kink-resistance to the inner tubing assembly. The structure of the inner tubing assembly provides resistance to premature inflation during introduction of infusate through the inner lumen.
摘要翻译：这是一种手术装置，特别是具有位于导管轴远端的可充气膜或囊的灌注导管。导管轴由外管组件和由开放环空间分开的内管组件组成，用于使可充气膜膨胀和放气。组件可以另外包括可拆卸的可充气膜。外管组件由至少一个聚合物层和编织物构成，其可以是聚合物或金属的，可能是超弹性合金。内管组件的至少一部分由至少一个聚合物层和优选的超弹性金属编织物构成。内管组件包括导丝可以通过的内腔。还期望内管组件包括通常与气囊沿其轴线共同延伸的线圈构件。该内腔优选内衬有润滑聚合物。外管组件允许导管的轮廓最小化，并且对内管组件提供显着的扭结阻力。内管组件的结构在通过内腔引入输液时提供抵抗过早充气的阻力。

5. 发明授权

US6090099A Multi-layer distal catheter section 失效
标题翻译：多层远端导管段
公开(公告)号：US6090099A
公开(公告)日：2000-07-18
申请号：US653602
申请日：1996-05-24
申请人： Gene Samson , Kim Nguyen
发明人： Gene Samson , Kim Nguyen
IPC分类号： A61B17/00 , A61M25/00
CPC分类号： A61M25/0045 , A61M25/005 , A61M25/0053
摘要： This is a distal-most section of a catheter suitable for treating a tissue target within the body, which target is accessible through the vascular system. Central to the invention is a multi-component or multi-layer catheter section used distally on an endovascular catheter. In particular, the inventive catheter section has at least one interior stiffener member and an exterior tubing member. Between the at least one interior stiffener member and the exterior tubing member is a metallic braid.
摘要翻译：这是适合于治疗身体内的组织靶的导管最远部分，该靶可通过血管系统进入。本发明的中心是在血管内导管上远端使用的多组分或多层导管部分。特别地，本发明的导管部分具有至少一个内部加强件和外部管件。在至少一个内部加强件和外部管件之间是金属编织物。

6. 发明授权

US06824553B1 High performance braided catheter 失效
标题翻译：高性能编织导管
公开(公告)号：US06824553B1
公开(公告)日：2004-11-30
申请号：US09648378
申请日：2000-08-25
申请人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
发明人： Gene Samson , Uriel Hiram Chee , Kim Nguyen , Edward J. Snyder , Erik T. Engelson
IPC分类号： A61M2900
CPC分类号： A61M25/005 , A61M25/0053 , A61M25/0054 , A61M2025/0081
摘要： This is a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of super-elastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composited materials in the stiffer section.
摘要翻译：这是导管组件和导管组件的一部分。该导管组件可用于进入体内的组织靶，通常是通过血管系统可接近的靶。本发明的中心是使用位于导管主体内的编织金属加强构件，通常为超弹性合金带，以形成具有特别薄壁，受控刚度，高抗扭结性的导管，以及从扭结情况完全恢复体内。编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。由于在刚性部分中存在刚性聚合物管或金属管或合成材料，所以导管组件的近端部分通常比较远的部分更坚硬。

7. 发明授权

US08267923B2 Detachable aneurysm neck bridge 失效
标题翻译：可拆卸动脉瘤颈桥
公开(公告)号：US08267923B2
公开(公告)日：2012-09-18
申请号：US12768659
申请日：2010-04-27
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61B17/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译：在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。编织或网状结构由弹性材料制成。

8. 发明授权

US07892248B2 Occlusive cinching devices and methods of use 有权
标题翻译：闭塞装置及使用方法
公开(公告)号：US07892248B2
公开(公告)日：2011-02-22
申请号：US11748221
申请日：2007-05-14
申请人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael P Wallace , Clifford Teoh
发明人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael P Wallace , Clifford Teoh
IPC分类号： A61B17/08
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063
摘要： Methods and devices for blocking orifices and occluding cavities within a patient are provided. The device in one variation comprises first and second tubular members attached to a collapsible sealing element. The device can be placed through an orifice and the collapsible sealing element can be collapsed to seal the orifice. An embolic may be introduced distal to the sealing element to occlude a cavity. The device may incorporate a locking mechanism which can be engaged to lock the sealing element into the collapsed position. The device may incorporate a valve to prevent flow through the tubular members, for example to prevent egress of the embolic from a cavity. The device can be detached to provide a permanent seal of the orifice, and can retain the embolic within the cavity. The device may be used in conjunction with a stent or other retention device to assist the sealing element in maintaining the seal.
摘要翻译：提供了用于阻断患者内的孔和闭塞腔的方法和装置。一个变型中的装置包括附接到可折叠密封元件的第一和第二管状构件。该装置可以通过孔口放置，并且可折叠密封元件可以折叠以密封孔口。可以在密封元件的远侧引入栓塞以封闭空腔。该装置可以包括可以接合以将密封元件锁定到折叠位置的锁定机构。该装置可以包括阀以防止流过管状构件，例如以防止栓塞从空腔排出。该装置可以被拆卸以提供孔口的永久性密封，并且可以将栓塞保持在空腔内。该装置可以与支架或其它保持装置结合使用以帮助密封元件保持密封。

9. 发明申请

US20100222804A1 DETACHABLE ANEURYSM NECK BRIDGE 失效
标题翻译：可拆卸的ANEURYSM NECK BRIDGE
公开(公告)号：US20100222804A1
公开(公告)日：2010-09-02
申请号：US12768659
申请日：2010-04-27
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译：在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。编织或网状结构由弹性材料制成。

10. 发明申请

US20070213764A1 Occlusive Cinching Devices and Methods of Use 有权
标题翻译：闭塞切割装置和使用方法
公开(公告)号：US20070213764A1
公开(公告)日：2007-09-13
申请号：US11748221
申请日：2007-05-14
申请人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael Wallace , Clifford Teoh
发明人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael Wallace , Clifford Teoh
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063
摘要： Methods and devices for blocking orifices and occluding cavities within a patient are provided. The device in one variation comprises first and second tubular members attached to a collapsible sealing element. The device can be placed through an orifice and the collapsible sealing element can be collapsed to seal the orifice. An embolic may be introduced distal to the sealing element to occlude a cavity. The device may incorporate a locking mechanism which can be engaged to lock the sealing element into the collapsed position. The device may incorporate a valve to prevent flow through the tubular members, for example to prevent egress of the embolic from a cavity. The device can be detached to provide a permanent seal of the orifice, and can retain the embolic within the cavity. The device may be used in conjunction with a stent or other retention device to assist the sealing element in maintaining the seal.
摘要翻译：提供了用于阻断患者内的孔和闭塞腔的方法和装置。一个变型中的装置包括附接到可折叠密封元件的第一和第二管状构件。该装置可以通过孔口放置，并且可折叠密封元件可以折叠以密封孔口。可以在密封元件的远侧引入栓塞以封闭空腔。该装置可以包括可以接合以将密封元件锁定到折叠位置的锁定机构。该装置可以包括阀以防止流过管状构件，例如以防止栓塞从空腔排出。该装置可以被拆卸以提供孔口的永久性密封，并且可以将栓塞保持在空腔内。该装置可以与支架或其它保持装置结合使用以帮助密封元件保持密封。

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