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1. 发明授权

US08731674B2 Method of stimulating fastigium nucleus to treat neurological disorders 有权
标题翻译：刺激ium核治疗神经系统疾病的方法
公开(公告)号：US08731674B2
公开(公告)日：2014-05-20
申请号：US13347434
申请日：2012-01-10
申请人： Michael P. Wallace , James C. Makous
发明人： Michael P. Wallace , James C. Makous
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/36103
摘要： A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient's head, locating the stimulation lead within the 4th ventricle of the patient's head, and placing the stimulation lead adjacent the fastigium nucleus of the patient's brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient's brain.
摘要翻译：治疗神经障碍的方法包括在患者头部内引入电刺激引线，将刺激引线置于患者头部的第四脑室内，并将刺激引线放置在患者大脑的快速核附近。该方法可以进一步包括用刺激引线刺激快镰核，以治疗神经障碍，例如通过增加患者脑内血液的流动。

2. 发明申请

US20140114315A1 TISSUE MODIFICATION DEVICES 审中-公开
标题翻译：组织修改设备
公开(公告)号：US20140114315A1
公开(公告)日：2014-04-24
申请号：US14061641
申请日：2013-10-23
申请人： Roy LEGUIDLEGUID , Robert Garabedian , Michael P. WALLACE
发明人： Roy LEGUIDLEGUID , Robert Garabedian , Michael P. WALLACE
IPC分类号： A61B17/16
CPC分类号： A61B17/1671 , A61B17/149 , A61B17/1659
摘要： Tissue modification devices, methods of using them, and devices, systems and methods of adapting them to form tissue modification devices.
摘要翻译：组织修饰装置，使用它们的方法，以及适应它们以形成组织修饰装置的装置，系统和方法。

3. 发明申请

US20120310270A1 DETACHABLE ANEURYSM NECK BRIDGE 有权
标题翻译：可拆卸的ANEURYSM NECK BRIDGE
公开(公告)号：US20120310270A1
公开(公告)日：2012-12-06
申请号：US13586280
申请日：2012-08-15
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.
摘要翻译：在一个实施例中，用于桥接动脉瘤颈部的颈桥包括连接区域，连接到接合区域的多个径向延伸的阵列元件以及附接到接合区域和阵列元件中的一个或两者的盖。阵列元件构造成在颈桥从输送装置部署之后定位在动脉瘤内。在第二实施例中，颈桥包括固定到接合区域的连接区域和编织或网状结构。编织或网状结构由弹性材料制成。

4. 发明申请

US20120191003A1 FLEXIBLE NEURAL LOCALIZATION DEVICES AND METHODS 审中-公开
标题翻译：灵活的神经定位设备和方法
公开(公告)号：US20120191003A1
公开(公告)日：2012-07-26
申请号：US13437214
申请日：2012-04-02
申请人： Robert Garabedian , Benjamin Kao-Shing Sun , Roy Leguidleguid , Michael P. Wallace
发明人： Robert Garabedian , Benjamin Kao-Shing Sun , Roy Leguidleguid , Michael P. Wallace
IPC分类号： A61B5/05
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/0488 , A61B5/1107 , A61B5/4519 , A61B5/4893 , A61B17/149 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/7092 , A61B17/8897 , A61B2017/32006 , A61B2562/0261 , A61B2562/046
摘要： Described herein are bimanually controlled neural localization devices capable of determining if a nerve is nearby a region of the device. In general, the device may include at least two electrodes including an anode in electrical communication with a anodal conductor and a cathode in electrical communication with a cathodal conductor. The device may further include a flexible elongate body, wherein the flexible elongate body has an axial length, a width and a thickness, wherein the axial length is greater than the width, and the width is greater than the thickness and is greater than a width of the at least two electrodes. The at least two electrodes may be disposed substantially in-line and centered along the length of the elongate body. In some embodiments, the device may further include a guidewire coupler at the distal end region of the elongate body.
摘要翻译：这里描述的是能够确定神经是否在装置的区域附近的双手控制的神经定位装置。通常，该装置可以包括至少两个电极，包括与阳极导体电连通的阳极和与阴极导体电连通的阴极。该装置还可以包括柔性细长主体，其中柔性细长主体具有轴向长度，宽度和厚度，其中轴向长度大于宽度，并且宽度大于厚度并且大于宽度的至少两个电极。所述至少两个电极可以沿着细长主体的长度基本上一直排列并居中。在一些实施例中，该装置还可包括在细长主体的远端区域处的导丝联接器。

5. 发明授权

US08206346B2 Targeted drug delivery device and method 有权
标题翻译：靶向药物输送装置及方法
公开(公告)号：US08206346B2
公开(公告)日：2012-06-26
申请号：US12838934
申请日：2010-07-19
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61M29/00
CPC分类号： A61M25/10 , A61M25/0141 , A61M25/0147 , A61M2025/0163 , A61M2025/105 , A61M2025/1086
摘要： A targeted drug delivery device is provided. The device comprises an elongated member with proximal and distal ends, a plurality of infusion ports associated with the distal end of the elongated member, and a selector mechanism for selectively placing an introducer port into fluid communication with at least one infusion port. A method for treating tissue is also provided. The method comprises introducing a medical device into the tissue, selecting a region of the tissue to treat, positioning the medical device in proximity to the region, and introducing a medicament through the device to treat only that region.
摘要翻译：提供了靶向药物递送装置。该装置包括具有近端和远端的细长构件，与细长构件的远端相关联的多个输注端口以及用于选择性地将引导器端口与至少一个输注端口流体连通的选择器机构。还提供了一种治疗组织的方法。该方法包括将医疗装置引入组织中，选择组织的区域以治疗，将医疗装置定位在该区域附近，以及通过该装置引入药物以仅治疗该区域。

6. 发明授权

US08172862B2 Polymer covered vaso-occlusive devices and methods of producing such devices 有权
标题翻译：聚合物覆盖的血管闭塞装置及其制造方法
公开(公告)号：US08172862B2
公开(公告)日：2012-05-08
申请号：US12723575
申请日：2010-03-12
申请人： Michael P. Wallace , Delilah Yin Hui
发明人： Michael P. Wallace , Delilah Yin Hui
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12154 , A61B2017/1205 , A61B2017/12063
摘要： This is a medical device for forming an embolism within the vasculature of a patient. More particularly, it concerns an occlusion device comprising an inner core covered with a polymer. The medical device encourages cellular attachment and growth while maintaining favorable handling, deployment and visualization characteristics.
摘要翻译：这是用于在患者的脉管系统内形成栓塞的医疗装置。更具体地说，它涉及包含被聚合物覆盖的内核的闭塞装置。医疗设备鼓励细胞附着和生长，同时保持良好的处理，部署和可视化特征。

7. 发明授权

US08128614B2 Modular steerable sheath catheters 有权
标题翻译：模块化导向鞘导管
公开(公告)号：US08128614B2
公开(公告)日：2012-03-06
申请号：US12353112
申请日：2009-01-13
申请人： Robert M. Abrams , Michael P. Wallace
发明人： Robert M. Abrams , Michael P. Wallace
IPC分类号： A61M25/01
CPC分类号： A61M25/0662 , A61M25/10 , A61M2025/0006 , A61M2025/0293 , A61M2025/0681 , A61M2025/09125 , A61M2025/1063
摘要： An apparatus for accessing a site within a body includes a cannula and an elongate member. The cannula has a proximal end, a distal end, and a lumen extending therebetween. The elongate member has a distal end configured for insertion into the lumen, wherein the distal end of the elongate member is attachable to and releasable from the distal end of the cannula. A method for accessing a site within a body includes inserting a distal end of an elongate member into a lumen of a cannula, detachably attaching the distal end of the elongate member to the cannula, and steering a distal end of the cannula to a desired site using the elongate member.
摘要翻译：用于进入体内部位的装置包括套管和细长构件。套管具有近端，远端和在其间延伸的内腔。细长构件具有构造成用于插入内腔的远端，其中细长构件的远端可附接到插管的远端并且可从插管的远端释放。用于访问体内部位的方法包括将细长构件的远端插入套管的内腔，将细长构件的远端可拆卸地连接到套管上，并将套管的远端转向所需位置使用细长构件。

8. 发明授权

US08060207B2 Method of intravascularly delivering stimulation leads into direct contact with tissue 失效
标题翻译：血管内传递刺激的方法导致与组织直接接触
公开(公告)号：US08060207B2
公开(公告)日：2011-11-15
申请号：US10744853
申请日：2003-12-22
申请人： Michael P. Wallace , Kamal Ramzipoor , Robert J. Garabedian , Robert M. Abrams
发明人： Michael P. Wallace , Kamal Ramzipoor , Robert J. Garabedian , Robert M. Abrams
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a disorder in a patient is provided. The method comprises delivering a stimulation lead within a blood vessel, intralumenally puncturing a wall of the blood vessel to create an exit point, and then introducing the stimulation lead through the exit point into direct contact with tissue the stimulation of which treats the disorder. Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead to the implanted stimulation source. Using the stimulation lead, the tissue can then be stimulated in order to treat the disorder.
摘要翻译：提供了一种治疗患者疾病的方法。该方法包括在血管内递送刺激引线，腔内穿刺血管的壁以产生出口点，然后将刺激引线通过出口点直接接触组织，其刺激治疗病症。可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电耦合到植入的刺激源。使用刺激铅，然后可以刺激组织以治疗该疾病。

9. 发明申请

US20110237982A1 Ultrasound-enhanced stenosis therapy 审中-公开
标题翻译：超声增强狭窄治疗
公开(公告)号：US20110237982A1
公开(公告)日：2011-09-29
申请号：US13134470
申请日：2011-06-08
申请人： Michael P. Wallace
发明人： Michael P. Wallace
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/2202 , A61B2017/22014 , A61B2017/22082 , A61B2017/22088 , A61B2018/00029
摘要： Apparatus and methods are disclosed for vein and arterial-venous fistulas stenosis and occlusion therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the vessel wall. Ultrasound energy may be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices. In some other embodiments, a therapeutic agent may be removed from the body after exposure to the vessel wall to minimize a systemic effect of the therapeutic drug.
摘要翻译：公开了用于静脉和动脉 - 静脉瘘狭窄和闭塞治疗的装置和方法，包括使用超声能量增强血管壁的渗透性并将治疗剂递送到血管壁中。超声能量可以使用经皮技术和血管内方法在小于10MHz的频率和功率小于20瓦的情况下递送。治疗剂可通过静脉内和血管内途径递送至治疗区域。在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合。在一些其它实施方案中，治疗剂可以在暴露于血管壁之后从体内除去，以使治疗药物的全身效应最小化。

10. 发明授权

US08019441B2 Collapsible/expandable tubular electrode leads 有权
标题翻译：可折叠/可扩展管状电极引线
公开(公告)号：US08019441B2
公开(公告)日：2011-09-13
申请号：US11459618
申请日：2006-07-24
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/05
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force. In one preferred method, the stimulation lead is used to stimulate tissue, such as spinal cord tissue.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。在一种优选的方法中，刺激引线用于刺激组织，例如脊髓组织。

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