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1. 发明申请

US20110143127A1 METHODS FOR COATING IMPLANTS 审中-公开
标题翻译：涂层的方法
公开(公告)号：US20110143127A1
公开(公告)日：2011-06-16
申请号：US12636379
申请日：2009-12-11
申请人： Gautam Gupta , Mukesh Kumar , Robert M. Ronk
发明人： Gautam Gupta , Mukesh Kumar , Robert M. Ronk
IPC分类号： B32B15/04 , C23C28/00 , B05D1/08 , C23C4/08 , C23C16/00
CPC分类号： A61L27/32 , A61L27/30 , A61L27/306 , A61L27/3604 , A61L27/365 , A61L27/54 , A61L2420/02 , A61L2420/08 , Y10T428/265
摘要： An implant and method for applying an osteoconductive coating on a non-conductive surface of an implant. The method includes depositing an electroconductive interlayer on at least a portion of a non-conductive implant surface. A secondary process is applied to the interlayer and an osteoconductive coating is thereby formed on the implant. In various embodiments, the electroconductive interlayer is deposited as a non-structural film and comprises a dense, non-porous metal such as titanium, titanium alloys, cobalt, cobalt alloys, chromium, chromium alloys, tantalum, tantalum alloys, iron alloys, stainless steel, and mixtures thereof. The osteoconductive coating may include a metal, a porous metal, or calcium phosphate. The osteoconductive coating may include additional agents, such as bone product, growth factor, bioactive agent, antibiotic, or combinations thereof.
摘要翻译：用于在植入物的非导电表面上施加骨传导性涂层的植入物和方法。该方法包括在非导电植入物表面的至少一部分上沉积导电中间层。将二次方法应用于中间层，由此在植入物上形成骨传导性涂层。在各种实施方案中，导电中间层作为非结构膜沉积并且包含致密的非多孔金属如钛，钛合金，钴，钴合金，铬，铬合金，钽，钽合金，铁合金，不锈钢钢及其混合物。骨传导性涂层可以包括金属，多孔金属或磷酸钙。骨传导性涂层可以包括另外的试剂，例如骨产品，生长因子，生物活性剂，抗生素或其组合。

2. 发明申请

US20140025181A1 METALLIC STRUCTURES HAVING POROUS REGIONS FROM IMAGED BONE AT PRE-DEFINED ANATOMIC LOCATIONS 有权
标题翻译：在预先确定的解剖位置的成像骨中有多个区域的金属结构
公开(公告)号：US20140025181A1
公开(公告)日：2014-01-23
申请号：US13554484
申请日：2012-07-20
申请人： Tom Vanasse , Gautam Gupta , Jason Meridew
发明人： Tom Vanasse , Gautam Gupta , Jason Meridew
IPC分类号： A61F2/28 , B23K9/04 , B23K26/00 , B23P17/04 , B23K15/00
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/30767 , A61F2/4003 , A61F2002/30011 , A61F2002/3092 , A61F2002/30943 , A61F2002/30948 , A61F2002/30962 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/30985 , B33Y50/00 , B33Y80/00 , Y10T29/49
摘要： A method of forming an implant having a porous region replicated from scanned bone, the method comprising imaging bone with a high resolution digital scanner to generate a three-dimensional design model of the bone; removing a three-dimensional section from the design model; fabricating a porous region on a digital representation of the implant by replacing a solid portion of the digital implant with the section removed from the digital representation; and using an additive manufacturing technique to create a physical implant including the fabricated porous region.
摘要翻译：一种形成具有从扫描骨复制的多孔区域的植入物的方法，所述方法包括用高分辨率数字扫描仪对骨骼进行成像以产生骨的三维设计模型; 从设计模型中删除三维部分; 通过用数字表示去除的部分替换数字植入物的固体部分来在植入物的数字表示上制造多孔区域; 以及使用添加剂制造技术来制造包括所制造的多孔区域的物理植入物。

3. 发明授权

US08529740B2 Electrochemical apparatus comprising modified disposable rectangular cuvette 有权
标题翻译：电化学装置，包括改进的一次性长方形比色皿
公开(公告)号：US08529740B2
公开(公告)日：2013-09-10
申请号：US12916085
申请日：2010-10-29
申请人： Andrew M Dattelbaum , Gautam Gupta , David E Morris
发明人： Andrew M Dattelbaum , Gautam Gupta , David E Morris
IPC分类号： G01N27/403
CPC分类号： G01N27/27
摘要： Electrochemical apparatus includes a disposable rectangular cuvette modified with at least one hole through a side and/or the bottom. Apparatus may include more than one cuvette, which in practice is a disposable rectangular glass or plastic cuvette modified by drilling the hole(s) through. The apparatus include two plates and some means of fastening one plate to the other. The apparatus may be interfaced with a fiber optic or microscope objective, and a spectrometer for spectroscopic studies. The apparatus are suitable for a variety of electrochemical experiments, including surface electrochemistry, bulk electrolysis, and flow cell experiments.
摘要翻译：电化学装置包括经由侧面和/或底部至少一个孔改性的一次性矩形试管。设备可以包括多于一个的比色皿，其实际上是通过钻孔来改造的一次性矩形玻璃或塑料比色皿。该装置包括两个板和一个将一个板固定到另一个板的装置。该装置可以与光纤或显微镜物镜和用于光谱研究的光谱仪接口。该设备适用于各种电化学实验，包括表面电化学，体积电解和流动池实验。

4. 发明授权

US08388887B2 Methods for making textured ceramic implants 有权
标题翻译：制作纹理陶瓷植入物的方法
公开(公告)号：US08388887B2
公开(公告)日：2013-03-05
申请号：US12758503
申请日：2010-04-12
申请人： Gautam Gupta , Daniel Norton , Derek King
发明人： Gautam Gupta , Daniel Norton , Derek King
IPC分类号： B28B3/10
CPC分类号： A61L27/10 , A61F2/30767 , A61F2/30771 , A61F2/34 , A61F2002/30968 , A61F2002/3446 , A61F2310/00179 , A61F2310/00592 , A61L27/306 , A61L2400/18 , C04B41/009 , C04B41/5025 , C04B41/87 , C04B2111/00836 , C04B35/00 , C04B35/10 , C04B35/48 , C04B35/46 , C04B35/565 , C04B35/581 , C04B41/4521 , C04B41/4545 , C04B41/4578
摘要： A ceramic implant having a rough surface texture and a method for forming the same. The method includes forming a green body of a first ceramic composition. The green body is reduced to smaller pieces thereby forming ceramic fragments. A mold is filled with a second ceramic composition to form a ceramic base. Ceramic fragments are added to the mold and an outer layer is formed over at least a portion of the ceramic base. Pressure is applied to the mold to compress the outer layer onto the ceramic base and to form a green assembly. The green assembly is sintered to form a ceramic implant having a rough surface texture.
摘要翻译：具有粗糙表面纹理的陶瓷植入物及其形成方法。该方法包括形成第一陶瓷组合物的生坯。生坯被还原成较小的碎片，从而形成陶瓷碎片。模具填充有第二陶瓷组合物以形成陶瓷基底。将陶瓷碎片加入到模具中，并且在至少一部分陶瓷基底上形成外层。将压力施加到模具以将外层压缩到陶瓷基底上并形成绿色组件。将绿色组件烧结以形成具有粗糙表面纹理的陶瓷植入物。

5. 发明授权

US08843229B2 Metallic structures having porous regions from imaged bone at pre-defined anatomic locations 有权
标题翻译：金属结构在预先定义的解剖位置处具有来自成像骨的多孔区域
公开(公告)号：US08843229B2
公开(公告)日：2014-09-23
申请号：US13554484
申请日：2012-07-20
申请人： Tom Vanasse , Gautam Gupta , Jason Meridew
发明人： Tom Vanasse , Gautam Gupta , Jason Meridew
IPC分类号： G06F19/00
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/30767 , A61F2/4003 , A61F2002/30011 , A61F2002/3092 , A61F2002/30943 , A61F2002/30948 , A61F2002/30962 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/30985 , B33Y50/00 , B33Y80/00 , Y10T29/49
摘要： A method of forming an implant having a porous region replicated from scanned bone, the method comprising imaging bone with a high resolution digital scanner to generate a three-dimensional design model of the bone; removing a three-dimensional section from the design model; fabricating a porous region on a digital representation of the implant by replacing a solid portion of the digital implant with the section removed from the digital representation; and using an additive manufacturing technique to create a physical implant including the fabricated porous region.
摘要翻译：一种形成具有从扫描骨复制的多孔区域的植入物的方法，所述方法包括用高分辨率数字扫描仪对骨骼进行成像以产生骨的三维设计模型; 从设计模型中删除三维部分; 通过用数字表示去除的部分替换数字植入物的固体部分来在植入物的数字表示上制造多孔区域; 以及使用添加剂制造技术来制造包括所制造的多孔区域的物理植入物。

6. 发明授权

US08383033B2 Method of bonding porous metal to metal substrates 有权
公开(公告)号：US08383033B2
公开(公告)日：2013-02-26
申请号：US12575998
申请日：2009-10-08
申请人： Gautam Gupta
发明人： Gautam Gupta
IPC分类号： B22F7/04
CPC分类号： B22F7/004 , A61F2/30767 , A61F2/3094 , A61F2/34 , A61F2002/30769 , A61F2002/3092 , A61F2002/30929 , A61F2002/30967 , A61F2002/30968 , A61L27/04 , A61L27/56 , B22F3/1134 , Y10T428/12042 , Y10T428/12076
摘要： A method for preparing an implant having a porous metal component. A loose powder mixture including a biocompatible metal powder and a spacing agent is prepared and compressed onto a metal base. After being compressed, the spacing agent is removed, thereby forming a compact including a porous metal structure pressed on the metal base. The compact is sintered, forming a subassembly, which is aligned with a metal substrate portion of an implant. A metallurgical bonding process, such as diffusion bonding, is performed at the interface of the subassembly and the metal substrate to form an implant having a porous metal component.

7. 发明申请

US20120068071A1 FLUORESCENT SINGLE WALLED NANOTUBE/SILICA COMPOSITE MATERIALS 有权
标题翻译：荧光单壁碳纳米管/二氧化硅复合材料
公开(公告)号：US20120068071A1
公开(公告)日：2012-03-22
申请号：US12888260
申请日：2010-09-22
申请人： Andrew M. Dattelbaum , Gautam Gupta , Juan G. Duque , Stephen K. Doorn , Christopher E. Hamilton , Kimberly A. DeFriend Obrey
发明人： Andrew M. Dattelbaum , Gautam Gupta , Juan G. Duque , Stephen K. Doorn , Christopher E. Hamilton , Kimberly A. DeFriend Obrey
IPC分类号： G01J5/02 , C09K11/65 , B82Y40/00 , B82Y20/00 , B82Y15/00
CPC分类号： C09K11/02 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B33/163 , C09K11/65
摘要： Fluorescent composites of surfactant-wrapped single-walled carbon nanotubes (SWNTs) were prepared by exposing suspensions of surfactant-wrapped carbon nanotubes to tetramethylorthosilicate (TMOS) vapor. Sodium deoxycholate (DOC) and sodium dodecylsulphate (SDS) were the surfactants. No loss in emission intensity was observed when the suspension of DOC-wrapped SWNTs were exposed to the TMOS vapors, but about a 50% decrease in the emission signal was observed from the SUS-wrapped SWNTs nanotubes. The decrease in emission was minimal by buffering the SDS/SWNT suspension prior to forming the composite. Fluorescent xerogels were prepared by adding glycerol to the SWNT suspensions prior to TMOS vapor exposure, followed by drying the gels. Fluorescent aerogels were prepared by replacing water in the gels with methanol and then exposing them to supercritical fluid drying conditions. The aerogels can be used for gas sensing.
摘要翻译：通过将表面活性剂包裹的碳纳米管的悬浮液暴露于原硅酸四甲酯（TMOS）蒸气来制备表面活性剂包裹的单壁碳纳米管（SWNT）的荧光复合材料。脱氧胆酸钠（DOC）和十二烷基硫酸钠（SDS）是表面活性剂。当DOC包裹的SWNT的悬浮液暴露于TMOS蒸气时，没有观察到发射强度的损失，但是从SUS缠绕的SWNT纳米管观察到约50％的发射信号降低。通过在形成复合材料之前缓冲SDS / SWNT悬浮液，发射的减少是最小的。通过在TMOS蒸气暴露之前将甘油加入到SWNT悬浮液中，然后干燥凝胶来制备荧光干凝胶。通过用甲醇代替凝胶中的水，然后将它们暴露于超临界流体干燥条件来制备荧光气凝胶。气凝胶可用于气体检测。

8. 发明授权

US08114464B2 Hybrid thin films that incorporate lamellar phospholipid layer assemblies and transmembrane proteins 有权
标题翻译：混合薄膜，其中包含层状磷脂层组件和跨膜蛋白
公开(公告)号：US08114464B2
公开(公告)日：2012-02-14
申请号：US11690922
申请日：2007-03-26
申请人： Gabriel Lopez , Plamen Atanasov , Gautam Gupta
发明人： Gabriel Lopez , Plamen Atanasov , Gautam Gupta
IPC分类号： A61K9/127
CPC分类号： A61K9/1274 , Y10T428/24997 , Y10T428/249978 , Y10T428/249987 , Y10T428/31663 , Y10T428/31678
摘要： The present disclosure provides various novel methods for forming hybrid thin films that contain multi-lamellar assemblies of phospholipid bilayers and can incorporate proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such bilayer lipid membranes including, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.
摘要翻译：本公开提供了用于形成含有磷脂双层的多层组件并可掺入蛋白质，多肽，生物复合物，跨膜蛋白和其它膜相关化合物的杂化薄膜的各种新颖方法。本公开进一步提供了这种双层脂质膜的用途，包括用于医疗诊断和环境监测的生物传感，化学和生物战剂螯合，致动器开发和生物燃料电池开发。

9. 发明授权

US08395123B2 Fluorescent single walled nanotube/silica composite materials 有权
标题翻译：荧光单壁纳米管/二氧化硅复合材料
公开(公告)号：US08395123B2
公开(公告)日：2013-03-12
申请号：US12888260
申请日：2010-09-22
申请人： Andrew M. Dattelbaum , Gautam Gupta , Juan G. Duque , Stephen K. Doorn , Christopher E. Hamilton , Kimberly A. DeFriend Obrey
发明人： Andrew M. Dattelbaum , Gautam Gupta , Juan G. Duque , Stephen K. Doorn , Christopher E. Hamilton , Kimberly A. DeFriend Obrey
IPC分类号： G01J5/02
CPC分类号： C09K11/02 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/174 , C01B33/163 , C09K11/65
摘要： Fluorescent composites of surfactant-wrapped single-walled carbon nanotubes (SWNTs) were prepared by exposing suspensions of surfactant-wrapped carbon nanotubes to tetramethylorthosilicate (TMOS) vapor. Sodium deoxycholate (DOC) and sodium dodecylsulphate (SDS) were the surfactants. No loss in emission intensity was observed when the suspension of DOC-wrapped SWNTs were exposed to the TMOS vapors, but about a 50% decrease in the emission signal was observed from the SDS-wrapped SWNTs nanotubes. The decrease in emission was minimal by buffering the SDS/SWNT suspension prior to forming the composite. Fluorescent xerogels were prepared by adding glycerol to the SWNT suspensions prior to TMOS vapor exposure, followed by drying the gels. Fluorescent aerogels were prepared by replacing water in the gels with methanol and then exposing them to supercritical fluid drying conditions. The aerogels can be used for gas sensing.
摘要翻译：通过将表面活性剂包裹的碳纳米管的悬浮液暴露于原硅酸四甲酯（TMOS）蒸气来制备表面活性剂包裹的单壁碳纳米管（SWNT）的荧光复合材料。脱氧胆酸钠（DOC）和十二烷基硫酸钠（SDS）是表面活性剂。当DOC包裹的SWNT的悬浮液暴露于TMOS蒸气时，没有观察到发射强度的损失，但是从SDS-包裹的SWNT纳米管观察到约50％的发射信号减少。通过在形成复合材料之前缓冲SDS / SWNT悬浮液，发射的减少是最小的。通过在TMOS蒸气暴露之前将甘油加入到SWNT悬浮液中，然后干燥凝胶来制备荧光干凝胶。通过用甲醇代替凝胶中的水，然后将它们暴露于超临界流体干燥条件来制备荧光气凝胶。气凝胶可用于气体检测。

10. 发明申请

US20120058327A1 Robust Hybrid Thin Films that Incorporate Lamellar Phospholipid Bilayer Assemblies and Transmembrane Proteins 审中-公开
标题翻译：结合层状磷脂双层组件和跨膜蛋白的稳健杂交薄膜
公开(公告)号：US20120058327A1
公开(公告)日：2012-03-08
申请号：US13232647
申请日：2011-09-14
申请人： Gabriel P. Lopez , Plamen Atanasov , Gautam Gupta
发明人： Gabriel P. Lopez , Plamen Atanasov , Gautam Gupta
IPC分类号： B32B9/04 , C08L83/08 , C08L43/04 , C08L83/06 , C08L83/02 , C08L29/04 , C08L39/06 , C08L71/02 , C08L33/02 , C08L25/18 , C08L33/26 , C08L47/00 , C08L33/14 , C09K3/00 , B32B5/18 , C08L89/00
CPC分类号： A61K9/1274 , Y10T428/24997 , Y10T428/249978 , Y10T428/249987 , Y10T428/31663 , Y10T428/31678
摘要： The present disclosure provides various novel methods for forming hybrid thin films that contain multi-lamellar assemblies of phospholipid bilayers and can incorporate proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such bilayer lipid membranes including, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.
摘要翻译：本公开提供了用于形成含有磷脂双层的多层组件并可掺入蛋白质，多肽，生物复合物，跨膜蛋白和其它膜相关化合物的杂化薄膜的各种新颖方法。本公开进一步提供了这种双层脂质膜的用途，包括用于医疗诊断和环境监测的生物传感，化学和生物战剂螯合，致动器开发和生物燃料电池开发。

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