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1. 发明申请

US20070065913A1 ISOLATION OF BINDING PROTEINS WITH HIGH AFFINITY TO LIGANDS 有权
标题翻译：分离具有高亲和力的结合蛋白
公开(公告)号：US20070065913A1
公开(公告)日：2007-03-22
申请号：US11461757
申请日：2006-08-01
申请人： Gang Chen , Andrew Hayhurst , Jeffrey Thomas , Brent Iverson , George Georgiou
发明人： Gang Chen , Andrew Hayhurst , Jeffrey Thomas , Brent Iverson , George Georgiou
IPC分类号： C12P21/06 , C07H21/04 , C12N9/00 , C12N1/21 , C07K14/195 , C12N15/74
CPC分类号： C12N15/1034
摘要： The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via “display-less” library screening. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in soluble form in the periplasmic space of gram negative bacteria, such as Escherichia coli, and are mixed with a labeled ligand. In clones expressing recombinant polypeptides with affinity for the ligand, the concentration of the labeled ligand bound to the binding protein is increased and allows the cells to be isolated from the rest of the library. Where fluorescent labeling of the target ligand is used, cells may be isolated by fluorescence activated cell sorting (FACS). The approach is more rapid than prior art methods and avoids problems associated with the surface-expression of ligand fusion proteins employed with phage display.
摘要翻译：本发明通过提供通过“无显示”文库筛选分离能够结合小分子和肽的结合蛋白的快速方法来克服现有技术的缺陷。在该技术中，候选结合蛋白（例如抗体序列）的文库以可溶形式表达在革兰氏阴性细菌如大肠杆菌的周质空间中，并与标记的配体混合。在表达对配体具有亲和性的重组多肽的克隆中，与结合蛋白结合的标记配体的浓度增加，并允许细胞与文库的其余部分分离。当使用靶配体的荧光标记时，可以通过荧光激活细胞分选（FACS）分离细胞。该方法比现有技术方法更快速，并避免与噬菌体展示所用配体融合蛋白的表面表达相关的问题。

2. 发明申请

US20060289495A1 Induction heating system having multiple temperature input control 有权
标题翻译：感应加热系统具有多个温度输入控制
公开(公告)号：US20060289495A1
公开(公告)日：2006-12-28
申请号：US11145285
申请日：2005-06-03
申请人： Jeffrey Thomas , Randall Baxter , Paul Verhagen , Edward Beistle
发明人： Jeffrey Thomas , Randall Baxter , Paul Verhagen , Edward Beistle
IPC分类号： H05B6/42
CPC分类号： H05B6/101 , H05B6/06 , H05B6/40
摘要： A system and method for inductively heating a work piece. The induction heating system is coupleable to a plurality of temperature feedback devices operable to provide a signal representative of work piece temperature. The induction heating system is operable to control the output of the induction heating system based on the plurality of signals representative of work piece temperature received from the plurality of temperature feedback devices.
摘要翻译：一种用于感应加热工件的系统和方法。感应加热系统可耦合到可操作以提供表示工件温度的信号的多个温度反馈装置。感应加热系统可操作以基于代表从多个温度反馈装置接收的工件温度的多个信号来控制感应加热系统的输出。

3. 发明申请

US20120298323A1 Use of Liquid Metal Filters in Forming Matrix Drill Bits 失效
标题翻译：液态金属过滤器在成型矩阵钻头中的应用
公开(公告)号：US20120298323A1
公开(公告)日：2012-11-29
申请号：US13300951
申请日：2011-11-21
申请人： Jeffrey Thomas , Clayton Ownby , Ron Joy , Gary Weaver , Seth Anderle
发明人： Jeffrey Thomas , Clayton Ownby , Ron Joy , Gary Weaver , Seth Anderle
IPC分类号： B22D25/00 , B22D19/14
CPC分类号： B23B51/00 , B22D19/06 , B22F3/004 , B22F3/26 , B22F5/007 , C22C29/08
摘要： Of the many embodiments provided, one embodiment is a drill bit mold assembly comprising: a mold having a bottom and at least one side; a core centrally disposed within the mold; and a filter disposed above the bottom of the mold and within a space formed between the at least one side of the mold and the core.
摘要翻译：在所提供的许多实施例中，一个实施例是钻头模具组件，其包括：具有底部和至少一个侧面的模具; 集中设置在模具内的芯体; 以及设置在模具的底部之上并且在形成在模具的至少一侧和芯之间的空间内的过滤器。

4. 发明申请

US20060090968A1 Brake assembly with brake pad position and wear sensor 审中-公开
标题翻译：制动总成与刹车片位置和磨损传感器
公开(公告)号：US20060090968A1
公开(公告)日：2006-05-04
申请号：US10978737
申请日：2004-11-01
申请人： Martin Taylor , Jeffrey Thomas , Royston Morris , Lester Clarke , Mark Norman
发明人： Martin Taylor , Jeffrey Thomas , Royston Morris , Lester Clarke , Mark Norman
IPC分类号： F16D66/00
CPC分类号： F16D55/2255 , F16D65/183 , F16D66/02 , F16D2065/386 , F16D2121/14
摘要： A brake assembly includes a sensor mounted to a brake component, and which is in communication with a transceiver. The sensor provides position information of the brake component, which is combined with known mechanical relationships between various brake components, to determine a wear state of a brake pad and a clearance between the brake pad and a rotor. The clearance is then adjusted based on signals from the sensor and the known mechanical relationship between the various brake components to maintain the clearance within desired limits.
摘要翻译：制动组件包括安装到制动部件并且与收发器通信的传感器。传感器提供制动部件的位置信息，其与各种制动部件之间的已知机械关系结合，以确定制动衬块的磨损状态和制动衬块与转子之间的间隙。然后基于来自传感器的信号和各种制动部件之间的已知机械关系来调节间隙，以将间隙保持在期望的限度内。

5. 发明授权

US08366551B2 Single player fantasy sports game 有权
标题翻译：单人幻想运动游戏
公开(公告)号：US08366551B2
公开(公告)日：2013-02-05
申请号：US12435695
申请日：2009-05-05
申请人： Jeffrey Thomas
发明人： Jeffrey Thomas
IPC分类号： A63F9/24
CPC分类号： A63F13/60 , A63F13/46 , A63F13/75 , A63F13/795 , A63F2300/69 , A63F2300/8052
摘要： A single user fantasy game, including a database of VFGMs, each having strategies and player rankings supplied by or for certain human remote GMs, together with a database of real-world athlete/participants. A draft is launched, with the user and at least selected VFGMs as participants. In that draft, the user and the VFGMs make selections of athlete/participants according to predetermined draft rules. Those selections made by the user and by the VFGMs are then saved as respective teams in a team database. Once the teams are selected, the performance of the teams is determined, using a database of real-world performances/statistics, for the athlete/participants in the database of athlete/participants, from a particular time period and according to a set of fantasy game scoring rules. A winner is determined from among the user and the VFGMs, based on the performance of the teams for the particular time period.
摘要翻译：一个单一的用户幻想游戏，包括VFGM数据库，每个都有一些人类远程GM提供的策略和玩家排名，以及真实世界运动员/参与者的数据库。启动了一个草案，用户和至少选定的VFGM作为参与者。在该草案中，用户和VFGM根据预定的草案规则选择运动员/参与者。用户和VFGM进行的选择随后作为相应的团队保存在团队数据库中。一旦选定了队伍，就可以使用现场表演/统计数据库，从运动员/参与者的数据库中的运动员/参与者的特定时间段以及一组幻想来确定队伍的表现游戏得分规则。取决于用户和VFGM之间的获胜者，这取决于特定时间段内队伍的表现。

6. 发明申请

US20060246972A1 Systems and methods for simulating a particular user in an interactive computer system 有权
公开(公告)号：US20060246972A1
公开(公告)日：2006-11-02
申请号：US11105734
申请日：2005-04-13
申请人： Jeffrey Thomas , Abraham Navarro , Gordon Read , David Zdyrko
发明人： Jeffrey Thomas , Abraham Navarro , Gordon Read , David Zdyrko
IPC分类号： A63F13/00
CPC分类号： A63F13/67 , A63F13/00 , A63F13/10 , A63F13/33 , A63F13/79 , A63F13/803 , A63F13/812 , A63F2300/208 , A63F2300/6009 , A63F2300/8011
摘要： The field of the invention relates to interactive computer systems and more particularly to systems and methods for simulating a particular user's behavior in an interactive computer system. In one embodiment, a computer program product includes a simulator configured to simulate a user interacting with a computer program. The simulator includes a learning mode of operation and a simulation mode of operation. During the learning mode, the simulator is configured to monitor the user's interaction with the computer program for one or more events and analyze one or more current circumstances during the occurrence of the one or more events. The simulator is further configured to record one or more user inputs in response to the occurrence of the one or more events, store the one or more user inputs in one or more data fields, and associate the one or more data fields with the one or more events and the one or more current circumstances. During the simulation mode of operation, the simulator is configured to monitor the computer program for the one or more particular events, retrieve the one or more data fields associated with the one or more particular events, analyze one or more current circumstances upon the occurrence of the one or more particular events, and invoke one or more simulated inputs based on the value of the one or more data fields in response to the occurrence of the one or more events and the one or more current circumstances.

7. 发明授权

US06911122B2 Method and apparatus for triggering oxygen scavenging composition with pulsed light 失效
标题翻译：用脉冲光触发氧气清除组合物的方法和装置
公开(公告)号：US06911122B2
公开(公告)日：2005-06-28
申请号：US10151358
申请日：2002-05-20
申请人： Philip H. Cook, Jr. , Melania M. Craddock , William A. Feehley , Nathanael R. Miranda , Drew V. Speer , Jeffrey Thomas
发明人： Philip H. Cook, Jr. , Melania M. Craddock , William A. Feehley , Nathanael R. Miranda , Drew V. Speer , Jeffrey Thomas
IPC分类号： C08J7/00 , A23L3/26 , A23L3/28 , A23L3/3436 , B65B55/08 , B65D81/26 , C08J3/28 , C08K5/00 , C08K5/098 , C08L101/00 , C07C1/00 , B65B29/00 , B65B47/02 , C01B3/00
CPC分类号： B65B55/08 , A23L3/26 , A23L3/28 , A23L3/3436 , C08J3/28 , C08K5/0008 , C08K5/098 , C08K2201/012
摘要： A method for triggering an oxygen scavenging composition for use in packaging an oxygen sensitive article includes the steps of providing an oxygen scavenging composition comprising an oxidizable organic compound and, optionally, a transition metal catalyst, and exposing the composition to a source of pulsed light wherein each pulse has a duration of between 1 microsecond and 1 millisecond, a frequency of between 0.1 to 100 Hertz, and a total intensity of at least 350 mW/cm2 so that each pulse provides the composition with a dose of UV light of at least 0.1 J/cm2 so as to provide a triggered composition. The triggered composition can be applied to an article so as to provide an oxygen scavenging package. An apparatus and packaging system are also disclosed.
摘要翻译：用于触发用于包装氧敏感物品的除氧组合物的方法包括提供包含可氧化有机化合物和任选的过渡金属催化剂的氧清除组合物并将组合物暴露于脉冲光源的步骤，其中每个脉冲具有1微秒和1毫秒之间的持续时间，0.1至100赫兹之间的频率和至少350mW / cm 2的总强度，使得每个脉冲为组合物提供一个剂量为至少0.1J / cm 2的UV光，以提供触发组合物。可以将触发的组合物施用于制品以提供除氧包装。还公开了一种装置和包装系统。

8. 发明授权

US06449923B1 Method and apparatus for triggering oxygen scavenging composition with pulsed light 失效
标题翻译：用脉冲光触发氧气清除组合物的方法和装置
公开(公告)号：US06449923B1
公开(公告)日：2002-09-17
申请号：US09230776
申请日：1999-08-13
申请人： Philip H. Cook, Jr. , Melania M. Craddock , William A. Feehley , Nathanael R. Miranda , Drew V. Speer , Jeffrey Thomas
发明人： Philip H. Cook, Jr. , Melania M. Craddock , William A. Feehley , Nathanael R. Miranda , Drew V. Speer , Jeffrey Thomas
IPC分类号： B65B2900
CPC分类号： B65B55/08 , A23L3/26 , A23L3/28 , A23L3/3436 , C08J3/28 , C08K5/0008 , C08K5/098 , C08K2201/012
摘要： A method for triggering an oxygen scavenging composition for use in packaging an oxygen sensitive article includes the steps of providing an oxygen scavenging composition including an oxidizable organic compound, and exposing the composition to a source of pulsed light wherein each pulse has a duration of between 1 microsecond and 1 millisecond, a frequency of between 0.1 to 100 Hertz, and an intensity of at least 350 mW/cm2 so that each pulse provides the composition with a dose of UV light of at least 0.1 J/cm2 so as to provide a triggered composition. The triggered composition can be applied to an article so as to provide an oxygen scavenging package. An apparatus and packaging system are also disclosed.
摘要翻译：用于引发用于包装氧敏感物品的除氧组合物的方法包括提供包含可氧化有机化合物的除氧组合物并将组合物暴露于脉冲光源的步骤，其中每个脉冲的持续时间为1 微秒和1毫秒，0.1至100赫兹的频率和至少350毫瓦/厘米2的强度，使得每个脉冲为组合物提供至少0.1J / cm 2的UV光剂量，以提供触发组成。可以将触发的组合物施用于制品以提供除氧包装。还公开了一种装置和包装系统。

9. 发明申请

US20100285856A1 SINGLE PLAYER FANTASY SPORTS GAME 有权
标题翻译：单人游戏幻想运动游戏
公开(公告)号：US20100285856A1
公开(公告)日：2010-11-11
申请号：US12435695
申请日：2009-05-05
申请人： Jeffrey Thomas
发明人： Jeffrey Thomas
IPC分类号： A63F9/24
CPC分类号： A63F13/60 , A63F13/46 , A63F13/75 , A63F13/795 , A63F2300/69 , A63F2300/8052
摘要： A single user fantasy game, including a database of VFGMs, each having strategies and player rankings supplied by or for certain human remote GMs, together with a database of real-world athlete/participants. A draft is launched, with the user and at least selected VFGMs as participants. In that draft, the user and the VFGMs make selections of athlete/participants according to predetermined draft rules. Those selections made by the user and by the VFGMs are then saved as respective teams in a team database. Once the teams are selected, the performance of the teams is determined, using a database of real-world performances/statistics, for the athlete/participants in the database of athlete/participants, from a particular time period and according to a set of fantasy game scoring rules. A winner is determined from among the user and the VFGMs, based on the performance of the teams for the particular time period.
摘要翻译：一个单一的用户幻想游戏，包括VFGM数据库，每个都有一些人类远程GM提供的策略和玩家排名，以及真实世界运动员/参与者的数据库。启动了一个草案，用户和至少选定的VFGM作为参与者。在该草案中，用户和VFGM根据预定的草案规则选择运动员/参与者。用户和VFGM进行的选择随后作为相应的团队保存在团队数据库中。一旦选定了队伍，就可以使用现场表演/统计数据库，从运动员/参与者的数据库中的运动员/参与者的特定时间段以及一组幻想来确定队伍的表现游戏得分规则。取决于用户和VFGM之间的获胜者，这取决于特定时间段内队伍的表现。

10. 发明申请

US20070042546A1 Method for forming floating gates within NVM process 有权
标题翻译：在NVM过程中形成浮动门的方法
公开(公告)号：US20070042546A1
公开(公告)日：2007-02-22
申请号：US11208670
申请日：2005-08-22
申请人： Jeffrey Thomas , Olubunmi Adetutu
发明人： Jeffrey Thomas , Olubunmi Adetutu
IPC分类号： H01L21/336
CPC分类号： H01L21/28123 , H01L21/28273 , H01L27/115 , H01L27/11521
摘要： A semiconductor process and apparatus includes forming a semiconductor device by depositing a layer of nitride (20) over a semiconductor structure (10), patterning and etching the nitride layer to form a patterned nitride layer (42, 44), depositing a layer of polysilicon (62), planarizing the polysilicon layer with a CMP process to remove any portion of the polysilicon layer (62) above the patterned dielectric layer (42, 44), and then removing the patterned nitride layer (42, 44), thereby defining one or more polysilicon features (72, 74, 76) that can be used as floating gates, transistors gates, bit lines or any other semiconductor device feature.
摘要翻译：半导体工艺和设备包括通过在半导体结构（10）上沉积氮化物层（20）来形成半导体器件，图案化和蚀刻氮化物层以形成图案化氮化物层（42,44），沉积多晶硅层（62），用CMP工艺平坦化多晶硅层，以去除图案化的介电层（42,44）上方的多晶硅层（62）的任何部分，然后去除图案化的氮化物层（42,44），由此限定一个或更多个可用作浮动栅极，晶体管栅极，位线或任何其它半导体器件特征的多晶硅特征（72,74,76）。

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