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1. 发明申请

US20050130167A1 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring 失效
标题翻译：用于细胞内分子成像和监测的多功能磁性纳米颗粒探针
公开(公告)号：US20050130167A1
公开(公告)日：2005-06-16
申请号：US10694243
申请日：2003-10-27
申请人： Gang Bao , Shuming Nie , Nitin Nitin , Leslie LaConte
发明人： Gang Bao , Shuming Nie , Nitin Nitin , Leslie LaConte
IPC分类号： A61K51/00 , A61M36/14 , C12Q1/68 , G02B20060101
CPC分类号： C12Q1/6818 , A61K49/0002 , A61K49/0041 , A61K49/0093 , A61K49/1836 , A61K49/186 , B82Y5/00 , B82Y30/00 , C12Q1/6834 , C12Q1/6841 , G01N33/5005 , G01N33/587 , C12Q2563/155 , C12Q2563/143 , C12Q2525/301 , C12Q2525/101
摘要： The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
摘要翻译：本发明提供用于分子成像和监测的多功能磁性纳米颗粒探针组合物，其包含核酸或多肽探针，递送配体和其上具有生物相容性涂层的磁性纳米颗粒。探针组合物还可以包含荧光或发光共振能量转移部分。还提供了包含两种或更多种用于分子成像或监测的这种多功能磁性纳米颗粒探针的组合物。特别地，核酸或多肽探针结合靶并产生可用磁共振成像（MRI）或光学成像观察到的相互作用。因此，本发明提供可检测的信号，用于在体内快速，特异和灵敏地检测核酸，多肽及其相互作用。

2. 发明授权

US07459145B2 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring 失效
标题翻译：用于细胞内分子成像和监测的多功能磁性纳米颗粒探针
公开(公告)号：US07459145B2
公开(公告)日：2008-12-02
申请号：US10694243
申请日：2003-10-27
申请人： Gang Bao , Shuming Nie , Nitin Nitin , Leslie LaConte
发明人： Gang Bao , Shuming Nie , Nitin Nitin , Leslie LaConte
IPC分类号： A61B5/055
CPC分类号： C12Q1/6818 , A61K49/0002 , A61K49/0041 , A61K49/0093 , A61K49/1836 , A61K49/186 , B82Y5/00 , B82Y30/00 , C12Q1/6834 , C12Q1/6841 , G01N33/5005 , G01N33/587 , C12Q2563/155 , C12Q2563/143 , C12Q2525/301 , C12Q2525/101
摘要： The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
摘要翻译：本发明提供用于分子成像和监测的多功能磁性纳米颗粒探针组合物，其包含核酸或多肽探针，递送配体和其上具有生物相容性涂层的磁性纳米颗粒。探针组合物还可以包含荧光或发光共振能量转移部分。还提供了包含两种或更多种用于分子成像或监测的这种多功能磁性纳米颗粒探针的组合物。特别地，核酸或多肽探针结合靶并产生可用磁共振成像（MRI）或光学成像观察到的相互作用。因此，本发明提供可检测的信号，用于在体内快速，特异和灵敏地检测核酸，多肽及其相互作用。

3. 发明授权

US07297494B2 Activatable probes and methods for in vivo gene detection 有权
标题翻译：可活化的探针和体内基因检测方法
公开(公告)号：US07297494B2
公开(公告)日：2007-11-20
申请号：US11041103
申请日：2005-01-21
申请人： Gang Bao , Nitin Nitin
发明人： Gang Bao , Nitin Nitin
IPC分类号： C12Q1/68 , C12N15/11 , C07H21/02 , C07H21/04
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/6818 , C12Q2565/107 , C12Q2565/1015 , C12Q2525/301
摘要： Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.
摘要翻译：提供了用于检测靶多核苷酸的探针。一个方面提供了一种分子信标探针组，其中供体分子信标包含量子点，受体分子信标包含至少一个记者。探针任选地包含蛋白质转导结构域，靶向信号或其组合。还提供了使用公开的探针检测靶多核苷酸的方法。

4. 发明申请

US20050287548A1 Activatable probes and methods for in vivo gene detection 有权
标题翻译：可活化的探针和体内基因检测方法
公开(公告)号：US20050287548A1
公开(公告)日：2005-12-29
申请号：US11041103
申请日：2005-01-21
申请人： Gang Bao , Nitin Nitin
发明人： Gang Bao , Nitin Nitin
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/6818 , C12Q2565/107 , C12Q2565/1015 , C12Q2525/301
摘要： Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.
摘要翻译：提供了用于检测靶多核苷酸的探针。一个方面提供了一种分子信标探针组，其中供体分子信标包含量子点，受体分子信标包含至少一个记者。探针任选地包含蛋白质转导结构域，靶向信号或其组合。还提供了使用公开的探针检测靶多核苷酸的方法。

5. 发明授权

US10530595B2 Small area MBSFN enhancement 有权
公开(公告)号：US10530595B2
公开(公告)日：2020-01-07
申请号：US15100932
申请日：2015-01-02
申请人： Xipeng Zhu , Jun Wang , Xiaoxia Zhang , Gang Bao , QUALCOMM Incorporated
发明人： Xipeng Zhu , Jun Wang , Xiaoxia Zhang , Gang Bao
IPC分类号： H04L12/18 , H04W4/06 , H04W72/00 , H04W36/26 , H04W4/021 , H04W76/40
摘要： A method, an apparatus, and a computer program product for wireless communication are provided. The apparatus may be a UE. The UE determines whether the UE is located within a sub-region of an MBSFN area based on one or more parameters. The UE receives based on the determination a service over broadcast in the sub-region of the MBSFN area or over unicast outside the sub-region. In an aspect, the MBSFN area may be smaller than a unicast area. In an aspect, adaptive retransmission with a group NACK approach may be used to improve an SNR and reliability.

6. 发明授权

US09107186B2 Carrier aggregation for evolved multimedia broadcast multicast service enhancement 有权
标题翻译：用于演进多媒体广播多播服务增强的载波聚合
公开(公告)号：US09107186B2
公开(公告)日：2015-08-11
申请号：US13402845
申请日：2012-02-22
申请人： Xiaoxia Zhang , Yongbin Wei , Durga Prasad Malladi , Jun Wang , Zhengwei Liu , Gang Bao
发明人： Xiaoxia Zhang , Yongbin Wei , Durga Prasad Malladi , Jun Wang , Zhengwei Liu , Gang Bao
IPC分类号： H04W72/00 , H04L5/00 , H04L5/14 , H04W48/12 , H04W72/04
CPC分类号： H04W72/005 , H04L5/001 , H04L5/0037 , H04L5/0048 , H04L5/0053 , H04L5/0098 , H04L5/143 , H04W48/12 , H04W72/042
摘要： Carrier aggregation to enhance Evolved Multimedia Broadcast Multicast Service (eMBMS) includes transmitting unicast signaling for a unicast service on an anchor carrier to mobile entities, transmitting eMBMS signaling on a second carrier different from the anchor carrier to the mobile entities for use with the unicast signaling, and various techniques for practical application of carrier aggregation for eMBMS enhancement. In addition, allocating subframes used for MBMS on a Single Frequency Network (MBSFN) includes allocating at least a portion of one or more subframes otherwise reserved for unicast subframes on a mixed carrier to provide an increased allocation of subframes carrying MBSFN information, transmitting MBSFN signals on the increased allocation of subframes, and more detailed aspects.
摘要翻译：用于增强演进的多媒体广播多播服务（eMBMS）的载波聚合包括将锚定载波上的单播业务的单播信令发送到移动实体，在不同于该锚定载波的第二载波上将eMBMS信令发送到移动实体以与单播信令一起使用，以及用于eMBMS增强的载波聚合的实际应用的各种技术。此外，在单频网络（MBSFN）上分配用于MBMS的子帧包括：在混合载波上分配另外保留用于单播子帧的一个或多个子帧的至少一部分，以提供携带MBSFN信息的子帧的增加分配，发送MBSFN信号对子帧的分配增加，以及更详细的方面。

7. 发明授权

US07072321B2 Forward-link scheduling in a wireless communication system 失效
标题翻译：无线通信系统中的前向链路调度
公开(公告)号：US07072321B2
公开(公告)日：2006-07-04
申请号：US10972198
申请日：2004-10-22
申请人： Jack Holtzman , Gang Bao
发明人： Jack Holtzman , Gang Bao
IPC分类号： H04B7/216
CPC分类号： H04W72/1226 , H04L1/0002 , H04L1/0015 , H04L1/0046 , H04W52/16 , H04W52/223 , H04W52/26 , H04W52/50 , H04W72/1242
摘要： A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel. A method of performing forward-link scheduling in a wireless communication system includes determining the available base station power at the beginning of a frame, predicting the required transmit power at the beginning of the frame for each supplemental channel, determining rates sustainable with the predicted transmit power, dividing by throughput over a recent window to obtain a supplemental channel priority index, and allowing the supplemental channel with the highest priority index to transmit over the next frame.
摘要翻译：一种用于选择有利的传输时隙的方法和装置，用于结合语音数据通信来传送非语音数据。基于在基本信道上由基站发送到远程站的语音数据的发送功率电平来选择反映用于在辅助信道上发送非语音数据的有利功率电平和传输速率的时隙。选择有利的传输时隙，而无需向基站发送关于用于补充信道的频率信道或干扰信息的远程站消息传递信息。在无线通信系统中执行前向链路调度的方法包括：确定帧开始处的可用基站功率，在每个补充信道的帧开始处预测所需的发射功率，确定具有预测的传输可持续的速率功率除以最近窗口的吞吐量以获得补充信道优先级索引，并允许具有最高优先级索引的补充信道在下一帧上进行传输。

8. 发明授权

US07068683B1 Method and apparatus for high rate packet data and low delay data transmissions 有权
标题翻译：用于高速率分组数据和低延迟数据传输的方法和装置
公开(公告)号：US07068683B1
公开(公告)日：2006-06-27
申请号：US09697375
申请日：2000-10-25
申请人： Stein A. Lundby , Leonid Razoumov , Gang Bao
发明人： Stein A. Lundby , Leonid Razoumov , Gang Bao
IPC分类号： H04J1/02 , H04L12/28 , H04Q7/00 , H04B7/216
CPC分类号： H04W72/1289 , H04L1/0002 , H04L1/0025 , H04W48/20
摘要： In a wireless communication system a method for combination transmission of packet data and low delay data. In one embodiment a parallel signaling channel provides a message to receivers indicating a target recipient of packet data. The message also identifies the transmission channels used for packet data transmissions. Each receiver may then selectively decode only packets where the message identifies the receiver as a target recipient. The data packets stored in a buffer are ignored if the target recipient is another mobile unit. In one embodiment, the message is sent concurrently with the data packet on a parallel channel. In one embodiment, the message is punctured into the high rate packet data transmission.
摘要翻译：在无线通信系统中，分组数据和低延迟数据的组合传输方法。在一个实施例中，并行信令信道向指示分组数据的目标接收者的接收机提供消息。该消息还标识用于分组数据传输的传输信道。然后，每个接收机可以仅选择性地仅解码消息将接收者标识为目标接收者的分组。如果目标收件人是另一个移动单元，则会忽略存储在缓冲区中的数据包。在一个实施例中，消息与并行信道上的数据分组同时发送。在一个实施例中，消息被打入高速率分组数据传输。

9. 发明申请

US20060127940A1 Dual resonance energy transfer nucleic acid probes 失效
公开(公告)号：US20060127940A1
公开(公告)日：2006-06-15
申请号：US11346072
申请日：2006-02-02
申请人： Gang Bao , Andrew Tsourkas , Yangqing Xu
发明人： Gang Bao , Andrew Tsourkas , Yangqing Xu
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6818 , C12Q2565/101 , C12Q2525/301
摘要： Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.

10. 发明授权

US06760587B2 Forward-link scheduling in a wireless communication system during soft and softer handoff 失效
标题翻译：在软和软切换过程中无线通信系统中的前向链路调度
公开(公告)号：US06760587B2
公开(公告)日：2004-07-06
申请号：US09792518
申请日：2001-02-23
申请人： Jack M. Holtzman , Gang Bao
发明人： Jack M. Holtzman , Gang Bao
IPC分类号： H04Q720
CPC分类号： H04W52/223 , H04W36/18 , H04W52/221 , H04W52/225 , H04W52/26 , H04W52/34 , H04W52/40
摘要： A method and apparatus for scheduling transmit rates and power levels for data in conjunction with a voice-data communication during conditions of soft and softer handoff. During conditions of no handoff, or hard handoff, an algorithm selects a slot reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel. The slot is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The algorithm applies to softer handoff using information from all the sectors of a base station involved in the softer handoff. During soft handoff, instead of scheduling forward link transmission based on recent power and rate, or C/I information, data is continuously transmitted to the user at a power level based on average required power.
摘要翻译：一种用于在软和更软切换的条件期间结合语音数据通信调度数据的传输速率和功率电平的方法和装置。在没有切换或硬切换的条件下，算法选择反映用于在辅助信道上发送非话音数据的有利功率电平和传输速率的时隙。基于由基站在基本信道上向远程站发送的语音数据的发送功率电平来选择时隙。该算法适用于使用来自涉及较软切换的基站的所有扇区的信息的较软切换。在软切换期间，代替基于最近的功率和速率或C / I信息调度前向链路传输，基于平均所需功率以数量的功率级别连续向用户发送数据。

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