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1. 发明授权

US5372580A Gel injection adjustable keratoplasty 失效
标题翻译：凝胶注射可调角膜移植术
公开(公告)号：US5372580A
公开(公告)日：1994-12-13
申请号：US836711
申请日：1992-02-19
申请人： Gabriel Simon , Jean-Marie A. Parel , William G. Lee
发明人： Gabriel Simon , Jean-Marie A. Parel , William G. Lee
IPC分类号： A61F2/14 , A61F9/007 , A61F9/013 , C08G65/30 , C08G65/32 , C08J3/28 , A61M31/00
CPC分类号： C08J3/28 , A61F2/147 , A61F9/007 , A61F9/0133 , C08G65/30 , C08G65/32 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

2. 发明授权

US5634943A Injectable polyethylene oxide gel implant and method for production 失效
标题翻译：注射聚乙烯氧化物凝胶植入物和生产方法
公开(公告)号：US5634943A
公开(公告)日：1997-06-03
申请号：US299583
申请日：1994-09-01
申请人： Franck L. Villain , Jean-Marie A. Parel , William G. Lee , Gabriel Simon
发明人： Franck L. Villain , Jean-Marie A. Parel , William G. Lee , Gabriel Simon
IPC分类号： A61L27/00 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/007 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02
CPC分类号： C08J3/075 , A61F2/0059 , A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/12 , C08J2371/02 , Y10S623/906
摘要： A biocompatible polyethylene oxide gel implant and method for production which can be injected into the human body for tissue replacement and augmentation. The implant is prepared by dissolving a sample of essentially pure polyethylene oxide in a saline solution in a sealed canister, removing all free oxygen from the container and replacing it with an inert gas, such as argon, and irradiating the canister with a gamma ray source to simultaneously crosslink the polyethylene oxide while sterilizing it. The gel can then be placed into a syringe and injected into the body.
摘要翻译：生物相容性聚环氧乙烷凝胶植入物和生产方法，可以注入人体进行组织更换和增殖。通过将基本上纯的聚环氧乙烷的样品溶解在密封的罐中的盐水溶液中，从容器中除去所有的游离氧并用惰性气体如氩气代替，并用伽马射线源以同时交联聚环氧乙烷同时对其进行灭菌。然后将凝胶置于注射器中并注入体内。

3. 发明授权

US5607437A Instruments for use in performing gel injection adjustable keratoplasty 失效
标题翻译：用于执行凝胶注射可调角膜移植术的仪器
公开(公告)号：US5607437A
公开(公告)日：1997-03-04
申请号：US299423
申请日：1994-09-01
申请人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B17/00
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

4. 发明授权

US5547468A Instruments for use in performing gel injection adjustable keratoplasty 失效
公开(公告)号：US5547468A
公开(公告)日：1996-08-20
申请号：US299582
申请日：1994-09-01
申请人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61M5/32
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.

5. 发明授权

US07494802B2 Amniotic membrane covering for a tissue surface and devices facilitating fastening of membranes 有权
标题翻译：用于组织表面的羊膜覆盖和促进膜紧固的装置
公开(公告)号：US07494802B2
公开(公告)日：2009-02-24
申请号：US10472117
申请日：2003-03-14
申请人： Scheffer C. G. Tseng , Helga Sandoval , William G. Lee
发明人： Scheffer C. G. Tseng , Helga Sandoval , William G. Lee
IPC分类号： C12M3/00
CPC分类号： A61F9/04 , A61F9/0017 , A61L27/3604 , A61L27/3679 , A61L27/3813 , A61L27/3882 , A61L31/005
摘要： The present invention relates to a biopolymer covering for a tissue surface including, for example, a dressing, a bandage, a drape such as a bandage contact lens, a composition or covering to protect tissue, a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, or to promote healing or growth of tissue. An example of such a composition is an amniotic membrane covering for an ocular surface. Use of a covering for a tissue surface according to the invention eliminates the need for suturing. The invention also includes devices facilitating the fastening of a membrane to a support, culture inserts, compositions, methods, and kits for making and using coverings for a tissue surface and culture inserts. Compositions according to the invention may include cells grown on a membrane or attached to a membrane, and such compositions may be used as scaffolds for tissue engineering or tissue grafts. A method of preparing and using an amniotic membrane covering for a tissue surface as a controlled release drug delivery vehicle is also disclosed.
摘要翻译：本发明涉及一种用于组织表面的生物聚合物覆盖物，包括例如敷料，绷带，诸如绷带隐形眼镜的覆盖物，保护组织的组合物或覆盖物，防止粘连的覆盖物，排除细菌，抑制细菌活性，或促进组织的愈合或生长。这种组合物的实例是用于眼表面的羊膜覆盖。使用根据本发明的组织表面的覆盖物消除了缝合的需要。本发明还包括便于将膜紧固到支持物上的装置，培养插入物，组合物，方法和用于制备和使用组织表面和培养插入物的覆盖物的试剂盒。根据本发明的组合物可以包括在膜上生长或连接到膜上的细胞，并且这样的组合物可以用作组织工程或组织移植物的支架。还公开了一种制备和使用用于组织表面的羊膜覆盖作为控释药物递送载体的方法。

6. 发明授权

US5423330A Capsule suction punch instrument and method of use 失效
标题翻译：胶囊吸punch器及其使用方法
公开(公告)号：US5423330A
公开(公告)日：1995-06-13
申请号：US29398
申请日：1993-03-10
申请人： William G. Lee
发明人： William G. Lee
IPC分类号： A61B10/00 , A61B10/02 , A61B17/30 , A61B17/32 , A61F9/007 , A61F9/013 , A61F9/00
CPC分类号： A61B10/0233 , A61B10/0283 , A61F9/00754 , A61F9/013 , A61B17/32053 , A61B2017/306
摘要： A surgical instrument is provided having a tubular body including a distal portion, a proximal portion and a mid portion. A cutting member having a cutting edge is longitudinally received within the tubular body for guided reciprocal movement therein between a cutting position wherein the cutting edge extends from the distal portion and a non-cutting position wherein the cutting edge is retracted within the tubular body. A urging mechanism is also provided within the mid portion of the tubular body for urging the cutting member to the cutting position. A vacuum source is coupled to the cutting member at a proximal end thereof and provides a vacuum directed to the distal portion to hold tissue to be cut. A method of cutting the tissue is also provided.
摘要翻译：提供了具有包括远侧部分，近端部分和中部部分的管状体的外科器械。具有切割边缘的切割构件被纵向容纳在管状体内，用于在其中切割边缘从远侧部分延伸的切割位置与切割边缘在管状体内缩回的非切割位置之间引导往复运动。在管状体的中部还设置有推动机构，用于将切割构件推动到切割位置。真空源在其近端处联接到切割构件，并且提供指向远侧部分的真空以保持待切割的组织。还提供了切割组织的方法。

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