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1. 发明授权

US07594899B2 Glaucoma implant device 有权
标题翻译：青光眼植入装置
公开(公告)号：US07594899B2
公开(公告)日：2009-09-29
申请号：US11561960
申请日：2006-11-21
申请人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
IPC分类号： A61M5/00 , A61M1/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： A surgical method is provided for diverting aqueous humor from the anterior chamber of the eye. A surgical tool is provided having a hollow support member that supports a portion of an aqueous humor drainage device. The device has an elongate duct structure and preferably at least one fixation member that extends therefrom. The distal end of the hollow support member is inserted into the anterior chamber of the eye through an opening passing through the sclera. The aqueous humor drainage device is deployed from the hollow support member for placement into the eye. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate duct structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate duct structure.
摘要翻译：提供了一种手术方法，用于将房水从眼睛的前房转移。提供具有中空支撑构件的手术工具，所述中空支撑构件支撑房水引流装置的一部分。该装置具有细长的管道结构，优选地至少一个从其延伸的固定构件。中空支撑构件的远端通过穿过巩膜的开口插入眼睛的前房。房水引流装置从中空支撑构件展开以放置到眼睛中。在一个实施例中，固定构件通过与细长管道结构的两个端部间隔开的突片来实现。在另一个实施例中，固定构件通过相对于细长管道结构的中心轴线在横向方向上延伸的一对尖齿实现。

2. 发明授权

US5653725A Instrument for initiating an intralamellar channel 失效
标题翻译：启动内镜通道的仪器
公开(公告)号：US5653725A
公开(公告)日：1997-08-05
申请号：US299592
申请日：1994-09-01
申请人： Gabriel Simon , William Gerald Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William Gerald Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B17/00
CPC分类号： C08G65/30 , A61F9/0133 , C08G65/32 , C08L71/02 , A61B2017/320044 , A61F9/0017
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

3. 发明授权

US5372580A Gel injection adjustable keratoplasty 失效
标题翻译：凝胶注射可调角膜移植术
公开(公告)号：US5372580A
公开(公告)日：1994-12-13
申请号：US836711
申请日：1992-02-19
申请人： Gabriel Simon , Jean-Marie A. Parel , William G. Lee
发明人： Gabriel Simon , Jean-Marie A. Parel , William G. Lee
IPC分类号： A61F2/14 , A61F9/007 , A61F9/013 , C08G65/30 , C08G65/32 , C08J3/28 , A61M31/00
CPC分类号： C08J3/28 , A61F2/147 , A61F9/007 , A61F9/0133 , C08G65/30 , C08G65/32 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

4. 发明申请

US20100241046A1 APPARATUS, METHODS AND DEVICES FOR TREATMENT OF OCULAR DISORDERS 审中-公开
标题翻译：用于治疗眼病的装置，方法和装置
公开(公告)号：US20100241046A1
公开(公告)日：2010-09-23
申请号：US12440096
申请日：2007-09-06
申请人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
IPC分类号： A61M1/00
CPC分类号： A61L27/56 , A61F9/00781 , A61L27/48 , A61L31/129 , A61L31/146 , C08L53/02
摘要： Apparatus and methods for relieving and treating glaucoma and other ocular disorders are disclosed. The apparatus includes a thin flexible membrane and preferably a tubular member. In another aspect of the invention, a surgical device for repairing ocular tissue includes a flexible membrane of a polymeric material comprising polyisobutylene. In the preferred embodiment, the polymeric material of the membrane is porous.
摘要翻译：公开了用于缓解和治疗青光眼和其它眼部疾病的装置和方法。该装置包括薄的柔性膜并且优选地为管状构件。在本发明的另一方面，用于修复眼组织的手术装置包括包含聚异丁烯的聚合物材料的柔性膜。在优选的实施方案中，膜的聚合物材料是多孔的。

5. 发明授权

US5931846A Instruments for use in performing gel injection adjustable keratoplasty 失效
标题翻译：用于执行凝胶注射可调角膜移植术的仪器
公开(公告)号：US5931846A
公开(公告)日：1999-08-03
申请号：US806730
申请日：1997-02-27
申请人： Gabriel Simon , William Gerald Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William Gerald Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B17/00
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

6. 发明授权

US5681869A Injectable polyethylene oxide gel implant and method for production 失效
标题翻译：注射聚乙烯氧化物凝胶植入物和生产方法
公开(公告)号：US5681869A
公开(公告)日：1997-10-28
申请号：US463591
申请日：1995-06-05
申请人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
发明人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
IPC分类号： A61L27/00 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/007 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , C09J7/00
CPC分类号： C08J3/075 , A61F2/0059 , A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/12 , C08J2371/02 , Y10S623/906
摘要： A biocompatible poly(ethylene oxide) gel implant and method for production which can be injected into the human body for tissue replacement and augmentation. The implant is prepared by dissolving a sample of essentially pure poly(ethylene oxide) in a saline solution in a sealed canister, removing all free oxygen from the container and replacing it with an inert gas, such as argon, and irradiating the canister with a gamma ray source to simultaneously crosslink the polyethylene oxide while sterilizing it. The gel can then be placed into a syringe and injected into the body.
摘要翻译：生物相容性聚（环氧乙烷）凝胶植入物和可以注入人体进行组织置换和增殖的生产方法。植入物通过将基本上纯的聚（环氧乙烷）样品溶解在盐溶液中的密封罐中来制备，从容器中除去所有游离氧并用惰性气体如氩气代替，并用 γ射线源同时交联聚环氧乙烷同时对其进行消毒。然后将凝胶置于注射器中并注入体内。

7. 发明授权

US5607437A Instruments for use in performing gel injection adjustable keratoplasty 失效
标题翻译：用于执行凝胶注射可调角膜移植术的仪器
公开(公告)号：US5607437A
公开(公告)日：1997-03-04
申请号：US299423
申请日：1994-09-01
申请人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B17/00
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.
摘要翻译：本发明提供了一种手术技术和仪器套件，其允许通过在保护光学区域的同时在角膜周边层间注射合成凝胶来微调角膜曲率。手术环形轨道内的凝胶粘度，体积和配置以及轨迹的直径，宽度，深度和位置都是获得的折射变化的参数。在中心进行超声波比重测量并且位于离顶点大约2.5至3.5mm的选定的伤口处，使用调节至约86％的微测金刚石刀片进行一毫米或更宽，约75-85％的角膜厚度深度径向切口，角膜厚度。通过部分深度切口插入，开瓶塞式解剖器或螺旋刮刀形成以顶点为中心的360°环形轨道。通过切口手动注入透明凝胶，填充环形通道。使用安装在手术显微镜上的外科角膜曲率计，通过在主要手术或随后程序中根据需要按摩和去除凝胶来调整最终的角膜功能，因为GIAK技术是可逆的。

8. 发明授权

US5547468A Instruments for use in performing gel injection adjustable keratoplasty 失效
公开(公告)号：US5547468A
公开(公告)日：1996-08-20
申请号：US299582
申请日：1994-09-01
申请人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
发明人： Gabriel Simon , William G. Lee , Jean-Marie A. Parel
IPC分类号： A61F9/007 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61M5/32
CPC分类号： A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/0059 , A61F2/12 , A61L2430/16 , C08J2371/02
摘要： The present invention provides a surgical technique and instrument kit that allows for subtle modification of the corneal curvature by interlamellar injection of a synthetic gel at the corneal periphery while sparing the optical zone. The gel viscosity, volume and disposition within the surgical annular track as well as the diameter of the track, width, depth, and location are all parameters in the refractive change obtained. Following ultrasonic pachymetry performed centrally and at a selected wound entrance located about 2.5 to 3.5 mm from the apex, a one millimeter or so wide, about 75-85% corneal thickness depth radial incision is performed with a micrometric diamond knife adjusted to about 86% corneal thickness. Inserted through the partial-depth incision, a corkscrew-like dissector or helicoidal spatula forms a 360.degree. annular track centered about the apex. A transparent gel is manually injected through the incision, filling the annular channel. Using a surgical keratometer mounted to an operation microscope, the final corneal power is adjusted by massaging and removing the gel as necessary during the primary procedure or subsequent procedures, as the GIAK technique is reversible.

9. 发明授权

US07837644B2 Glaucoma implant device 有权
标题翻译：青光眼植入装置
公开(公告)号：US07837644B2
公开(公告)日：2010-11-23
申请号：US11561956
申请日：2006-11-21
申请人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
发明人： Leonard Pinchuk , Jean-Marie A. Parel , Francisco Fantes
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： An aqueous humor drainage device having an elongate structure that provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. The device is formed from a biocompatible soft polymeric material with a hardness less than Shore 80A. Preferably, the polymeric material includes polyisobutylene and a glassy segment. The device preferably includes at least one fixation member that extends from the elongate structure. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate structure. The tines are spaced apart for positioning on opposite sides of the sclera of the eye during use.
摘要翻译：一种房水引流装置，其具有细长结构，其提供用于将房水从眼睛前房转向的流体通道。该装置由硬度小于肖氏80A的生物相容性软聚合材料形成。优选地，聚合物材料包括聚异丁烯和玻璃质部分。该装置优选地包括从细长结构延伸的至少一个固定构件。在一个实施例中，固定构件通过与细长结构的两个端部间隔开的突片来实现。在另一个实施例中，固定构件通过相对于细长结构的中心轴线在横向方向上延伸的一对齿来实现。在使用期间，齿相间隔开定位在眼睛的巩膜的相对两侧。

10. 发明授权

US5645583A Injectable polyethylene oxide gel implant and method for production 失效
公开(公告)号：US5645583A
公开(公告)日：1997-07-08
申请号：US463595
申请日：1995-06-05
申请人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
发明人： Franck L. Villain , Jean-Marie A. Parel , William Gerald Lee , Gabriel Simon
IPC分类号： A61L27/00 , A61B17/32 , A61F2/00 , A61F2/12 , A61F2/14 , A61F9/007 , A61F9/013 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/075 , C08J3/28 , C08L71/02 , A61F2/16
CPC分类号： C08J3/075 , A61F2/0059 , A61F2/147 , A61F9/007 , A61F9/0133 , A61L27/18 , C08G65/30 , C08G65/32 , C08J3/28 , C08L71/02 , A61B2017/320044 , A61F2/12 , C08J2371/02 , Y10S623/906
摘要： A biocompatible polyethylene oxide gel implant and method for production which can be injected into the human body for tissue replacement and augmentation. The implant is prepared by dissolving a sample of essentially pure polyethylene oxide in a saline solution in a sealed canister, removing all free oxygen from the container and replacing it with an inert gas, such as argon, and irradiating the canister with a gamma ray source to simultaneously crosslink the polyethylene oxide while sterilizing it. The gel can then be placed into a syringe and injected into the body.

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