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1. 发明授权

US4358451A Pyrimido- and imidazo-pyridoindole derivatives 失效
标题翻译：嘧啶并咪唑并 - 吡啶并吲哚衍生物
公开(公告)号：US4358451A
公开(公告)日：1982-11-09
申请号：US112238
申请日：1980-01-15
申请人： Gabor I. Koletar , Jonathan R. Frost , Regis DuPont , Patrick Lardenois , Claude Morel , Henry Najer
发明人： Gabor I. Koletar , Jonathan R. Frost , Regis DuPont , Patrick Lardenois , Claude Morel , Henry Najer
IPC分类号： A61K31/435 , A61K31/505 , A61P25/24 , A61P25/26 , A61P25/28 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Pyrimido- and imidazo-pyridoindole derivatives, in the form of racemates or optically active isomers, of formula: ##STR1## in which n=0 or 1, R.sub.1 =H, Hal, alkyl or alkoxy or CF.sub.3, R.sub.2 =H, alkyl, cycloalkyl-alkyl, cycloalkyl, N,N-dialkylaminoalkyl or phenyl, R.sub.3 =H or alkyl and R.sub.4 =H, alkyl or benzyl are useful as anti-anoxia or psychotropic agents in therapy. They are prepared by cyclizing a compound of formula: ##STR2## wherein R.sub.5 is alkyl, by heating it in an acidic medium, such as ethanolic hydrogen chloride.
摘要翻译：嘧啶并咪唑并 - 吡啶并吲哚衍生物，其为n = 0或1，R1 = H，Hal，烷基或烷氧基或CF3，R2 = H的式（I）的外消旋体或光学活性异构体烷基，环烷基 - 烷基，环烷基，N，N-二烷基氨基烷基或苯基，R3 = H或烷基，R4 = H，烷基或苄基可用作治疗中的抗缺氧或精神药物。它们通过在酸性介质如氯化氢乙醇中加热而使其中R 5为烷基的式（II）化合物环化来制备。

2. 发明授权

US4272539A Pyridoindole derivatives 失效
标题翻译：吡啶并吲哚衍生物
公开(公告)号：US4272539A
公开(公告)日：1981-06-09
申请号：US112212
申请日：1980-01-15
申请人： Gabor I. Koletar , Jonathan R. Frost , Regis Dupont , Patrick Lardenois , Claude Morel , Henry Najer
发明人： Gabor I. Koletar , Jonathan R. Frost , Regis Dupont , Patrick Lardenois , Claude Morel , Henry Najer
IPC分类号： A61K31/435 , A61P25/24 , A61P25/26 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04 , Y10S514/923
摘要： Pyridoindole derivatives of formula ##STR1## n=0 or 1; R.sub.1 =H, Hal, alk, alk-O-, CF.sub.3 ; R.sub.2 =--COOalk; --CONHR.sub.5 (R.sub.5 =H or various substituents); R.sub.3 =H, alk, --COOalk; R.sub.4 =H, Ac, alk, --CONHR.sub.6 (R.sub.6 =H or various substituents), and acid addition salts, except certain known compounds, are useful in treating anoxia and depression and in psychotropic therapy. They are prepared from tryptamine or a derivative thereof by reaction thereof with a pyruvic ester or 3-ethoxycarbonyl-1,2-dioxo-1-ethoxypropane to form compounds in which R.sub.4 is H and R.sub.2 is --COOalk. These compounds are reacted with amines, isocyanates or usual N-acylating or N-alkylating reagents to prepare the other compounds.
摘要翻译：式（I）的吡啶并吲哚衍生物n = 0或1; R1 = H，Hal，alk，alk-O-，CF3; R2 = -COOalk; -CONHR5（R5 = H或各种取代基）; R3 = H，alk，-COOalk; R4 = H，Ac，alk，-CONHR6（R6 = H或各种取代基），除了某些已知化合物之外，酸加成盐可用于治疗缺氧和抑郁症以及精神药物治疗。它们由色胺或其衍生物通过与丙酮酸酯或3-乙氧基羰基-1,2-二氧代-1-乙氧基丙烷的反应制备，以形成其中R 4为H且R 2为-COOalk的化合物。这些化合物与胺，异氰酸酯或通常的N-酰化或N-烷基化试剂反应以制备其它化合物。

3. 发明授权

US4336256A Pyridoindole derivatives 失效
标题翻译：吡啶并吲哚衍生物
公开(公告)号：US4336256A
公开(公告)日：1982-06-22
申请号：US184070
申请日：1980-09-04
申请人： Gabor I. Koletar , Jonathan B. Frost , Regis DuPont , Patrick Lardenois , Claude Morel , Henry Najer
发明人： Gabor I. Koletar , Jonathan B. Frost , Regis DuPont , Patrick Lardenois , Claude Morel , Henry Najer
IPC分类号： A61K31/435 , A61P25/24 , A61P25/26 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04 , Y10S514/923
摘要： Pyridoindole derivatives of formula ##STR1## n=0 or 1; R.sub.1 =H, Hal, alk, alk--O--, CF.sub.3 ; R.sub.2 =--COOalk; --CONHR.sub.5 (R.sub.5 =H or various substituents); R.sub.3 =H, alk, --COOalk; R.sub.4 =H, Ac, alk, --CONHR.sub.6 (R.sub.6 =H or various substituents), and acid addition salts, except certain known compounds, are useful in treating anoxia and depression and in psychotropic therapy. They are prepared from tryptamine or a derivative thereof by reaction thereof with a pyruvic ester or 3-ethoxycarbonyl-1,2-dioxo-1-ethoxypropane to form compounds in which R.sub.4 is H and R.sub.2 is --COOalk. These compounds are reacted with amines, isocyanates or usual N-acylating or N-alkylating reagents to prepare the other compounds.
摘要翻译：式（I）的吡啶并吲哚衍生物n = 0或1; R1 = H，Hal，alk，alk-O-，CF3; R2 = -COOalk; -CONHR5（R5 = H或各种取代基）; R3 = H，alk，-COOalk; R4 = H，Ac，alk，-CONHR6（R6 = H或各种取代基），除了某些已知化合物之外，酸加成盐可用于治疗缺氧和抑郁症以及精神药物治疗。它们由色胺或其衍生物通过与丙酮酸酯或3-乙氧基羰基-1,2-二氧代-1-乙氧基丙烷的反应制备，以形成其中R 4为H且R 2为-COOalk的化合物。这些化合物与胺，异氰酸酯或通常的N-酰化或N-烷基化试剂反应以制备其它化合物。

4. 发明授权

US4277476A Derivatives of fluorenes and fluoranthenes and process for their preparation 失效
标题翻译：芴和荧蒽的衍生物及其制备方法
公开(公告)号：US4277476A
公开(公告)日：1981-07-07
申请号：US60857
申请日：1979-07-26
申请人： Regis DuPont , Patrick Lardenois , Claude Morel , Jonathan Frost , Gabor I. Koletar
发明人： Regis DuPont , Patrick Lardenois , Claude Morel , Jonathan Frost , Gabor I. Koletar
IPC分类号： C07D471/04 , C07D471/14 , C07D471/16 , A01N43/48 , A61K31/495
CPC分类号： C07D471/04 , C07D471/14
摘要： Derivatives of fluorenes and fluoranthenes, in the form of racemates or of enantiomers, of the formula (I) ##STR1## in which n is 1 or 2, R.sub.1 is a hydrogen or halogen atom or an alkyl or alkoxy radical, R.sub.2 is a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, benzyl, halogenobenzyl, alkylbenzyl, alkoxybenzyl, acyl, alkoxycarbonyl or alkylaminocarbonyl radical, R.sub.3 is a hydrogen atom or an alkyl radical, R.sub.4 is a hydrogen atom or an alkyl, acyl or aroyl radical, the alkyl and alkoxy radicals or parts of radicals having from 1 to 4 carbon atoms and pharmaceutically acceptable acid addition salts thereof, are therapeutically valuable as anti-anoxia and psychotropic agents.
摘要翻译：式（I）其中n为1或2的式（I）的外消旋物或对映异构体的芴和荧蒽衍生物，R1为氢或卤素原子或烷基或烷氧基，R2 是氢原子或烷基，环烷基，环烷基烷基，苄基，卤代苄基，烷基苄基，烷氧基苄基，酰基，烷氧基羰基或烷基氨基羰基，R3是氢原子或烷基，R4是氢原子或烷基，酰基或芳酰基，烷基和烷氧基或具有1至4个碳原子的基团部分及其药学上可接受的酸加成盐作为抗缺氧和精神药物具有治疗价值。

5. 发明授权

US4190657A Naphthyridine derivatives 失效
标题翻译：萘啶衍生物
公开(公告)号：US4190657A
公开(公告)日：1980-02-26
申请号：US786557
申请日：1977-04-11
申请人： Gabor I. Koletar , Henry Najer , Jean P. G. LeFevre , Regis Dupont , Don Pierre R. L. Giudicelli , Claude C. H. Morel
发明人： Gabor I. Koletar , Henry Najer , Jean P. G. LeFevre , Regis Dupont , Don Pierre R. L. Giudicelli , Claude C. H. Morel
IPC分类号： A61K31/435 , A61K31/437 , A61P9/00 , A61P25/26 , A61P25/28 , C07D471/04 , C07D471/16 , A61K31/445 , C07D471/12
CPC分类号： C07D471/04
摘要： The present invention relates to new indolo [3,2,1-de]-[1,5]naphthyridine derivatives and their addition salts with pharmaceutically acceptable acids, the preparation of such derivatives and salts and medicaments in which they are present as active principle.
摘要翻译：本发明涉及新的吲哚并[3,2,1-de] - [1,5]萘啶衍生物及其与药学上可接受的酸的加成盐，这些衍生物和盐的制备及其作为活性成分存在的药物。

6. 发明授权

US5686221A Negative working peel apart color proofing process 失效
标题翻译：负工作剥离分色过程
公开(公告)号：US5686221A
公开(公告)日：1997-11-11
申请号：US579658
申请日：1995-12-27
申请人： Gabor I. Koletar
发明人： Gabor I. Koletar
IPC分类号： G03F7/004 , G03F3/10 , G03F7/038 , G03F7/11 , G03F7/34
CPC分类号： G03F3/102
摘要： A negative-acting color proofing method provides a photosensitive element having a cover sheet; release layer having a polymer with phenolic groups; color layer having a binder, polymerizable monomer, colorant, and optional photoinitiator; a photoadhering layer, having a photosensitive polymer having unsaturated, photocrosslinkable groups and a molecular weight greater than about 3,000, a polymerizable monomer having at least one unsaturated group, and an optional photoinitiator. A at least one of the color layer and the photoadhering layer has a photoinitiator; and a first thermoplastic adhesive layer. A photomask is applied onto the thermoplastic adhesive layer and one imagewise exposes the color layer and photoadhering layers to actinic radiation through the photomask. After removing the photomask, the photosensitive element is laminated to a temporary receiver. After peeling apart the temporary receiver and the cover sheet, exposed areas of the color layer attach to the temporary receiver and unexposed areas are removed with the cover sheet thereby forming a colored negative image on the temporary receiver sheet. These steps are optionally repeated with another photosensitive element having a different colorant and adhere an image to the image previously produced on the temporary receiver sheet. The temporary receiver sheet is laminated to a permanent receiver sheet via the images with heat and pressure. The temporary receiver sheet is optionally removed.
摘要翻译：一种负面作用的彩色打样方法提供一种具有覆盖片的感光元件; 具有酚基的聚合物的脱模层; 具有粘合剂，可聚合单体，着色剂和任选的光引发剂的着色层; 具有不饱和，可光交联的基团和分子量大于约3,000的光敏聚合物，具有至少一个不饱和基团的可聚合单体和任选的光引发剂的光引发剂层。所述着色层和所述光引发层中的至少一个具有光引发剂; 和第一热塑性粘合剂层。将光掩模施加到热塑性粘合剂层上，并且一个成像方式将着色层和光致粘合层暴露于通过光掩模的光化辐射。在去除光掩模之后，感光元件层压到临时接收器上。在剥离临时接收器和盖板之后，彩色层的暴露区域附着到临时接收器，并且用盖片去除未曝光的区域，从而在临时接收片材上形成着色的负像。可选地，使用具有不同着色剂的另一光敏元件重复这些步骤，并将图像粘附到先前在临时接收片上产生的图像上。临时接收片通过热和压力的图像层压到永久接收片上。可选地删除临时接收片。

7. 发明授权

US5039590A Coating positive or negative working color proofing system 失效
标题翻译：涂层正或负工作色彩打样系统
公开(公告)号：US5039590A
公开(公告)日：1991-08-13
申请号：US425373
申请日：1989-10-17
申请人： Stephan J. W. Platzer , Gabor I. Koletar
发明人： Stephan J. W. Platzer , Gabor I. Koletar
IPC分类号： G03F3/10
CPC分类号： G03F3/10
摘要： This invention relates to a single positive or negative working photosensitive layer on a substrate which, upon exposure to an actinic radiation source through a screened image, can accurately reproduce said image after processing and lamination. The construction is useful as a color proofing film which can be employed to predict the image quality from a lithographic printing process.
摘要翻译：本发明涉及一种在衬底上的单一正或负工作感光层，其在通过屏蔽图像曝光于光化辐射源之后，可以在加工和层压之后精确地再现所述图像。该结构可用作可用于从平版印刷工艺预测图像质量的防色膜。

8. 发明授权

US4751166A Negative working diazo color proofing method 失效
标题翻译：负面工作重氮色彩打样方法
公开(公告)号：US4751166A
公开(公告)日：1988-06-14
申请号：US906483
申请日：1986-09-12
申请人： Stephan J. Platzer , Gabor I. Koletar
发明人： Stephan J. Platzer , Gabor I. Koletar
IPC分类号： G03F3/10 , G03C1/54 , G03C1/60 , G03C1/76 , G03C1/80
CPC分类号： G03F3/10
摘要： This invention relates to negative photosensitized sheet contructions which, upon exposure to an actinic radiation source through a screened image, can accurately reproduce said image. The construction is useful as a color proofing film which can be employed to predict the image quality from a lithographic printing process.
摘要翻译：本发明涉及负光敏片材引用，其通过经过筛选的图像曝光于光化辐射源，可以精确地再现所述图像。该结构可用作可用于从平版印刷工艺预测图像质量的防色膜。

9. 发明授权

US4659642A Positive working naphthoquinone diazide color proofing transfer process 失效
标题翻译：正性工作萘醌二氮嗪色彩打样转印工艺
公开(公告)号：US4659642A
公开(公告)日：1987-04-21
申请号：US663607
申请日：1984-10-22
申请人： Stephan J. W. Platzer , Gabor I. Koletar , Richard L. Shadrach
发明人： Stephan J. W. Platzer , Gabor I. Koletar , Richard L. Shadrach
IPC分类号： G03F7/26 , G03C1/00 , G03C1/72 , G03C5/00 , G03F3/10 , G03F7/004 , G03F7/023 , G03F7/11
CPC分类号： G03F3/10 , G03F7/0233 , G03F7/11
摘要： This invention relates to positive working photosensitized sheet constructions which, upon exposure to an actinic radiation source through a screened image, can accurately reproduce said image. The construction is useful as a color proofing film which can be employed to predict the image quality from a lithographic printing process.
摘要翻译：本发明涉及正工作光敏片材结构，其在通过屏蔽图像曝光于光化辐射源时可以精确地再现所述图像。该结构可用作可用于从平版印刷工艺预测图像质量的防色膜。

10. 发明授权

US5660968A Negative working, peel developeable, single sheet color proofing system with improved background color 失效
标题翻译：负面工作，可开发的单面彩色打样系统，具有改进的背景颜色
公开(公告)号：US5660968A
公开(公告)日：1997-08-26
申请号：US435906
申请日：1995-05-05
申请人： Wojciech A. Wilczak , Gabor I. Koletar
发明人： Wojciech A. Wilczak , Gabor I. Koletar
IPC分类号： G03F7/004 , G03F3/10 , G03F7/027 , G03F7/028 , G03F7/34 , G03C3/00
CPC分类号： G03F3/102 , G03F7/028 , Y10S430/114 , Y10S430/116 , Y10S430/12 , Y10S430/121
摘要： In the present invention, one produces a negative-acting color proofing element comprising, sequentially: a strippable cover sheet which is transparent to actinic radiation; a crosslinked layer containing a polymer having phenolic groups; a color layer, containing a colorant, a polymeric binder, a polymerizable monomer and, optionally, a photoinitiator; a photoadhering layer, containing a linear photosensitive polymer containing ethylenically unsaturated, free-radical polymerizable groups and having a weight average molecular weight greater than 3,000, a polymerizable monomer, and, optionally, a free radical photoinitiator, a thermoplastic adhesive layer; and a receiver sheet, at least one of the color layer and the photoadhering layer containing a photoinitiator, which is brightener.
摘要翻译：在本发明中，产生负作用的着色元件，其顺序地包括：对光化辐射透明的可剥离覆盖片; 含有酚基的聚合物的交联层; 包含着色剂，聚合物粘合剂，可聚合单体和任选的光引发剂的着色层; 含有含有烯属不饱和的自由基聚合性基团，重均分子量大于3,000的线性光敏聚合物，可聚合单体和任选的自由基光引发剂，热塑性粘合剂层的光引发层; 和接收片，所述着色层和所述光分解层中的至少一个含有光引发剂，所述光引发剂是增白剂。

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