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1. 发明授权

US06972324B2 Antibodies specific for CD44v6 有权
公开(公告)号：US06972324B2
公开(公告)日：2005-12-06
申请号：US10147849
申请日：2002-05-20
申请人： Günther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Günther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
IPC分类号： C07K16/28 , C07K16/00
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.

2. 发明授权

US07417127B2 Antibodies specific for CD44v6 有权
标题翻译： CD44v6特异性抗体
公开(公告)号：US07417127B2
公开(公告)日：2008-08-26
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
IPC分类号： C12P21/08
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译：本发明属于肿瘤学领域。本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。本发明还提供编码所述抗体蛋白质的核酸分子。本发明还涉及生产所述抗体蛋白质的方法。本发明还提供包含所述抗体蛋白质的药物组合物。本发明还涉及在制备用于治疗癌症的药物中的用途。

3. 发明申请

US20050214212A1 Antibodies specific for CD44v6 有权
标题翻译： CD44v6特异性抗体
公开(公告)号：US20050214212A1
公开(公告)日：2005-09-29
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John Miglietta , Augustinus Antonius Van Dongen
IPC分类号： C07K16/28 , A61K51/00 , A61K39/395 , C07H21/04 , C12N15/09 , C12P21/06
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译：本发明属于肿瘤学领域。本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。本发明还提供编码所述抗体蛋白质的核酸分子。本发明还涉及生产所述抗体蛋白质的方法。本发明还提供包含所述抗体蛋白质的药物组合物。本发明还涉及在制备用于治疗癌症的药物中的用途。

4. 发明授权

US08568727B2 Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them 有权
标题翻译：对成纤维细胞活化蛋白和含有它们的免疫缀合物的抗体分子
公开(公告)号：US08568727B2
公开(公告)日：2013-10-29
申请号：US12159070
申请日：2006-12-22
申请人： Guenther Adolf , Elinborg Ostermann , Milena Kalat , Karl-Heinz Heider
发明人： Guenther Adolf , Elinborg Ostermann , Milena Kalat , Karl-Heinz Heider
IPC分类号： A61K39/395 , C07K1/107 , C07K16/00
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6871 , C07K2317/24 , C07K2317/33 , C07K2317/92
摘要： Anti-FAP-antibodies and immunoconjugates, pharmaceutical compositions containing such conjugates, and their use in cancer therapy.
摘要翻译：抗FAP抗体和免疫偶联物，含有这些缀合物的药物组合物及其在癌症治疗中的应用。

5. 发明申请

US20090304718A1 Antibody Molecules Specific for Fibroblast Activation Protein and Immunoconjugates Containing Them 有权
标题翻译：成纤维细胞活化蛋白和含有免疫偶联物的抗体分子
公开(公告)号：US20090304718A1
公开(公告)日：2009-12-10
申请号：US12159070
申请日：2006-12-22
申请人： Guenther Adolf , Elinborg Ostermann , Milena Kalat , Karl-Heinz Heider
发明人： Guenther Adolf , Elinborg Ostermann , Milena Kalat , Karl-Heinz Heider
IPC分类号： A61K39/395 , C07K16/00 , C07K1/107 , A61P35/00 , A61P37/00
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6871 , C07K2317/24 , C07K2317/33 , C07K2317/92
摘要： Anti-FAP-antibodies and immunoconjugates, pharmaceutical compositions containing such conjugates, and their use in cancer therapy.
摘要翻译：抗FAP抗体和免疫偶联物，含有这些缀合物的药物组合物及其在癌症治疗中的应用。

6. 发明申请

US20100189722A1 ANTI CD37 ANTIBODIES 审中-公开
标题翻译：抗CD37抗体
公开(公告)号：US20100189722A1
公开(公告)日：2010-07-29
申请号：US12672378
申请日：2008-08-08
申请人： Karl-Heinz Heider , Eric Borges , Elinborg Ostermann
发明人： Karl-Heinz Heider , Eric Borges , Elinborg Ostermann
IPC分类号： A61K39/395 , C07K16/16 , C07H21/04 , C12N15/74 , C12N5/10 , C12P21/00 , A61P35/00 , A61P35/02
CPC分类号： C07K16/28 , A01K67/0275 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Chimeric and humanized anti-CD37 antibodies and pharmaceutical compositions containing them are useful for the treatment of B cell malignancies and autoimmune and inflammatory diseases that involve B cells in their pathology.
摘要翻译：嵌合和人源化抗CD37抗体和含有它们的药物组合物可用于治疗涉及B细胞病理学的B细胞恶性肿瘤和自身免疫性和炎性疾病。

7. 发明申请

US20100196395A1 ANTI-IGF ANTIBODIES 有权
标题翻译：抗IGF抗体
公开(公告)号：US20100196395A1
公开(公告)日：2010-08-05
申请号：US12665373
申请日：2008-06-19
申请人： Paul Adam , Elinborg Ostermann
发明人： Paul Adam , Elinborg Ostermann
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/74 , C12N5/10 , C12P21/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Antibody molecules, in particular fully human antibodies that bind to human IGF-1 and cross-react with IGF-2 such that binding of IGF-1 and IGF-2 to the IGF-1 receptor is prevented and IGF-1 receptor-mediated signaling is inhibited. The antibodies do not bind to insulin and thus do not affect the mitogenic properties of insulin that are mediated by its binding to the insulin receptors. The antibodies are useful for the treatment of hyperproliferative diseases, in particular cancer.
摘要翻译：抗体分子，特别是与人IGF-1结合并与IGF-2交叉反应的完全人类抗体，使得IGF-1和IGF-2与IGF-1受体的结合被阻止，并且IGF-1受体介导的信号传导被抑制。抗体不结合胰岛素，因此不影响胰岛素与胰岛素受体结合介导的促有丝分裂特性。抗体可用于治疗过度增生性疾病，特别是癌症。

8. 发明授权

US06759211B1 Tumor growth inhibition- and apoptosis-associated genes and polypeptides and methods of use thereof 失效
标题翻译：肿瘤生长抑制和凋亡相关基因和多肽及其使用方法
公开(公告)号：US06759211B1
公开(公告)日：2004-07-06
申请号：US09462625
申请日：2000-07-28
申请人： Georgii Georgiev , Sergei Kiselev , Egor Prokhorchouk , Elinborg Ostermann
发明人： Georgii Georgiev , Sergei Kiselev , Egor Prokhorchouk , Elinborg Ostermann
IPC分类号： C12P2106
CPC分类号： C07K14/525 , A61K38/00
摘要： The present invention is generally directed to the identification of mouse and human genes that inhibit the growth of a tumor and induce apoptosis in cancer cells, and to polypeptides encoded by such genes. In particular, the invention concerns the nucleotide sequence of one such tumor-inhibiting gene, tag7, and the amino acid sequence of a polypeptide encoded by tag7. The invention also provides isolated nucleic acid molecules comprising tag7 polynucleotides, and vectors and host cells comprising these isolated nucleic acid molecules. The invention also provides methods of producing tag7 polynucleotides using these nucleic acid molecules, vectors and host cells, tag7 polypeptides made by three methods and antibodies that specifically bind to the tag7 polypeptide. The invention also concerns methods of inhibiting tumor growth and inducing tumor cell apoptosis, and methods of cancer therapy, using the present tag7 nucleic acid molecules and polypeptides.
摘要翻译：本发明一般涉及抑制肿瘤生长和诱导癌细胞凋亡的小鼠和人基因以及由这些基因编码的多肽的鉴定。特别地，本发明涉及一种这样的肿瘤抑制基因tag7的核苷酸序列，以及由tag7编码的多肽的氨基酸序列。本发明还提供包含tag7多核苷酸的分离的核酸分子，以及包含这些分离的核酸分子的载体和宿主细胞。本发明还提供了使用这些核酸分子，载体和宿主细胞，通过三种方法制备的tag7多肽和特异性结合tag7多肽的抗体产生tag7多核苷酸的方法。本发明还涉及使用本发明的tag7核酸分子和多肽抑制肿瘤生长和诱导肿瘤细胞凋亡的方法以及癌症治疗的方法。

9. 发明授权

US5589371A Human manganese superoxide dismutase (hMn-SOD) 失效
公开(公告)号：US5589371A
公开(公告)日：1996-12-31
申请号：US413367
申请日：1995-03-30
申请人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
发明人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
IPC分类号： C12N1/20 , A61K38/44 , A61K38/45 , A61P29/00 , A61P37/08 , C07H21/04 , C07K14/00 , C12N1/16 , C12N1/19 , C12N1/21 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/62 , C12P21/00 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C12N9/0089 , C12N15/625 , C07K2319/02 , C07K2319/07
摘要： The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.

10. 发明授权

US5240847A Human manganese superoxide dismutase (hMn-SOD) 失效
标题翻译：人造锰超氧化物歧化酶（HMN-SOD）
公开(公告)号：US5240847A
公开(公告)日：1993-08-31
申请号：US167261
申请日：1988-03-11
申请人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
发明人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
IPC分类号： C12N1/20 , A61K38/44 , A61K38/45 , A61P29/00 , A61P37/08 , C07H21/04 , C07K14/00 , C12N1/16 , C12N1/19 , C12N1/21 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/62 , C12P21/00 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C12N9/0089 , C12N15/625 , C07K2319/02 , C07K2319/07
摘要： The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.
摘要翻译：本发明涉及通过遗传工程制备人类Mn超氧化物歧化酶（hMn-SOD）的方法，编码该酶的DNA序列，含有这些DNA序列的合适载体和可表达这些DNA序列的宿主细胞，以及酶hMn-SOD本身。还描述了关于使用该酶的建议。

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