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1. 发明授权

US06759211B1 Tumor growth inhibition- and apoptosis-associated genes and polypeptides and methods of use thereof 失效
标题翻译：肿瘤生长抑制和凋亡相关基因和多肽及其使用方法
公开(公告)号：US06759211B1
公开(公告)日：2004-07-06
申请号：US09462625
申请日：2000-07-28
申请人： Georgii Georgiev , Sergei Kiselev , Egor Prokhorchouk , Elinborg Ostermann
发明人： Georgii Georgiev , Sergei Kiselev , Egor Prokhorchouk , Elinborg Ostermann
IPC分类号： C12P2106
CPC分类号： C07K14/525 , A61K38/00
摘要： The present invention is generally directed to the identification of mouse and human genes that inhibit the growth of a tumor and induce apoptosis in cancer cells, and to polypeptides encoded by such genes. In particular, the invention concerns the nucleotide sequence of one such tumor-inhibiting gene, tag7, and the amino acid sequence of a polypeptide encoded by tag7. The invention also provides isolated nucleic acid molecules comprising tag7 polynucleotides, and vectors and host cells comprising these isolated nucleic acid molecules. The invention also provides methods of producing tag7 polynucleotides using these nucleic acid molecules, vectors and host cells, tag7 polypeptides made by three methods and antibodies that specifically bind to the tag7 polypeptide. The invention also concerns methods of inhibiting tumor growth and inducing tumor cell apoptosis, and methods of cancer therapy, using the present tag7 nucleic acid molecules and polypeptides.
摘要翻译：本发明一般涉及抑制肿瘤生长和诱导癌细胞凋亡的小鼠和人基因以及由这些基因编码的多肽的鉴定。特别地，本发明涉及一种这样的肿瘤抑制基因tag7的核苷酸序列，以及由tag7编码的多肽的氨基酸序列。本发明还提供包含tag7多核苷酸的分离的核酸分子，以及包含这些分离的核酸分子的载体和宿主细胞。本发明还提供了使用这些核酸分子，载体和宿主细胞，通过三种方法制备的tag7多肽和特异性结合tag7多肽的抗体产生tag7多核苷酸的方法。本发明还涉及使用本发明的tag7核酸分子和多肽抑制肿瘤生长和诱导肿瘤细胞凋亡的方法以及癌症治疗的方法。

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