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1. 发明授权

US06727451B1 Method and device for manipulating microparticles in fluid flows 有权
标题翻译：用于操纵流体流中微粒的方法和装置
公开(公告)号：US06727451B1
公开(公告)日：2004-04-27
申请号：US09673034
申请日：2000-11-30
申请人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
发明人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
IPC分类号： B01D5702
CPC分类号： B03C5/026 , C12M47/04
摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.
摘要翻译：为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向（17）。结果，微粒可以在流动流体之间来回移动。优选的应用包括处理，分离，分选或限制程序。

2. 发明授权

US06492175B1 Microsystem for cell permeation and cell fusion 有权
标题翻译：用于细胞渗透和细胞融合的微系统
公开(公告)号：US06492175B1
公开(公告)日：2002-12-10
申请号：US09868022
申请日：2001-08-06
申请人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
发明人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
IPC分类号： C12N1502
CPC分类号： C12N15/87 , C12M35/02 , C12N13/00
摘要： An electroporation and/or fusion treatment of microscopic objects occurs in a medium between at least two electrodes, with the electrodes being miniaturized electrodes in a microsystem with a channel structure which is set up for the flow-through of the medium with the objects.
摘要翻译：在至少两个电极之间的介质中发生微观物体的电穿孔和/或融合处理，其中电极是具有通道结构的微系统中的小型化电极，其被设置用于具有物体的介质的流过。

3. 发明授权

US07070684B1 Electrode arrangement for generating functional field barriers in microsystems 失效
标题翻译：用于在微系统中产生功能场屏障的电极装置
公开(公告)号：US07070684B1
公开(公告)日：2006-07-04
申请号：US09720275
申请日：1999-06-28
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01F13/0076 , B01F13/0077 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B03C5/026 , C12M33/00 , C12M47/04
摘要： A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.
摘要翻译：一种适用于悬浮液中颗粒的介电电泳操作的微系统，其中微系统具有通道壁和纵向延伸的通道。存在在至少一个通道壁上具有至少一个微电极的电极布置。这用于产生至少部分穿过通道的场屏障。微电极具有带状或具有彼此连接的多个直电极部分。带状具有预定的曲率或直线电极部分以预定的不同角度布置，使得场屏障相对于通道的纵向延伸具有预定的曲率。

4. 发明授权

US06749736B1 Electrode arrangement for the dielectrophoretic diversion of particles 有权
标题翻译：用于介电电泳转移颗粒的电极布置
公开(公告)号：US06749736B1
公开(公告)日：2004-06-15
申请号：US09720222
申请日：2001-02-22
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27453
CPC分类号： B03C5/026 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0825 , B01L2400/0409 , B01L2400/0415 , B01L2400/0424 , B01L2400/0457 , B03C5/005 , B03C2201/26 , C12M33/00 , C12M35/02 , C12M47/04
摘要： Electrode arrangement (10) in a microsystem adapted for dielectrophoretic manipulation of particles (30) in a suspension fluid in a channel (21), wherein at least one electrode (11, 11a, 11b, 12) is arranged on a lateral wall of the channel (21), the electrode (11, 11a, 11b, 12) consisting of a plurality of electrode segments adapted to generate at least one field gradient for influencing the movement paths of the particles (30) in the channel (21). In one embodiment of the invention, the particles are moved in the microsystem by exposure to centrifugal and/or gravitational forces.
摘要翻译：在微系统中的电极装置（10），其适用于在通道（21）中的悬浮液中的颗粒（30）的介电电泳操作，其中至少一个电极（11,11a，11b，12）布置在所述通道通道（21），由多个电极段组成的电极（11,11a，11b，12），其适于产生用于影响通道（21）中的颗粒（30）的运动路径的至少一个场梯度。在本发明的一个实施方案中，颗粒通过暴露于离心和/或重力而在微系统中移动。

5. 发明授权

US06991906B1 Method and device for measuring, calibrating and using laser tweezers 失效
标题翻译：用于测量，校准和使用激光镊子的方法和装置
公开(公告)号：US06991906B1
公开(公告)日：2006-01-31
申请号：US09582609
申请日：1998-12-21
申请人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
发明人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： H05H3/04 , G21K1/006
摘要： To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.
摘要翻译：为了在光学保持架的焦点的至少一个颗粒上测量或施加光学诱导的力，采取以下步骤：a）焦点位于具有场梯度的三维电场的微电极布置中，形成电捕获区域，并且聚焦距离捕获的距离为b）电场的幅度，形成光学笼的光束的光功率和/或捕获区域距离改变焦点以检测哪个变化的场性质将粒子从焦点移动到捕获区域，反之亦然，或至少临时将颗粒移动到捕获区域中。

6. 发明授权

US06801311B1 Process and device for the detection of microscopically small objects 有权
标题翻译：检测微小物体的过程和设备
公开(公告)号：US06801311B1
公开(公告)日：2004-10-05
申请号：US09889908
申请日：2001-12-12
申请人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
IPC分类号： G01N1502
CPC分类号： B03C5/028 , B03C5/026 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N2015/1006 , G01N2015/105 , G01N2015/1075 , G01N2015/1415 , G01N2015/1447 , G01N2015/1495
摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.
摘要翻译：对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10）至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

7. 发明授权

US06465225B1 Method and device for manipulating particles in microsystems 失效
标题翻译：在微系统中操纵粒子的方法和装置
公开(公告)号：US06465225B1
公开(公告)日：2002-10-15
申请号：US09720219
申请日：2001-02-22
申请人： Günter Fuhr , Rolf Hagedorn
发明人： Günter Fuhr , Rolf Hagedorn
IPC分类号： C12N1300
CPC分类号： B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0825 , B01L2400/0409 , B01L2400/0415 , B01L2400/0424 , B01L2400/0457 , B03C5/026 , Y10S977/904
摘要： For manipulation of particles in a fluidic microsystem (15) in which the particles are moved in a predetermined reference direction in a suspension liquid, the microsystem (15) is closed off at least at its end (17a, 17b) pointing to the reference direction. The particles move under the influence of centrifugal forces and/or gravitational forces in the suspension liquid which is stationary in relation to the microsystem (15), with the centrifugal forces and/or gravitational forces essentially extending parallel to the reference direction. Furthermore, the particles in the microsystem (15) are exposed to deflection forces whose direction differs from that of the reference direction. (FIG. 1).
摘要翻译：为了在流体微系统（15）中处理颗粒，其中颗粒在悬浮液体中以预定的参考方向移动，微系统（15）至少在其指向参考方向的端部（17a，17b）处被封闭。在离心力和/或重力作用下，颗粒在离心力和/或重力基本上平行于参考方向延伸的悬浮液中相对于微系统（15）静止的运动。此外，微系统（15）中的颗粒暴露于方向不同于参考方向的偏转力。（图。1）。

8. 发明授权

US06931864B2 Cryostorage method and device 有权
标题翻译：冷藏方法和装置
公开(公告)号：US06931864B2
公开(公告)日：2005-08-23
申请号：US10433691
申请日：2001-12-07
申请人： Günter Fuhr , Rolf Hagedorn , Heiko Zimmermann
发明人： Günter Fuhr , Rolf Hagedorn , Heiko Zimmermann
IPC分类号： A01N1/02 , B01L3/00 , B01L7/00 , G01N1/42 , F25D25/00 , C12M1/00 , C12M3/00 , G06F17/00
CPC分类号： B01L3/5085 , A01N1/02 , A01N1/0263 , A01N1/0268 , B01L7/00 , G01N1/42
摘要： With a method for cryo-preservation, at least one specimen is arranged on a storage substrate and specimen data, which are characteristic for features of the specimen, are stored at specific positions. Also, a storage substrate for cryo-preservation with such a method is described.
摘要翻译：采用低温保存方法，将至少一个样本设置在存储基板上，并且将样本特征的样本数据存储在特定位置。此外，描述了用于这种方法的用于低温保存的存储基板。

9. 发明授权

US06646238B1 Method and device for a accomodating samples on cryosubstrates 有权
标题翻译：用于在低温底物上容纳样品的方法和装置
公开(公告)号：US06646238B1
公开(公告)日：2003-11-11
申请号：US10009911
申请日：2002-03-19
申请人： Günter Fuhr , Rolf Hagedorn
发明人： Günter Fuhr , Rolf Hagedorn
IPC分类号： H05B306
CPC分类号： G01N1/42
摘要： For sample picking on a cryosubstrate, on which multiple cryopreserved samples are each positioned at preselected sample positions, individual samples are selectively separated mechanically or thermally from the cryosubstrate and transferred to a target substrate.
摘要翻译：对于低温基板上的样品采集，多个冷冻保存样品各自定位在预先选定的样品位置，单独的样品选择性地与冷冻底物分离或分离，并转移到靶基质。

10. 发明授权

US06542778B1 Process and device for permeation of biological objects 失效
标题翻译：生物体渗透过程和装置
公开(公告)号：US06542778B1
公开(公告)日：2003-04-01
申请号：US09718797
申请日：2000-11-22
申请人： Günter Fuhr , Ulrich Zimmermann , Rolf Hagedorn
发明人： Günter Fuhr , Ulrich Zimmermann , Rolf Hagedorn
IPC分类号： A61N118
CPC分类号： C12M35/02 , A61N1/325
摘要： A process for treating a biological or synthetic object subjected to an electrical field in a surrounding liquid medium for a predetermined pulse time (t1), the electrical field being formed by at least two electrodes including actuating at least once during the pulse time (t1) each of the electrodes as an anode and as a cathode, to cause at each electrode a polarity reversal and alternating electrolytic increases and reductions in pH of at least a portion of the liquid medium, subjecting the object during the pulse time (t1) to a number of electrical partial pulses which have a frequency in the range of 1 kHz to 1 MHz and which possess partial pulse durations, with sequentially reversing polarity or field direction such that the partial pulses possess sequentially varying partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes, and selecting the partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes such that, due to the electrolytic increases and reductions in pH value, substantially equal H+ and OH− ion concentrations are created.
摘要翻译：一种用于在预定脉冲时间（t1）下处理在周围液体介质中受到电场的生物或合成物体的过程，所述电场由至少两个电极形成，包括在脉冲时间（t1）期间至少致动一次，每个电极作为阳极和阴极，在每个电极处引起极性反转和交替电解增加并降低液体介质的至少一部分的pH值，在脉冲时间（t1）期间使物体经受具有频率在1kHz至1MHz范围内且具有部分脉冲持续时间的电部分脉冲数，具有顺序反转的极性或场方向，使得部分脉冲具有顺序变化的部分脉冲持续时间（t11，t12），脉冲形式和/或脉冲幅度，以及选择部分脉冲持续时间（t11，t12），脉冲形式和/或脉冲幅度，使得由于电解增加和再次产生pH值范围内的基本相等的H +和OH-离子浓度。

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