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1. 发明授权

US07070684B1 Electrode arrangement for generating functional field barriers in microsystems 失效
标题翻译：用于在微系统中产生功能场屏障的电极装置
公开(公告)号：US07070684B1
公开(公告)日：2006-07-04
申请号：US09720275
申请日：1999-06-28
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01F13/0076 , B01F13/0077 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B03C5/026 , C12M33/00 , C12M47/04
摘要： A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.
摘要翻译：一种适用于悬浮液中颗粒的介电电泳操作的微系统，其中微系统具有通道壁和纵向延伸的通道。存在在至少一个通道壁上具有至少一个微电极的电极布置。这用于产生至少部分穿过通道的场屏障。微电极具有带状或具有彼此连接的多个直电极部分。带状具有预定的曲率或直线电极部分以预定的不同角度布置，使得场屏障相对于通道的纵向延伸具有预定的曲率。

2. 发明授权

US06727451B1 Method and device for manipulating microparticles in fluid flows 有权
标题翻译：用于操纵流体流中微粒的方法和装置
公开(公告)号：US06727451B1
公开(公告)日：2004-04-27
申请号：US09673034
申请日：2000-11-30
申请人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
发明人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
IPC分类号： B01D5702
CPC分类号： B03C5/026 , C12M47/04
摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.
摘要翻译：为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向（17）。结果，微粒可以在流动流体之间来回移动。优选的应用包括处理，分离，分选或限制程序。

3. 发明授权

US06749736B1 Electrode arrangement for the dielectrophoretic diversion of particles 有权
标题翻译：用于介电电泳转移颗粒的电极布置
公开(公告)号：US06749736B1
公开(公告)日：2004-06-15
申请号：US09720222
申请日：2001-02-22
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27453
CPC分类号： B03C5/026 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0825 , B01L2400/0409 , B01L2400/0415 , B01L2400/0424 , B01L2400/0457 , B03C5/005 , B03C2201/26 , C12M33/00 , C12M35/02 , C12M47/04
摘要： Electrode arrangement (10) in a microsystem adapted for dielectrophoretic manipulation of particles (30) in a suspension fluid in a channel (21), wherein at least one electrode (11, 11a, 11b, 12) is arranged on a lateral wall of the channel (21), the electrode (11, 11a, 11b, 12) consisting of a plurality of electrode segments adapted to generate at least one field gradient for influencing the movement paths of the particles (30) in the channel (21). In one embodiment of the invention, the particles are moved in the microsystem by exposure to centrifugal and/or gravitational forces.
摘要翻译：在微系统中的电极装置（10），其适用于在通道（21）中的悬浮液中的颗粒（30）的介电电泳操作，其中至少一个电极（11,11a，11b，12）布置在所述通道通道（21），由多个电极段组成的电极（11,11a，11b，12），其适于产生用于影响通道（21）中的颗粒（30）的运动路径的至少一个场梯度。在本发明的一个实施方案中，颗粒通过暴露于离心和/或重力而在微系统中移动。

4. 发明授权

US06801311B1 Process and device for the detection of microscopically small objects 有权
标题翻译：检测微小物体的过程和设备
公开(公告)号：US06801311B1
公开(公告)日：2004-10-05
申请号：US09889908
申请日：2001-12-12
申请人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Christoph Reichle , Henning Glasser , Torsten Müller
IPC分类号： G01N1502
CPC分类号： B03C5/028 , B03C5/026 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N2015/1006 , G01N2015/105 , G01N2015/1075 , G01N2015/1415 , G01N2015/1447 , G01N2015/1495
摘要： For object detection, particularly in fluidic microsystems, optical imaging of at least one resting or moving object (10) on a structured mask (20) with at least one segment from a flat section (80), in which the object (10) is located at least partially or temporarily and which has a characteristic dimension smaller than the dimension of the object (10) or its movement path, to a detector unit, detection of the quantity of light transmitted by the structured mask (20), and generation of a detector signal which has a predetermined relationship with the quantity of light, and evaluation of the detector signal in regard to the presence of the object (10), its position, its shape and/or the temporal change of the position are performed.
摘要翻译：对于物体检测，特别是在流体微系统中，至少一个静止或移动的物体（10）在结构化掩模（20）上的光学成像，其具有来自平坦部分（80）的至少一个部分，其中物体（10）至少部分地或临时地定位，并且具有比物体（10）或其移动路径的尺寸小的特征尺寸，到检测器单元，由结构化掩模（20）传输的光量的检测，以及执行与光量具有预定关系的检测器信号，以及关于物体（10）的存在，其位置，形状和/或位置的时间变化的检测器信号的评估。

5. 发明授权

US06492175B1 Microsystem for cell permeation and cell fusion 有权
标题翻译：用于细胞渗透和细胞融合的微系统
公开(公告)号：US06492175B1
公开(公告)日：2002-12-10
申请号：US09868022
申请日：2001-08-06
申请人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
发明人： Torsten Müller , Thomas Schnelle , Günter Fuhr , Stephen Graham Shirley , Gabriele Gradl
IPC分类号： C12N1502
CPC分类号： C12N15/87 , C12M35/02 , C12N13/00
摘要： An electroporation and/or fusion treatment of microscopic objects occurs in a medium between at least two electrodes, with the electrodes being miniaturized electrodes in a microsystem with a channel structure which is set up for the flow-through of the medium with the objects.
摘要翻译：在至少两个电极之间的介质中发生微观物体的电穿孔和/或融合处理，其中电极是具有通道结构的微系统中的小型化电极，其被设置用于具有物体的介质的流过。

6. 发明授权

US06991906B1 Method and device for measuring, calibrating and using laser tweezers 失效
标题翻译：用于测量，校准和使用激光镊子的方法和装置
公开(公告)号：US06991906B1
公开(公告)日：2006-01-31
申请号：US09582609
申请日：1998-12-21
申请人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
发明人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： H05H3/04 , G21K1/006
摘要： To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.
摘要翻译：为了在光学保持架的焦点的至少一个颗粒上测量或施加光学诱导的力，采取以下步骤：a）焦点位于具有场梯度的三维电场的微电极布置中，形成电捕获区域，并且聚焦距离捕获的距离为b）电场的幅度，形成光学笼的光束的光功率和/或捕获区域距离改变焦点以检测哪个变化的场性质将粒子从焦点移动到捕获区域，反之亦然，或至少临时将颗粒移动到捕获区域中。

7. 发明申请

US20120305398A1 METHODS AND DEVICES FOR SEPARATING PARTICLES IN A LIQUID FLOW 有权
标题翻译：用于在液体流中分离颗粒的方法和装置
公开(公告)号：US20120305398A1
公开(公告)日：2012-12-06
申请号：US13586988
申请日：2012-08-16
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01D43/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）相对于液体沿偏转方向移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

8. 发明授权

US06663757B1 Method and device for the convective movement of liquids in microsystems 失效
标题翻译：微系统中液体对流运动的方法和装置
公开(公告)号：US06663757B1
公开(公告)日：2003-12-16
申请号：US09868199
申请日：2001-08-06
申请人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01L300
CPC分类号： B01F13/0076 , B01F3/1235 , B01F13/0077 , F15D1/02
摘要： The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial section of the channel, subjected to an electric field gradient and optionally to a thermal gradient. The gradients are generated in the partial section corresponding to a predetermined field direction, whereby the field direction differs from the channel direction.
摘要翻译：本发明的目的是对流地移动包括预定通道方向的微系统的通道中的至少一个液体。为此，液体在通道的部分部分中经历电场梯度并且任选地经受热梯度。在对应于预定场方向的部分部分中生成梯度，由此场方向与频道方向不同。

9. 发明授权

US08262883B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US08262883B2
公开(公告)日：2012-09-11
申请号：US10549886
申请日：2004-03-17
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01D57/02
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

10. 发明授权

US09149813B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US09149813B2
公开(公告)日：2015-10-06
申请号：US13586988
申请日：2012-08-16
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N27/447 , B03C5/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

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