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1. 发明授权

US08481254B2 Substrate probe for use in measuring enzyme activity 有权
标题翻译：用于测量酶活性的底物探针
公开(公告)号：US08481254B2
公开(公告)日：2013-07-09
申请号：US12675511
申请日：2008-09-08
申请人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
发明人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
IPC分类号： C12Q1/00
CPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/34 , G01N24/088 , G01R33/281 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/5601 , Y02P20/582
摘要： Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.
摘要翻译：能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在活动。或者，通过多维核共振成像方法进行酶活性的成像。

2. 发明申请

US20100248279A1 SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD 有权
标题翻译：基质探针，酶活性检测方法多维核磁共振法和酶活性成像方法
公开(公告)号：US20100248279A1
公开(公告)日：2010-09-30
申请号：US12675511
申请日：2008-09-08
申请人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
发明人： Fumio Yamauchi , Kimihiro Yoshimura , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama , Shinsuke Sando
IPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/37
CPC分类号： C12Q1/54 , C12Q1/32 , C12Q1/34 , G01N24/088 , G01R33/281 , G01R33/4633 , G01R33/465 , G01R33/483 , G01R33/5601 , Y02P20/582
摘要： Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.
摘要翻译：能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在活动。或者，通过多维核共振成像方法进行酶活性的成像。

3. 发明授权

US08773126B2 Nuclear magnetic resonance measuring method using an isotope-labeled compound 有权
标题翻译：使用同位素标记化合物的核磁共振测量方法
公开(公告)号：US08773126B2
公开(公告)日：2014-07-08
申请号：US12676239
申请日：2008-09-08
申请人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： G01V3/00 , G01R33/485 , G01R33/46 , G01R33/483 , G01R33/56
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.
摘要翻译：本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以将空间位置信息附加到上述核磁共振信号，因此装置。

4. 发明申请

US20100247444A1 COMPOUND, DIAGNOSTIC AGENT, NUCLEAR MAGNETIC RESONANCE ANALYSIS METHOD, NUCLEAR MAGNETIC RESONANCE IMAGING METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY IMAGING METHOD 审中-公开
标题翻译：化合物，诊断剂，核磁共振分析方法，核磁共振成像方法，质谱法和质谱法成像方法
公开(公告)号：US20100247444A1
公开(公告)日：2010-09-30
申请号：US12675581
申请日：2008-09-08
申请人： Kimihiro Yoshimura , Fumio Yamauchi , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Kimihiro Yoshimura , Fumio Yamauchi , Katsuaki Kuge , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： A61K49/10 , C07F9/02 , A61P43/00
CPC分类号： C07C215/40 , A61K49/10 , C07B2200/05 , C07C219/06 , C07F9/091 , C07F9/106 , G01N24/08 , G01R33/4608 , G01R33/5601 , G01R33/5605
摘要： To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15N and 13C and used as a diagnostic agent.
摘要翻译：为了生产不使用具有暴露于放射性和限制处理时间但使用稳定同位素原子的放射性同位素原子的选定生物物质的标记化合物; 并且可以以与稳定同位素原子取代的所选择的生物物质的天然存在的化合物分离地具有良好的灵敏度来测量标记的化合物。胆碱作为生物物质通过用各自的同位素15N和13C替代季铵基团的氮原子和与氮原子连接的甲基的所有碳原子并用作诊断剂进行标记。

5. 发明申请

US20100225314A1 NUCLEAR MAGNETIC RESONANCE MEASURING METHOD 有权
标题翻译：核磁共振测量方法
公开(公告)号：US20100225314A1
公开(公告)日：2010-09-09
申请号：US12676239
申请日：2008-09-08
申请人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
发明人： Katsuaki Kuge , Kimihiro Yoshimura , Fumio Yamauchi , Tetsuya Yano , Masahiro Shirakawa , Yasuhiro Aoyama
IPC分类号： G01R33/44
CPC分类号： G01R33/485 , G01R33/4608 , G01R33/4633 , G01R33/4833 , G01R33/5605 , G01R33/5607
摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.
摘要翻译：本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以将空间位置信息附加到上述核磁共振信号，因此装置。

6. 发明申请

US20080124706A1 Nucleic acid probe, nucleic acid chip, method for detecting target nucleic acid, method for screening drug, apparatus for detecting target nucleic acid, and, gene diagnosis method 审中-公开
标题翻译：核酸探针，核酸芯片，靶核酸检测方法，药物筛选方法，靶核酸检测装置，基因诊断方法
公开(公告)号：US20080124706A1
公开(公告)日：2008-05-29
申请号：US11384858
申请日：2006-03-21
申请人： Yasuhiro Aoyama , Shinsuke Sando , Toshinori Sasaki , Atsushi Narita
发明人： Yasuhiro Aoyama , Shinsuke Sando , Toshinori Sasaki , Atsushi Narita
IPC分类号： C12Q1/68 , C07H21/04 , C12M1/00
CPC分类号： C12Q1/683 , C12Q2525/301 , C12Q2525/161 , C12Q2521/337
摘要： The nucleic acid probe of the invention is a nucleic acid probe for detecting a trace amount of target nucleic acid highly sensitively, highly accurately, and highly quickly, and is designed so that the nucleic acid probe undergoes a conformational change after hybridization to the target nucleic acid and that the nucleic acid probe, which underwent the conformational change, has a decreased binding strength of hybridization and dissociates from the target nucleic acid, where the conformational change comprises forming a self-cleaving nucleic acid enzyme intramolecularly and the self-cleaving nucleic acid enzyme has cleavage activity toward a cleavage portion within the nucleic acid probe's own molecule.
摘要翻译：本发明的核酸探针是用于高灵敏度，高度精确和高度快速检测微量靶核酸的核酸探针，其设计使得核酸探针在与靶核酸杂交后经历构象变化并且经历构象变化的核酸探针具有降低的杂交结合强度并与靶核酸解离，其中构象变化包括分子内形成自切割核酸酶，并且自切割核酸酶对核酸探针自身分子内的切割部分具有切割活性。

7. 发明授权

US06771599B1 Method and unit for control of communication 失效
标题翻译：控制通信的方法和单元
公开(公告)号：US06771599B1
公开(公告)日：2004-08-03
申请号：US09694794
申请日：2000-10-24
申请人： Yasuhiro Aoyama , Yuji Hashimoto
发明人： Yasuhiro Aoyama , Yuji Hashimoto
IPC分类号： G01R3108
CPC分类号： H04L12/5602 , H04L2012/5681
摘要： A communication control method accomplishes minimum bandwidth guarantee and maximum bandwidth restriction and further allocates an extra-bandwidth in accordance with user's contact bandwidth. Fixed-length packets are once stored in corresponding partitions of a buffer in accordance with connection information contained in the packets and then transmits the packets from the storage sections in succession. Retrieval of a connection where the number of transmitted packets does not reach a lower-limit throughput and a packet to be transmitted exists in the corresponding partition is made with first priority, and retrieval is further made in order for a connection where the number of transmitted packets does not reach an intermediate throughput and a connection where the number of transmitted packets does not reach an upper-limit throughput. If the retrieval shows a hit connection, the packets are transmitted from the corresponding partition and one-time retrieval comes to an end.
摘要翻译：通信控制方法实现最小带宽保证和最大带宽限制，并根据用户的接触带宽进一步分配额外带宽。固定长度的数据包根据数据包中包含的连接信息一次存储在缓冲器的相应分区中，然后连续发送存储部分的数据包。在对应的分区中存在传送分组数目未达到下限吞吐量和分组的连接的检索以第一优先级进行，并进一步进行检索，以进行连接，其中发送的数量分组没有达到中间吞吐量和传输分组数未达到上限吞吐量的连接。如果检索显示命中连接，则从相应的分区发送分组，一次性检索结束。

8. 发明授权

US6082760A Air bag apparatus for passenger seat 失效
标题翻译：乘客座椅气囊装置
公开(公告)号：US6082760A
公开(公告)日：2000-07-04
申请号：US58856
申请日：1998-04-13
申请人： Junzo Ukai , Yasuhiro Aoyama , Masahiro Ono
发明人： Junzo Ukai , Yasuhiro Aoyama , Masahiro Ono
IPC分类号： B60R21/215 , B60R21/216 , B60R21/2165 , B60R21/20
CPC分类号： B60R21/2165 , B60R2021/2163
摘要： In an air bag apparatus for a passenger seat, an air bag door has three layers: a door base member, a shell and a foam layer charged between the door base member and the shell. A groove-shaped rib is formed in a rearward end-side portion of the door base member of the air bag door. A grommet is fixed at each of the opposite ends of the rib. A strap formed of a looped resin-made cord formed by knotting the two end portions of the cord is laid in the rib, extending through the grommets. The strap is covered with a heat-shrink tube that prevents degradation of the strap due to influence of a component material of the foam layer.
摘要翻译：在用于乘客座椅的气囊装置中，气囊门具有三层：门基座构件，壳体和充电在门基座构件和壳体之间的泡沫层。在气囊门的门基部件的后端部形成有槽状的肋。索环固定在肋的相对两端。由通过打结绳索的两个端部而形成的环形树脂制的帘线形成的条带放置在肋中，延伸穿过索环。带子被热收缩管覆盖，该热收缩管防止由于泡沫层的组分材料的影响引起的带的劣化。

9. 发明授权

US08659766B2 Image reading apparatus, multifunction printer, and image reading method 有权
标题翻译：图像读取装置，多功能打印机和图像读取方法
公开(公告)号：US08659766B2
公开(公告)日：2014-02-25
申请号：US12955529
申请日：2010-11-29
申请人： Yasuhiro Aoyama , Noriko Takeuchi
发明人： Yasuhiro Aoyama , Noriko Takeuchi
IPC分类号： G06F3/12 , H04N1/40 , H04N1/04 , G11C7/10
CPC分类号： H04N1/053 , H04N1/484 , H04N5/3577 , H04N5/3694 , H04N5/3765 , H04N2201/0094 , H04N2201/02443 , H04N2201/04768 , H04N2201/04774 , H04N2201/04798
摘要： This invention is directed to image reading capable of suppressing EMI unwanted radiation while maintaining image quality. To accomplish this, the following processing is executed when reading an original image by a photoelectric transducer. More specifically, a first driving signal where SSCG spread modulation is applied, and a second driving signal where no SSCG spread modulation is applied are generated from a reference signal. Either the first or second driving signal is selected, and a timing signal for reading the original image is generated based on the selected driving signal. The image signal obtained by the photoelectric transducer is latched using the timing signal. The latched image signal is transferred for subsequent image processing. Upon reading a one-line image original, the second driving signal is selected till the completion of the latch operation, and after the latch operation, the first driving signal is selected for an image signal transfer operation.
摘要翻译：本发明涉及能够在保持图像质量的同时抑制EMI不需要的辐射的图像读取。为了实现这一点，当通过光电传感器读取原始图像时，执行以下处理。更具体地，从参考信号产生施加SSCG扩展调制的第一驱动信号和不施加SSCG扩展调制的第二驱动信号。选择第一或第二驱动信号，并且基于所选择的驱动信号产生用于读取原始图像的定时信号。使用定时信号来锁存由光电变换器获得的图像信号。被锁定的图像信号被传送用于随后的图像处理。在读取单行图像原稿时，选择第二驱动信号直到锁存操作完成，并且在锁存操作之后，选择第一驱动信号进行图像信号传送操作。

10. 发明授权

US5933364A Semiconductor device with a metal layer for supplying a predetermined potential to a memory cell section 有权
标题翻译：具有用于向存储单元部分提供预定电位的金属层的半导体器件
公开(公告)号：US5933364A
公开(公告)日：1999-08-03
申请号：US237853
申请日：1999-01-27
申请人： Yasuhiro Aoyama , Kiyoto Oota , Kazuhiko Shimakawa
发明人： Yasuhiro Aoyama , Kiyoto Oota , Kazuhiko Shimakawa
IPC分类号： H01L27/108 , G11C5/02 , G11C5/06 , G11C5/14 , G11C11/401 , H01L21/8242
CPC分类号： G11C5/14 , G11C5/025 , G11C5/063
摘要： A semiconductor device according to the present invention includes: a semiconductor chip; and memory and logic sections formed on the semiconductor chip. The memory section includes: an array of memory cells; a sense amplifier circuit; and memory interconnects respectively provided in a number n (where n is a positive integer) of interconnect layers. The logic section includes logic circuits having logic interconnects respectively provided in a number n+m (where m is a positive integer) of interconnect layers. A metal layer is formed in one of (n+1)th to (n+m)th interconnect layers, covers the array of memory cells and supplies a predetermined potential to the memory section.
摘要翻译：根据本发明的半导体器件包括：半导体芯片; 以及形成在半导体芯片上的存储器和逻辑部分。存储器部分包括：存储器单元阵列; 一个读出放大器电路; 和分别设置在n个（其中n是正整数））互连层的存储器互连。逻辑部分包括逻辑电路，逻辑电路具有分别以互连层数n + m（其中m为正整数）提供的逻辑互连。在（n + 1）至（n + m）个互连层之一中形成金属层，覆盖存储单元阵列并向存储部分提供预定电位。

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