专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06835714B1 Heterocyclic compounds, intermediates thereof and elastase inhibitors 失效
标题翻译：杂环化合物，其中间体和弹性蛋白酶抑制剂
公开(公告)号：US06835714B1
公开(公告)日：2004-12-28
申请号：US09913538
申请日：2001-08-15
申请人： Fuminori Sato , Yasunao Inoue , Tomoki Omodani , Ryotaro Shiratake , Seiji Honda , Masanobu Komiya , Tadashi Takemura
发明人： Fuminori Sato , Yasunao Inoue , Tomoki Omodani , Ryotaro Shiratake , Seiji Honda , Masanobu Komiya , Tadashi Takemura
IPC分类号： C07K506
CPC分类号： C07D403/12 , A61K38/00 , C07K5/0202 , C07K5/0222 , C07K5/0806 , C07K5/0821 , C07K5/1008
摘要： The present invention relates to a heterocyclic compound of the following formula (I-a), its ester, or a salt thereof, and a human neutrophilic elastase inhibitor containing the same as the active ingredient, etc. wherein A and B are the same or different and each is a lower alkylene group being optionally substituted by an oxo group, D is a heteromonocyclic or heterobicyclic group being optionally substituted by an oxo group, R1 and R2 are the same or different and each is a lower alkyl group, R3 and R4 are different from each other, and each is a hydrogen atom or a hydroxy group, or both combine together to form an oxo group, and R5 is 2-benzoxazolyl, trifluoromethyl, benzylamino-carbonyl, etc.
摘要翻译：本发明涉及下式（Ia）的杂环化合物，其酯或其盐，以及含有与活性成分相同的人嗜中性弹性蛋白酶抑制剂等。其中A和B相同或不同，每个是任选被氧代基取代的低级亚烷基，D是任选被氧代基取代的杂单环或杂双环基团，R 1和R 2相同或不同，并且各自为低级烷基 R 3和R 4彼此不同，各自为氢原子或羟基，或两者结合在一起形成氧代基，R 5为2-苯并恶唑基，三氟甲基，苄基氨基羰基等

2. 发明授权

US06646150B1 Processes for producing (aminomethyl)trifluorocarbinol derivatives 失效
标题翻译：（氨基甲基）三氟甲醇衍生物的制备方法
公开(公告)号：US06646150B1
公开(公告)日：2003-11-11
申请号：US10149674
申请日：2002-06-13
申请人： Fuminori Sato , Tomoki Omodani , Ryotaro Shiratake , Yasunao Inoue , Takashi Deguchi
发明人： Fuminori Sato , Tomoki Omodani , Ryotaro Shiratake , Yasunao Inoue , Takashi Deguchi
IPC分类号： C07C21302
CPC分类号： C07C213/02 , C07C269/06 , Y02P20/55 , C07C215/08 , C07C271/16
摘要： The present invention provides a process for industrially producing (aminomethyl)trifluoromethylcarbinol derivatives, in particularly, optically active compounds thereof, which are useful as starting compounds for drugs such as protease inhibitors, etc.
摘要翻译：本发明提供工业上制备（氨基甲基）三甲基甲醇衍生物的方法，特别是其光学活性化合物，其可用作药物如蛋白酶抑制剂等的起始化合物。

3. 发明申请

US20050085424A1 Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof 失效
标题翻译：具有弹性蛋白酶抑制活性的杂环化合物及其中间体
公开(公告)号：US20050085424A1
公开(公告)日：2005-04-21
申请号：US10502768
申请日：2003-02-05
申请人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
发明人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
IPC分类号： A61K38/00 , A61P11/00 , A61P43/00 , C07K5/06 , A61K38/04 , C07K5/04 , C07D43/02
CPC分类号： C07K5/06191 , A61K38/00
摘要： Heterocyclic compounds represented by the general formula (I) and having elastase inhibiting activity; and intermediates for the synthesis thereof: (I) wherein R1 is a heterocyclic group represented by the general formula (II): (II) [wherein A represents the presence or absence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogen or CH], and the heterocyclic group may be substituted with one to three substituents which may be the same or different and are selected from the group consisting of lower alkyl, lower alkoxy, and phenyl which may be substituted with optionally halogenated lower alkyl, lower alkoxy or halogeno; and R2 and R3 are each hydrogen or hydroxyl, or R2 and R3 may be united to form an oxo group, with the proviso that both are not hydrogen.
摘要翻译：由通式（I）表示的具有弹性蛋白酶抑制活性的杂环化合物; 及其合成中间体：（I）其中R 1为由通式（II）表示的杂环基：（II）[其中A表示苯环的存在或不存在; X是氧，硫或NH; 并且Y是氮或CH]，并且杂环基可以被一至三个可以相同或不同并且选自低级烷基，低级烷氧基和苯基的取代基取代，所述取代基可被任选卤代低级烷基，低级烷氧基或卤素; R 2和R 3各自为氢或羟基，或R 2和R 3可以结合到形成氧代基，条件是两者都不是氢。

4. 发明授权

US06852744B2 Pyrrolidine derivatives and their use as chymase inhibitor 失效
标题翻译：吡咯烷衍生物及其作为胃促胰酶抑制剂的用途
公开(公告)号：US06852744B2
公开(公告)日：2005-02-08
申请号：US10363036
申请日：2001-08-21
申请人： Takashi Deguchi , Ryotaro Shiratake , Fuminori Sato , Buichi Fujitani , Yayoi Honda , Akihiko Kiyoshi , Mitsue Notake , Graham Andrew Showell , Robert George Boyle , Sukhbinder Singh Klair
发明人： Takashi Deguchi , Ryotaro Shiratake , Fuminori Sato , Buichi Fujitani , Yayoi Honda , Akihiko Kiyoshi , Mitsue Notake , Graham Andrew Showell , Robert George Boyle , Sukhbinder Singh Klair
IPC分类号： C12N9/99 , A61K38/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/08 , C07K5/10 , A61K31/42 , A61K31/41 , C07D261/18 , C07D285/06
CPC分类号： C07K5/06026 , A61K38/00 , C07K5/06034 , C07K5/06191 , C07K5/0827 , C07K5/1027
摘要： Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R1 is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substituted or unsubstituted indolyl, benzofuryl, substituted or unsubstituted benzothienyl, etc.; R2 is H, alkyl, phenyl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; R3 is (i) substituted or unsubstituted monocyclic heterocyclic group, (ii) substituted or unsubstituted benzene- or pyridine-fused heterocyclic group, or (iii) a group (a): R4 and R5 are independently H or OH, but R4 and R5 are not simultaneously H, or both form oxo; n is 0, 1, 2 or 3; or a salt thereof.
摘要翻译：新型吡咯烷衍生物可用作合成活性化合物的胃促胰酶抑制剂或中间体，其具有式（I）：其中R 1是环烷基，取代或未取代的苯基或萘基，茚满基，噻吩基，呋喃基，取代或未取代的吲哚基，苯并呋喃基，取代或未取代的苯并噻吩基等; R 2是H，烷基，苯基 - 低级烷基，环烷基或环烷基 - 低级烷基; R 3是（i）取代或未取代的单环杂环基，（ii）取代或未取代的苯 - 或吡啶稠合杂环基，或（iii）基团（a）：R 4和R 5是独立地是H或OH，但R 4和R 5不同时为H，或两者都形成氧代; n为0,1,2或3; 或其盐。

5. 发明授权

US07067491B2 Heterocyclic compounds having elastase-inhibiting activity and intermediates thereof 失效
标题翻译：具有弹性蛋白酶抑制活性的杂环化合物及其中间体
公开(公告)号：US07067491B2
公开(公告)日：2006-06-27
申请号：US10502768
申请日：2003-02-05
申请人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
发明人： Fuminori Sato , Takashi Deguchi , Ryotaro Shiratake , Hiroshi Okazaki , Akemi Kuromiya
IPC分类号： A61K38/00
CPC分类号： C07K5/06191 , A61K38/00
摘要： Heterocyclic compounds represented by the general formula (I) and having elastase inhibiting activity; and intermediates for the synthesis thereof: (I) wherein R1 is a heterocyclic group represented by the general formula (II): (II) [wherein A represents the presence or absence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogen or CH], and the heterocyclic group may be substituted with one to three substituents which may be the same or different and are selected from the group consisting of lower alkyl, lower alkoxy, and phenyl which may be substituted with optionally halogenated lower alkyl, lower alkoxy or halogeno; and R2 and R3 are each hydrogen or hydroxyl, or R2 and R3 may be united to form an oxo group, with the proviso that both are not hydrogen.
摘要翻译：由通式（I）表示的具有弹性蛋白酶抑制活性的杂环化合物; 及其合成中间体：（I）其中R 1为由通式（II）表示的杂环基：（II）[其中A表示苯环的存在或不存在; X是氧，硫或NH; 并且Y是氮或CH]，并且杂环基可以被一至三个可以相同或不同并且选自低级烷基，低级烷氧基和苯基的取代基取代，所述取代基可被任选卤代低级烷基，低级烷氧基或卤素; R 2和R 3各自为氢或羟基，或R 2和R 3可以结合到形成氧代基，条件是两者都不是氢。

6. 发明授权

US07122265B2 Single cell for fuel cell and solid oxide fuel cell 有权
公开(公告)号：US07122265B2
公开(公告)日：2006-10-17
申请号：US10181258
申请日：2001-11-22
申请人： Keiko Kushibiki , Fuminori Sato , Naoki Hara , Mitsugu Yamanaka , Masaharu Hatano , Makoto Uchiyama , Itaru Shibata , Tatsuhiro Fukuzawa
发明人： Keiko Kushibiki , Fuminori Sato , Naoki Hara , Mitsugu Yamanaka , Masaharu Hatano , Makoto Uchiyama , Itaru Shibata , Tatsuhiro Fukuzawa
IPC分类号： H01M8/10 , H01M8/12 , H01M8/02
CPC分类号： H01M8/2425 , H01M8/1213 , H01M8/1226 , H01M8/1231 , H01M8/1286 , H01M8/2404 , H01M8/2432 , H01M2300/0074 , Y02P70/56
摘要： A single cell for a solid oxide fuel cell, in which a solid electrolyte layer is sandwiched by an upper electrode layer and a lower electrode layer. This single cell includes a substrate having openings and an insulating and stress absorbing layer stacked on an upper surface of this substrate. The solid electrolyte layer is formed on an upper surface of the insulating and stress absorbing layer so as to cover the openings, the upper electrode layer is stacked on an upper surface of the solid electrolyte layer, and the lower electrode layer is coated on a lower surface of the solid electrolyte layer via the openings from a lower surface of the substrate. A cell plate, in which these single cells are disposed two-dimensionally on a common substrate. Furthermore, a solid oxide fuel cell, in which these cell plates and plate-shaped separators including gas passages on both surfaces thereof are alternately stacked.

7. 发明申请

US20060030453A1 Structure and manufacturing process for continuously-variable transmission 审中-公开
标题翻译：无级变速器的结构和制造工艺
公开(公告)号：US20060030453A1
公开(公告)日：2006-02-09
申请号：US11189820
申请日：2005-07-27
申请人： Taichirou Yokoyama , Hiroyuki Ochiai , Fuminori Sato
发明人： Taichirou Yokoyama , Hiroyuki Ochiai , Fuminori Sato
IPC分类号： B60W10/04
CPC分类号： F16H61/0009 , F16H61/66259 , F16H2057/0056 , Y10T477/619
摘要： In a continuously-variable transmission, a powertrain is arranged to continuously vary a transmission ratio. An upper body of a control valve unit is disposed at a surface of the control valve unit confronting the powertrain. A lower body of the control valve unit is connected to the upper body. A shift control actuator is arranged to operate in accordance with an electrical signal. A shift control valve is arranged to perform a hydraulic control for the powertrain. A transmission ratio detecting section is arranged to operate mechanically in accordance with variation of the transmission ratio. A link member is disposed adjacent to the upper body and inside a plane of projection of the surface confronting the powertrain, and links the shift control actuator, the shift control valve and the transmission ratio detecting section.
摘要翻译：在无级变速器中，动力传动系被布置成连续变化传动比。控制阀单元的上部设置在面对动力系的控制阀单元的表面。控制阀单元的下部主体连接到上部主体。换档控制致动器被布置成根据电信号进行操作。变速控制阀被布置成对动力系进行液压控制。传动比检测部分被布置成根据传动比的变化机械地操作。连杆构件邻近上体并且位于面对动力系的表面的投影平面内，并且连接变速控制致动器，变速控制阀和变速比检测部。

8. 发明授权

US4749703A Calcium antagonist piperazine derivatives, and compositions therefor 失效
标题翻译：钙拮抗剂哌嗪衍生物及其组合物
公开(公告)号：US4749703A
公开(公告)日：1988-06-07
申请号：US855849
申请日：1986-04-10
申请人： Hitoshi Uno , Mikio Kurokawa , Fuminori Sato , Naonobu Hatano
发明人： Hitoshi Uno , Mikio Kurokawa , Fuminori Sato , Naonobu Hatano
IPC分类号： C07D311/88 , A61K31/00 , A61K31/435 , A61K31/495 , A61K31/55 , A61P3/00 , A61P9/00 , A61P9/10 , A61P9/12 , C07D213/74 , C07D215/38 , C07D219/10 , C07D239/42 , C07D243/00 , C07D277/38 , C07D295/14 , C07D295/15 , C07D313/12 , C07D335/18 , C07D337/00 , C07D337/12 , C07D401/04 , C07D409/12 , A61K31/38 , C07D241/02
CPC分类号： C07D215/38 , C07D213/74 , C07D239/42 , C07D277/38 , C07D295/15 , C07D337/12 , C07D409/12
摘要： Compounds of the formula: ##STR1## wherein A means an alkylene; Y--Z means ##STR2## --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or ##STR3## R.sub.1 and R.sub.2 are each a substituent; R.sub.3 is hydrogen atom, alkyl, or alkoxy; R.sub.4 is phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl, or phenylsulfonyl; a is 2 or 3, b and c are each 1 or 2, and d is an integer of 0 to 2, provided that the phenyl, phenyl moiety and naphthyl may optionally be substituted, and a pharmaceutically acceptable salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. The compounds and salt thereof show potent calcium antagonistic activity and are useful for prophylaxis and treatment of hypertension and/or ischemic heart disease.
摘要翻译： PCT No.PCT / JP85 / 00445 Sec。一九八六年四月十日 102（e）日期1986年4月10日PCT提交1985年8月9日PCT公布。公开号WO86 / 01203 日期：1986年2月27日。下式的化合物：其中A表示亚烷基; Y-Z表示 -CH = CH-，-CH2CH2-或R1，R2和R2各自为取代基; R3是氢原子，烷基或烷氧基; R4是苯基，苯基烷基，苯基链烯基，二苯甲基，萘基，噻唑基，任选取代的吡啶基，任选取代的嘧啶基，喹啉基，苯甲酰基烷基，苯甲酰基，糠酰基，噻吩甲酰基，苯氧基羰基，苯氧基磺酰基或苯基磺酰基; a为2或3，b和c各自为1或2，d为0至2的整数，条件是苯基，苯基部分和萘基可任选被取代，及其药学上可接受的盐，其制备方法及含有该组合物的药物组合物。化合物及其盐显示出有效的钙拮抗活性，可用于预防和治疗高血压和/或缺血性心脏病。

9. 发明授权

US07377510B2 Delivery apparatus and delivery method 有权
标题翻译：送货方式和送货方式
公开(公告)号：US07377510B2
公开(公告)日：2008-05-27
申请号：US10952851
申请日：2004-09-30
申请人： Fuminori Sato
发明人： Fuminori Sato
IPC分类号： B65H5/12
CPC分类号： B65H29/6609 , B65H29/16 , B65H29/40 , B65H2301/15 , B65H2301/44732 , B65H2301/4474 , B65H2301/44765 , B65H2301/4491 , B65H2513/10 , B65H2513/106 , B65H2513/40 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： In a delivery apparatus having a delivery conveyor for receiving and transporting a signature discharged from a printing press, the delivery conveyor is continuously driven if the drive speed of the printing press is higher than a predetermined speed, or the delivery conveyor is intermittently driven if the drive speed of the printing press is lower than the predetermined speed.
摘要翻译：在具有用于接收和运送从印刷机排出的签名的输送输送机的输送装置中，如果印刷机的驱动速度高于预定速度，则传送输送机被连续驱动，或者如果印刷机的驱动速度低于预定速度。

10. 发明授权

US07235807B2 Near field analysis apparatus having irradiation-side guide light and light-collection-side guide light 有权
标题翻译：近场分析装置具有照射侧引导灯和集光侧引导光
公开(公告)号：US07235807B2
公开(公告)日：2007-06-26
申请号：US11316402
申请日：2005-12-22
申请人： Yoshihito Narita , Shigeyuki Kimura , Fuminori Sato , Atsushi Yamada
发明人： Yoshihito Narita , Shigeyuki Kimura , Fuminori Sato , Atsushi Yamada
IPC分类号： G01N21/86
CPC分类号： G01Q60/22
摘要： A near field analysis apparatus comprising: an irradiation optical system comprising an irradiation-side adjustable optical system for adjusting the position or angle of an optical axis thereof, and irradiating irradiation-side guide light onto an adjustment surface via the irradiation-side adjustable optical system; a light collecting optical system comprising a light-collection-side adjustable optical system for adjusting the position or angle of an optical axis thereof, and irradiating light-collection-side guide light onto the adjustment surface via the light-collection-side adjustable optical system; an irradiation-side adjustment device for adjusting the position or angle of the irradiation-side adjustable optical system such that the spots of the guide light, which are observed at the adjustment surface, match; and a light-collection-side adjustment device for adjusting the position or angle of the light-collection-side adjustable optical system such that the spots of the guide light, which are observed at the adjustment surface, match.
摘要翻译：一种近场分析装置，包括：照射光学系统，包括用于调节其光轴的位置或角度的照射侧可调节光学系统，并且经由照射侧可调节光学系统将照射侧引导光照射到调整表面上 ; 光收集光学系统，包括用于调节其光轴的位置或角度的采光侧可调光学系统，以及经由采光侧可调节光学系统将光收集侧引导光照射到调节表面上 ; 照射侧调节装置，用于调节照射侧可调节光学系统的位置或角度，使得在调节表面观察到的引导光点相匹配; 以及采集侧调整装置，其用于调整所述收光侧可调光学系统的位置或角度，使得在所述调整面观察到的所述引导光的光斑匹配。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式