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1. 发明授权

US5192330A Orthopedic device of biocompatible polymer with oriented fiber reinforcement 失效
标题翻译：具有定向纤维增强的生物相容性聚合物的矫形装置
公开(公告)号：US5192330A
公开(公告)日：1993-03-09
申请号：US740723
申请日：1991-08-06
申请人： Fu-Kuo Chang , Kenneth Reifsnider , James A. Davidson , Frederick S. Georgette
发明人： Fu-Kuo Chang , Kenneth Reifsnider , James A. Davidson , Frederick S. Georgette
IPC分类号： A61F2/00 , A61F2/30 , A61F2/36 , A61L27/44 , B29C70/46 , B29D99/00
CPC分类号： B29D99/0007 , A61F2/30965 , A61F2/36 , A61L27/443 , B29C70/46 , A61F2/3094 , A61F2002/30009 , A61F2002/3686 , A61F2250/0028 , B29L2031/7532
摘要： Orthopedic device of biocompatible polymer with oriented fiber reinforcement. There is provided a device such as a hip stem which has a longitudinally curved body. The reinforcing fibers are continuous filament fiber plies with parallel orienated fibers in each ply. The plies are curved longitudinally to approximately correspond to the curve of the body. In one embodiment, there are longitudinally oriented fiber plies at or near the surfaces of the device and plies with fibers offset at 5.degree.-40.degree. from the longitudinal axis between the surface layers. The fiber orientation is balanced by providing a ply of negatively angled offset fibers of a similar angle for each positively angled offset ply. The device is made by molding plies preimpregnated with polymer (prepregs) simultaneously, by molding a plurality of prepregs into segments which are then molded together, or by molding a segment and incrementally molding additional layers of prepregs thereto in a series of progressively larger molds.
摘要翻译：具有定向纤维增强的生物相容性聚合物的矫形装置。提供了具有纵向弯曲体的诸如髋部杆的装置。增强纤维是在每个层中具有平行疏散纤维的连续长丝纤维层。帘布层纵向弯曲成大致对应于身体的曲线。在一个实施例中，在装置的表面处或附近存在纵向定向的纤维层，并且纤维在表面层之间的纵向轴线偏离5°-40°。通过为每个成角度的偏移层提供具有相似角度的负角偏移光纤的层，来平衡纤维取向。该装置是通过将多个预浸料坯模制成一起模制成段，然后通过模制一段并逐渐模制附加的一层预浸料到一系列逐渐变大的模具中，同时将聚合物（预浸料坯）预先浸渍的层压成型而成的。

2. 发明授权

US5064439A Orthopedic device of biocompatible polymer with oriented fiber reinforcement 失效
标题翻译：具有定向纤维增强的生物聚合聚合物的正交装置
公开(公告)号：US5064439A
公开(公告)日：1991-11-12
申请号：US5091
申请日：1987-01-20
申请人： Fu-Kuo Chang , Kenneth Reifsnider , James A. Davidson , Frederick S. Georgette
发明人： Fu-Kuo Chang , Kenneth Reifsnider , James A. Davidson , Frederick S. Georgette
IPC分类号： A61F2/02 , A61F2/00 , A61F2/30 , A61F2/36 , A61L27/00 , A61L27/44 , B29C70/46 , B29D99/00 , B32B27/12
CPC分类号： B29D99/0007 , A61F2/30965 , A61F2/36 , A61L27/443 , B29C70/46 , A61F2/3094 , A61F2002/30009 , A61F2002/3686 , A61F2250/0028 , B29L2031/7532 , Y10S623/911
摘要： Orthopedic device of biocompatible polymer with oriented fiber reinforcement. There is provided a device such as a hip stem which has a longitudinally curved body. The reinforcing fibers are continuous filament fiber plies with parallel oriented fibers in each ply. The plies are curved longitudinally to approximately correspond to the curve of the body. In one embodiment, there are longitudinally oriented fiber plies at or near the surfaces of the device and plies with fibers offset at 5.degree.-40.degree. from the longitudinal axis between the surface layers. The fiber orientation is balanced by providing a ply of negatively angled offset fibers of a similar angle for each positively angled offset ply. The device is made by molding plies preimpregnated with polymer (prepregs) simultaneously, by molding a plurality of prepregs into segments which are then molded together, or by molding a segment and incrementally molding additional layers of prepregs thereto in a series of progressively larger molds.

3. 发明授权

US5782910A Cardiovascular implants of enhanced biocompatibility 失效
公开(公告)号：US5782910A
公开(公告)日：1998-07-21
申请号：US468536
申请日：1996-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/02 , A61B17/22 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/80 , A61B17/86 , A61C7/12 , A61C8/00 , A61F2/00 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/84 , A61F2/90 , A61K6/04 , A61L27/00 , A61L27/06 , A61L27/50 , A61L31/02 , A61L33/00 , A61L33/02 , A61M1/10 , A61N1/05 , C22C14/00 , C22C30/00 , A61F2/22
CPC分类号： A61M25/09 , A61B17/72 , A61B17/746 , A61B17/80 , A61B17/866 , A61C7/12 , A61C8/0012 , A61F2/2403 , A61F2/2448 , A61F2/30767 , A61L27/06 , A61L27/507 , A61L31/022 , A61L33/022 , A61M1/1037 , A61M1/1051 , A61M1/122 , A61N1/05 , A61N1/056 , C22C14/00 , C22C30/00 , A61B17/7275 , A61B17/8061 , A61B17/86 , A61B2017/22038 , A61F2/0077 , A61F2/07 , A61F2/2406 , A61F2/2421 , A61F2/2424 , A61F2/2442 , A61F2/367 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2/91 , A61F2/958 , A61F2002/30677 , A61F2002/30922 , A61F2002/3631 , A61F2002/368 , A61F2250/0067 , A61F2310/00023 , A61F2310/0058 , A61F2310/00592 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00658 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61L2430/36 , A61M1/10 , A61M2025/0062
摘要： Cardiovascular and other medical implants fabricated from low-modulus Ti--Nb--Zr alloys to provide enhanced biocompatibility and hemocompatibility. The cardiovascular implants may be surface hardened by oxygen or nitrogen diffusion or by coating with a tightly adherent, hard, wear-resistant, hemocompatible ceramic coating. The cardiovascular implants include heart valves, total artificial heart implants, ventricular assist devices, vascular grafts, stents, electrical signal carrying devices such as pacemaker and neurological leads, defibrillator leads, and the like. It is contemplated that the Ti--Nb--Zr alloy can be substituted as a fabrication material for any cardiovascular implant that either comes into contact with blood thereby demanding high levels of hemocompatibility, or that is subject to microfretting, corrosion, or other wear and so that a low modulus metal with a corrosion-resistant, hardened surface would be desirable.

4. 发明授权

US5683442A Cardiovascular implants of enhanced biocompatibility 失效
标题翻译：增强生物相容性的心血管植入物
公开(公告)号：US5683442A
公开(公告)日：1997-11-04
申请号：US745221
申请日：1996-11-08
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61B17/22 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/80 , A61B17/86 , A61F2/00 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/84 , A61F2/90 , A61L27/06 , A61L27/50 , A61L31/02 , A61L33/02 , A61M1/10 , A61N1/05 , C22C14/00 , C22C30/00 , A61N1/04
CPC分类号： A61F2/2448 , A61L27/06 , A61L27/507 , A61L31/022 , A61L33/022 , A61M1/1051 , A61N1/05 , A61N1/056 , C22C14/00 , C22C30/00 , A61F2/0077 , A61F2/07 , A61F2/2406 , A61F2/2421 , A61F2/2424 , A61F2250/0067 , A61M1/10 , A61M1/1037
摘要： Medical leads fabricated from low-modulus Ti-Nb-Zr alloys to provide enhanced biocompatibility and hemocompatibility. The medical leads may be surface hardened by oxygen or nitrogen diffusion or by coating with a tightly adherent, hard, wear-resistant, hemocompatible ceramic coating. It is contemplated that the Ti-Nb-Zr alloy can be substituted as a fabrication material for any portion of a medical lead that either comes into contact with blood thereby demanding high levels of hemocompatibility, or that is subject to microfretting, corrosion, or other wear and so that a low modulus metal with a corrosion-resistant, hardened surface would be desirable.
摘要翻译：由低模量Ti-Nb-Zr合金制造的医疗导线提供增强的生物相容性和血液相容性。医用引线可以通过氧气或氮气扩散进行表面硬化，也可以通过用紧密粘附，耐磨，耐溶血的兼容陶瓷涂层进行涂覆。可以预期，Ti-Nb-Zr合金可以被替代为用于与血液接触的任何部分医疗铅的制造材料，从而要求高水平的血液相容性，或者要经受微阵列，腐蚀或其它因此具有耐腐蚀，硬化表面的低模量金属将是理想的。

5. 发明授权

US5676632A Ventricular assist devices of enhanced hemocompatibility 失效
标题翻译：增强血液相容性的心室辅助装置
公开(公告)号：US5676632A
公开(公告)日：1997-10-14
申请号：US469234
申请日：1995-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/02 , A61B17/22 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/80 , A61B17/86 , A61C7/12 , A61C8/00 , A61F2/00 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/84 , A61F2/90 , A61K6/04 , A61L27/00 , A61L27/06 , A61L27/50 , A61L31/02 , A61L33/00 , A61L33/02 , A61M1/10 , A61N1/05 , C22C14/00 , C22C30/00 , A61M1/12
CPC分类号： A61M25/09 , A61B17/72 , A61B17/746 , A61B17/80 , A61B17/866 , A61C7/12 , A61C8/0012 , A61F2/2403 , A61F2/2448 , A61F2/30767 , A61L27/06 , A61L27/507 , A61L31/022 , A61L33/022 , A61M1/1037 , A61M1/1051 , A61M1/122 , A61N1/05 , A61N1/056 , C22C14/00 , C22C30/00 , A61B17/7275 , A61B17/8061 , A61B17/86 , A61B2017/22038 , A61F2/0077 , A61F2/07 , A61F2/2406 , A61F2/2421 , A61F2/2424 , A61F2/2442 , A61F2/367 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2/91 , A61F2/958 , A61F2002/30677 , A61F2002/30922 , A61F2002/3631 , A61F2002/368 , A61F2250/0067 , A61F2310/00023 , A61F2310/0058 , A61F2310/00592 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00658 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61L2430/36 , A61M1/10 , A61M2025/0062
摘要： Ventricular assist devices fabricated from low-modulus Ti--Nb--Zr alloys to provide enhanced biocompatibility and hemocompatibility. The ventricular assist devices may be surface hardened by oxygen or nitrogen diffusion or by coating with a tightly adherent, hard, wear-resistant, hemocompatible ceramic coating. It is contemplated that the Ti--Nb--Zr alloy can be substituted as a fabrication material for any portion of a ventricular assist device that either comes into contact with blood thereby demanding high levels of hemocompatibility, or that is subject to microfretting, corrosion, or other wear and so that a low modulus metal with a corrosion-resistant, hardened surface would be desirable.
摘要翻译：室性辅助装置由低模量Ti-Nb-Zr合金制成，以提供增强的生物相容性和血液相容性。心室辅助装置可以通过氧气或氮气扩散进行表面硬化，或者通过用紧密粘附的硬质耐磨的血液相容性陶瓷涂层进行表面硬化。考虑到可以将Ti-Nb-Zr合金替代为与血液接触的心室辅助装置的任何部分的制造材料，从而要求高水平的血液相容性，或者经受微淋丝，腐蚀或因此，具有耐腐蚀，硬化表面的低模量金属将是理想的。

6. 发明授权

US4790850A Phosthetic ligament 失效
标题翻译：假韧带
公开(公告)号：US4790850A
公开(公告)日：1988-12-13
申请号：US64634
申请日：1987-06-22
申请人： Richard L. Dunn , Danny H. Lewis , Thomas W. Sander , James A. Davidson , Neil B. Beals , Yancy L. Gill
发明人： Richard L. Dunn , Danny H. Lewis , Thomas W. Sander , James A. Davidson , Neil B. Beals , Yancy L. Gill
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , D04C1/12 , D10B2509/00
摘要： A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament. A sheath may be friction fit or molded onto the exterior of the gage section. The assembly also includes one or two bone screws for complimentary engagement with the loops of the load bearing member. The bone screws have a tapered section extending beneath the head of the screw to the shank for tensioning the prosthetic ligament during implantation.
摘要翻译：假肢韧带组件包括用于永久地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的修饰韧带，以及适于在植入期间张紧假体韧带的骨螺钉。假体韧带包括从多个生物相容的高强度超高分子量聚乙烯纱线缠绕成平纹编织物的承载构件。每个纱线包括至少五十根纤维，并且具有大于或等于约100,000psi的拉伸强度。承载构件在其每个端部具有一定量部分和一个环，用于将承载构件锚固到主体构件上。承载构件被预加载以从其中移除松弛。承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以允许假体韧带的放射线显影。护套可以摩擦配合或模制到计量部分的外部。组件还包括一个或两个骨螺钉，用于与承载构件的环互补接合。骨螺钉具有在螺钉头部下方延伸到柄部的锥形部分，用于在植入期间张紧假体韧带。

7. 发明授权

US11213393B2 Compressible heart valve annulus sizing templates 有权
公开(公告)号：US11213393B2
公开(公告)日：2022-01-04
申请号：US13429123
申请日：2012-03-23
申请人： Matthew T. Winston , Da-Yu Chang , Louis A. Campbell , James A. Davidson
发明人： Matthew T. Winston , Da-Yu Chang , Louis A. Campbell , James A. Davidson
IPC分类号： A61F2/24
摘要： Compressible heart valve annulus sizing templates suitable for minimally-invasive or otherwise reduced accessibility surgeries. The sizing templates may be folded, rolled, or otherwise compressed into a reduced configuration for passage through an access tube or other such access channel. Once expelled from the access tube the sizing templates expand to their original shape for use in sizing the annulus. The templates may be formed of an elastomeric polymer material such as silicone, a highly elastic metal such as NITINOL, or both. Grasping tabs or connectors for handles permit manipulation from outside the body. A NITINOL wireform may be compressed for passage through an access tube and expelled from the distal end thereof into a cloth cover to assume a sizer shape.

8. 发明申请

US20110146361A1 Method of Peening Metal Heart Valve Stents 审中-公开
标题翻译：硬化心脏瓣膜支架的方法
公开(公告)号：US20110146361A1
公开(公告)日：2011-06-23
申请号：US12950799
申请日：2010-11-19
申请人： James A. Davidson , Louis A. Campbell
发明人： James A. Davidson , Louis A. Campbell
IPC分类号： C21D7/06
CPC分类号： C21D7/06 , A61F2/2418 , A61F2220/0075 , A61F2230/0054 , C21D10/005 , C21D2221/00
摘要： Medical devices, such as percutaneous prosthetic heart valves can include a stent or frame structure component. The stent can be shot peened, laser peened, and/or ultrasonically peened, thereby reducing surface abnormalities, improving surface appearance, and/or increasing fatigue life of the device.
摘要翻译：医疗装置，例如经皮假体心脏瓣膜，可以包括支架或框架结构部件。可以对支架进行喷丸硬化，激光喷丸处理和/或超声波喷丸处理，从而减少装置的表面异常，改善表面外观和/或增加疲劳寿命。

9. 发明授权

US06238491B1 Niobium-titanium-zirconium-molybdenum (nbtizrmo) alloys for dental and other medical device applications 失效
标题翻译：用于牙科和其他医疗器械应用的铌 - 钛 - 锆 - 钼（nbtizrmo）合金
公开(公告)号：US06238491B1
公开(公告)日：2001-05-29
申请号：US09305881
申请日：1999-05-05
申请人： James A. Davidson , Lee H. Tuneberg
发明人： James A. Davidson , Lee H. Tuneberg
IPC分类号： C22C2702
CPC分类号： A61F2/30767 , A61B2017/0084 , A61C5/42 , A61C7/00 , A61C8/0012 , A61F2/28 , A61F2/2803 , A61F2/2875 , A61F2/30907 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/367 , A61F2/44 , A61F2/82 , A61F2002/30332 , A61F2002/30922 , A61F2002/3611 , A61F2002/3631 , A61F2002/365 , A61F2220/0033 , A61F2310/00095 , A61F2310/0097 , A61F2310/00976 , A61K6/04 , A61L27/06 , C22C14/00 , C22C16/00 , C22C27/02 , C22C30/00
摘要： The present invention is a medical implant or device fabricated, in any manner, from a niobium (Nb)—titanium (Ti)—zirconium (Zr)—Molybdenum (Mo) alloy (NbTiZrMo alloy). The implant or device has components at least partially fabricated from a metal alloy comprising a) between about 29 and 70 weight percent Nb; b) between about 10 and 46 weight percent Zr; c) between about 3 and 15 weight percent Mo; and a balance of titanium. The inventive alloy provides for a uniform beta structure which is corrosion resistant, and can be readily processed to develop high-strength and low-modulus, with the ability for conversion oxidation or nitridization surface hardening of the medical implant or device.
摘要翻译：本发明是以任何方式由铌（Nb） - 钛（Ti） - 锆（Zr） - 钼（Mo）合金（NbTiZrMo合金）制造的医用植入物或器件。植入物或装置具有至少部分地由金属合金制成的部件，该金属合金包括：a）约29-70重量％的Nb; b）约10至46重量％的Zr; c）约3至15重量％的Mo; 和钛的平衡。本发明的合金提供了具有耐腐蚀性的均匀的β结构，并且可以容易地加工以开发高强度和低模量，具有医用植入物或器件的转化氧化或氮化表面硬化的能力。

10. 发明授权

US06197043B1 Isoelastic suture material and device 有权
标题翻译：等弹性缝合材料及装置
公开(公告)号：US06197043B1
公开(公告)日：2001-03-06
申请号：US09376227
申请日：1999-08-18
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61B1704
CPC分类号： A61L17/10 , A61B17/06166 , A61B2017/1107 , A61L17/04
摘要： A flexible, isoelastic polymer surgical suture and suture construct formed from a material selected from the group consisting of silicone, polyurethane, polyurethane copolymers, rubber, and other hemocompatible and biocompatible thermoplastic elastomers, wherein the suture and suture construct is formed from a single or multiple filament, the suture and suture construct having an elastic modulus between about 50 to 2000 psi, a tensile strength between about 500 to 50,000 psi, and a tensile elongation between about 100 to 1000 percent. In an alternate suture construct, the construct includes a base material and an inner core formed from a higher-strength fiber or group of fibers having a helical orientation. The low-modulus base material is selected from the group consisting of silicone, polyurethane, polyurethane copolymers, rubber, and other hemocompatible and biocompatible thermoplastic elastomers. In an alternate suture construct, the construct includes a base material and an inner core formed from a higher-strength fiber or group of fibers having a helical orientation. The inner core has an elastic modulus above about 2,000 psi, a tensile strength above about 10,000 psi, and a tensile elongation between about 1 to 80 percent.
摘要翻译：由选自硅氧烷，聚氨酯，聚氨酯共聚物，橡胶和其它血液相容性和生物相容性热塑性弹性体的材料形成的柔性，等弹性聚合物外科缝合线和缝合线构造物，其中缝合线和缝合线构造体由单个或多个细丝，缝合线和缝合线构造具有约50至2000psi之间的弹性模量，约500至50,000psi之间的拉伸强度和约100至1000％之间的拉伸伸长率。在替代的缝合线构造中，构造物包括由具有螺旋取向的较高强度纤维或纤维组形成的基材和内芯。低模量基材选自硅氧烷，聚氨酯，聚氨酯共聚物，橡胶和其它血液相容性和生物相容性热塑性弹性体。在替代的缝合线构造中，构造物包括由具有螺旋取向的较高强度纤维或纤维组形成的基材和内芯。内芯具有高于约2,000psi的弹性模量，高于约10,000psi的拉伸强度和约1至80％之间的拉伸伸长率。

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