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1. 发明授权

US06767332B1 Active ankle support 失效
标题翻译：主动脚踝支撑
公开(公告)号：US06767332B1
公开(公告)日：2004-07-27
申请号：US09583476
申请日：2000-05-31
申请人： Chris C. Pardue , James A. Davidson
发明人： Chris C. Pardue , James A. Davidson
IPC分类号： A61F500
CPC分类号： A61F5/0111
摘要： An ankle support for protecting an injured or uninjured ankle which includes lateral support members having a flexion region operable to limit plantar and dorsal flexion to 40 degrees. Lateral support members are connected with lower-leg supports which together act to limit rotation to 15 degrees and medial and lateral bending to 10 degrees. Ankle support is preferably contoured with a low component-profile such that ankle support can be worn within a shoe to provide user with support and stabilization during rigorous activity. Adjustable straps are utilized to firmly engage ankle support with user's lower leg which operably reduces or minimizes load to the foot. Ankle support component parts are preferably formed from a low melting temperature thermo-forming polymer, polymer alloy, or composite material which provides the user with an advantageous ankle support and method for maintaining ankle supports fit to the lower leg.
摘要翻译：用于保护受伤或未受伤的脚踝的脚踝支撑，其包括具有可操作以将足底和背屈屈曲限制到40度的屈曲区域的侧向支撑构件。横向支撑构件与小腿支撑连接，它们一起起作用以将旋转限制在15度，内侧和外侧弯曲到10度。踝关节支撑件优选具有低的部件轮廓，使得脚踝支撑件可以穿在鞋中以在严格活动期间为使用者提供支撑和稳定。可调节带被用来牢固地接合脚踝支撑件与使用者的小腿，其可操作地减小或最小化对脚的负荷。踝支撑部件优选地由低熔点温度的热成型聚合物，聚合物合金或复合材料形成，其为使用者提供了一种有利的脚踝支撑和用于维持与小腿配合的踝部支撑的方法。

2. 发明授权

US5685306A Flexible, biocompatible, metal alloy catheter 失效
标题翻译：柔性，生物相容性，金属合金导管
公开(公告)号：US5685306A
公开(公告)日：1997-11-11
申请号：US471750
申请日：1995-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/02 , A61B17/22 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/80 , A61B17/86 , A61C7/12 , A61C8/00 , A61F2/00 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/84 , A61F2/90 , A61K6/04 , A61L27/00 , A61L27/06 , A61L27/50 , A61L31/02 , A61L33/00 , A61L33/02 , A61M1/10 , A61N1/05 , C22C14/00 , C22C30/00 , A61B5/00
CPC分类号： A61M25/09 , A61B17/72 , A61B17/746 , A61B17/80 , A61B17/866 , A61C7/12 , A61C8/0012 , A61F2/2403 , A61F2/2448 , A61F2/30767 , A61L27/06 , A61L27/507 , A61L31/022 , A61L33/022 , A61M1/1037 , A61M1/1051 , A61M1/122 , A61N1/05 , A61N1/056 , C22C14/00 , C22C30/00 , A61B17/7275 , A61B17/8061 , A61B17/86 , A61B2017/22038 , A61F2/0077 , A61F2/07 , A61F2/2406 , A61F2/2421 , A61F2/2424 , A61F2/2442 , A61F2/367 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2/91 , A61F2/958 , A61F2002/30677 , A61F2002/30922 , A61F2002/3631 , A61F2002/368 , A61F2250/0067 , A61F2310/00023 , A61F2310/0058 , A61F2310/00592 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00658 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61L2430/36 , A61M1/10 , A61M2025/0062
摘要： Cardiovascular and other medical implants fabricated from low-modulus Ti--Nb--Zr alloys to provide enhanced biocompatibility and hemocompatibility. The cardiovascular implants may be surface hardened by oxygen or nitrogen diffusion or by coating with a tightly adherent, hard, wear-resistant, hemocompatible ceramic coating. The cardiovascular implants include heart valves, total artificial heart implants, ventricular assist devices, vascular grafts, stents, electrical signal carrying devices such as pacemaker and neurological leads, defibrillator leads, and the like. It is contemplated that the Ti--Nb--Zr alloy can be substituted as a fabrication material for any cardiovascular implant that either comes into contact with blood thereby demanding high levels of hemocompatibility, or that is subject to microfretting, corrosion, or other wear and so that a low modulus metal with a corrosion-resistant, hardened surface would be desirable.
摘要翻译：由低模量Ti-Nb-Zr合金制造的心血管和其他医疗植入物，以提供增强的生物相容性和血液相容性。心血管植入物可以通过氧气或氮气扩散进行表面硬化，或通过用紧密粘附，耐磨，抗血液相容的陶瓷涂层进行涂层。心血管植入物包括心脏瓣膜，总人造心脏植入物，心室辅助装置，血管移植物，支架，诸如起搏器和神经系统引线的电信号传输装置，除颤器引线等。可以预期，Ti-Nb-Zr合金可以被替代为用于与血液接触的任何心血管植入物的制造材料，从而要求高水平的血液相容性，或者受到微纤丝，腐蚀或其它磨损等等。具有耐腐蚀，硬化表面的低模量金属将是期望的。

3. 发明授权

US5649951A Zirconium oxide and zirconium nitride coated stents 失效
标题翻译：氧化锆和氮化锆涂层支架
公开(公告)号：US5649951A
公开(公告)日：1997-07-22
申请号：US470682
申请日：1995-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/00 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/38 , A61L27/04 , A61L27/30 , A61L27/50 , A61L29/02 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02 , A61M1/10 , A61M25/09 , A61M25/16 , A61B19/00
CPC分类号： A61L33/027 , A61F2/0077 , A61F2/06 , A61F2/07 , A61F2/2448 , A61F2/30767 , A61F2/91 , A61L27/047 , A61L27/306 , A61L27/507 , A61L29/02 , A61L29/106 , A61L31/022 , A61L31/088 , A61M1/10 , A61F2/38 , A61F2/88 , A61F2/90 , A61F2/958 , A61F2002/30107 , A61F2210/0009 , A61F2230/0054 , A61F2310/00089 , A61F2310/00634 , A61F2310/00892
摘要： Stents fabricated from a substrate of a low modulus metal coated with blue to black zirconium oxide or zirconium nitride. The coating provides enhanced thrombogenicity, biocompatibility, blood compatibility, corrosion-resistance, friction and microfretting resistance, durability, and electrical insulation, where applicable. The coatings may be applied to low modulus metallic substrates by physical or chemical vapor deposition as well as other ion-beam assisted methods. Preferably, however, for optimizing attachment strength, the stents are fabricated from zirconium or zirconium-containing alloys and the coatings are formed by oxidizing or nitriding through an in situ method that develops a coating from and on the metal surface of the stent, without need for depositing a coating on the metal surface.
摘要翻译：由涂覆有蓝色至黑色氧化锆或氮化锆的低模量金属的基材制成的支架。如果适用，涂层可提供增强的血栓形成，生物相容性，血液相容性，耐腐蚀性，摩擦力和抗微生物抗性，耐久性和电绝缘性。涂层可以通过物理或化学气相沉积以及其他离子束辅助方法施加到低模量金属基底上。然而，优选地，为了优化附着强度，支架由含锆或锆的合金制成，并且涂层通过原位方法进行氧化或氮化形成，该方法从支架的金属表面上和其上形成涂层，而不需要用于在金属表面上沉积涂层。

4. 发明授权

US5647858A Zirconium oxide and zirconium nitride coated catheters 失效
标题翻译：氧化锆和氮化锆涂层导管
公开(公告)号：US5647858A
公开(公告)日：1997-07-15
申请号：US469688
申请日：1995-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/00 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/38 , A61L27/04 , A61L27/30 , A61L27/50 , A61L29/02 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02 , A61M1/10 , A61M25/09 , A61M25/16 , A61M5/00
CPC分类号： A61L33/027 , A61F2/0077 , A61F2/06 , A61F2/07 , A61F2/2448 , A61F2/30767 , A61F2/91 , A61L27/047 , A61L27/306 , A61L27/507 , A61L29/02 , A61L29/106 , A61L31/022 , A61L31/088 , A61M1/10 , A61F2/38 , A61F2/88 , A61F2/90 , A61F2/958 , A61F2002/30107 , A61F2210/0009 , A61F2230/0054 , A61F2310/00089 , A61F2310/00634 , A61F2310/00892
摘要： Catheters fabricated from a core or substrate of a low modulus metal coated with blue to black zirconium oxide or zirconium nitride. The coating provides enhanced thrombogenicity, biocompatibility, blood compatibility, corrosion-resistance, friction and microfretting resistance, durability, and electrical insulation, where applicable. The coatings may be applied to low modulus metallic substrates by physical or chemical vapor deposition as well as other ion-beam assisted methods. Preferably, however, for optimizing attachment strength, the catheters are fabricated from zirconium or zirconium-containing alloys and the coatings are formed by oxidizing or nitriding through an in situ method that develops a coating from and on the metal surface of the catheter, without need for depositing a coating on the metal surface.
摘要翻译：由涂覆有蓝色至黑色氧化锆或氮化锆的低模量金属的芯或衬底制造的导管。如果适用，涂层可提供增强的血栓形成，生物相容性，血液相容性，耐腐蚀性，摩擦力和抗微生物抗性，耐久性和电绝缘性。涂层可以通过物理或化学气相沉积以及其他离子束辅助方法施加到低模量金属基底上。然而，优选地，为了优化附着强度，导管由含锆或锆的合金制成，并且涂层通过原位法氧化或渗氮形成，该方法从导管的金属表面上和其上形成涂层，而不需要用于在金属表面上沉积涂层。

5. 发明授权

US5628790A Zirconium oxide zirconium nitride coated valvular annuloplasty rings 失效
标题翻译：氧化锆氮化锆涂层瓣膜瓣环成形术环
公开(公告)号：US5628790A
公开(公告)日：1997-05-13
申请号：US547127
申请日：1995-10-24
申请人： James A. Davidson , Kenneth P. Daigle
发明人： James A. Davidson , Kenneth P. Daigle
IPC分类号： A61F2/00 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/38 , A61F2/84 , A61L27/04 , A61L27/30 , A61L27/50 , A61L29/02 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02 , A61M1/10 , A61M25/09 , A61M25/16
CPC分类号： A61F2/2448 , A61L27/047 , A61L27/306 , A61L27/507 , A61L33/027 , A61F2/0077 , A61F2/30767 , A61F2/38 , A61F2002/30107 , A61F2210/0009 , A61F2310/00634 , A61F2310/00892
摘要： An annuloplasty ring fabricated from a component of a low elastic modulus metal coated with blue to black zirconium oxide or yellow to orange zirconium nitride. The coating provides enhanced thrombogenicity, biocompatibility, hemocompatibility, corrosion-resistance, friction and microfretting resistance, durability, and electrical insulation. The coatings can be applied to the underlying low modulus metallic components by physical or chemical vapor deposition as well as other ion-beam assisted methods. Preferably, however, for optimizing attachment strength, the annuloplasty ring components are fabricated from zirconium or zirconium-containing alloys and the coatings are formed by oxidizing or nitriding through an in situ method.
摘要翻译：由涂覆有蓝色至黑色氧化锆或黄色至橙色氮化锆的低弹性模量金属的组分制成的瓣膜成形术环。该涂层提供增强的血栓形成，生物相容性，血液相容性，耐腐蚀性，摩擦和微纺丝抗性，耐久性和电绝缘。涂层可以通过物理或化学气相沉积以及其他离子束辅助方法施加到潜在的低模量金属组分。然而，优选地，为了优化附着强度，瓣膜成形术环组件由含锆或锆的合金制成，并且涂层通过原位法氧化或氮化形成。

6. 发明授权

US5562730A Total artificial heart device of enhanced hemocompatibility 失效
标题翻译：总人造心脏装置增强血液相容性
公开(公告)号：US5562730A
公开(公告)日：1996-10-08
申请号：US469897
申请日：1995-06-06
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/02 , A61B17/22 , A61B17/72 , A61B17/74 , A61B17/78 , A61B17/80 , A61B17/86 , A61C7/12 , A61C8/00 , A61F2/00 , A61F2/04 , A61F2/06 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/84 , A61F2/90 , A61K6/04 , A61L27/00 , A61L27/06 , A61L27/50 , A61L31/02 , A61L33/00 , A61L33/02 , A61M1/10 , A61N1/05 , C22C14/00 , C22C30/00 , A61F2/22
CPC分类号： A61M25/09 , A61B17/72 , A61B17/746 , A61B17/80 , A61B17/866 , A61C7/12 , A61C8/0012 , A61F2/2403 , A61F2/2448 , A61F2/30767 , A61L27/06 , A61L27/507 , A61L31/022 , A61L33/022 , A61M1/1037 , A61M1/1051 , A61M1/122 , A61N1/05 , A61N1/056 , C22C14/00 , C22C30/00 , A61B17/7275 , A61B17/8061 , A61B17/86 , A61B2017/22038 , A61F2/0077 , A61F2/07 , A61F2/2406 , A61F2/2421 , A61F2/2424 , A61F2/2442 , A61F2/367 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2/91 , A61F2/958 , A61F2002/30677 , A61F2002/30922 , A61F2002/3631 , A61F2002/368 , A61F2250/0067 , A61F2310/00023 , A61F2310/0058 , A61F2310/00592 , A61F2310/00616 , A61F2310/00634 , A61F2310/0064 , A61F2310/00658 , A61F2310/00748 , A61F2310/00766 , A61F2310/00772 , A61F2310/0088 , A61F2310/00892 , A61F2310/00898 , A61L2430/36 , A61M1/10 , A61M2025/0062
摘要： Cardiovascular and other medical implants fabricated from low-modulus Ti--Nb--Zr alloys to provide enhanced biocompatibility and hemocompatibility. The cardiovascular implants may be surface hardened by oxygen or nitrogen diffusion or by coating with a tightly adherent, hard, wear-resistant, hemocompatible ceramic coating. The cardiovascular implants include heart valves, total artificial heart implants, ventricular assist devices, vascular grafts, stents, electrical signal carrying devices such as pacemaker and neurological leads, defibrillator leads, and the like. It is contemplated that the Ti--Nb--Zr alloy can be substituted as a fabrication material for any cardiovascular implant that either comes into contact with blood thereby demanding high levels of hemocompatibility, or that is subject to microfretting, corrosion, or other wear and so that a low modulus metal with a corrosion-resistant, hardened surface would be desirable.
摘要翻译：由低模量Ti-Nb-Zr合金制造的心血管和其他医疗植入物，以提供增强的生物相容性和血液相容性。心血管植入物可以通过氧气或氮气扩散进行表面硬化，或通过用紧密粘附，耐磨，抗血液相容的陶瓷涂层进行涂层。心血管植入物包括心脏瓣膜，总人造心脏植入物，心室辅助装置，血管移植物，支架，诸如起搏器和神经系统引线的电信号传输装置，除颤器引线等。可以预期，Ti-Nb-Zr合金可以被替代为用于与血液接触的任何心血管植入物的制造材料，从而要求高水平的血液相容性，或者受到微纤丝，腐蚀或其它磨损等等。具有耐腐蚀，硬化表面的低模量金属将是期望的。

7. 发明授权

US5549667A Mechanical heart with wear resistant coatings of reduced thrombogenicity 失效
标题翻译：机械心脏具有降低血栓形成的耐磨涂层
公开(公告)号：US5549667A
公开(公告)日：1996-08-27
申请号：US320456
申请日：1994-10-11
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/00 , A61F2/06 , A61F2/24 , A61F2/30 , A61F2/38 , A61F2/84 , A61L27/04 , A61L27/30 , A61L27/50 , A61L29/02 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02 , A61M1/10 , A61M25/09 , A61M25/16
CPC分类号： A61F2/0077 , A61F2/30767 , A61L33/027 , A61M1/10 , A61F2/38 , A61F2002/30107 , A61F2210/0009 , A61F2310/00089 , A61F2310/00634 , A61F2310/00892
摘要： Hard, wear resistant, biocompatible and blood compatible coatings for components of external blood-contacting pumps including mechanical heart devices that are exposed to conditions of wear in the body and that may be exposed to blood components. The components may be fabricated from zirconium or the alloys of zirconium and the coatings comprise either blue-black or black zirconium oxide or zirconium nitride that are tightly adhered to the underlying metal substrate. In the event that the component is used under conditions which subject it to wear, then the coating should have a thickness that provides sufficient residual compressive stresses to withstand these conditions.
摘要翻译：硬的，耐磨的，生物兼容的和兼容血液的涂层，用于外部血液接触泵的组件，包括暴露于身体磨损状况并可能暴露于血液成分的机械心脏装置。组分可以由锆或锆的合金制成，并且涂层包括牢固粘附在下面的金属基底上的蓝黑色或黑色氧化锆或氮化锆。如果组件在使其磨损的条件下使用，则涂层应具有提供足够的残余压应力以承受这些条件的厚度。

8. 发明授权

US5458653A Prosthetic implants with bioabsorbable coatings 失效
标题翻译：具有生物可吸收涂层的假体植入物
公开(公告)号：US5458653A
公开(公告)日：1995-10-17
申请号：US60484
申请日：1993-05-11
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61B17/60 , A61F2/00 , A61F2/30 , A61F2/36 , A61F2/38 , A61F2/78 , A61L27/34 , A61F2/34 , A61F2/28
CPC分类号： A61L27/34 , A61F2/30767 , A61F2/30907 , A61F2/36 , A61F2/38 , A61F2/367 , A61F2/3676 , A61F2002/30064 , A61F2002/30677 , A61F2002/30738 , A61F2002/30919 , A61F2002/3631
摘要： A novel coated prosthesis that can be tailored to avoid the problem of bone resorption caused by stress shielding. The permanent, load-bearing skeletal replacement prosthesis is coated or covered with a bioabsorbable polymer at selected sites on its surface so that bone affixation is preferentially delayed at these covered sites and bone adjacent to uncoated areas are not stress shielded. Thus, resorption is avoided. When the bioabsorbable polymer is gradually absorbed away, bone affixation takes place on the exposed surfaces, as needed.
摘要翻译：一种新颖的涂层假体，可以定制，以避免由应力屏蔽引起的骨吸收问题。永久的，承重的骨骼替代假体在其表面上的选定位置用生物可吸收聚合物涂覆或覆盖，使得在这些覆盖部位优先延迟骨固定，并且与未涂覆区域相邻的骨没有受到应力屏蔽。因此，避免吸收。当生物可吸收聚合物逐渐被吸收时，根据需要在露出的表面上发生骨固定。

9. 发明授权

US5152794A Zirconium oxide and nitride coated prothesis for reduced microfretting 失效
标题翻译：氧化锆和氮化物涂层保护膜，用于减少微纺丝
公开(公告)号：US5152794A
公开(公告)日：1992-10-06
申请号：US557173
申请日：1990-07-23
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/00 , A61F2/06 , A61F2/30 , A61F2/38 , A61L27/04 , A61L27/30 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02
CPC分类号： A61L31/088 , A61F2/0077 , A61F2/06 , A61F2/30767 , A61L27/047 , A61L27/306 , A61L29/106 , A61L31/022 , A61L33/027 , A61F2/38 , A61F2002/30107 , A61F2210/0009 , A61F2310/00089 , A61F2310/00634 , A61F2310/00892 , Y10S606/907
摘要： Orthopedic implants of zirconium or zirconium-based alloy coated with blue or blue-black zirconium oxide or zirconium nitride to provide low friction, highly wear resistant coatings especially useful in artificial joints, such as hip joints, knee joints, elbows, etc. The invention zirconium oxide or nitride coated prostheses are also useful to reduce microfretting wear in multi-component surgical implants subject to such wear. Further, the coatings provide a barrier against implant corrosion caused by ionization of the metal prosthesis. Such protection can be extended by the use of oxidized or nitrided porous coatings of zirconium or zirconium alloy beads or wire mesh into which bone spicules may grow so that the prosthesis may be integrated into the living skeleton.
摘要翻译：涂覆有蓝色或蓝黑色氧化锆或氮化锆的锆或锆基合金的矫形植入物，以提供特别适用于人造关节（例如髋关节，膝关节，弯头等）的低摩擦，高度耐磨的涂层。本发明氧化锆或氮化物涂覆的假体也可用于减少经受这种磨损的多组分手术植入物中的微丝磨损。此外，涂层提供了抵抗由金属假体的离子化引起的植入物腐蚀的屏障。这种保护可以通过使用锆或锆合金珠或金属丝网的氧化或氮化多孔涂层来延长，其中骨针可以生长，使得假体可以整合到活骨架中。

10. 发明授权

US5037438A Zirconium oxide coated prosthesis for wear and corrosion resistance 失效
标题翻译：氧化锆涂层假体耐磨损和耐腐蚀
公开(公告)号：US5037438A
公开(公告)日：1991-08-06
申请号：US385285
申请日：1989-07-25
申请人： James A. Davidson
发明人： James A. Davidson
IPC分类号： A61F2/00 , A61F2/06 , A61F2/30 , A61F2/38 , A61L27/04 , A61L27/30 , A61L29/10 , A61L31/02 , A61L31/08 , A61L33/02
CPC分类号： A61F2/06 , A61F2/0077 , A61F2/30767 , A61L27/047 , A61L27/306 , A61L29/106 , A61L31/022 , A61L31/088 , A61L33/027 , A61F2/38 , A61F2002/30107 , A61F2210/0009 , A61F2310/00089 , A61F2310/00634 , A61F2310/00892
摘要： Orthopedic implants of zirconium or zirconium-based alloy coated with zirconium oxide to provide low friction, highly wear resistant coatings especially useful in artificial joints, such as hip joints, knee joints, elbows, etc. The invention zirconium oxide coated prostheses are also useful in that the zirconium oxide coatings provide a barrier against implant corrosion caused by ionization of the metal prosthesis. Such protection can be extended by the use of oxidized porous coatings of zirconium or zirconium alloy beads or wire mesh into which bone spicules may grow so that the prosthesis may be integrated into the living skeleton.
摘要翻译：用氧化锆涂覆的锆或锆基合金的矫形植入物，以提供特别适用于人造关节，例如髋关节，膝关节，弯头等的低摩擦，高度耐磨的涂层。本发明的氧化锆涂覆的假体也可用于氧化锆涂层提供了抵抗由金属假体的离子化引起的植入物腐蚀的障碍。这种保护可以通过使用锆或锆合金珠或丝网的氧化多孔涂层来延长，其中骨针可以生长，使得假体可以整合到活骨架中。

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