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1. 发明申请

US20120189554A1 MULTI-FUNCTIONAL DRUG CARRIERS 审中-公开
标题翻译：多功能药物载体
公开(公告)号：US20120189554A1
公开(公告)日：2012-07-26
申请号：US13437557
申请日：2012-04-02
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
IPC分类号： A61K47/48 , A61K49/12 , A61P35/00 , C08G69/48
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

2. 发明申请

US20120107264A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
标题翻译：核酸递送化合物
公开(公告)号：US20120107264A1
公开(公告)日：2012-05-03
申请号：US13273106
申请日：2011-10-13
申请人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
发明人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
IPC分类号： A61K47/48 , C08F220/60 , A61P35/00 , A61K47/32 , C12N5/071 , C08F120/60 , C08G65/333
CPC分类号： C12N15/87 , C08F293/005 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.
摘要翻译：包括两种或更多种不同重复单元的聚合物在本文中公开。本文还公开了使用这种聚合物将核酸递送至细胞的方法。

3. 发明申请

US20100028416A1 DRUG CARRIERS 审中-公开
标题翻译：药物承运人
公开(公告)号：US20100028416A1
公开(公告)日：2010-02-04
申请号：US12210125
申请日：2008-09-12
申请人： Lei Yu , Gang Zhao , Sang Van , Fu Chen
发明人： Lei Yu , Gang Zhao , Sang Van , Fu Chen
IPC分类号： A61K9/127 , A61K31/7088
CPC分类号： A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要： Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：可以包括载体，靶向剂和治疗剂的组合物在本文中公开。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

4. 发明申请

US20070128118A1 POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS 审中-公开
标题翻译：聚氨基酸 - 氨基酸共聚物和方法
公开(公告)号：US20070128118A1
公开(公告)日：2007-06-07
申请号：US11566141
申请日：2006-12-01
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号： A61K49/10 , A61K49/00 , A61K31/785
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这些聚合物可用于各种药物，生物分子和成像剂递送应用。

5. 发明授权

US06488812B2 Soft tissue with improved lint and slough properties 有权
公开(公告)号：US06488812B2
公开(公告)日：2002-12-03
申请号：US09736924
申请日：2000-12-14
申请人： Thomas Gerard Shannon , Mike Thomas Goulet , Fu Chen
发明人： Thomas Gerard Shannon , Mike Thomas Goulet , Fu Chen
IPC分类号： D21H1734
CPC分类号： D21H21/22 , D21H17/375 , D21H17/455
摘要： A synthetic polymer having hydrogen bonding capability and containing a hydrophobic aliphatic hydrocarbon moiety can reduce lint and slough in soft tissue products while maintaining softness and strength.

6. 发明授权

US5707533A Process for the preparation of aqueous dispersion polymers 失效
标题翻译：水性分散体聚合物的制备方法
公开(公告)号：US5707533A
公开(公告)日：1998-01-13
申请号：US794126
申请日：1997-02-03
申请人： Edward J. Connors , Michelle L. Cotter , Fu Chen
发明人： Edward J. Connors , Michelle L. Cotter , Fu Chen
IPC分类号： C08F220/44 , C02F1/56 , C08F2/06 , C08F2/10 , C08F2/44 , C08F216/36 , C08F220/34 , C08F220/54 , C08F220/56 , C08F220/60 , B01D21/01
CPC分类号： C08F220/34 , C02F1/56 , C08F220/54 , C08F220/60 , Y10S210/928
摘要： A process for preparing a water-soluble polymer dispersion is herein provided which is characterized by polymerizing from about 10 to 50 mole percent of a monomer having a formula (II); from about 1 to 50 mole percent of N-alkylacrylamide, N, N-dialkylacrylamide or mixtures thereof; having a formula (III) from about 1 to 70 mole percent acrylamide; and optionally up to about 4 mole percent of a monomer having a formula (I) having a benzyl functionality. The polymerization is carried out in the presence of an aqueous solution of a polyvalent anionic salt which contains (1) a water soluble cationic polymer which is insoluble in the aqueous salt solution and (2) a water soluble cationic polymer which is soluble in the aqueous salt solution.
摘要翻译：本文提供一种制备水溶性聚合物分散体的方法，其特征在于聚合约10至50摩尔％的具有式（II）的单体; 约1至50摩尔％的N-烷基丙烯酰胺，N，N-二烷基丙烯酰胺或其混合物; 具有约1至70摩尔％丙烯酰胺的式（III）; 和任选地至多约4摩尔％的具有式（I）的具有苄基官能团的单体。聚合反应在多价阴离子盐水溶液的存在下进行，该多价阴离子盐含有（1）不溶于盐水溶液的水溶性阳离子聚合物和（2）可溶于水溶液的水溶性阳离子聚合物盐溶液。

7. 发明授权

US5391238A Method and composition for treatment of aluminum 失效
公开(公告)号：US5391238A
公开(公告)日：1995-02-21
申请号：US142751
申请日：1993-10-22
申请人： David W. Reichgott , Fu Chen
发明人： David W. Reichgott , Fu Chen
IPC分类号： C23C22/34 , C23C22/56 , C23C22/06
CPC分类号： C23C22/34 , C23C22/56
摘要： Methods of forming a dried in place conversion coating on metal surfaces such as aluminum and aluminum alloys. The methods comprise contacting the metal with an aqueous solution of a water soluble maleic or acrylic acid/allyl ether copolymer alone or with an acid.

8. 发明授权

US5271847A Polymers for the treatment of boiler water 失效
标题翻译：聚合物用于处理锅炉水
公开(公告)号：US5271847A
公开(公告)日：1993-12-21
申请号：US957326
申请日：1992-10-06
申请人： Fu Chen , Scott M. Boyette , Keith A. Bair
发明人： Fu Chen , Scott M. Boyette , Keith A. Bair
IPC分类号： C02F5/10 , C02F5/14
CPC分类号： C02F5/10 , C02F5/105
摘要： A method for controlling the deposition of silica on the structural surfaces of steam generating systems comprising the use of a water soluble polymer having the structure ##STR1## wherein E is the repeat unit remaining after polymerization of an alpha, beta ethylenically unsaturated compound.This polymer may also be used in concert with topping agents such as phosphoric acids, phosphonic acids, polyvalent metal salts, metal chelating agents and oxygen scavengers.

9. 发明授权

US5242599A Polymers for the treatment of boiler water 失效
标题翻译：聚合物用于处理锅炉水
公开(公告)号：US5242599A
公开(公告)日：1993-09-07
申请号：US832547
申请日：1992-02-07
申请人： Fu Chen , Keith A. Bair , Scott M. Boyette
发明人： Fu Chen , Keith A. Bair , Scott M. Boyette
IPC分类号： C02F5/10 , C02F5/14 , C23F11/08 , C23F11/10
CPC分类号： C02F5/14 , C02F5/10 , C02F5/105 , C23F11/08 , C23F11/10 , C02F2303/08
摘要： A method for controlling the deposition of scale imparting species on the structural surfaces of steam generating systems comprising the use of a water soluble polymer having the structure ##STR1## wherein R.sub.1 is H or lower (C.sub.1 -C.sub.4) alkyl, R.sub.2 is (CH.sub.2 --CH.sub.2 --O).sub.n, ##STR2## or a mixture of both, and n is an integer of from about 1 to about 40, R.sub.3 is H, lower (C.sub.1 -C.sub.4) alkyl or an acetate. This polymer may also be used in concert with topping agents such as phosphoric acids, phosphonic acids, amines, metal chelating agents and oxygen scavengers.
摘要翻译：一种用于控制在蒸汽发生系统的结构表面上沉积氧化皮的物质的方法，包括使用具有结构的水溶性聚合物，其中R1是H或更低（C1-C4）烷基，R2是（CH2- CH 2 -O）n，或两者的混合物，n为约1至约40的整数，R 3为H，低级（C 1 -C 4）烷基或乙酸酯。该聚合物也可以与顶级剂如磷酸，膦酸，胺，金属螯合剂和除氧剂一起使用。

10. 发明授权

US5211854A Water soluble graft copolymers and methods of use thereof 失效
标题翻译：水溶性接枝共聚物及其使用方法
公开(公告)号：US5211854A
公开(公告)日：1993-05-18
申请号：US691206
申请日：1991-04-25
申请人： Wen P. Liao , Fu Chen
发明人： Wen P. Liao , Fu Chen
IPC分类号： C08F290/04
CPC分类号： C08F290/046
摘要： A water soluble graft copolymer useful for dewatering wastewater having the structure: ##STR1## wherein E is the repeat unit obtained after polymerization of an .alpha.,.beta. ethylenically unsaturated compound the molar percentage of a:b is from about 95:5 to 5:95 with the proviso that the sum of a and b equals 100%; G comprises the structure: ##STR2## wherein d is a cationic monomer, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen or a lower alkyl group having C.sub.1 to C.sub.3, F is the salt of an ammonium cation and the molar percentage of c:d is from 95:5 to 5:95 with the proviso that the sum of c and d equals 100%.
摘要翻译：一种可用于脱水废水的水溶性接枝共聚物，其结构如下：其中E是α，β烯键式不饱和化合物聚合后获得的重复单元，a：b的摩尔百分比为约95:5至5:95 条件是a和b之和等于100％; G包括以下结构：其中d为阳离子单体，R1，R2和R3相同或不同，为氢或C1至C3的低级烷基，F为铵阳离子的盐，摩尔百分数的c：d为95:5至5:95，条件是c和d之和等于100％。

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