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1. 发明申请

US20060036087A1 2'-deoxy-2'-fluoro modified RNA 审中-公开
标题翻译： 2'-脱氧-2'-氟修饰的RNA
公开(公告)号：US20060036087A1
公开(公告)日：2006-02-16
申请号：US10656270
申请日：2003-09-05
申请人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David Olsen , David Williams , Olaf Heindenreich
发明人： Fritz Eckstein , Wolfgang Pieken , Fritz Benseler , David Olsen , David Williams , Olaf Heindenreich
IPC分类号： C07H21/02
CPC分类号： C07H21/02 , B65G47/846
摘要： The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2′-position of the ribose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino and disubstituted amino groups, a process for the preparation of modified RNA molecules and the use of modified RNA molecules as therapeutic agents and biocatalysts.
摘要翻译：本发明涉及具有至少一种修饰核苷的催化活性的RNA分子，其中核糖2'-位的羟基被选自卤素，巯基，叠氮基，氨基，单取代的修饰基团氨基和二取代的氨基，制备修饰的RNA分子的方法和使用修饰的RNA分子作为治疗剂和生物催化剂。

2. 发明申请

US20220235041A1 COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS 有权
公开(公告)号：US20220235041A1
公开(公告)日：2022-07-28
申请号：US17619338
申请日：2020-06-02
申请人： Brendan M. CROWLEY , Philippe NANTERMET , David OLSEN , Takao SUZUKI , Merck Sharp & Dohme Corp.
发明人： Brendan M. Crowley , Philippe Nantermet , David Olsen , Takao Suzuki
IPC分类号： C07D413/14 , C07D413/12 , C07D417/10 , A61K31/422 , A61K31/541 , C07D471/04 , A61K31/437 , C07D413/10 , A61K45/06 , A61P31/06 , A61P31/08
摘要： Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Also disclosed are compositions which comprise at least one of these dihydroisoxazole compounds, methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of these dihydroisoxazole compounds and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

3. 植物专利

USPP31444P2 Pear tree named ‘Olsen Bosc’ 有权
公开(公告)号：USPP31444P2
公开(公告)日：2020-02-18
申请号：US16350847
申请日：2019-01-22
申请人： David Olsen
发明人： David Olsen
IPC分类号： A01H5/08 , A01H6/74
摘要： The ‘Olsen Bosc’ pear tree, a mutation of ‘Bosc’, is notable for its distinctive fruit. Profound russeting on substantially the entire surface of the skin gives ‘Olsen Bosc’ pears a distinctive bronze appearance.

4. 发明授权

US08882252B2 Fluid cartridge 有权
标题翻译：流体盒
公开(公告)号：US08882252B2
公开(公告)日：2014-11-11
申请号：US13816695
申请日：2010-10-22
申请人： David C. Harvey , Curt Gonzales , Ralph L. Stathem , David Olsen , David Welter
发明人： David C. Harvey , Curt Gonzales , Ralph L. Stathem , David Olsen , David Welter
IPC分类号： B41J2/175
CPC分类号： B41J2/17526 , B41J2/17513 , B41J2/1752 , B41J2/1755 , B41J2/17553
摘要： An ink cartridge for an inkjet printer includes a bottom face and a front face; interfaces on the front face for connection to a cartridge receiving structure, the interfaces including an ink interface; a guide interface in the bottom face for guiding the cartridge along a straight line for connecting the interfaces; and a latch stop and a latch track, disposed in the bottom face, to guide and retain a latch of the cartridge receiving structure.
摘要翻译：用于喷墨打印机的墨盒包括底面和正面; 在前表面上的接口，用于连接到盒接收结构，所述接口包括墨接口; 位于底面的引导界面，用于沿着直线引导盒，用于连接接口; 以及设置在底面中的闩锁止动器和闩锁轨道，以引导和保持盒接收结构的闩锁。

5. 外观设计

USD712464S1 Ink cartridge 有权
公开(公告)号：USD712464S1
公开(公告)日：2014-09-02
申请号：US29402514
申请日：2011-09-23
申请人： David C. Harvey , David Olsen , Ralph L. Stathem
设计人： David C. Harvey , David Olsen , Ralph L. Stathem

6. 发明申请

US20130271538A1 INTEGRATED MULTIFUNCTIONAL VALVE DEVICE 有权
标题翻译：集成多功能阀装置
公开(公告)号：US20130271538A1
公开(公告)日：2013-10-17
申请号：US13977211
申请日：2011-01-07
申请人： Patrick V. Boyd , David Olsen , Milo A. Undlin
发明人： Patrick V. Boyd , David Olsen , Milo A. Undlin
IPC分类号： F16K31/16 , B41J2/175 , F16K7/16
CPC分类号： F16K31/16 , B41J2/17513 , F16K7/16 , F16K17/14
摘要： An integrated multifunctional valve device includes a surface member having a first port and a second port formed therein, a flexible disk member having a central portion and a surrounding portion, a first seat member extending outward from the surface member and coupled to the surrounding portion of the flexible disk member, a second seat member extending outward from the surface member and surrounded by the first seat member. The central portion is movable between an open port position to establish fluid communication between the respective ports and a close port position to stop the fluid communication between the respective ports. The second seat member is configured to selectively receive the central portion of the flexible disk member corresponding to the close port position. The integrated multifunctional valve device also includes an actuator member configured to selectively move the central portion of the flexible disk member into the open port position and the close port position.
摘要翻译：一种集成的多功能阀装置，包括具有形成在其中的第一端口和第二端口的表面构件，具有中心部分和周围部分的柔性盘构件，从表面构件向外延伸并连接到表面构件的周围部分的第一座构件柔性盘构件，从表面构件向外延伸并被第一座构件包围的第二座构件。中心部分可以在打开的端口位置之间移动，以在各个端口之间建立流体连通，以及关闭端口位置以停止各个端口之间的流体连通。第二座椅构件被配置为选择性地接收对应于关闭端口位置的柔性盘构件的中心部分。集成多功能阀装置还包括致动器构件，构造成选择性地将柔性盘构件的中心部分移动到打开端口位置和关闭端口位置。

7. 发明申请

US20130208061A1 FLUID CARTRIDGE 有权
标题翻译：流体盒
公开(公告)号：US20130208061A1
公开(公告)日：2013-08-15
申请号：US13880332
申请日：2011-07-22
申请人： David C. Harvey , David Olsen , Ralph L. Stathem
发明人： David C. Harvey , David Olsen , Ralph L. Stathem
IPC分类号： B41J2/175
CPC分类号： B41J2/1752 , B41J2/1755 , B41J2/17553
摘要： In one example, a fluid cartridge includes a reservoir for holding a fluid, an electrical interface, an alignment feature, and a keying feature. The alignment feature is configured to, as the cartridge is inserted into a receiver, bias the electrical interface against a corresponding electrical interface on the receiver. The keying feature discriminates the cartridge from other fluid cartridges to prevent the cartridge from being inserted incorrectly into the receiver.
摘要翻译：在一个示例中，流体盒包括用于保持流体的储存器，电接口，对准特征和键合特征。对准特征被配置为当盒被插入接收器时，将电接口偏压抵靠接收器上相应的电接口。键控功能将墨盒与其他流体墨盒区分开，以防止墨盒错误地插入接收器。

8. 发明申请

US20130141497A1 FLUID CONTAINER HAVING PLURALITY OF CHAMBERS, VALVES, AND AIR BAG ASSEMBLY 有权
标题翻译：具有气囊，阀和空气袋组件的多孔容器的流体容器
公开(公告)号：US20130141497A1
公开(公告)日：2013-06-06
申请号：US13484983
申请日：2012-05-31
申请人： Patrick V. Boyd , David Olsen , Patricia A. Kellar
发明人： Patrick V. Boyd , David Olsen , Patricia A. Kellar
IPC分类号： B41J2/175
CPC分类号： B41J2/17596 , B41J2/175 , B41J2/17513 , B65D83/0055
摘要： A fluid container includes a housing unit including a free-fluid chamber, a regulated chamber, and a plurality of valves. The free-fluid chamber is configured to store fluid. The regulated chamber includes an air bag assembly, an outlet, and a plurality of states. The air bag assembly is configured to regulate respective fluid therein and includes at least one air bag including an internal chamber having a volume capacity. The outlet is configured to transport the respective fluid from the regulated chamber. At least one of the plurality of valves is configured to selectively stop fluid communication between the regulated chamber and the free-fluid chamber based on the respective state of the regulated chamber.
摘要翻译：流体容器包括包括自由流体室，调节室和多个阀的壳体单元。自由流体室配置成存储流体。调节室包括气囊组件，出口和多个状态。气囊组件构造成在其中调节相应的流体，并且包括至少一个包括具有体积容量的内部腔的气囊。出口构造成从调节室输送相应的流体。多个阀中的至少一个被配置为基于调节室的相应状态选择性地停止调节室和自由流体室之间的流体连通。

9. 发明申请

US20120263263A1 MEDIA CLOCK NEGOTIATION 有权
标题翻译：媒体时钟谈判
公开(公告)号：US20120263263A1
公开(公告)日：2012-10-18
申请号：US13156866
申请日：2011-06-09
申请人： David Olsen , Levi Pearson
发明人： David Olsen , Levi Pearson
IPC分类号： H04L7/00
CPC分类号： H04L67/16 , H04J3/0641 , H04J3/0664 , H04L69/24 , H04L69/28 , H04N21/242 , H04N21/4305 , H04N21/4307
摘要： Media Clock Negotiation (MCN) Advertise packets may advertise one or more media clock streams. Each media clock stream may include values of a real-time clock sampled according to a first media clock. A second media clock may be recoverable from the media clock stream such that the second media clock is synchronized with the first media clock. One or more transmitters that receive the packets may determine whether the advertised media clock stream meets a set of media clock conditions. If the advertised media clock stream meets the set of media clock conditions, then the transmitter may add the advertised media clock stream to a set of qualified streams. Each transmitter may select a reference media clock stream from the set of qualified streams. By selecting the same reference media clock stream, media clocks at two or more transmitters may be synchronized.
摘要翻译：媒体时钟协商（MCN）广告包可能会广告一个或多个媒体时钟流。每个媒体时钟流可以包括根据第一媒体时钟采样的实时时钟的值。可以从媒体时钟流恢复第二媒体时钟，使得第二媒体时钟与第一媒体时钟同步。接收分组的一个或多个发射机可以确定所通告的媒体时钟流是否满足一组媒体时钟条件。如果通告的媒体时钟流满足媒体时钟条件集合，则发射机可以将所通告的媒体时钟流添加到一组合格的流。每个发射机可以从合格流集合中选择参考媒体时钟流。通过选择相同的参考媒体时钟流，可以同步两个或更多发射机的媒体时钟。

10. 发明申请

US20120050417A1 Printing device having supply of colorant that is non-refillable and at least substantially non-removable from end user perspective 审中-公开
标题翻译：印刷装置具有不可重新填充并且至少基本上不可移除的着色剂的终端用户观点
公开(公告)号：US20120050417A1
公开(公告)日：2012-03-01
申请号：US13189429
申请日：2011-07-22
申请人： David Olsen , Kevin D. Almen , Marc A. Baldwin , Patrick Therien , Tony S. Cruz-Uribe
发明人： David Olsen , Kevin D. Almen , Marc A. Baldwin , Patrick Therien , Tony S. Cruz-Uribe
IPC分类号： B41J2/175
CPC分类号： B41J2/175 , B41J2/17509 , B41J2/17513 , B41J2/1752 , B41J2/17553 , B41J2/17566 , B41J29/02 , B41J29/13
摘要： A printing device includes a supply of colorant that is non-refillable from an end user perspective and that is at least substantially non-removable from the printing device from the end user perspective. The printing device also includes a printing mechanism that forms images on media using the supply of colorant.
摘要翻译：打印装置包括从最终用户的角度不可重新填充并且从终端用户角度至少基本上不能从打印装置移除的着色剂的供应。打印装置还包括使用着色剂供应在介质上形成图像的打印机构。

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