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1. 发明授权

US07282034B2 Tissue accessing and anchoring device and method 有权
标题翻译：组织进入和锚定装置和方法
公开(公告)号：US07282034B2
公开(公告)日：2007-10-16
申请号：US10729086
申请日：2003-12-05
申请人： Fred H. Burbank , Paul Lubock , John Wardle , Frank Louw , Richard L. Quick
发明人： Fred H. Burbank , Paul Lubock , John Wardle , Frank Louw , Richard L. Quick
IPC分类号： A61B10/00
CPC分类号： A61B10/0266 , A61B6/4258 , A61B10/02 , A61B17/00491 , A61B18/1477 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1815 , A61B90/39 , A61B2010/0208 , A61B2017/00115 , A61B2017/00867 , A61B2017/3488 , A61B2018/00208 , A61B2018/00273 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00916 , A61B2018/00958 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3904 , A61B2090/3908 , A61B2090/392
摘要： The invention provides systems, methods and a node accessing and anchoring device, comprising an elongated shaft, a tissue cutting member, at least one anchoring element extending from a position at or near the distal end of the shaft; and a radiation detector. The radiation detector is effective to locate and identify sentinel lymph nodes following injection of radioactive material into a primary lesion site within a patient. The tissue cutting member, which may be activated with radio frequency energy, is effective to allow access of the elongated shaft to a sentinel lymph node. The anchoring elements are effective to anchor the device to or adjacent a sentinel lymph node accessed by the device. Anchoring elements may assume radially, longitudinally, or mixed radially and longitudinally curved or coiled configurations when deployed.
摘要翻译：本发明提供系统，方法和节点访问和锚定装置，包括细长轴，组织切割构件，至少一个锚固元件，其从所述轴的远端处或附近的位置延伸; 和辐射探测器。放射线检测器在将放射性物质注入患者的原发性病变部位之后，有效地定位和识别前哨淋巴结。可以用射频能量激活的组织切割构件有效地允许细长轴进入前哨淋巴结。锚定元件有效地将装置锚定到或邻近由装置访问的前哨淋巴结。锚定元件在展开时可以呈径向，纵向或混合的径向和纵向弯曲或卷绕构型。

2. 发明授权

US06679851B2 Tissue accessing and anchoring device and method 有权
公开(公告)号：US06679851B2
公开(公告)日：2004-01-20
申请号：US09880218
申请日：2001-06-12
申请人： Fred H. Burbank , Paul Lubock , John Wardle , Frank Louw , Richard L. Quick
发明人： Fred H. Burbank , Paul Lubock , John Wardle , Frank Louw , Richard L. Quick
IPC分类号： A61B1000
CPC分类号： A61B10/0266 , A61B6/4258 , A61B10/02 , A61B17/00491 , A61B18/1477 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1815 , A61B90/39 , A61B2010/0208 , A61B2017/00115 , A61B2017/00867 , A61B2017/3488 , A61B2018/00208 , A61B2018/00273 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00916 , A61B2018/00958 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3904 , A61B2090/3908 , A61B2090/392
摘要： The invention provides systems, methods and a node accessing and anchoring device, comprising an elongated shaft, a tissue cutting member, at least one anchoring element extending from a position at or near the distal end of the shaft; and a radiation detector. The radiation detector is effective to locate and identify sentinel lymph nodes following injection of radioactive material into a primary lesion site within a patient. The tissue cutting member, which may be activated with radio frequency energy, is effective to allow access of the elongated shaft to a sentinel lymph node. The anchoring elements are effective to anchor the device to or adjacent a sentinel lymph node accessed by the device. Anchoring elements may assume radially, longitudinally, or mixed radially and longitudinally curved or coiled configurations when deployed.

3. 发明申请

US20050197594A1 Tissue accessing and anchoring device and method 审中-公开
标题翻译：组织进入和锚定装置和方法
公开(公告)号：US20050197594A1
公开(公告)日：2005-09-08
申请号：US11112449
申请日：2005-04-21
申请人： Fred Burbank , Paul Lubock , John Wardle , Frank Louw , Richard Quick
发明人： Fred Burbank , Paul Lubock , John Wardle , Frank Louw , Richard Quick
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , A61B6/00
CPC分类号： A61B10/0266 , A61B6/4258 , A61B10/02 , A61B17/00491 , A61B18/1477 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1815 , A61B90/39 , A61B2010/0208 , A61B2017/00115 , A61B2017/00867 , A61B2017/3488 , A61B2018/00208 , A61B2018/00273 , A61B2018/00333 , A61B2018/00577 , A61B2018/00601 , A61B2018/00916 , A61B2018/00958 , A61B2018/1407 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3904 , A61B2090/3908 , A61B2090/392
摘要： The invention provides systems, methods and a node accessing and anchoring device, comprising an elongated shaft, a tissue cutting member, at least one anchoring element extending from a position at or near the distal end of the shaft; and a radiation detector. The radiation detector is effective to locate and identify sentinel lymph nodes following injection of radioactive material into a primary lesion site within a patient. The tissue cutting member, which may be activated with radio frequency energy, is effective to allow access of the elongated shaft to a sentinel lymph node. The anchoring elements are effective to anchor the device to or adjacent a sentinel lymph node accessed by the device. Anchoring elements may assume radially, longitudinally, or mixed radially and longitudinally curved or coiled configurations when deployed.
摘要翻译：本发明提供系统，方法和节点访问和锚定装置，包括细长轴，组织切割构件，至少一个锚固元件，其从所述轴的远端处或附近的位置延伸; 和辐射探测器。放射线检测器在将放射性物质注入患者的原发性病变部位之后，有效地定位和识别前哨淋巴结。可以用射频能量激活的组织切割构件有效地允许细长轴进入前哨淋巴结。锚定元件有效地将装置锚定到或邻近由装置访问的前哨淋巴结。锚定元件在展开时可以呈径向，纵向或混合的径向和纵向弯曲或卷绕构型。

4. 发明申请

US20050187489A1 Electrosurgical specimen-collection system 审中-公开
公开(公告)号：US20050187489A1
公开(公告)日：2005-08-25
申请号：US11098963
申请日：2005-04-04
申请人： John Wardle , Fred Burbank , Paul Lubock
发明人： John Wardle , Fred Burbank , Paul Lubock
IPC分类号： A61B20060101 , A61B10/00 , A61B10/02 , A61B10/04 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00
CPC分类号： A61B10/0233 , A61B10/02 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/37 , A61B2010/0208 , A61B2010/0225 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00291 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1455 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： Devices, methods and systems for obtaining biopsy tissue samples are provided. Flexible hollow tubes with a rail and a tip cutting element advance within a shaft with an aperture and a bore having a ramp, so that the cutting element emerges from the aperture and cuts tissue as it moves over the ramp. Either or both shaft and bore may have guides, which may engage each other to guide the tube along a tissue cutting pathway. A tube may have a rail and the bore a channel which engages the rail and guides the tube. Cut tissue may be acquired and transported proximally within the tube by suction to a tissue collection chamber. Multiple tissue samples may be obtained from a single insertion point by rotation and/or translation of the shaft between biopsies.

5. 发明授权

US08663150B2 Delivering ocular implants into the eye 有权
标题翻译：将眼部植入物投入眼睛
公开(公告)号：US08663150B2
公开(公告)日：2014-03-04
申请号：US13330592
申请日：2011-12-19
申请人： John Wardle , Andrew T. Schieber
发明人： John Wardle , Andrew T. Schieber
IPC分类号： A61F9/007 , A61M5/00
CPC分类号： A61F9/0026 , A61B17/3421 , A61B17/3468 , A61B2017/3454 , A61F9/0017 , A61F9/00781 , A61F2220/0033
摘要： A method of deploying an ocular implant into Schlemm's canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall; placing the distal opening of the cannula into fluid communication with Schlemm's canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening. The invention also includes a system for practicing the method.
摘要翻译：将眼部植入物部署到施莱姆的眼睛的运河中的方法。该方法包括以下步骤：将套管的远端插入眼睛的角膜并插入眼睛的前房，该套管具有从远端延伸并穿过侧壁的远端开口; 放置套管的远端开口与施莱姆氏管流体连通; 通过具有与眼部植入物接合的输送工具将眼部植入物向远端推进通过套管，眼睛植入物的近端部分接近输送工具的远端部分; 并且当眼部植入物的近端部分到达套管远端开口时，使眼部植入物和递送工具脱离接合。本发明还包括实施该方法的系统。

6. 发明申请

US20130331761A1 Methods and Apparatus for Treating Glaucoma 有权
公开(公告)号：US20130331761A1
公开(公告)日：2013-12-12
申请号：US13968051
申请日：2013-08-15
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

7. 发明申请

US20100121342A1 Methods and Apparatus for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼睛植入眼睛的方法和装置
公开(公告)号：US20100121342A1
公开(公告)日：2010-05-13
申请号：US12632738
申请日：2009-12-07
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A cannula for an ocular implant delivery system. In some embodiments, the cannula includes a tubular member having a curved portion, a distal opening surrounded by a distal opening surface, and a distal tip, the distal tip being adapted to be inserted into an anterior chamber of a human subject's eye, through trabecular meshwork and into Schlemm's canal of the eye, a proximal portion of the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm's canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance an ocular implant through the tubular member toward and through the distal opening into Schlemm's canal of the eye when the distal tip is disposed in Schlemm's canal. The invention also includes a method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.
摘要翻译：用于眼部植入物输送系统的插管。在一些实施例中，套管包括管状构件，其具有弯曲部分，由远侧开口表面包围的远侧开口和远侧末端，远侧末端适于通过小梁插入人类受试者眼睛的前房中网状物并进入眼睛的施莱姆氏管，管状构件的近端部分适于当远侧末端位于眼睛的施莱姆氏管中时从眼睛外部延伸，套管还适于与前进机构配合当远侧末端设置在施莱姆氏管中时，将眼部植入物穿过管状构件朝向并穿过远端开口进入眼睛的施莱姆氏管。本发明还包括将眼部植入物部署到人眼的施莱姆氏管中的方法，包括以下步骤：将眼睛的前房中的输送工具的远端通过眼睛的小梁网插入眼睛的施莱姆氏管 ; 并且将眼睛植入物推进通过输送工具的弯曲部分和远端开口，以将眼部植入物的主体部分放置在施莱姆氏管中，并将眼部植入物的入口部分放置在前房中。

8. 发明申请

US20060079769A1 Transmembrane access systems and methods 审中-公开
标题翻译：跨膜进入系统和方法
公开(公告)号：US20060079769A1
公开(公告)日：2006-04-13
申请号：US11239174
申请日：2005-09-28
申请人： James Whiting , Neal Eigler , John Wardle , Werner Hafelfinger , Brian Mann
发明人： James Whiting , Neal Eigler , John Wardle , Werner Hafelfinger , Brian Mann
IPC分类号： A61M25/00
CPC分类号： A61M25/007 , A61B2017/06076 , A61M25/0041 , A61M25/005 , A61M25/0051 , A61M25/0052 , A61M25/0054 , A61M25/0067 , A61M25/0068 , A61M25/0082 , A61M25/0084 , A61M25/09 , A61M2025/0004 , A61M2025/0089
摘要： Systems and methods for penetrating a tissue membrane to gain access to a target site are disclosed. In some examples, systems and methods for accessing the left atrium from the right atrium of a patient's heart are carried out by puncturing the intra-atrial septal wall. One embodiment provides a system for transseptal cardiac access that includes a stabilizer sheath having a side port, a shaped guiding catheter configured to exit the side port and a tissue penetration member disposed within and extendable from the distal end of the guide catheter. The tissue penetration member may be configured to penetrate tissue upon rotation and may be coupled to a distal portion of a torquable shaft. In some embodiments, the stabilizer sheath and shaped guiding catheter may be moved relative to the patient's body structure and relative to each other so that a desired approach angle may be obtained for the tissue penetration member with respect to the target tissue.
摘要翻译：公开了渗透组织膜以获得进入目标部位的系统和方法。在一些实例中，通过穿刺房间隔壁来进行从患者心脏的右心房进入左心房的系统和方法。一个实施例提供了一种经心脏通道的系统，其包括具有侧端口的稳定器护套，构造成离开侧端口的成形引导导管和设置在引导导管的远端内并且可从引导导管的远端延伸的组织穿透构件。组织穿透构件可以构造成在旋转时穿透组织并且可以联接到可扭转轴的远侧部分。在一些实施例中，稳定器护套和成形引导导管可以相对于患者的身体结构相对于彼此移动，使得组织穿透构件相对于目标组织可以获得期望的接近角。

9. 发明授权

US06979317B2 Device for delivering non-biodegradable bulking composition to a urological site 失效
标题翻译：将不可生物降解的填充组合物递送到泌尿部位的装置
公开(公告)号：US06979317B2
公开(公告)日：2005-12-27
申请号：US10188749
申请日：2002-07-05
申请人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
发明人： Kenneth M. Galt , John Wardle , Thomas J. Berryman
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61M5/178
CPC分类号： A61B17/00491 , A61B17/062 , A61B17/12022 , A61B17/12099 , A61B17/12186 , A61B17/3478 , A61B2017/00495 , A61B2017/00805 , A61B2017/1205 , A61F2/0036
摘要： A device for delivery of a biocompatible polymer composition for treatment of urinary incontinence provides for delivery of biocompatible polymer material and a solidification agent through two lumens. The delivery device provides better control of the precipitation of the polymer in the periurethral tissue and detachment of the precipitated mass from the delivery device. The medical device includes a needle having a lumen and an inner cannula positioned within the needle lumen and movable longitudinally in the needle lumen from an extended position to a withdrawn position to sheer or cut the delivered mass of polymer material away from the needle tip.
摘要翻译：用于递送用于治疗尿失禁的生物相容性聚合物组合物的装置提供通过两个流明递送生物相容性聚合物材料和固化剂。递送装置可以更好地控制聚合物在尿道周围组织中的沉淀，并将沉淀的物质与输送装置分离。医疗装置包括具有内腔和位于针内腔内的内套管的针，并且可在针内腔中从延伸位置纵向移动到撤回位置，以将输送的聚合物材料的质量远离针尖切割或切割。

10. 发明申请

US20130281907A1 Ocular Implants for Delivery into an Anterior Chamber of the Eye 有权
标题翻译：用于输送到眼睛前房的眼部植入物
公开(公告)号：US20130281907A1
公开(公告)日：2013-10-24
申请号：US13793638
申请日：2013-03-11
申请人： John Wardle , Andrew T. Schieber
发明人： John Wardle , Andrew T. Schieber
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An ocular implant adapted to be disposed within Schlemm's canal of a human eye with a body extending along a curved longitudinal central axis in a curvature plane, a first strut on one side of the implant and a second strut on an opposite side of the implant, the circumferential extent of the first strut with respect to the plane of curvature being greater than the circumferential extent of the second strut with respect to the plane of curvature. The invention also includes methods of using the implant.
摘要翻译：一种眼部植入物，其适于设置在人眼的施莱姆氏管内，其主体沿着曲率平面中的弯曲纵向中心轴线延伸，植入物一侧上的第一支柱和植入物相对侧上的第二支柱，第一支柱相对于曲面平面的圆周范围大于第二支柱相对于曲面平面的圆周范围。本发明还包括使用植入物的方法。

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