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1. 发明授权

US08529494B2 Methods and apparatus for treating glaucoma 有权
公开(公告)号：US08529494B2
公开(公告)日：2013-09-10
申请号：US13610769
申请日：2012-09-11
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007 , A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

2. 发明申请

US20130231603A1 Ocular Implants and Methods for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼部植入物和将眼部植入物植入眼睛的方法
公开(公告)号：US20130231603A1
公开(公告)日：2013-09-05
申请号：US13865770
申请日：2013-04-18
申请人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
发明人： John Wardle , Andrew T. Schieber , Kenneth M. Galt
IPC分类号： A61F9/007
CPC分类号： A61F9/0017 , A61F9/0026 , A61F9/00781
摘要： An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.
摘要翻译：提供眼部植入物。在一些实施例中，眼部植入物包括围绕纵向中心轴线弯曲的主体和限定包括通道开口的纵向通道的远侧主体部分。植入物的尺寸和构造使得眼睛植入物呈现出当眼部植入物置于施莱姆氏管中时通道开口邻近施莱姆管道的主侧的取向。还提供了将眼部植入物输送到施莱姆氏管中的方法。一些方法包括覆盖眼部植入物中的开口，将植入物推进到施莱姆氏管中，同时至少一些开口被覆盖，并且在植入物的远端部分设置在施莱姆管中时露出开口。

3. 发明申请

US20130079701A1 Methods and Apparatus for Delivering Ocular Implants Into the Eye 有权
公开(公告)号：US20130079701A1
公开(公告)日：2013-03-28
申请号：US13681365
申请日：2012-11-19
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.

4. 发明申请

US20130006165A1 Methods and Apparatus for Treating Glaucoma 有权
公开(公告)号：US20130006165A1
公开(公告)日：2013-01-03
申请号：US13610769
申请日：2012-09-11
申请人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
发明人： Charles L. Euteneuer , Thomas R. Hektner , Andrew T. Schieber , John Wardle
IPC分类号： A61F9/007 , A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F9/007 , A61F2009/00885 , A61F2009/00891 , A61K9/0051 , A61M27/002 , A61M2210/0612 , Y10S623/905 , Y10S623/906
摘要： An ocular implant for treating glaucoma is provided, which may include any number of features. More particularly, the present invention relates to implants that facilitate the transfer of fluid from within one area of the eye to another area of the eye. One feature of the implant is that it includes a proximal inlet portion and a distal inlet portion adapted to be inserted into the anterior chamber of the eye, and an intermediate portion adapted to be inserted into Schlemm's canal. Another feature of the implant is that it can be biased to assume a predetermined shape to aid in placement within the eye.

5. 发明申请

US20100222733A1 Glaucoma Treatment Method 有权
标题翻译：青光眼治疗方法
公开(公告)号：US20100222733A1
公开(公告)日：2010-09-02
申请号：US12775266
申请日：2010-05-06
申请人： Andrew T. Schieber , Charles L. Euteneuer
发明人： Andrew T. Schieber , Charles L. Euteneuer
IPC分类号： A61M1/00 , A61F2/14
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2009/00891 , A61M27/002 , A61M2210/0612
摘要： An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas extending over more than 50% of a surface defining the curved volume, the strut areas surrounding the open areas, the body having a diameter of between 0.005 inches and 0.04 inches. The invention also provides a method of treating glaucoma including the steps of supporting tissue forming Schlemm's canal in an eye with an implant extending at least partially in the canal along an axial length within the canal; and contacting with the implant less than 50% of the tissue forming the canal along the axial length.
摘要翻译：适于至少部分地居住在眼睛的施莱姆氏管的一部分中的眼部植入物。在一些实施例中，植入物具有在弯曲体积中延伸的主体，其纵向轴线形成圆弧，以及形成在主体中的多个开放区域和支柱区域，所述开放区域延伸超过表面的50％以上弯曲的体积，围绕开放区域的支柱区域，主体具有在0.005英寸和0.04英寸之间的直径。本发明还提供一种治疗青光眼的方法，包括以下步骤：在眼睛中支撑组织形成施莱姆氏管，其中植入物至少部分地沿着管内的轴向长度延伸至管内; 并且沿着轴向长度与植入物接触形成管的少于50％的组织。

6. 发明申请

US20090082860A1 Ocular Implants with Asymmetric Flexibility 有权
标题翻译：具有不对称柔性的眼植入物
公开(公告)号：US20090082860A1
公开(公告)日：2009-03-26
申请号：US12236225
申请日：2008-09-23
申请人： Andrew T. Schieber , Charles L. Euteneuer
发明人： Andrew T. Schieber , Charles L. Euteneuer
IPC分类号： A61F2/14 , A61K9/00 , A61P27/02
CPC分类号： A61F9/00781 , A61F2/14 , A61F2/15 , A61F2220/0008 , A61F2250/0067
摘要： An ocular implant having a body extending along a generally curved longitudinal axis, the curved longitudinal axis defining a first plane, the body having a diameter of between 0.005 inches and 0.04 inches and being adapted to be disposed within a canal of Schlemm in a human subject's eye; wherein the body has a first flexibility when bent along the first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane. Another aspect of the invention provides a method of treating a human eye, including the steps of: inserting an implant into Schlemm's canal of a human eye, the implant having a first flexibility when bent along a first plane and a second flexibility different from the first flexibility when bent along a second plane that intersects the first plane and is not coincident with the first plane; and supporting tissue forming Schlemm's canal with the implant.
摘要翻译：一种眼部植入物，其具有沿着大致弯曲的纵向轴线延伸的主体，所述弯曲纵向轴线限定第一平面，所述主体具有在0.005英寸和0.04英寸之间的直径，并且适于设置在人类受试者的Schlemm的管道内眼; 其中当沿着与所述第一平面相交并且与所述第一平面不一致的第二平面弯曲时，所述主体沿着所述第一平面弯曲时具有第一柔性，并且所述第二柔性不同于所述第一柔性。本发明的另一方面提供了一种治疗人眼的方法，包括以下步骤：将植入物插入人眼的施莱姆氏管中，所述植入物沿着第一平面弯曲时具有第一柔性，并且具有与第一平面不同的第二柔性当沿着与第一平面相交并且不与第一平面重合的第二平面弯曲时的柔性; 并用植入物支撑组织形成Schlemm的运河。

7. 发明申请

US20160250072A1 OCULAR IMPLANTS FOR DELIVERY INTO AN ANTERIOR CHAMBER OF THE EYE 审中-公开
标题翻译：用于输送到眼睛前庭的OCALAR植入物
公开(公告)号：US20160250072A1
公开(公告)日：2016-09-01
申请号：US15150175
申请日：2016-05-09
申请人： John WARDLE , Andrew T. SCHIEBER
发明人： John WARDLE , Andrew T. SCHIEBER
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An ocular implant adapted to be disposed within Schlemm's canal of a human eye with a body extending along a curved longitudinal central axis in a curvature plane, a first strut on one side of the implant and a second strut on an opposite side of the implant, the circumferential extent of the first strut with respect to the plane of curvature being greater than the circumferential extent of the second strut with respect to the plane of curvature. The invention also includes methods of using the implant.
摘要翻译：一种眼部植入物，其适于设置在人眼的施莱姆氏管内，其主体沿着曲率平面中的弯曲纵向中心轴线延伸，植入物一侧上的第一支柱和植入物相对侧上的第二支柱，第一支柱相对于曲面平面的圆周范围大于第二支柱相对于曲面平面的圆周范围。本发明还包括使用植入物的方法。

8. 发明申请

US20160051406A1 OCULAR IMPLANTS AND METHODS FOR DELIVERING OCULAR IMPLANTS INTO THE EYE 审中-公开
标题翻译：用于将眼部植入物输送到眼睛的OCALAR植入物和方法
公开(公告)号：US20160051406A1
公开(公告)日：2016-02-25
申请号：US14932658
申请日：2015-11-04
申请人： John WARDLE , Andrew T. SCHIEBER , Kenneth M. GALT
发明人： John WARDLE , Andrew T. SCHIEBER , Kenneth M. GALT
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F9/0026 , A61F9/00781
摘要： An ocular implant is provided. In some embodiments, the ocular implant includes a body that is curved about a longitudinal central axis and a distal body portion that defines a longitudinal channel including a channel opening. The implant is sized and configured such that the ocular implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal when the ocular implant is disposed in Schlemm's canal. Methods for delivering ocular implants into Schlemm's canal are also provided. Some methods include covering openings in the ocular implant, advancing the implant into Schlemm's canal while at least some of the openings are covered, and uncovering the openings while the distal portion of the implant is disposed in Schlemm's canal.
摘要翻译：提供眼部植入物。在一些实施例中，眼部植入物包括围绕纵向中心轴线弯曲的主体和限定包括通道开口的纵向通道的远侧主体部分。植入物的尺寸和构造使得眼睛植入物呈现出当眼部植入物置于施莱姆氏管中时通道开口邻近施莱姆管道的主侧的取向。还提供了将眼部植入物输送到施莱姆氏管中的方法。一些方法包括覆盖眼部植入物中的开口，将植入物推进到施莱姆氏管中，同时至少一些开口被覆盖，并且在植入物的远端部分设置在施莱姆管中时露出开口。

9. 发明申请

US20130281907A1 Ocular Implants for Delivery into an Anterior Chamber of the Eye 有权
标题翻译：用于输送到眼睛前房的眼部植入物
公开(公告)号：US20130281907A1
公开(公告)日：2013-10-24
申请号：US13793638
申请日：2013-03-11
申请人： John Wardle , Andrew T. Schieber
发明人： John Wardle , Andrew T. Schieber
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An ocular implant adapted to be disposed within Schlemm's canal of a human eye with a body extending along a curved longitudinal central axis in a curvature plane, a first strut on one side of the implant and a second strut on an opposite side of the implant, the circumferential extent of the first strut with respect to the plane of curvature being greater than the circumferential extent of the second strut with respect to the plane of curvature. The invention also includes methods of using the implant.
摘要翻译：一种眼部植入物，其适于设置在人眼的施莱姆氏管内，其主体沿着曲率平面中的弯曲纵向中心轴线延伸，植入物一侧上的第一支柱和植入物相对侧上的第二支柱，第一支柱相对于曲面平面的圆周范围大于第二支柱相对于曲面平面的圆周范围。本发明还包括使用植入物的方法。

10. 发明授权

US08512404B2 Ocular implant delivery system and method 有权
标题翻译：眼植入物输送系统及方法
公开(公告)号：US08512404B2
公开(公告)日：2013-08-20
申请号：US11943289
申请日：2007-11-20
申请人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
发明人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F2/16
CPC分类号： A61F9/00781
摘要： A method of inserting an ocular implant into a patient's eye, the ocular implant being mounted on a carrier, the method comprising: inserting a cannula into an anterior chamber of the eye; moving a distal exit port of the cannula into communication with Schlemm's canal; and advancing the ocular implant and carrier through an exit port of the cannula into Schlemm's canal. The invention also provides an ocular implant and delivery system comprising: a cannula comprising a distal exit port adapted to be inserted into a Schlemm's canal portion of an eye; an ocular implant; a carrier disposed within the implant and movable with the implant within the cannula; and a proximal control adapted to be operated from exterior to an eye to move at least one of the carrier and the implant when the distal exit port of the cannula is within the eye.
摘要翻译：一种将眼部植入物插入患者眼睛中的方法，所述眼部植入物安装在载体上，所述方法包括：将插管插入眼睛的前房; 将插管的远端出口移动与施莱姆氏管连通; 并将眼部植入物和载体通过套管的出口延伸进入施莱姆氏管。本发明还提供一种眼部植入物和递送系统，包括：套管，其包括适于插入眼睛的施莱姆氏管部分的远端出口; 眼部植入物; 布置在所述植入物内并与所述植入物在所述插管内移动的载体; 以及当所述套管的远端出口在眼睛内时适于从外部操作到眼睛以移动载体和植入物中的至少一个的近端控制器。

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